PERSPECTIVES IN PHARMACOLOGY:

Martin Dutertre and Carolyn L. Smith

Molecular Mechanisms of Selective Estrogen Receptor Modulator (SERM) Action
J Pharmacol Exp Ther 2000 295: 431-437. [Abstract] [Full Text] [PDF]  

Jerry J. Buccafusco and Alvin V. Terry, Jr.

Multiple Central Nervous System Targets for Eliciting Beneficial Effects on Memory and Cognition
J Pharmacol Exp Ther 2000 295: 438-446. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Sean Ekins and R. Scott Obach

Three-Dimensional Quantitative Structure Activity Relationship Computational Approaches for Prediction of Human In Vitro Intrinsic Clearance
J Pharmacol Exp Ther 2000 295: 463-473. [Abstract] [Full Text] [PDF]  

Hao Xiong, Kenneth C. Turner, E. Stacy Ward, Peter L. M. Jansen, and Kim L. R. Brouwer

Altered Hepatobiliary Disposition of Acetaminophen Glucuronide in Isolated Perfused Livers from Multidrug Resistance-Associated Protein 2-Deficient TR Rats
J Pharmacol Exp Ther 2000 295: 512-518. [Abstract] [Full Text] [PDF]  

Marc P. Maillard, Julien Rossat, Hans-R. Brunner, and Michel Burnier

Tasosartan, Enoltasosartan, and Angiotensin II Receptor Blockade: The Confounding Role of Protein Binding
J Pharmacol Exp Ther 2000 295: 649-654. [Abstract] [Full Text] [PDF]  

J. Craig Rowlands, Huamin Wang, Reza Hakkak, Martin J. J. Ronis, Henry W. Strobel, and Thomas M. Badger

Chronic Intragastric Infusion of Ethanol-Containing Diets Induces CYP3A9 While Decreasing CYP3A2 in Male Rats
J Pharmacol Exp Ther 2000 295: 747-752. [Abstract] [Full Text] [PDF]  

Elke Störmer, Lisa L. von Moltke, and David J. Greenblatt

Scaling Drug Biotransformation Data from cDNA-Expressed Cytochrome P-450 to Human Liver: A Comparison of Relative Activity Factors and Human Liver Abundance in Studies of Mirtazapine Metabolism
J Pharmacol Exp Ther 2000 295: 793-801. [Abstract] [Full Text] [PDF]  

Connie Y. Ng, Hany Ghabrial, Denis J. Morgan, Michael S. Ching, Richard A. Smallwood, and Peter W. Angus

Right Heart Failure Impairs Hepatic Elimination of p-Nitrophenol without Inducing Changes in Content or Latency of Hepatic UDP-Glucuronosyltransferases
J Pharmacol Exp Ther 2000 295: 830-835. [Abstract] [Full Text] [PDF]  

Selma Sahin and Malcolm Rowland

Evaluation of Route of Input on the Hepatic Disposition of Diazepam
J Pharmacol Exp Ther 2000 295: 836-843. [Abstract] [Full Text] [PDF]  

Yan Shu, Lian-Sheng Wang, Zhen-Hua Xu, Nan He, Wei-Min Xiao, Wei Wang, Song-Lin Huang, and Hong-Hao Zhou

5-Hydroxylation of Omeprazole by Human Liver Microsomal Fractions from Chinese Populations Related to CYP2C19 Gene Dose and Individual Ethnicity
J Pharmacol Exp Ther 2000 295: 844-851. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Brent J. F. Hill, Laxmansa C. Katwa, Brian R. Wamhoff, and Michael Sturek

Enhanced Endothelin_A Receptor-Mediated Calcium Mobilization and Contraction in Organ Cultured Porcine Coronary Arteries
J Pharmacol Exp Ther 2000 295: 484-491. [Abstract] [Full Text] [PDF]  

Jinbao Huang, Edward M. Driscoll, Michael L. Gonzales, Andrew M. Park, and Benedict R. Lucchesi

Prevention of Arterial Thrombosis by Intravenously Administered Platelet P2T Receptor Antagonist AR-C69931MX in a Canine Model
J Pharmacol Exp Ther 2000 295: 492-499. [Abstract] [Full Text] [PDF]  

Gemma A. Figtree, Carolyn M. Webb, and Peter Collins

Tamoxifen Acutely Relaxes Coronary Arteries by an Endothelium-, Nitric Oxide-, and Estrogen Receptor-Dependent Mechanism
J Pharmacol Exp Ther 2000 295: 519-523. [Abstract] [Full Text] [PDF]  

Haiquan Li, Kai Y. Xu, Lan Zhou, Tamas Kalai, Jay L. Zweier, Kalman Hideg, and Periannan Kuppusamy

A Pyrroline Derivative of Mexiletine Offers Marked Protection against Ischemia/Reperfusion-Induced Myocardial Contractile Dysfunction
J Pharmacol Exp Ther 2000 295: 563-571. [Abstract] [Full Text] [PDF]  

Jodan D. Ratz, Amy B. Fraser, Karen J. Rees-Milton, Michael A. Adams, and Brian M. Bennett

Endothelin Receptor Antagonism Does Not Prevent the Development of In Vivo Glyceryl Trinitrate Tolerance in the Rat
J Pharmacol Exp Ther 2000 295: 578-585. [Abstract] [Full Text] [PDF]  

Javier Angulo, Pedro Cuevas, Ignacio Moncada, Antonio Martín-Morales, Antonio Allona, Argentina Fernández, Sonia Gabancho, Peter Ney, and Iñigo Sáenz de Tejada

Rationale for the Combination of PGE₁ and S-Nitroso-glutathione to Induce Relaxation of Human Penile Smooth Muscle
J Pharmacol Exp Ther 2000 295: 586-593. [Abstract] [Full Text] [PDF]  

Britt H. Tonnessen, Sandra R. Severson, Richard D. Hurt, and Virginia M. Miller

Modulation of Nitric-Oxide Synthase by Nicotine
J Pharmacol Exp Ther 2000 295: 601-606. [Abstract] [Full Text] [PDF]  

Yuri A. Kuryshev, Arthur M. Brown, Lin Wang, Claude R. Benedict, and David Rampe

Interactions of the 5-Hydroxytryptamine 3 Antagonist Class of Antiemetic Drugs with Human Cardiac Ion Channels
J Pharmacol Exp Ther 2000 295: 614-620. [Abstract] [Full Text] [PDF]  

Charles Blais, Jr., David Fortin, Jean-Lucien Rouleau, Giuseppe Molinaro, and Albert Adam

Protective Effect of Omapatrilat, a Vasopeptidase Inhibitor, on the Metabolism of Bradykinin in Normal and Failing Human Hearts
J Pharmacol Exp Ther 2000 295: 621-626. [Abstract] [Full Text] [PDF]  

Sally Anne Argyle and John Christie McGrath

An _1A/_1L-Adrenoceptor Mediates Contraction of Canine Subcutaneous Resistance Arteries
J Pharmacol Exp Ther 2000 295: 627-633. [Abstract] [Full Text] [PDF]  

Laine J. Murphey, Sandeep Kumar, and Nancy J. Brown

Endogenous Bradykinin and the Renin and Pressor Responses to Furosemide in Humans
J Pharmacol Exp Ther 2000 295: 644-648. [Abstract] [Full Text] [PDF]  

Martin J. Quinn, Dermot Cox, J. Brendan Foley, and Desmond J. Fitzgerald

Glycoprotein IIb/IIIa Receptor Number and Occupancy during Chronic Administration of an Oral Antagonist
J Pharmacol Exp Ther 2000 295: 670-676. [Abstract] [Full Text] [PDF]  

William E. Louch, Gregory R. Ferrier, and Susan E. Howlett

Losartan Improves Recovery of Contraction and Inhibits Transient Inward Current in a Cellular Model of Cardiac Ischemia and Reperfusion
J Pharmacol Exp Ther 2000 295: 697-704. [Abstract] [Full Text] [PDF]  

Loïc Perchenet and Odile Clément-Chomienne

Characterization of Mibefradil Block of the Human Heart Delayed Rectifier hKv1.5
J Pharmacol Exp Ther 2000 295: 771-778. [Abstract] [Full Text] [PDF]  

M. J. Pekka Raatikainen, Timothy E. Morey, Pascal Druzgala, Peter Milner, Mario D. Gonzalez, and Donn M. Dennis

Potent and Reversible Effects of ATI-2001 on Atrial and Atrioventricular Nodal Electrophysiological Properties in Guinea Pig Isolated Perfused Heart
J Pharmacol Exp Ther 2000 295: 779-785. [Abstract] [Full Text] [PDF]  

Xin L. Ma, Feng Gao, Chen-Ling Yao, Jun Chen, Bernard L. Lopez, Theodore A. Christopher, Jyoti Disa, Juan-Li Gu, Eliot H. Ohlstein, and Tian-Li Yue

Nitric Oxide Stimulatory and Endothelial Protective Effects of Idoxifene, a Selective Estrogen Receptor Modulator, in the Splanchnic Artery of the Ovariectomized Rat
J Pharmacol Exp Ther 2000 295: 786-792. [Abstract] [Full Text] [PDF]  

Regina Gisbert, Maria Antonia Noguera, Maria Dolores Ivorra, and Pilar D'Ocon

Functional Evidence of a Constitutively Active Population of _1D-Adrenoceptors in Rat Aorta
J Pharmacol Exp Ther 2000 295: 810-817. [Abstract] [Full Text] [PDF]  

Antonella Zampolli, Giuseppina Basta, Guido Lazzerini, Martin Feelisch, and Raffaele De Caterina

Inhibition of Endothelial Cell Activation by Nitric Oxide Donors
J Pharmacol Exp Ther 2000 295: 818-823. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Brian B. Hasinoff, Michael E. Abram, Gaik-Lean Chee, Erwin Huebner, Edward H. Byard, Norman Barnabé, Victor J. Ferrans, Zu-Xi Yu, and Jack C. Yalowich

The Catalytic DNA Topoisomerase II Inhibitor Dexrazoxane (ICRF-187) Induces Endopolyploidy in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 2000 295: 474-483. [Abstract] [Full Text] [PDF]  

Paul L. Prather, Lei Song, Elemer T. Piros, Ping Y. Law, and Tim G. Hales

-Opioid Receptors Are More Efficiently Coupled to Adenylyl Cyclase Than to L-Type Ca²⁺ Channels in Transfected Rat Pituitary Cells
J Pharmacol Exp Ther 2000 295: 552-562. [Abstract] [Full Text] [PDF]  

Chan-Guk Park, Subhas C. Ganguli, Delia I. Pinon, Elizabeth M. Hadac, and Laurence J. Miller

Cross-Chimeric Analysis of Selectivity of Secretin and VPAC₁ Receptor Activation
J Pharmacol Exp Ther 2000 295: 682-688. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Shantini D. Gamage, Eric D. Bischoff, Kevin D. Burroughs, William W. Lamph, Marco M. Gottardis, Cheryl L. Walker, and Robin Fuchs-Young

Efficacy of LGD1069 (Targretin), a Retinoid X Receptor-Selective Ligand, for Treatment of Uterine Leiomyoma
J Pharmacol Exp Ther 2000 295: 677-681. [Abstract] [Full Text] [PDF]  

Michael J. McCabe, Jr., Kameshwar P. Singh, Srikar A. Reddy, Bhadrani Chelladurai, Joel G. Pounds, John J. Reiners, Jr., and J. Christopher States

Sensitivity of Myelomonocytic Leukemia Cells to Arsenite-Induced Cell Cycle Disruption, Apoptosis, and Enhanced Differentiation Is Dependent on the Inter-Relationship between Arsenic Concentration, Duration of Treatment, and Cell Cycle Phase
J Pharmacol Exp Ther 2000 295: 724-733. [Abstract] [Full Text] [PDF]  

Lena E. Friberg, Agneta Freijs, Marie Sandström, and Mats O. Karlsson

Semiphysiological Model for the Time Course of Leukocytes after Varying Schedules of 5-Fluorouracil in Rats
J Pharmacol Exp Ther 2000 295: 734-740. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Cindy Q. Xia, Jeff Wang, and Wei-Chiang Shen

Hypoglycemic Effect of Insulin-Transferrin Conjugate in Streptozotocin-Induced Diabetic Rats
J Pharmacol Exp Ther 2000 295: 594-600. [Abstract] [Full Text] [PDF]  

James C. Russell, Denis Ravel, Jean-Paul Pégorier, Pascal Delrat, Roeline Jochemsen, Sheila F. O'Brien, Sandra E. Kelly, Sandra T. Davidge, and David N. Brindley

Beneficial Insulin-Sensitizing and Vascular Effects of S15261 in the Insulin-Resistant JCR:LA-cp Rat
J Pharmacol Exp Ther 2000 295: 753-760. [Abstract] [Full Text] [PDF]  

Sam R. J. Hoare and Ted B. Usdin

Tuberoinfundibular Peptide (7-39) [TIP(7-39)], a Novel, Selective, High-Affinity Antagonist for the Parathyroid Hormone-1 Receptor with No Detectable Agonist Activity
J Pharmacol Exp Ther 2000 295: 761-770. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Wei-Hao Sun, Shingo Tsuji, Masahiko Tsujii, Edhi S. Gunawan, Naoki Kawai, Arata Kimura, Yoshimi Kakiuchi, Masakazu Yasumaru, Hideki Iijima, Yoshiko Okuda, Yutaka Sasaki, Masatsugu Hori, and Sunao Kawano

Induction of Cyclooxygenase-2 in Rat Gastric Mucosa by Rebamipide, a Mucoprotective Agent
J Pharmacol Exp Ther 2000 295: 447-452. [Abstract] [Full Text] [PDF]  

Beata Kamosinska, Anna Radomski, Shu Fu Paul Man, Marek W. Radomski, and Marek Duszyk

Role of Inducible Nitric-Oxide Synthase in Regulation of Whole-Cell Current in Lung Epithelial Cells
J Pharmacol Exp Ther 2000 295: 500-505. [Abstract] [Full Text] [PDF]  

Luke J. Janssen, Mahmood Premji, Stuart Netherton, Adrianna Catalli, Gerard Cox, Shaf Keshavjee, and Denis J. Crankshaw

Excitatory and Inhibitory Actions of Isoprostanes in Human and Canine Airway Smooth Muscle
J Pharmacol Exp Ther 2000 295: 506-511. [Abstract] [Full Text] [PDF]  

John J. Lee and Michael E. Parsons

Signaling Mechanisms Coupled to Presynaptic A₁- and H₃-Receptors in the Inhibition of Cholinergic Contractile Responses of the Guinea Pig Ileum
J Pharmacol Exp Ther 2000 295: 607-613. [Abstract] [Full Text] [PDF]  

Angela Äbelö, Ulf G. Eriksson, Mats O. Karlsson, Håkan Larsson, and Johan Gabrielsson

A Turnover Model of Irreversible Inhibition of Gastric Acid Secretion by Omeprazole in the Dog
J Pharmacol Exp Ther 2000 295: 662-669. [Abstract] [Full Text] [PDF]  

Noriko Okudaira, Izumi Komiya, and Yuichi Sugiyama

Polarized Efflux of Mono- and Diacid Metabolites of ME3229, an Ester-Type Prodrug of a Glycoprotein IIb/IIIa Receptor Antagonist, in Rat Small Intestine
J Pharmacol Exp Ther 2000 295: 717-723. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Jean Van Wauwe, Frans Aerts, Marina Cools, Frederik Deroose, Eddy Freyne, Jan Goossens, Bart Hermans, Jean Lacrampe, Heidi Van Genechten, Frans Van Gerven, and Greta Van Nyen

Identification of R146225 as a Novel, Orally Active Inhibitor of Interleukin-5 Biosynthesis
J Pharmacol Exp Ther 2000 295: 655-661. [Abstract] [Full Text] [PDF]  

Ajoy Kumar Ghosh, Noriyasu Hirasawa, Hisae Niki, and Kazuo Ohuchi

Cyclooxygenase-2-Mediated Angiogenesis in Carrageenin-Induced Granulation Tissue in Rats
J Pharmacol Exp Ther 2000 295: 802-809. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Attila Köfalvi, Beáta Sperlágh, Tibor Zelles, and E. Sylvester Vizi

Long-Lasting Facilitation of 4-Amino-n-[2,3-³H]butyric Acid ([³H]GABA) Release from Rat Hippocampal Slices by Nicotinic Receptor Activation
J Pharmacol Exp Ther 2000 295: 453-462. [Abstract] [Full Text] [PDF]  

Xin Wang, Ai Ying Xiao, Tomomi Ichinose, and Shan Ping Yu

Effects of Tetraethylammonium Analogs on Apoptosis and Membrane Currents in Cultured Cortical Neurons
J Pharmacol Exp Ther 2000 295: 524-530. [Abstract] [Full Text] [PDF]  

Roger Marrannes and Erik De Prins

Site of Action of Lubeluzole on Voltage-Sensitive Ca²⁺ Channels in Isolated Dorsal Root Ganglion Cells of the Rat: Influence of pH
J Pharmacol Exp Ther 2000 295: 531-545. [Abstract] [Full Text] [PDF]  

Yuri A. Kolesnikov, Igor Chereshnev, and Gavril W. Pasternak

Analgesic Synergy between Topical Lidocaine and Topical Opioids
J Pharmacol Exp Ther 2000 295: 546-551. [Abstract] [Full Text] [PDF]  

Elias Aizenman, Jeroo D. Sinor, Jessica C. Brimecombe, and Greta Ann Herin

Alterations of N-Methyl-D-aspartate Receptor Properties after Chemical Ischemia
J Pharmacol Exp Ther 2000 295: 572-577. [Abstract] [Full Text] [PDF]  

Chyan E. Lau, Lei Sun, Qiao Wang, Allan Simpao, and John L. Falk

Oral Cocaine Pharmacokinetics and Pharmacodynamics in a Cumulative-Dose Regimen: Pharmacokinetic-Pharmacodynamic Modeling of Concurrent Operant and Spontaneous Behavior within an Operant Context
J Pharmacol Exp Ther 2000 295: 634-643. [Abstract] [Full Text] [PDF]  

Ming Li, Andras Szabo, and Howard C. Rosenberg

Down-Regulation of Benzodiazepine Binding to 5 Subunit-Containing -Aminobutyric Acid_A Receptors in Tolerant Rat Brain Indicates Particular Involvement of the Hippocampal CA1 Region
J Pharmacol Exp Ther 2000 295: 689-696. [Abstract] [Full Text] [PDF]  

Wolfgang Poelchen, William R. Proctor, and Thomas V. Dunwiddie

The In Vitro Ethanol Sensitivity of Hippocampal Synaptic -Aminobutyric Acid_A Responses Differs in Lines of Mice and Rats Genetically Selected for Behavioral Sensitivity or Insensitivity to Ethanol
J Pharmacol Exp Ther 2000 295: 741-746. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Courtney E. W. Sulentic, Michael P. Holsapple, and Norbert E. Kaminski

Putative Link between Transcriptional Regulation of IgM Expression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin and the Aryl Hydrocarbon Receptor/Dioxin-Responsive Enhancer Signaling Pathway
J Pharmacol Exp Ther 2000 295: 705-716. [Abstract] [Full Text] [PDF]  

Anna B. Alfieri and Luigi X. Cubeddu

Nitric Oxide and NK₁-Tachykinin Receptors in Cyclophosphamide-Induced Cystitis, in Rats
J Pharmacol Exp Ther 2000 295: 824-829. [Abstract] [Full Text] [PDF]  

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