PERSPECTIVES IN PHARMACOLOGY:

Brian S. Cummings, Jane McHowat, and Rick G. Schnellmann

Phospholipase A₂s in Cell Injury and Death
J Pharmacol Exp Ther 2000 294: 793-799. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Richard A. Walgren, Karl J. Karnaky, Jr., George E. Lindenmayer, and Thomas Walle

Efflux of Dietary Flavonoid Quercetin 4'--Glucoside across Human Intestinal Caco-2 Cell Monolayers by Apical Multidrug Resistance-Associated Protein-2
J Pharmacol Exp Ther 2000 294: 830-836. [Abstract] [Full Text] [PDF]  

Richard A. Walgren, Jiann-Trzuo Lin, Rolf K.-H. Kinne, and Thomas Walle

Cellular Uptake of Dietary Flavonoid Quercetin 4'--Glucoside by Sodium-Dependent Glucose Transporter SGLT1
J Pharmacol Exp Ther 2000 294: 837-843. [Abstract] [Full Text] [PDF]  

Saiko Wada, Minoru Tsuda, Takashi Sekine, Seok Ho Cha, Miyako Kimura, Yoshikatsu Kanai, and Hitoshi Endou

Rat Multispecific Organic Anion Transporter 1 (rOAT1) Transports Zidovudine, Acyclovir, and Other Antiviral Nucleoside Analogs
J Pharmacol Exp Ther 2000 294: 844-849. [Abstract] [Full Text] [PDF]  

Brigitte C. Widemann, Edward Sung, Lawrence Anderson, Wanda L. Salzer, Frank M. Balis, Karen S. Monitjo, Cynthia McCully, Mary Hawkins, and Peter C. Adamson

Pharmacokinetics and Metabolism of the Methotrexate Metabolite 2,4-Diamino-N¹⁰-methylpteroic Acid
J Pharmacol Exp Ther 2000 294: 894-901. [Abstract] [Full Text] [PDF]  

Benoît Schilter, Mark R. Andersen, Chetana Acharya, and Curtis J. Omiecinski

Activation of Cytochrome P450 Gene Expression in the Rat Brain by Phenobarbital-Like Inducers
J Pharmacol Exp Ther 2000 294: 916-922. [Abstract] [Full Text] [PDF]  

Marie-Anne Robin, Véronique Descatoire, Marie Le Roy, Alain Berson, François-Pierre Lebreton, Michel Maratrat, François Ballet, Jacqueline Loeper, and Dominique Pessayre

Vesicular Transport of Newly Synthesized Cytochromes P4501A to the Outside of Rat Hepatocyte Plasma Membranes
J Pharmacol Exp Ther 2000 294: 1063-1069. [Abstract] [Full Text] [PDF]  

Julie A. Johnson, Vanessa L. Herring, Michael S. Wolfe, and Mary V. Relling

CYP1A2 and CYP2D6 4-Hydroxylate Propranolol and Both Reactions Exhibit Racial Differences
J Pharmacol Exp Ther 2000 294: 1099-1105. [Abstract] [Full Text] [PDF]  

Chad M. Thompson, Jorge H. Capdevila, and Henry W. Strobel

Recombinant Cytochrome P450 2D18 Metabolism of Dopamine and Arachidonic Acid
J Pharmacol Exp Ther 2000 294: 1120-1130. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Tsunehisa Noto, Hirotaka Inoue, Tomihiro Ikeo, and Kohei Kikkawa

Potentiation of Penile Tumescence by T-1032, a New Potent and Specific Phosphodiesterase Type V Inhibitor, in Dogs
J Pharmacol Exp Ther 2000 294: 870-875. [Abstract] [Full Text] [PDF]  

Maurizio Sabbatini, Lucia Vitaioli, Emilia Baldoni, and Francesco Amenta

Nephroprotective Effect of Treatment with Calcium Channel Blockers in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2000 294: 948-954. [Abstract] [Full Text] [PDF]  

Iris C.-H. Yang, Michael W. Scherz, Anthony Bahinski, Paul B. Bennett, and Katherine T. Murray

Stereoselective Interactions of the Enantiomers of Chromanol 293B with Human Voltage-Gated Potassium Channels
J Pharmacol Exp Ther 2000 294: 955-962. [Abstract] [Full Text] [PDF]  

Martin Steinmetz, Truc Van Le, Peter Hollah, Gert Gabriëls, Helge Hohage, Karl Heinz Rahn, and Eberhard Schlatter

Influence of Purinoceptor Antagonism on Diadenosine Pentaphosphate-Induced Hypotension in Anesthetized Rats
J Pharmacol Exp Ther 2000 294: 963-968. [Abstract] [Full Text] [PDF]  

Elizabeth J. Kelso, Barbara J. McDermott, Bernard Silke, and J. Paul Spiers

Endothelin_A Receptor Subtype Mediates Endothelin-Induced Contractility in Left Ventricular Cardiomyocytes Isolated from Rabbit Myocardium
J Pharmacol Exp Ther 2000 294: 1047-1052. [Abstract] [Full Text] [PDF]  

Martin Steinmetz, Eberhard Schlatter, Harry Alexander Jozef Struijker Boudier, Karl Heinz Rahn, and Jozef Gabriel Rita De Mey

Diadenosine Polyphosphates Cause Contraction and Relaxation in Isolated Rat Resistance Arteries
J Pharmacol Exp Ther 2000 294: 1175-1181. [Abstract] [Full Text] [PDF]  

Martin Steinmetz, Stefan Bierer, Peter Hollah, Karl Heinz Rahn, and Eberhard Schlatter

Heterogenous Vascular Effects of AP5A in Different Rat Resistance Arteries Are Due to Heterogenous Distribution of P2X and P2Y₁ Purinoceptors
J Pharmacol Exp Ther 2000 294: 1182-1187. [Abstract] [Full Text] [PDF]  

Lena Brynne, Lennart K. Paalzow, and Mats O. Karlsson

Consequence of Exercise on the Cardiovascular Effects of l-Propranolol in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 2000 294: 1201-1208. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Stéphanie Choisy, Corinne Huchet-Cadiou, and Claude Léoty

Differential Effects of 4-Chloro-m-cresol and Caffeine on Skinned Fibers from Rat Fast and Slow Skeletal Muscles
J Pharmacol Exp Ther 2000 294: 884-893. [Abstract] [Full Text] [PDF]  

Anish A. Konkar, Zhengxian Zhu, and James G. Granneman

Aryloxypropanolamine and Catecholamine Ligand Interactions with the ₁-Adrenergic Receptor: Evidence for Interaction with Distinct Conformations of ₁-Adrenergic Receptors
J Pharmacol Exp Ther 2000 294: 923-932. [Abstract] [Full Text] [PDF]  

Sharon A. McGrath-Morrow and Jennifer L. Stahl

G₁ Phase Growth Arrest and Induction of p21^{Waf1/Cip1/Sdi1} in IB3-1 Cells Treated with 4-Sodium Phenylbutyrate
J Pharmacol Exp Ther 2000 294: 941-947. [Abstract] [Full Text] [PDF]  

Ithaar H. Derweesh, Marcia A. Wheeler, and Robert M. Weiss

Alterations in G-Proteins and -Adrenergic Responsive Adenylyl Cyclase in Rat Urinary Bladder during Aging
J Pharmacol Exp Ther 2000 294: 969-974. [Abstract] [Full Text] [PDF]  

Chris Ulens, Maurits Van Boven, Paul Daenens, and Jan Tytgat

Interaction of p-Fluorofentanyl on Cloned Human Opioid Receptors and Exploration of the Role of Trp-318 and His-319 in µ-Opioid Receptor Selectivity
J Pharmacol Exp Ther 2000 294: 1024-1033. [Abstract] [Full Text] [PDF]  

Yuhmei Lin, Xiaoying Jian, Zolan Lin, Glenn S. Kroog, Samuel Mantey, Robert T. Jensen, James Battey, and John Northup

Two Amino Acids in the Sixth Transmembrane Segment of the Mouse Gastrin-Releasing Peptide Receptor Are Important for Receptor Activation
J Pharmacol Exp Ther 2000 294: 1053-1062. [Abstract] [Full Text] [PDF]  

Tracy L. Ediger and Myron L. Toews

Synergistic Stimulation of Airway Smooth Muscle Cell Mitogenesis
J Pharmacol Exp Ther 2000 294: 1076-1082. [Abstract] [Full Text] [PDF]  

Richard D. Griner and Wendy B. Bollag

Inhibition of [³H]Thymidine Transport Is a Nonspecific Effect of PDMP in Primary Cultures of Mouse Epidermal Keratinocytes
J Pharmacol Exp Ther 2000 294: 1219-1224. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Andreas Vogt, Kenji Tamura, Shawndra Watson, and John S. Lazo

Antitumor Imidazolyl Disulfide IV-2 Causes Irreversible G₂/M Cell Cycle Arrest without Hyperphosphorylation of Cyclin-Dependent Kinase Cdk1
J Pharmacol Exp Ther 2000 294: 1070-1075. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Nancy K. Mello, Jack H. Mendelson, Maureen Kelly, and Carrie A. Bowen

The Effects of Cocaine on Basal and Human Chorionic Gonadotropin-Stimulated Ovarian Steroid Hormones in Female Rhesus Monkeys
J Pharmacol Exp Ther 2000 294: 1137-1145. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Haiyan Zhou and Satoru Mineshita

The Effect of Berberine Chloride on Experimental Colitis in Rats In Vivo and In Vitro
J Pharmacol Exp Ther 2000 294: 822-829. [Abstract] [Full Text] [PDF]  

Karnam S. Murthy, Yuen San Yee, John R. Grider, and Gabriel M. Makhlouf

Phorbol-Stimulated Ca²⁺ Mobilization and Contraction in Dispersed Intestinal Smooth Muscle Cells
J Pharmacol Exp Ther 2000 294: 991-996. [Abstract] [Full Text] [PDF]  

Satish Rattan and Sushanta Chakder

Influence of Heme Oxygenase Inhibitors on the Basal Tissue Enzymatic Activity and Smooth Muscle Relaxation of Internal Anal Sphincter
J Pharmacol Exp Ther 2000 294: 1009-1016. [Abstract] [Full Text]  

Naoaki Harada, Kenji Okajima, Kazunori Murakami, Sadaharu Usune, Chiemi Sato, Koichi Ohshima, and Takeshi Katsuragi

Adenosine and Selective A_2A Receptor Agonists Reduce Ischemia/Reperfusion Injury of Rat Liver Mainly by Inhibiting Leukocyte Activation
J Pharmacol Exp Ther 2000 294: 1034-1042. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Theoharis C. Theoharides, Linghua Wang, Xinzhu Pang, Richard Letourneau, Kerry E. Culm, Subimal Basu, Ying Wang, and Ivan Correia

Cloning and Cellular Localization of the Rat Mast Cell 78-kDa Protein Phosphorylated in Response to the Mast Cell "Stabilizer" Cromolyn
J Pharmacol Exp Ther 2000 294: 810-821. [Abstract] [Full Text] [PDF]  

Chi Dae Kim, Yong Ki Kim, So Hyun Lee, and Ki Whan Hong

Rebamipide Inhibits Neutrophil Adhesion to Hypoxia/Reoxygenation-Stimulated Endothelial Cells via Nuclear Factor-B-Dependent Pathway
J Pharmacol Exp Ther 2000 294: 864-869. [Abstract] [Full Text] [PDF]  

Inge Depoortere, Theo Thijs, Gert Van Assche, James C. Keith, Jr., and Theo L. Peeters

Dose-Dependent Effects of Recombinant Human Interleukin-11 on Contractile Properties in Rabbit 2,4,6-Trinitrobenzene Sulfonic Acid Colitis
J Pharmacol Exp Ther 2000 294: 983-990. [Abstract] [Full Text] [PDF]  

Hitoshi Ando, Toshinari Takamura, Tsuguhito Ota, Yukihiro Nagai, and Ken-ichi Kobayashi

Cerivastatin Improves Survival of Mice with Lipopolysaccharide-Induced Sepsis
J Pharmacol Exp Ther 2000 294: 1043-1046. [Abstract] [Full Text] [PDF]  

Jodie L. Wilson, John J. Carmody, and Judith S. Walker

The Importance of the Hypothalamo-Hypophyseal-Adrenal Axis to the Anti-Inflammatory Actions of the -Opioid Agonist PNU-50,488H in Rats with Adjuvant Arthritis
J Pharmacol Exp Ther 2000 294: 1131-1136. [Abstract] [Full Text] [PDF]  

Kathleen M. Gilbert, Rahnuma Wahid, Nuria Portabella Fecher, James P. Freeman, and E. Kim Fifer

Potential Clinical Use of Butyric Acid Derivatives to Induce Antigen-Specific T Cell Inactivation
J Pharmacol Exp Ther 2000 294: 1146-1153. [Abstract] [Full Text] [PDF]  

Aleksi Lahti, Mari Lähde, Hannu Kankaanranta, and Eeva Moilanen

Inhibition of Extracellular Signal-Regulated Kinase Suppresses Endotoxin-Induced Nitric Oxide Synthesis in Mouse Macrophages and in Human Colon Epithelial Cells
J Pharmacol Exp Ther 2000 294: 1188-1194. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Ann Bond, Nicole M. Jones, Caroline A. Hicks, Gary M. Whiffin, Mark A. Ward, Michael F. O'Neill, Ann E. Kingston, James A. Monn, Paul L. Ornstein, Darryle D. Schoepp, David Lodge, and Michael J. O'Neill

Neuroprotective Effects of LY379268, a Selective mGlu2/3 Receptor Agonist: Investigations into Possible Mechanism of Action In Vivo
J Pharmacol Exp Ther 2000 294: 800-809. [Abstract] [Full Text] [PDF]  

Karen E. Sabol, Jerry B. Richards, and Kenneth Yung

The Effects of High-Dose Methamphetamine in the Aging Rat: Differential Reinforcement of Low-Rate 72-s Schedule Behavior and Neurochemistry
J Pharmacol Exp Ther 2000 294: 850-863. [Abstract] [Full Text] [PDF]  

Aziz U. R. Asghar, Sibte S. Hasan, and Anne E. King

Actions of the Anticonvulsant Remacemide Metabolite AR-R12495AA on Afferent-Evoked Spinal Synaptic Transmission In Vitro and on Models of Acute and Chronic Inflammation in the Rat
J Pharmacol Exp Ther 2000 294: 876-883. [Abstract] [Full Text] [PDF]  

Snjezana Lelas, Lisa R. Gerak, and Charles P. France

Antagonism of the Discriminative Stimulus Effects of Positive -Aminobutyric Acid_A Modulators in Rhesus Monkeys Discriminating Midazolam
J Pharmacol Exp Ther 2000 294: 902-908. [Abstract] [Full Text] [PDF]  

Doodipala S. Reddy and Michael A. Rogawski

Enhanced Anticonvulsant Activity of Ganaxolone after Neurosteroid Withdrawal in a Rat Model of Catamenial Epilepsy
J Pharmacol Exp Ther 2000 294: 909-915. [Abstract] [Full Text] [PDF]  

Jillian H. Broadbear, Tina L. Sumpter, Timothy F. Burke, Stephen M Husbands, John W. Lewis, James H. Woods, and John R. Traynor

Methocinnamox Is a Potent, Long-Lasting, and Selective Antagonist of Morphine-Mediated Antinociception in the Mouse: Comparison with Clocinnamox, -Funaltrexamine, and -Chlornaltrexamine
J Pharmacol Exp Ther 2000 294: 933-940. [Abstract] [Full Text] [PDF]  

Thomas J. Martin, Susy A. Kim, David G. Cannon, Glen M. Sizemore, Di Bian, Frank Porreca, and James E. Smith

Antagonism of ₂-Opioid Receptors by Naltrindole-5'-isothiocyanate Attenuates Heroin Self-Administration but Not Antinociception in Rats
J Pharmacol Exp Ther 2000 294: 975-982. [Abstract] [Full Text] [PDF]  

Carrie K. Jones and Harlan E. Shannon

Muscarinic Cholinergic Modulation of Prepulse Inhibition of the Acoustic Startle Reflex
J Pharmacol Exp Ther 2000 294: 1017-1023. [Abstract] [Full Text] [PDF]  

Junko Ishizaki, Koichi Yokogawa, Fujio Ichimura, and Shoji Ohkuma

Uptake of Imipramine in Rat Liver Lysosomes In Vitro and Its Inhibition by Basic Drugs
J Pharmacol Exp Ther 2000 294: 1088-1098. [Abstract] [Full Text] [PDF]  

Masahiro Ohsawa, Hirokazu Mizoguchi, Minoru Narita, Mei Chu, Hiroshi Nagase, and Leon F. Tseng

Differential Mechanisms Mediating Descending Pain Controls for Antinociception Induced by Supraspinally Administered Endomorphin-1 and Endomorphin-2 in the Mouse
J Pharmacol Exp Ther 2000 294: 1106-1111. [Abstract] [Full Text] [PDF]  

Andrew J. Grottick, Gerhard Trube, William A. Corrigall, Joerg Huwyler, Parichehr Malherbe, Rene Wyler, and Guy A. Higgins

Evidence That Nicotinic ₇ Receptors Are Not Involved in the Hyperlocomotor and Rewarding Effects of Nicotine
J Pharmacol Exp Ther 2000 294: 1112-1119. [Abstract] [Full Text] [PDF]  

Charlie Reavill, Stephen G. Taylor, Martyn D. Wood, Tracey Ashmeade, Nigel E. Austin, Kim Y. Avenell, Izzy Boyfield, Clive L. Branch, Jackie Cilia, Martyn C. Coldwell, Michael S. Hadley, A. Jackie Hunter, Phil Jeffrey, Frances Jewitt, Christopher N. Johnson, Declan N. C. Jones, Andrew D. Medhurst, Derek N. Middlemiss, David J. Nash, Graham J. Riley, Carol Routledge, Geoff Stemp, Kevin M. Thewlis, Brenda Trail, Antonio K. K. Vong, and Jim J. Hagan

Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D₃ Receptor Antagonist, SB-277011-A
J Pharmacol Exp Ther 2000 294: 1154-1165. [Abstract] [Full Text] [PDF]  

Charles R. Ashby, Jr., Yoshio Minabe, Geoff Stemp, Jim J. Hagan, and Derek N. Middlemiss

Acute and Chronic Administration of the Selective D₃ Receptor Antagonist SB-277011-A Alters Activity of Midbrain Dopamine Neurons in Rats: An In Vivo Electrophysiological Study
J Pharmacol Exp Ther 2000 294: 1166-1174. [Abstract] [Full Text] [PDF]  

Daniel C. Broom, Li Guo, Andrew Coop, Stephen M. Husbands, John W. Lewis, James H. Woods, and John R. Traynor

BU48: A Novel Buprenorphine Analog That Exhibits -Opioid-Mediated Convulsions but Not -Opioid-Mediated Antinociception in Mice
J Pharmacol Exp Ther 2000 294: 1195-1200. [Abstract] [Full Text] [PDF]  

Billy R. Martin, Irina Beletskaya, Gray Patrick, Reneé Jefferson, Ramona Winckler, Dale G. Deutsch, Vincenzo Di Marzo, Olivier Dasse, Ann Mahadevan, and Raj K. Razdan

Cannabinoid Properties of Methylfluorophosphonate Analogs
J Pharmacol Exp Ther 2000 294: 1209-1218. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Ali Banan, Jeremy Z. Fields, Heather Decker, Yang Zhang, and Ali Keshavarzian

Nitric Oxide and Its Metabolites Mediate Ethanol-Induced Microtubule Disruption and Intestinal Barrier Dysfunction
J Pharmacol Exp Ther 2000 294: 997-1008. [Abstract] [Full Text] [PDF]  

Jay F. Harriman, Shayla Waters-Williams, Der-Lun Chu, James C. Powers, and Rick G. Schnellmann

Efficacy of Novel Calpain Inhibitors in Preventing Renal Cell Death
J Pharmacol Exp Ther 2000 294: 1083-1087. [Abstract] [Full Text] [PDF]  

ERRATA:

J Pharmacol Exp Ther 2000 294: 1225. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.