PERSPECTIVES IN PHARMACOLOGY:

W. Kent Hansen and Mark R. Kelley

Review of Mammalian DNA Repair and Translational Implications
J Pharmacol Exp Ther 2000 295: 1-9. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Andrew S. Mulato, Edmund S. Ho, and Tomas Cihlar

Nonsteroidal Anti-Inflammatory Drugs Efficiently Reduce the Transport and Cytotoxicity of Adefovir Mediated by the Human Renal Organic Anion Transporter 1
J Pharmacol Exp Ther 2000 295: 10-15. [Abstract] [Full Text] [PDF]  

Lucia Sabordo, Benedetta C. Sallustio, Allan M. Evans, and Roger L. Nation

Hepatic Disposition of the Acyl Glucuronide 1-O-Gemfibrozil--D-glucuronide: Effects of Clofibric Acid, Acetaminophen, and Acetaminophen Glucuronide
J Pharmacol Exp Ther 2000 295: 44-50. [Abstract] [Full Text] [PDF]  

Ikumi Tamai, Junko Yamashita, Yasuto Kido, Aki Ohnari, Yoshimichi Sai, Yuichiro Shima, Kazumasa Naruhashi, Shoichi Koizumi, and Akira Tsuji

Limited Distribution of New Quinolone Antibacterial Agents into Brain Caused by Multiple Efflux Transporters at the Blood-Brain Barrier
J Pharmacol Exp Ther 2000 295: 146-152. [Abstract] [Full Text] [PDF]  

William T. Phillips, Robert Klipper, and Beth Goins

Novel Method of Greatly Enhanced Delivery of Liposomes to Lymph Nodes
J Pharmacol Exp Ther 2000 295: 309-313. [Abstract] [Full Text] [PDF]  

Hiroaki Yamaguchi, Ikuko Yano, Yukiya Hashimoto, and Ken-Ichi Inui

Secretory Mechanisms of Grepafloxacin and Levofloxacin in the Human Intestinal Cell Line Caco-2
J Pharmacol Exp Ther 2000 295: 360-366. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Lindon H. Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer

Wortmannin, a Potent Antineutrophil Agent, Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion
J Pharmacol Exp Ther 2000 295: 37-43. [Abstract] [Full Text] [PDF]  

Pancras C. Wong, Earl J. Crain, Robert M. Knabb, Raymond P. Meade, Mimi L. Quan, Carol A. Watson, Ruth R. Wexler, Matthew R. Wright, and Andrew M. Slee

Nonpeptide Factor Xa Inhibitors II. Antithrombotic Evaluation in a Rabbit Model of Electrically Induced Carotid Artery Thrombosis
J Pharmacol Exp Ther 2000 295: 212-218. [Abstract] [Full Text] [PDF]  

Anindya Bhattacharya and Marlene L. Cohen

Vascular Contraction and Relaxation to Thrombin and Trypsin: Thrombomodulin Preferentially Attenuates Thrombin-Induced Contraction
J Pharmacol Exp Ther 2000 295: 284-290. [Abstract] [Full Text] [PDF]  

Ruth L. Martin, Jung-Ha Lee, Leanne L. Cribbs, Edward Perez-Reyes, and Dorothy A. Hanck

Mibefradil Block of Cloned T-Type Calcium Channels
J Pharmacol Exp Ther 2000 295: 302-308. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Edwin K. Jackson and Zaichuan Mi

Preglomerular Microcirculation Expresses the cAMP-Adenosine Pathway
J Pharmacol Exp Ther 2000 295: 23-28. [Abstract] [Full Text] [PDF]  

Jon R. Inglefield and Timothy J. Shafer

Polychlorinated Biphenyl-Stimulation of Ca²⁺ Oscillations in Developing Neocortical Cells: A Role for Excitatory Transmitters and L-Type Voltage-Sensitive Ca²⁺ Channels
J Pharmacol Exp Ther 2000 295: 105-113. [Abstract] [Full Text] [PDF]  

Elisabeth Buchdunger, Catherine L. Cioffi, Norman Law, David Stover, Sayuri Ohno-Jones, Brian J. Druker, and Nicholas B. Lydon

Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
J Pharmacol Exp Ther 2000 295: 139-145. [Abstract] [Full Text] [PDF]  

Prudence H. Tso and Yung H. Wong

G_z Can Mediate the Acute Actions of µ- and -Opioids but Is Not Involved in Opioid-Induced Adenylyl Cyclase Supersensitization
J Pharmacol Exp Ther 2000 295: 168-176. [Abstract] [Full Text] [PDF]  

Yogesh Dwivedi, Hooriyah S. Rizavi, Jagadeesh S. Rao, and Ghanshyam N. Pandey

Modifications in the Phosphoinositide Signaling Pathway by Adrenal Glucocorticoids in Rat Brain: Focus on Phosphoinositide-Specific Phospholipase C and Inositol 1,4,5-Trisphosphate
J Pharmacol Exp Ther 2000 295: 244-254. [Abstract] [Full Text] [PDF]  

Jurgen F. M. Vanhauwe, Katty Josson, Walter H. M. L. Luyten, Arnold J. Driessen, and Josée E. Leysen

G-Protein Sensitivity of Ligand Binding to Human Dopamine D₂ and D₃ Receptors Expressed in Escherichia coli: Clues for a Constrained D₃ Receptor Structure
J Pharmacol Exp Ther 2000 295: 274-283. [Abstract] [Full Text] [PDF]  

Hans Keller, Bernhard Schu, Reinhardt Rüdel, and Heinrich Brinkmeier

Cellular Uptake and Efficacy of Antisense Oligonucleotides against RNAs of Two Na⁺ Channel Isoforms
J Pharmacol Exp Ther 2000 295: 367-372. [Abstract] [Full Text] [PDF]  

Yuji Nagayama, Eijun Nishihara, Hiroyuki Namba, Shunichi Yamashita, and Masami Niwa

Identification of the Sites of Asparagine-Linked Glycosylation on the Human Thyrotropin Receptor and Studies on Their Role in Receptor Function and Expression
J Pharmacol Exp Ther 2000 295: 404-409. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Chantal Maertens, Lin Wei, Guy Droogmans, and Bernd Nilius

Inhibition of Volume-Regulated and Calcium-Activated Chloride Channels by the Antimalarial Mefloquine
J Pharmacol Exp Ther 2000 295: 29-36. [Abstract] [Full Text] [PDF]  

Sunny Hong Chapel, Peter Veng-Pedersen, Robert L. Schmidt, and John A. Widness

A Pharmacodynamic Analysis of Erythropoietin-Stimulated Reticulocyte Response in Phlebotomized Sheep
J Pharmacol Exp Ther 2000 295: 346-351. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Ashvani K. Singh, Bruce D. Schultz, John A. Katzenellenbogen, Elmer M. Price, Robert J. Bridges, and Neil A. Bradbury

Estrogen Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator-Mediated Chloride Secretion
J Pharmacol Exp Ther 2000 295: 195-204. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Wladimiro Jiménez, Claudine Serradeil-Le Gal, Josefa Ros, Carmen Cano, Pilar Cejudo, Manuel Morales-Ruiz, Vicente Arroyo, Marc Pascal, Francisca Rivera, Jean-Pierre Maffrand, and Juan Rodés

Long-Term Aquaretic Efficacy of a Selective Nonpeptide V₂-Vasopressin Receptor Antagonist, SR121463, in Cirrhotic Rats
J Pharmacol Exp Ther 2000 295: 83-90. [Abstract] [Full Text] [PDF]  

Markus Wegmann, Antje Kämpen, Susanne Weber, Hannsjörg W. Seyberth, and Arnold Köckerling

Effect of Hydroxyeicosatetraenoic Acids on Furosemide-Sensitive Chloride Secretion in Rat Distal Colon
J Pharmacol Exp Ther 2000 295: 133-138. [Abstract] [Full Text] [PDF]  

Tomoyuki Suzuki, Hideki Sakai, Akira Ikari, and Noriaki Takeguchi

Inhibition of Thromboxane A₂-Induced Cl Secretion by Antidiarrhea Drug Loperamide in Isolated Rat Colon
J Pharmacol Exp Ther 2000 295: 233-238. [Abstract] [Full Text] [PDF]  

Yuichi Uwai, Hideyuki Saito, Yukiya Hashimoto, and Ken-Ichi Inui

Interaction and Transport of Thiazide Diuretics, Loop Diuretics, and Acetazolamide via Rat Renal Organic Anion Transporter rOAT1
J Pharmacol Exp Ther 2000 295: 261-265. [Abstract] [Full Text] [PDF]  

Benedict T. Green, Nigel W. Bunnett, Anjali Kulkarni-Narla, Martin Steinhoff, and David R. Brown

Intestinal Type 2 Proteinase-Activated Receptors: Expression in Opioid-Sensitive Secretomotor Neural Circuits That Mediate Epithelial Ion Transport
J Pharmacol Exp Ther 2000 295: 410-416. [Abstract] [Full Text] [PDF]  

Lisa M. Walker, Patrick D. Walker, Syed Z. Imam, Syed F. Ali, and Philip R. Mayeux

Evidence for Peroxynitrite Formation in Renal Ischemia-Reperfusion Injury: Studies with the Inducible Nitric Oxide Synthase Inhibitor L-N⁶-(1-Iminoethyl)lysine
J Pharmacol Exp Ther 2000 295: 417-422. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Shingo Kato, Ryota Hokari, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Toru Miyahara, Kazuro Itoh, Hiromasa Ishii, and Soichiro Miura

Amelioration of Murine Experimental Colitis by Inhibition of Mucosal Addressin Cell Adhesion Molecule-1
J Pharmacol Exp Ther 2000 295: 183-189. [Abstract] [Full Text] [PDF]  

Agnès Rouleau, Holger Stark, Walter Schunack, and Jean-Charles Schwartz

Anti-Inflammatory and Antinociceptive Properties of BP 2-94, a Histamine H₃-Receptor Agonist Prodrug
J Pharmacol Exp Ther 2000 295: 219-225. [Abstract] [Full Text] [PDF]  

Motonori Aoki, Miki Kobayashi, Jun Ishikawa, Yuji Saita, Yoshiya Terai, Kazuhisa Takayama, Keiji Miyata, and Toshimitsu Yamada

A Novel Phosphodiesterase Type 4 Inhibitor, YM976 (4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with Little Emetogenic Activity
J Pharmacol Exp Ther 2000 295: 255-260. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Ajit G. Thomas, James J. Vornov, Jennifer L. Olkowski, Aviva T. Merion, and Barbara S. Slusher

N-Acetylated -Linked Acidic Dipeptidase Converts N-Acetylaspartylglutamate from a Neuroprotectant to a Neurotoxin
J Pharmacol Exp Ther 2000 295: 16-22. [Abstract] [Full Text] [PDF]  

Madina R. Gerasimov, Maja Franceschi, Nora D. Volkow, Andrew Gifford, Samuel J. Gatley, Douglas Marsteller, Patricia E. Molina, and Stephen L. Dewey

Comparison between Intraperitoneal and Oral Methylphenidate Administration: A Microdialysis and Locomotor Activity Study
J Pharmacol Exp Ther 2000 295: 51-57. [Abstract] [Full Text] [PDF]  

Tony P. George, Christopher D. Verrico, Marina R. Picciotto, and Robert H. Roth

Nicotinic Modulation of Mesoprefrontal Dopamine Neurons: Pharmacologic and Neuroanatomic Characterization
J Pharmacol Exp Ther 2000 295: 58-66. [Abstract] [Full Text] [PDF]  

Becky Kinkead, Shanna Shahid, Michael J. Owens, and Charles B. Nemeroff

Effects of Acute and Subchronic Administration of Typical and Atypical Antipsychotic Drugs on the Neurotensin System of the Rat Brain
J Pharmacol Exp Ther 2000 295: 67-73. [Abstract] [Full Text] [PDF]  

Carsten K. Nielsen, Fraser B. Ross, and Maree T. Smith

Incomplete, Asymmetric, and Route-Dependent Cross-Tolerance between Oxycodone and Morphine in the Dark Agouti Rat
J Pharmacol Exp Ther 2000 295: 91-99. [Abstract] [Full Text] [PDF]  

A. Urban Höglund, Charlotte Hamilton, and Lars Lindblom

Effects of Microdialyzed Oxotremorine, Carbachol, Epibatidine, and Scopolamine on Intraspinal Release of Acetylcholine in the Rat
J Pharmacol Exp Ther 2000 295: 100-104. [Abstract] [Full Text] [PDF]  

Kenzie L. Preston and George E. Bigelow

Effects of Agonist-Antagonist Opioids in Humans Trained in a Hydromorphone/Not Hydromorphone Discrimination
J Pharmacol Exp Ther 2000 295: 114-124. [Abstract] [Full Text] [PDF]  

Bin Liu, Jian-Wei Jiang, Belinda C. Wilson, Lina Du, San-Nan Yang, Jiz-Yuh Wang, Gen-Cheng Wu, Xiao-Ding Cao, and Jau-Shyong Hong

Systemic Infusion of Naloxone Reduces Degeneration of Rat Substantia Nigral Dopaminergic Neurons Induced by Intranigral Injection of Lipopolysaccharide
J Pharmacol Exp Ther 2000 295: 125-132. [Abstract] [Full Text] [PDF]  

Maciej Gasior, Jesse T. Ungard, and Jeffrey M. Witkin

Chlormethiazole: Effectiveness against Toxic Effects of Cocaine in Mice
J Pharmacol Exp Ther 2000 295: 153-161. [Abstract] [Full Text] [PDF]  

Helene Eutamene, Anne-Marie Coelho, Vassilia Theodorou, Magali Toulouse, Maria Chovet, Annette Doherty, Jean Fioramonti, and Lionel Bueno

Antinociceptive Effect of Pregabalin in Septic Shock-Induced Rectal Hypersensitivity in Rats
J Pharmacol Exp Ther 2000 295: 162-167. [Abstract] [Full Text] [PDF]  

Chun-Su Yuan, Anoja S. Attele, Lucy Dey, and Jing-Tian Xie

Gastric Effects of Cholecystokinin and Its Interaction with Leptin on Brainstem Neuronal Activity in Neonatal Rats
J Pharmacol Exp Ther 2000 295: 177-182. [Abstract] [Full Text] [PDF]  

Eve M. Taylor, Deborah A. Otero, William A. Banks, and John S. O'Brien

Retro-Inverso Prosaptide Peptides Retain Bioactivity, Are Stable In Vivo, and Are Blood-Brain Barrier Permeable
J Pharmacol Exp Ther 2000 295: 190-194. [Abstract] [Full Text] [PDF]  

Becky Kinkead, Steven M. Lorch, Michael J. Owens, and Charles B. Nemeroff

Sex- and Estrous Cycle-Related Differences in the Effects of Acute Antipsychotic Drug Administration on Neurotensin-Containing Neurons in the Rat Brain
J Pharmacol Exp Ther 2000 295: 205-211. [Abstract] [Full Text] [PDF]  

Katharine Herrick-Davis, Ellinor Grinde, and Milt Teitler

Inverse Agonist Activity of Atypical Antipsychotic Drugs at Human 5-Hydroxytryptamine2C Receptors
J Pharmacol Exp Ther 2000 295: 226-232. [Abstract] [Full Text] [PDF]  

Ruben J. Boado, Aleksey Kazantsev, Barbara L. Apostol, Leslie M. Thompson, and William M. Pardridge

Antisense-Mediated Down-Regulation of the Human Huntingtin Gene
J Pharmacol Exp Ther 2000 295: 239-243. [Abstract] [Full Text] [PDF]  

Luca Steardo, Palmiero Monteleone, Luigia Trabace, Carla Cannizzaro, Mario Maj, and Vincenzo Cuomo

Serotonergic Modulation of Rat Pineal Gland Activity: In Vivo Evidence for a 5-Hydroxytryptamine_2C Receptor Involvement
J Pharmacol Exp Ther 2000 295: 266-273. [Abstract] [Full Text] [PDF]  

Robert B. Raffa, Dennis J. Stone, Jr., and Ronald J. Tallarida

Discovery of "Self-Synergistic" Spinal/Supraspinal Antinociception Produced by Acetaminophen (Paracetamol)
J Pharmacol Exp Ther 2000 295: 291-294. [Abstract] [Full Text] [PDF]  

Jan Oberdoerster, Marina Guizzetti, and Lucio G. Costa

Effect of Phenylalanine and Its Metabolites on the Proliferation and Viability of Neuronal and Astroglial Cells: Possible Relevance in Maternal Phenylketonuria
J Pharmacol Exp Ther 2000 295: 295-301. [Abstract] [Full Text] [PDF]  

Gayathri Jeyarasasingam, Michael Yeluashvili, and Maryka Quik

Nitric Oxide Is Involved in Acetylcholinesterase Inhibitor-Induced Myopathy in Rats
J Pharmacol Exp Ther 2000 295: 314-320. [Abstract] [Full Text] [PDF]  

Jennifer E. Slemmer, Billy R. Martin, and M. Imad Damaj

Bupropion Is a Nicotinic Antagonist
J Pharmacol Exp Ther 2000 295: 321-327. [Abstract] [Full Text] [PDF]  

Christopher S. Breivogel and Steven R. Childers

Cannabinoid Agonist Signal Transduction in Rat Brain: Comparison of Cannabinoid Agonists in Receptor Binding, G-Protein Activation, and Adenylyl Cyclase Inhibition
J Pharmacol Exp Ther 2000 295: 328-336. [Abstract] [Full Text] [PDF]  

Kimberly E. Vanover, Sharon Rosenzweig-Lipson, Jon E. Hawkinson, Nancy C. Lan, James D. Belluzzi, Larry Stein, James E. Barrett, Paul L. Wood, and Richard B. Carter

Characterization of the Anxiolytic Properties of a Novel Neuroactive Steroid, Co 2-6749 (GMA-839; WAY-141839; 3, 21-Dihydroxy-3-trifluoromethyl-19-nor-5-pregnan-20-one), a Selective Modulator of -Aminobutyric Acid_A Receptors
J Pharmacol Exp Ther 2000 295: 337-345. [Abstract] [Full Text] [PDF]  

María J. Garrido, Marta Valle, Miguel A. Campanero, Rosario Calvo, and Iñaki F. Trocóniz

Modeling of the In Vivo Antinociceptive Interaction between an Opioid Agonist, (+)-O-Desmethyltramadol, and a Monoamine Reuptake Inhibitor, ()-O-Desmethyltramadol, in Rats
J Pharmacol Exp Ther 2000 295: 352-359. [Abstract] [Full Text] [PDF]  

Henry M. Sarau, Don E. Griswold, Brian Bush, William Potts, Punam Sandhu, Dave Lundberg, James J. Foley, Dulcie B. Schmidt, Edward F. Webb, Lenox D. Martin, Jeffrey J. Legos, Robert G. Whitmore, Frank C. Barone, Andrew D. Medhurst, Mark A. Luttmann, Giuseppe A. M. Giardina, and Douglas W. P. Hay

Nonpeptide Tachykinin Receptor Antagonists. II. Pharmacological and Pharmacokinetic Profile of SB-222200, a Central Nervous System Penetrant, Potent and Selective NK-3 Receptor Antagonist
J Pharmacol Exp Ther 2000 295: 373-381. [Abstract] [Full Text] [PDF]  

Roxanne Brandsgaard, James E. Barrett, and Sharon Rosenzweig-Lipson

Pharmacological Characterization of the Discriminative Stimulus Effects of the Potassium Channel Blocker 4-Aminopyridine in Rats
J Pharmacol Exp Ther 2000 295: 382-391. [Abstract] [Full Text] [PDF]  

Wei Huang, Haiping Wang, Ramesh Kekuda, You-Jun Fei, Anne Friedrich, Jian Wang, Simon J. Conway, Richard S. Cameron, Frederick H. Leibach, and Vadivel Ganapathy

Transport of N-Acetylaspartate by the Na⁺-Dependent High-Affinity Dicarboxylate Transporter NaDC3 and Its Relevance to the Expression of the Transporter in the Brain
J Pharmacol Exp Ther 2000 295: 392-403. [Abstract] [Full Text] [PDF]  

Brigitte van Zundert, Felipe A. Albarran, and Luis G. Aguayo

Effects of Chronic Ethanol Treatment on -Aminobutyric Acid_A and Glycine Receptors in Mouse Glycinergic Spinal Neurons
J Pharmacol Exp Ther 2000 295: 423-429. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Rudolfs K. Zalups and James Koropatnick

Temporal Changes in Metallothionein Gene Transcription in Rat Kidney and Liver: Relationship to Content of Mercury and Metallothionein Protein
J Pharmacol Exp Ther 2000 295: 74-82. [Abstract] [Full Text] [PDF]  

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