PERSPECTIVES IN PHARMACOLOGY:

Karl K. Rozman and John Doull

The Role of Time as a Quantifiable Variable of Toxicity and the Experimental Conditions When Haber's c × t Product Can Be Observed: Implications for Therapeutics
J Pharmacol Exp Ther 2001 296: 663-668. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Masayo Yamazaki, William E. Neway, Tomoyuki Ohe, I-Wu Chen, Janice F. Rowe, Jerome H. Hochman, Masato Chiba, and Jiunn H. Lin

In Vitro Substrate Identification Studies for P-glycoprotein-Mediated Transport: Species Difference and Predictability of in Vivo Results
J Pharmacol Exp Ther 2001 296: 723-735. [Abstract] [Full Text] [PDF]  

Leslie L. Muldoon, Shannan L. Walker-Rosenfeld, Christopher Hale, Shawna E. Purcell, Lisa C. Bennett, and Edward A. Neuwelt

Rescue from Enhanced Alkylator-Induced Cell Death with Low Molecular Weight Sulfur-Containing Chemoprotectants
J Pharmacol Exp Ther 2001 296: 797-805. [Abstract] [Full Text] [PDF]  

Richard S. Geary, Tanya A. Watanabe, LoAnne Truong, Sue Freier, Elena A. Lesnik, Namir B. Sioufi, Henri Sasmor, Muthiah Manoharan, and Arthur A. Levin

Pharmacokinetic Properties of 2'-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats
J Pharmacol Exp Ther 2001 296: 890-897. [Abstract] [Full Text] [PDF]  

Richard S. Geary, Oleg Khatsenko, Keith Bunker, Rosanne Crooke, Max Moore, Todd Burckin, LoAnne Truong, Henri Sasmor, and Arthur A. Levin

Absolute Bioavailability of 2'-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides following Intraduodenal Instillation in Rats
J Pharmacol Exp Ther 2001 296: 898-904. [Abstract] [Full Text] [PDF]  

Tom C. Krejcie, Zhao Wang, and Michael J. Avram

Drug-Induced Hemodynamic Perturbations Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water
J Pharmacol Exp Ther 2001 296: 922-930. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Gaétan Thibault, Patrick Tardif, and Geneviève Lapalme

Comparative Specificity of Platelet _IIb3 Integrin Antagonists
J Pharmacol Exp Ther 2001 296: 690-696. [Abstract] [Full Text] [PDF]  

Jennifer C. Sullivan and Cathy A. Davison

Gender Differences in the Effect of Age on Electrical Field Stimulation (EFS)-Induced Adrenergic Vasoconstriction in Rat Mesenteric Resistance Arteries
J Pharmacol Exp Ther 2001 296: 782-788. [Abstract] [Full Text] [PDF]  

Mark E. Anderson, Alexander Mazur, Tao Yang, and Dan M. Roden

Potassium Current Antagonist Properties and Proarrhythmic Consequences of Quinolone Antibiotics
J Pharmacol Exp Ther 2001 296: 806-810. [Abstract] [Full Text] [PDF]  

Peter W. Stengel and Marlene L. Cohen

Low-Affinity M₂ Receptor Binding State Mediates Mouse Atrial Bradycardia: Comparative Effects of Carbamylcholine and the M₁ Receptor Agonists Sabcomeline and Xanomeline
J Pharmacol Exp Ther 2001 296: 818-824. [Abstract] [Full Text] [PDF]  

Sandra Filippi, Astrid Parenti, Sandra Donnini, Harris J. Granger, Alessandro Fazzini, and Fabrizio Ledda

_1D-Adrenoceptors Cause Endothelium-Dependent Vasodilatation in the Rat Mesenteric Vascular Bed
J Pharmacol Exp Ther 2001 296: 869-875. [Abstract] [Full Text] [PDF]  

Manuela Tramontana, Alessandro Lecci, Stefania Meini, Xavier Montserrat, Jaume Pascual, Sandro Giuliani, Laura Quartara, and Carlo Alberto Maggi

Differences between Peptide and Nonpeptide B₂ Bradykinin Receptor Antagonists in Blocking Bronchoconstriction and Hypotension Induced by Bradykinin in Anesthetized Guinea Pigs
J Pharmacol Exp Ther 2001 296: 1051-1057. [Abstract] [Full Text] [PDF]  

Chi Dae Kim, Hyung Hwan Kim, Yong Ki Kim, Yong Keun Kwak, Sun-Ok Kim, Sung-Eun Yoo, and Ki Whan Hong

Antiangiogenic Effect of KR31372 in Rat Sponge Implant Model
J Pharmacol Exp Ther 2001 296: 1085-1090. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Eugenia Bloch-Shilderman, Hao Jiang, Saleh Abu-Raya, Michal Linial, and Philip Lazarovici

Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells
J Pharmacol Exp Ther 2001 296: 704-711. [Abstract] [Full Text] [PDF]  

Sarinee Kalandakanond and Julie A. Coffield

Cleavage of Intracellular Substrates of Botulinum Toxins A, C, and D in a Mammalian Target Tissue
J Pharmacol Exp Ther 2001 296: 749-755. [Abstract] [Full Text] [PDF]  

Nambi Aiyar, Robert A. Daines, Jyoti Disa, Pamela A. Chambers, Charles F. Sauermelch, Marie-J. Quiniou, Nassirah Khandoudi, Bernard Gout, Stephen A. Douglas, and Robert N. Willette

Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist
J Pharmacol Exp Ther 2001 296: 768-775. [Abstract] [Full Text] [PDF]  

Suzanne Doolen and Nancy R. Zahniser

Protein Tyrosine Kinase Inhibitors Alter Human Dopamine Transporter Activity in Xenopus Oocytes
J Pharmacol Exp Ther 2001 296: 931-938. [Abstract] [Full Text] [PDF]  

A. D. Hibell, K. M. Thompson, M. Xing, P. P. A. Humphrey, and A. D. Michel

Complexities of Measuring Antagonist Potency at P2X₇ Receptor Orthologs
J Pharmacol Exp Ther 2001 296: 947-957. [Abstract] [Full Text] [PDF]  

Sarinee Kalandakanond and Julie A. Coffield

Cleavage of SNAP-25 by Botulinum Toxin Type A Requires Receptor-Mediated Endocytosis, pH-Dependent Translocation, and Zinc
J Pharmacol Exp Ther 2001 296: 980-986. [Abstract] [Full Text] [PDF]  

Kelley L. Morse, Jiang Behan, Thomas M. Laz, Robert E. West, Jr., Scott A. Greenfeder, John C. Anthes, Shelby Umland, Yuntao Wan, R. William Hipkin, Waldemar Gonsiorek, Niu Shin, Eric L. Gustafson, Xudong Qiao, Suke Wang, Joseph A. Hedrick, Jonathan Greene, Marvin Bayne, and Frederick J. Monsma, Jr.

Cloning and Characterization of a Novel Human Histamine Receptor
J Pharmacol Exp Ther 2001 296: 1058-1066. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Zhong-Ping Chen, Zhi-Min Wang, Christopher A. Carter, Michael C. Alley, Gérard Mohr, and Lawrence C. Panasci

Both Extraneuronal Monoamine Transporter and O⁶-Methylguanine-DNA Methyltransferase Expression Influence the Antitumor Efficacy of 2-Chloroethyl-3-sarcosinamide- 1-nitrosourea in Human Tumor Xenografts
J Pharmacol Exp Ther 2001 296: 712-715. [Abstract] [Full Text] [PDF]  

Yi Xu, W. Kent Hansen, Thomas A. Rosenquist, David A. Williams, Melissa Limp-Foster, and Mark R. Kelley

Protection of Mammalian Cells against Chemotherapeutic Agents Thiotepa, 1,3-N,N'-Bis(2-chloroethyl)-N-nitrosourea, and Mafosfamide Using the DNA Base Excision Repair Genes Fpg and -hOgg1: Implications for Protective Gene Therapy Applications
J Pharmacol Exp Ther 2001 296: 825-831. [Abstract] [Full Text] [PDF]  

Stephanie L. Matheson, James McNamee, and Bertrand J. Jean-Claude

Design of a Chimeric 3-Methyl-1,2,3-triazene with Mixed Receptor Tyrosine Kinase and DNA Damaging Properties: A Novel Tumor Targeting Strategy
J Pharmacol Exp Ther 2001 296: 832-840. [Abstract] [Full Text] [PDF]  

Anthony E. Pegg, Karina Goodtzova, Natalia A. Loktionova, Sreenivas Kanugula, Gary T. Pauly, and Robert C. Moschel

Inactivation of Human O⁶-Alkylguanine-DNA Alkyltransferase by Modified Oligodeoxyribonucleotides Containing O⁶-Benzylguanine
J Pharmacol Exp Ther 2001 296: 958-965. [Abstract] [Full Text] [PDF]  

Seong Hoon Jang, M. Guillaume Wientjes, and Jessie L.-S. Au

Enhancement of Paclitaxel Delivery to Solid Tumors by Apoptosis-Inducing Pretreatment: Effect of Treatment Schedule
J Pharmacol Exp Ther 2001 296: 1035-1042. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Mar Trujillo, Luz Candenas, Cristina G. Cintado, Josefina Magraner, Javier Fernandez, Julio D. Martín, and Francisco M. Pinto

Hormonal Regulation of the Contractile Response Induced by Okadaic Acid in the Rat Uterus
J Pharmacol Exp Ther 2001 296: 841-848. [Abstract] [Full Text] [PDF]  

Jack H. Mendelson, Michelle B. Sholar, Arthur J. Siegel, and Nancy K. Mello

Effects of Cocaine on Luteinizing Hormone in Women during the Follicular and Luteal Phases of the Menstrual Cycle and in Men
J Pharmacol Exp Ther 2001 296: 972-979. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Char-Chang Shieh, Jianlin Feng, Steven A. Buckner, Jorge D. Brioni, Michael J. Coghlan, James P. Sullivan, and Murali Gopalakrishnan

Functional Implication of Spare ATP-Sensitive K⁺ Channels in Bladder Smooth Muscle Cells
J Pharmacol Exp Ther 2001 296: 669-675. [Abstract] [Full Text] [PDF]  

Shuichi Sato, Akiyoshi Ohtake, Hiroshi Matsushima, Chikashi Saitoh, Shinji Usuda, and Keiji Miyata

Pharmacological Effect of Tamsulosin in Relation to Dog Plasma and Tissue Concentrations: Prostatic and Urethral Retention Possibly Contributes to Uroselectivity of Tamsulosin
J Pharmacol Exp Ther 2001 296: 697-703. [Abstract] [Full Text] [PDF]  

Ganesh Prasanna, Adnan Dibas, Christina Hulet, and Thomas Yorio

Inhibition of Na⁺/K⁺-ATPase by Endothelin-1 in Human Nonpigmented Ciliary Epithelial Cells
J Pharmacol Exp Ther 2001 296: 966-971. [Abstract] [Full Text] [PDF]  

Rodney F. Minchin, Denise Carpenter, and Rebecca J. Orr

Polyinosinic Acid and Polycationic Liposomes Attenuate the Hepatic Clearance of Circulating Plasmid DNA
J Pharmacol Exp Ther 2001 296: 1006-1012. [Abstract] [Full Text] [PDF]  

Hiroyuki Konomi, Charmaine M. Woods, Adrian C. B. Meedeniya, Lynne C. Giles, James Toouli, and Gino T. P. Saccone

Effects of Diaspirin Cross-linked Hemoglobin on Motor Function of the Duodenum and Biliary System in the Australian Brush-Tailed Possum in Vivo
J Pharmacol Exp Ther 2001 296: 1067-1073. [Abstract] [Full Text] [PDF]  

Mahin D. Maines, James F. Ewing, Tian J. Huang, and Nariman Panahian

Nuclear Localization of Biliverdin Reductase in the Rat Kidney: Response to Nephrotoxins That Induce Heme Oxygenase-1
J Pharmacol Exp Ther 2001 296: 1091-1097. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Stefano Bellosta, Monica Canavesi, Elda Favari, Luciano Cominacini, Giovanni Gaviraghi, Remo Fumagalli, Rodolfo Paoletti, and Franco Bernini

Lacidipine Modulates the Secretion of Matrix Metalloproteinase-9 by Human Macrophages
J Pharmacol Exp Ther 2001 296: 736-743. [Abstract] [Full Text] [PDF]  

Juan J. Moreno

Antiflammin-2 Prevents HL-60 Adhesion to Endothelial Cells and Prostanoid Production Induced by Lipopolysaccharides
J Pharmacol Exp Ther 2001 296: 884-889. [Abstract] [Full Text] [PDF]  

John J. E. Haddad, Bared Safieh-Garabedian, Nayef E. Saadé, and Stephen C. Land

Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium
J Pharmacol Exp Ther 2001 296: 996-1005. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Machiko Matsumoto, Hiroko Togashi, Kiyoshi Mori, Ken-ichi Ueno, Satoshi Ohashi, Taku Kojima, and Mitsuhiro Yoshioka

Evidence for Involvement of Central 5-HT₄ Receptors in Cholinergic Function Associated with Cognitive Processes: Behavioral, Electrophysiological, and Neurochemical Studies
J Pharmacol Exp Ther 2001 296: 676-682. [Abstract] [Full Text] [PDF]  

Ying-Jun Cao, John C. Dreixler, Jeffrey D. Roizen, Michael T. Roberts, and Khaled M. Houamed

Modulation of Recombinant Small-Conductance Ca²⁺-Activated K⁺ Channels by the Muscle Relaxant Chlorzoxazone and Structurally Related Compounds
J Pharmacol Exp Ther 2001 296: 683-689. [Abstract] [Full Text] [PDF]  

Elizabeth L. Godden, R. Adron Harris, and Thomas V. Dunwiddie

Correlation between Molecular Volume and Effects of n-Alcohols on Human Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 2001 296: 716-722. [Abstract] [Full Text] [PDF]  

Robin James Goody and Ian Kitchen

Influence of Maternal Milk on Functional Activation of -Opioid Receptors in Postnatal Rats
J Pharmacol Exp Ther 2001 296: 744-748. [Abstract] [Full Text] [PDF]  

Christopher W. Loomis, Hemal Khandwala, Geraldine Osmond, and Michael P. Hefferan

Coadministration of Intrathecal Strychnine and Bicuculline Effects Synergistic Allodynia in the Rat: An Isobolographic Analysis
J Pharmacol Exp Ther 2001 296: 756-761. [Abstract] [Full Text] [PDF]  

Jeffrey M. Brown, Glen R. Hanson, and Annette E. Fleckenstein

Regulation of the Vesicular Monoamine Transporter-2: A Novel Mechanism for Cocaine and Other Psychostimulants
J Pharmacol Exp Ther 2001 296: 762-767. [Abstract] [Full Text] [PDF]  

John J. Wagner, Lida R. Etemad, and Angela M. Thompson

Opioid-Mediated Facilitation of Long-Term Depression in Rat Hippocampus
J Pharmacol Exp Ther 2001 296: 776-781. [Abstract] [Full Text] [PDF]  

Lee Koetzner, Shixian Deng, Tina L. Sumpter, Michael Weisslitz, Ronald T. Abner, Donald W. Landry, and James H. Woods

Titer-Dependent Antagonism of Cocaine following Active Immunization in Rhesus Monkeys
J Pharmacol Exp Ther 2001 296: 789-796. [Abstract] [Full Text] [PDF]  

Miao-Kun Sun, Dennis Dahl, and Daniel L. Alkon

Heterosynaptic Transformation of GABAergic Gating in the Hippocampus and Effects of Carbonic Anhydrase Inhibition
J Pharmacol Exp Ther 2001 296: 811-817. [Abstract] [Full Text] [PDF]  

Kenneth A. Perkins, Debra Gerlach, Michelle Broge, James E. Grobe, Mark Sanders, Carolyn Fonte, Josh Vender, Christine Cherry, and Annette Wilson

Dissociation of Nicotine Tolerance from Tobacco Dependence in Humans
J Pharmacol Exp Ther 2001 296: 849-856. [Abstract] [Full Text] [PDF]  

Subhash C. Pandey, Adip Roy, and Navdha Mittal

Effects of Chronic Ethanol Intake and Its Withdrawal on the Expression and Phosphorylation of the CREB Gene Transcription Factor in Rat Cortex
J Pharmacol Exp Ther 2001 296: 857-868. [Abstract] [Full Text] [PDF]  

Ronald Kuczenski and David S. Segal

Locomotor Effects of Acute and Repeated Threshold Doses of Amphetamine and Methylphenidate: Relative Roles of Dopamine and Norepinephrine
J Pharmacol Exp Ther 2001 296: 876-883. [Abstract] [Full Text] [PDF]  

Melissa Phillips, Cheng Wang, and Kenneth M. Johnson

Pharmacological Characterization of Locomotor Sensitization Induced by Chronic Phencyclidine Administration
J Pharmacol Exp Ther 2001 296: 905-913. [Abstract] [Full Text] [PDF]  

Tomoko Ikeda, Xilong Zhao, Keiichi Nagata, Yoshiaki Kono, Toshio Shono, Jay Z. Yeh, and Toshio Narahashi

Fipronil Modulation of -Aminobutyric Acid_A Receptors in Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 2001 296: 914-921. [Abstract] [Full Text] [PDF]  

Michael R. Brandt, M. Scott Furness, Nancy K. Mello, Kenner C. Rice, and S. Stevens Negus

Antinociceptive Effects of -Opioid Agonists in Rhesus Monkeys: Effects on Chemically Induced Thermal Hypersensitivity
J Pharmacol Exp Ther 2001 296: 939-946. [Abstract] [Full Text] [PDF]  

Gabriella Gobbi, Dennis L. Murphy, Klaus-Peter Lesch, and Pierre Blier

Modifications of the Serotonergic System in Mice Lacking Serotonin Transporters: An in Vivo Electrophysiological Study
J Pharmacol Exp Ther 2001 296: 987-995. [Abstract] [Full Text] [PDF]  

Jenny L. Wiley, Renée G. Jefferson, Mark C. Grier, Anu Mahadevan, Raj K. Razdan, and Billy R. Martin

Novel Pyrazole Cannabinoids: Insights into CB₁ Receptor Recognition and Activation
J Pharmacol Exp Ther 2001 296: 1013-1022. [Abstract] [Full Text] [PDF]  

Dennis K. Miller, Peter A. Crooks, Lihong Teng, Jeffrey M. Witkin, Patrik Munzar, Steven R. Goldberg, Jane B. Acri, and Linda P. Dwoskin

Lobeline Inhibits the Neurochemical and Behavioral Effects of Amphetamine
J Pharmacol Exp Ther 2001 296: 1023-1034. [Abstract] [Full Text] [PDF]  

Min Liu, Brian F. King, Philip M. Dunn, Weifang Rong, Andrea Townsend-Nicholson, and Geoffrey Burnstock

Coexpression of P2X₃ and P2X₂ Receptor Subunits in Varying Amounts Generates Heterogeneous Populations of P2X Receptors That Evoke a Spectrum of Agonist Responses Comparable to That Seen in Sensory Neurons
J Pharmacol Exp Ther 2001 296: 1043-1050. [Abstract] [Full Text] [PDF]  

Takanori Hayakawa, Michael C. J. Chang, Stanley I. Rapoport, and Nathan M. Appel

Selective Dopamine Receptor Stimulation Differentially Affects [³H]Arachidonic Acid Incorporation, a Surrogate Marker for Phospholipase A₂-Mediated Neurotransmitter Signal Transduction, in a Rodent Model of Parkinson's Disease
J Pharmacol Exp Ther 2001 296: 1074-1084. [Abstract] [Full Text] [PDF]  

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