PERSPECTIVES IN PHARMACOLOGY:

Robert B. Moreland, Gin Hsieh, Masaki Nakane, and Jorge D. Brioni

The Biochemical and Neurologic Basis for the Treatment of Male Erectile Dysfunction
J Pharmacol Exp Ther 2001 296: 225-234. [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

John M. Hevko, Rebecca C. Bowers, and Robert C. Murphy

Synthesis of 5-Oxo-6,8,11,14-eicosatetraenoic Acid and Identification of Novel -Oxidized Metabolites in the Mouse Macrophage
J Pharmacol Exp Ther 2001 296: 293-305. [Abstract] [Full Text] [PDF]  

Jens M. Baron, Lay Beng Goh, Denggao Yao, C. Roland Wolf, and Thomas Friedberg

Modulation of P450 CYP3A4-Dependent Metabolism by P-glycoprotein: Implications for P450 Phenotyping
J Pharmacol Exp Ther 2001 296: 351-358. [Abstract] [Full Text] [PDF]  

Rosie Z. Yu, Hong Zhang, Richard S. Geary, Mark Graham, Lilit Masarjian, Kristina Lemonidis, Rosanne Crooke, Nicholas M. Dean, and Arthur A. Levin

Pharmacokinetics and Pharmacodynamics of an Antisense Phosphorothioate Oligonucleotide Targeting Fas mRNA in Mice
J Pharmacol Exp Ther 2001 296: 388-395. [Abstract] [Full Text] [PDF]  

Yong-Hae Han, Douglas H. Sweet, Dan-Ning Hu, and John B. Pritchard

Characterization of a Novel Cationic Drug Transporter in Human Retinal Pigment Epithelial Cells
J Pharmacol Exp Ther 2001 296: 450-457. [Abstract] [Full Text] [PDF]  

Bertrand Rochat, Janine M. Morsman, Graeme I. Murray, William D. Figg, and Howard L. McLeod

Human CYP1B1 and Anticancer Agent Metabolism: Mechanism for Tumor-Specific Drug Inactivation?
J Pharmacol Exp Ther 2001 296: 537-541. [Abstract] [Full Text] [PDF]  

Xiaoming Cui, Hidenori Kawashima, Thomas B. Barclay, Jeffrey M. Peters, Frank J. Gonzalez, Edward T. Morgan, and Henry W. Strobel

Molecular Cloning and Regulation of Expression of Two Novel Mouse CYP4F Genes: Expression in Peroxisome Proliferator-Activated Receptor -Deficient Mice upon Lipopolysaccharide and Clofibrate Challenges
J Pharmacol Exp Ther 2001 296: 542-550. [Abstract] [Full Text] [PDF]  

Elena V. Batrakova, Donald W. Miller, Shu Li, Valery Yu Alakhov, Alexander V. Kabanov, and William F. Elmquist

Pluronic P85 Enhances the Delivery of Digoxin to the Brain: In Vitro and in Vivo Studies
J Pharmacol Exp Ther 2001 296: 551-557. [Abstract] [Full Text] [PDF]  

R. H. Stephens, C. A. O'Neill, A. Warhurst, G. L. Carlson, M. Rowland, and G. Warhurst

Kinetic Profiling of P-glycoprotein-Mediated Drug Efflux in Rat and Human Intestinal Epithelia
J Pharmacol Exp Ther 2001 296: 584-591. [Abstract] [Full Text] [PDF]  

Shakil A. Saghir, Kristian Fried, and Karl K. Rozman

Kinetics of Monochloroacetic Acid in Adult Male Rats after Intravenous Injection of a Subtoxic and a Toxic Dose
J Pharmacol Exp Ther 2001 296: 612-622. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Andrea L. Bardell and Kathleen M. MacLeod

Evidence for Inducible Nitric-Oxide Synthase Expression and Activity in Vascular Smooth Muscle of Streptozotocin-Diabetic Rats
J Pharmacol Exp Ther 2001 296: 252-259. [Abstract] [Full Text] [PDF]  

Bert Vanheel and Johan Van de Voorde

Regional Differences in Anandamide- and Methanandamide-Induced Membrane Potential Changes in Rat Mesenteric Arteries
J Pharmacol Exp Ther 2001 296: 322-328. [Abstract] [Full Text] [PDF]  

Jennifer R. Ballew, Stephanie W. Watts, and Gregory D. Fink

Effects of Salt Intake and Angiotensin II on Vascular Reactivity to Endothelin-1
J Pharmacol Exp Ther 2001 296: 345-350. [Abstract] [Full Text] [PDF]  

S. Bova, L. Trevisi, L. Cima, S. Luciani, V. Golovina, and G. Cargnelli

Signaling Mechanisms for the Selective Vasoconstrictor Effect of Norbormide on the Rat Small Arteries
J Pharmacol Exp Ther 2001 296: 458-463. [Abstract] [Full Text] [PDF]  

Ming-Hui Liu, Hong-Kui Jin, H. Storm Floten, Qin Yang, Anthony P. C. Yim, Anthony Furnary, Thomas F. Zioncheck, Stuart Bunting, and Guo-Wei He

Vascular Endothelial Growth Factor-Mediated Endothelium-Dependent Relaxation Is Blunted in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2001 296: 473-477. [Abstract] [Full Text] [PDF]  

James J. Galligan, Margaret C. Hess, Sara B. Miller, and Gregory D. Fink

Differential Localization of P2 Receptor Subtypes in Mesenteric Arteries and Veins of Normotensive and Hypertensive Rats
J Pharmacol Exp Ther 2001 296: 478-485. [Abstract] [Full Text] [PDF]  

Dana R. Abendschein, Pamela K. Baum, Peter Verhallen, Paul R. Eisenberg, Mark E. Sullivan, and David R. Light

A Novel Synthetic Inhibitor of Factor Xa Decreases Early Reocclusion and Improves 24-h Patency after Coronary Fibrinolysis in Dogs
J Pharmacol Exp Ther 2001 296: 567-572. [Abstract] [Full Text] [PDF]  

Teresa González, Mónica Longobardo, Ricardo Caballero, Eva Delpón, Juan Tamargo, and Carmen Valenzuela

Effects of Bupivacaine and a Novel Local Anesthetic, IQB-9302, on Human Cardiac K⁺ Channels
J Pharmacol Exp Ther 2001 296: 573-583. [Abstract] [Full Text] [PDF]  

Ryan M. Fryer, Phillip F. Pratt, Anna K. Hsu, and Garrett J. Gross

Differential Activation of Extracellular Signal Regulated Kinase Isoforms in Preconditioning and Opioid-Induced Cardioprotection
J Pharmacol Exp Ther 2001 296: 642-649. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

James E. Dunford, Keith Thompson, Fraser P. Coxon, Steven P. Luckman, Frederick M. Hahn, C. Dale Poulter, Frank H. Ebetino, and Michael J. Rogers

Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates
J Pharmacol Exp Ther 2001 296: 235-242. [Abstract] [Full Text] [PDF]  

John A. Schetz and David R. Sibley

The Binding-Site Crevice of the D₄ Dopamine Receptor Is Coupled to Three Distinct Sites of Allosteric Modulation
J Pharmacol Exp Ther 2001 296: 359-363. [Abstract] [Full Text] [PDF]  

Pavel Babál, Mykhaylo Ruchko, Clayton C. Campbell, Susan P. Gilmour, John L. Mitchell, Jack W. Olson, and Mark N. Gillespie

Regulation of Ornithine Decarboxylase Activity and Polyamine Transport by Agmatine in Rat Pulmonary Artery Endothelial Cells
J Pharmacol Exp Ther 2001 296: 372-377. [Abstract] [Full Text] [PDF]  

Kuniaki Ishii, Kazuo Nunoki, Toshio Yamagishi, Hitoshi Okada, and Norio Taira

Differential Sensitivity of Kv1.4, Kv1.2, and Their Tandem Channel to Acidic pH: Involvement of a Histidine Residue in High Sensitivity to Acidic pH
J Pharmacol Exp Ther 2001 296: 405-411. [Abstract] [Full Text] [PDF]  

Hiroyuki Iwamura, Hidekazu Suzuki, Yoshifumi Ueda, Tetsudo Kaya, and Takashi Inaba

In Vitro and in Vivo Pharmacological Characterization of JTE-907, a Novel Selective Ligand for Cannabinoid CB₂ Receptor
J Pharmacol Exp Ther 2001 296: 420-425. [Abstract] [Full Text] [PDF]  

Yunling Gao, Shaoqing Tang, Sharon Zhou, and J. Anthony Ware

The Thromboxane A2 Receptor Activates Mitogen-Activated Protein Kinase via Protein Kinase C-Dependent Gi Coupling and Src-Dependent Phosphorylation of the Epidermal Growth Factor Receptor
J Pharmacol Exp Ther 2001 296: 426-433. [Abstract] [Full Text] [PDF]  

Layla Al-Nakkash, Shenghui Hu, Min Li, and Tzyh-Chang Hwang

A Common Mechanism for Cystic Fibrosis Transmembrane Conductance Regulator Protein Activation by Genistein and Benzimidazolone Analogs
J Pharmacol Exp Ther 2001 296: 464-472. [Abstract] [Full Text] [PDF]  

Robert F. Spurney

Regulation of Thromboxane Receptor (TP) Phosphorylation by Protein Phosphatase 1 (PP1) and PP2A
J Pharmacol Exp Ther 2001 296: 592-599. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Daniela Bellarosa, Alessandra Ciucci, Angela Bullo, Federica Nardelli, Stefano Manzini, Carlo Alberto Maggi, and Cristina Goso

Apoptotic Events in a Human Ovarian Cancer Cell Line Exposed to Anthracyclines
J Pharmacol Exp Ther 2001 296: 276-283. [Abstract] [Full Text] [PDF]  

John S. Lazo, Kenji Tamura, Andreas Vogt, Jae-Kyu Jung, Sonia Rodriguez, Raghavan Balachandran, Billy W. Day, and Peter Wipf

Antimitotic Actions of a Novel Analog of the Fungal Metabolite Palmarumycin CP₁
J Pharmacol Exp Ther 2001 296: 364-371. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Robert Elsby, James L. Maggs, John Ashby, David Paton, John P. Sumpter, and B. Kevin Park

Assessment of the Effects of Metabolism on the Estrogenic Activity of Xenoestrogens: A Two-Stage Approach Coupling Human Liver Microsomes and a Yeast Estrogenicity Assay
J Pharmacol Exp Ther 2001 296: 329-337. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Christen P. Larsen, Ronald R. Regal, and Jean F. Regal

Trimellitic Anhydride-Induced Allergic Response in the Guinea Pig Lung Involves Antibody-Dependent and -Independent Complement System Activation
J Pharmacol Exp Ther 2001 296: 284-292. [Abstract] [Full Text] [PDF]  

Lluís Valle, Olga Pol, and Margarita M. Puig

Intestinal Inflammation Enhances the Inhibitory Effects of Opioids on Intestinal Permeability in Mice
J Pharmacol Exp Ther 2001 296: 378-387. [Abstract] [Full Text] [PDF]  

Junji Yamashita, Makoto Itoh, Toshihiko Kuro, Yutaka Kobayashi, Masaya Ogata, Masanori Takaoka, and Yasuo Matsumura

Pre- or Post-Ischemic Treatment with a Novel Na⁺/Ca²⁺ Exchange Inhibitor, KB-R7943, Shows Renal Protective Effects in Rats with Ischemic Acute Renal Failure
J Pharmacol Exp Ther 2001 296: 412-419. [Abstract] [Full Text] [PDF]  

Martin Andreas Unmack, Patangi K. Rangachari, and Erik Skadhauge

Effects of Isoprostanes and Prostanoids on Porcine Small Intestine
J Pharmacol Exp Ther 2001 296: 434-441. [Abstract] [Full Text] [PDF]  

Sangeeta Singh, Colin A. Syme, Ashvani K. Singh, Daniel C. Devor, and Robert J. Bridges

Benzimidazolone Activators of Chloride Secretion: Potential Therapeutics for Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
J Pharmacol Exp Ther 2001 296: 600-611. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Tom J. Parry, Todd A. Riccobene, Steven J. Strawn, Rita Williams, Rami Daoud, Jeffrey Carrell, Svetlana Sosnovtseva, Renée C. Miceli, Carol M. Poortman, Les Sekut, Yuling Li, James Fikes, and Cynthia Sung

Pharmacokinetics and Immunological Effects of Exogenously Administered Recombinant Human B Lymphocyte Stimulator (BLyS) in Mice
J Pharmacol Exp Ther 2001 296: 396-404. [Abstract] [Full Text] [PDF]  

David L. Boyle, Elizabeth A. Kowaluk, Michael F. Jarvis, Chih-Hung Lee, Shripad S. Bhagwat, Michael Williams, and Gary S. Firestein

Anti-Inflammatory Effects of ABT-702, a Novel Non-Nucleoside Adenosine Kinase Inhibitor, in Rat Adjuvant Arthritis
J Pharmacol Exp Ther 2001 296: 495-500. [Abstract] [Full Text] [PDF]  

Steve McGaraughty, Katharine L. Chu, Carol T. Wismer, Joe Mikusa, Chang Z. Zhu, Marlon Cowart, Elizabeth A. Kowaluk, and Michael F. Jarvis

Effects of A-134974, a Novel Adenosine Kinase Inhibitor, on Carrageenan-Induced Inflammatory Hyperalgesia and Locomotor Activity in Rats: Evaluation of the Sites of Action
J Pharmacol Exp Ther 2001 296: 501-509. [Abstract] [Full Text] [PDF]  

D. Riendeau, M. D. Percival, C. Brideau, S. Charleson, D. Dubé, D. Ethier, J.-P. Falgueyret, R. W. Friesen, R. Gordon, G. Greig, J. Guay, J. Mancini, M. Ouellet, E. Wong, L. Xu, S. Boyce, D. Visco, Y. Girard, P. Prasit, R. Zamboni, I. W. Rodger, M. Gresser, A. W. Ford-Hutchinson, R. N. Young, and C.-C. Chan

Etoricoxib (MK-0663): Preclinical Profile and Comparison with Other Agents That Selectively Inhibit Cyclooxygenase-2
J Pharmacol Exp Ther 2001 296: 558-566. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Manuel Ferreira, Steven N. Ebert, David C. Perry, Robert P. Yasuda, Chandra M. Baker, Martha I. Dávila-García, Kenneth J. Kellar, and Richard A. Gillis

Evidence of a Functional 7-Neuronal Nicotinic Receptor Subtype Located on Motoneurons of the Dorsal Motor Nucleus of the Vagus
J Pharmacol Exp Ther 2001 296: 260-269. [Abstract] [Full Text] [PDF]  

Ichiro Takasaki, Tsugunobu Andoh, Hiroshi Nojima, Kimiyasu Shiraki, and Yasushi Kuraishi

Gabapentin Antinociception in Mice with Acute Herpetic Pain Induced by Herpes Simplex Virus Infection
J Pharmacol Exp Ther 2001 296: 270-275. [Abstract] [Full Text] [PDF]  

Yasuaki Aoki, Masaru Tamura, Yoshinori Itoh, Toshie Seto, Kiyoko Nonaka, Hideya Mukai, and Yojiro Ukai

Effective Plasma Concentration of a Novel Na⁺/Ca²⁺ Channel Blocker NS-7 for Its Cerebroprotective Actions in Rats with a Transient Middle Cerebral Artery Occlusion
J Pharmacol Exp Ther 2001 296: 306-311. [Abstract] [Full Text] [PDF]  

F. C. Barone, E. A. Irving, A. M. Ray, J. C. Lee, S. Kassis, S. Kumar, A. M. Badger, R. F. White, M. J. McVey, J. J. Legos, J. A. Erhardt, A. H. Nelson, E. H. Ohlstein, A. J. Hunter, K. Ward, B. R. Smith, J. L. Adams, and A. A. Parsons

SB 239063, a Second-Generation p38 Mitogen-Activated Protein Kinase Inhibitor, Reduces Brain Injury and Neurological Deficits in Cerebral Focal Ischemia
J Pharmacol Exp Ther 2001 296: 312-321. [Abstract] [Full Text] [PDF]  

Amit G. Gulwadi, Carolyn D. Korpinen, Richard B. Mailman, David E. Nichols, Sing-Yuen Sit, and Matthew T. Taber

Dinapsoline: Characterization of a D₁ Dopamine Receptor Agonist in a Rat Model of Parkinson's Disease
J Pharmacol Exp Ther 2001 296: 338-344. [Abstract] [Full Text] [PDF]  

Amy J. Eshleman, Katherine Wolfrum, Deborah C. Mash, Kevin Christensen, and Aaron Janowsky

Drug Interactions with the Dopamine Transporter in Cryopreserved Human Caudate
J Pharmacol Exp Ther 2001 296: 442-449. [Abstract] [Full Text] [PDF]  

Bridgette E. Garrett and Roland R. Griffiths

Intravenous Nicotine and Caffeine: Subjective and Physiological Effects in Cocaine Abusers
J Pharmacol Exp Ther 2001 296: 486-494. [Abstract] [Full Text] [PDF]  

David E. Chapman, Glen R. Hanson, Raymond P. Kesner, and Kristen A. Keefe

Long-Term Changes in Basal Ganglia Function after a Neurotoxic Regimen of Methamphetamine
J Pharmacol Exp Ther 2001 296: 520-527. [Abstract] [Full Text] [PDF]  

Satoshi Ohmori, Teruaki Hayashi, Masami Kawase, Setsuo Saito, and Yasunori Morimoto

Pharmacokinetic and Pharmacodynamic Evaluations of a Potent Analgesic, Dihydroetorphine, in Hairless Rat
J Pharmacol Exp Ther 2001 296: 528-536. [Abstract] [Full Text] [PDF]  

Dwaine F. Emerich, Pamela Snodgrass, Reginald L. Dean, Denise Lafreniere, Mary Agostino, Tania Wiens, Hua Xiong, Brant Hasler, Joanne Marsh, Melissa Pink, Byong Su Kim, and Raymond T. Bartus

Bradykinin Modulation of Tumor Vasculature: I. Activation of B₂ Receptors Increases Delivery of Chemotherapeutic Agents into Solid Peripheral Tumors, Enhancing Their Efficacy
J Pharmacol Exp Ther 2001 296: 623-631. [Abstract] [Full Text] [PDF]  

Dwaine F. Emerich, Reginald L. Dean, Pamela Snodgrass, Denise Lafreniere, Mary Agostino, Tania Wiens, Hua Xiong, Brant Hasler, Joanne Marsh, Melissa Pink, Byong Su Kim, Brigido Perdomo, and Raymond T. Bartus

Bradykinin Modulation of Tumor Vasculature: II. Activation of Nitric Oxide and Phospholipase A₂/Prostaglandin Signaling Pathways Synergistically Modifies Vascular Physiology and Morphology to Enhance Delivery of Chemotherapeutic Agents to Tumors
J Pharmacol Exp Ther 2001 296: 632-641. [Abstract] [Full Text] [PDF]  

Ryuichi Sakai, Geoffrey T. Swanson, Keiko Shimamoto, Tim Green, Anis Contractor, Andrea Ghetti, Yoshiko Tamura-Horikawa, Chie Oiwa, and Hisao Kamiya

Pharmacological Properties of the Potent Epileptogenic Amino Acid Dysiherbaine, a Novel Glutamate Receptor Agonist Isolated from the Marine Sponge Dysidea herbacea
J Pharmacol Exp Ther 2001 296: 650-658. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lawrence H. Lash, David A. Putt, and Rudolfs K. Zalups

Biochemical and Functional Characteristics of Cultured Renal Epithelial Cells from Uninephrectomized Rats: Factors Influencing Nephrotoxicity
J Pharmacol Exp Ther 2001 296: 243-251. [Abstract] [Full Text] [PDF]  

Michael A. Shultz, Dexter Morin, Ai-Min Chang, and Alan Buckpitt

Metabolic Capabilities of CYP2F2 with Various Pulmonary Toxicants and Its Relative Abundance in Mouse Lung Subcompartments
J Pharmacol Exp Ther 2001 296: 510-519. [Abstract] [Full Text] [PDF]  

ASPET MEETING REPORT:

Robert Schwarcz

Glutamate 2000: Old Dog, New Tricks
J Pharmacol Exp Ther 2001 296: 659-667. [Full Text] [PDF]  

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