ARTICLES:

Toshio Narahashi

Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future
J Pharmacol Exp Ther 2000 294: 1-26. [Abstract] [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

Cecilia J. Hillard

Endocannabinoids and Vascular Function
J Pharmacol Exp Ther 2000 294: 27-32. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Bo Gao, Bruno Hagenbuch, Gerd A. Kullak-Ublick, Dietmar Benke, Adriano Aguzzi, and Peter J. Meier

Organic Anion-Transporting Polypeptides Mediate Transport of Opioid Peptides across Blood-Brain Barrier
J Pharmacol Exp Ther 2000 294: 73-79. [Abstract] [Full Text] [PDF]  

Shoji Kudo, Ken Umehara, Masakiyo Hosokawa, Gohachiro Miyamoto, Kan Chiba, and Tetsuo Satoh

Phenacetin Deacetylase Activity in Human Liver Microsomes: Distribution, Kinetics, and Chemical Inhibition and Stimulation
J Pharmacol Exp Ther 2000 294: 80-88. [Abstract] [Full Text] [PDF]  

R. Scott Obach

Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression
J Pharmacol Exp Ther 2000 294: 88-95. [Abstract] [Full Text] [PDF]  

Ketty Kichenin and Michel Seman

Chronic Oral Administration of ATP Modulates Nucleoside Transport and Purine Metabolism in Rats
J Pharmacol Exp Ther 2000 294: 126-133. [Abstract] [Full Text] [PDF]  

Aleksandra Pastrakuljic, Lidia O. Derewlany, Brenda Knie, and Gideon Koren

The Effects of Cocaine and Nicotine on Amino Acid Transport across the Human Placental Cotyledon Perfused In Vitro
J Pharmacol Exp Ther 2000 294: 141-146. [Abstract] [Full Text] [PDF]  

Bhagavatula Moorthy

Persistent Expression of 3-Methylcholanthrene-Inducible Cytochromes P4501A in Rat Hepatic and Extrahepatic Tissues
J Pharmacol Exp Ther 2000 294: 313-322. [Abstract] [Full Text] [PDF]  

Cornelis J. J. G. Bol, John P. W. Vogelaar, Jian-Ping Tang, and Jaap W. Mandema

Quantification of Pharmacodynamic Interactions between Dexmedetomidine and Midazolam in the Rat
J Pharmacol Exp Ther 2000 294: 347-355. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Masayuki Ogishima, Muneshige Kaibara, Shigeru Ueki, Tadashi Kurimoto, and Kohtaro Taniyama

Z-338 Facilitates Acetylcholine Release from Enteric Neurons Due to Blockade of Muscarinic Autoreceptors in Guinea Pig Stomach
J Pharmacol Exp Ther 2000 294: 33-37. [Abstract] [Full Text] [PDF]  

Steeve Houle, Michelle Landry, Ritchie Audet, Johanne Bouthillier, Dimcho R. Bachvarov, and François Marceau

Effect of Allelic Polymorphism of the B₁ and B₂ Receptor Genes on the Contractile Responses of the Human Umbilical Vein to Kinins
J Pharmacol Exp Ther 2000 294: 45-51. [Abstract] [Full Text] [PDF]  

Yingzi Chang, Donald B. Hoover, John C. Hancock, and Frank M. Smith

Tachykinin Receptor Subtypes in the Isolated Guinea Pig Heart and Their Role in Mediating Responses to Neurokinin A
J Pharmacol Exp Ther 2000 294: 147-154. [Abstract] [Full Text] [PDF]  

Suraj S. Shetty and Dominick DelGrande

Differential Inhibition of the Prejunctional Actions of Angiotensin II in Rat Atria by Valsartan, Irbesartan, Eprosartan, and Losartan
J Pharmacol Exp Ther 2000 294: 179-186. [Abstract] [Full Text] [PDF]  

Marc Thibonnier, Patrick Coles, Doreen M. Conarty, Christine L. Plesnicher, and Menachem Shoham

A Molecular Model of Agonist and Nonpeptide Antagonist Binding to the Human V₁ Vascular Vasopressin Receptor
J Pharmacol Exp Ther 2000 294: 195-203. [Abstract] [Full Text] [PDF]  

Shigeji Matsumoto, Toshiaki Takahashi, Mizuho Ikeda, Toshimi Nishikawa, Shinki Yoshida, and Tomoyuki Kawase

Effects of N^G-Monomethyl-L-arginine on Ca²⁺ Current and Nitric-Oxide Synthase in Rat Ventricular Myocytes
J Pharmacol Exp Ther 2000 294: 216-223. [Abstract] [Full Text] [PDF]  

Manuel Ferreira, Anu Singh, Kenneth L. Dretchen, Kenneth J. Kellar, and Richard A. Gillis

Brainstem Nicotinic Receptor Subtypes That Influence Intragastric and Arterial Blood Pressures
J Pharmacol Exp Ther 2000 294: 230-238. [Abstract] [Full Text] [PDF]  

Ryushi Maruyama, Eiichiro Hatta, Keishu Yasuda, Neil C. E. Smith, and Roberto Levi

Angiotensin-Converting Enzyme-Independent Angiotensin Formation in a Human Model of Myocardial Ischemia: Modulation of Norepinephrine Release by Angiotensin Type 1 and Angiotensin Type 2 Receptors
J Pharmacol Exp Ther 2000 294: 248-254. [Abstract] [Full Text] [PDF]  

Laine J. Murphey, David L. Hachey, John A. Oates, Jason D. Morrow, and Nancy J. Brown

Metabolism of Bradykinin In Vivo in Humans: Identification of BK1-5 as a Stable Plasma Peptide Metabolite
J Pharmacol Exp Ther 2000 294: 263-269. [Abstract] [Full Text] [PDF]  

Yusuke Katayama, Akikazu Fujita, Tohru Ohe, Ian Findlay, and Yoshihisa Kurachi

Inhibitory Effects of Vesnarinone on Cloned Cardiac Delayed Rectifier K⁺ Channels Expressed in a Mammalian Cell Line
J Pharmacol Exp Ther 2000 294: 339-346. [Abstract] [Full Text] [PDF]  

David M. Weinstein, Michael John Mihm, and John Anthony Bauer

Cardiac Peroxynitrite Formation and Left Ventricular Dysfunction following Doxorubicin Treatment in Mice
J Pharmacol Exp Ther 2000 294: 396-401. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Nanda Tilakaratne, George Christopoulos, Emma T. Zumpe, Steven M. Foord, and Patrick M. Sexton

Amylin Receptor Phenotypes Derived from Human Calcitonin Receptor/RAMP Coexpression Exhibit Pharmacological Differences Dependent on Receptor Isoform and Host Cell Environment
J Pharmacol Exp Ther 2000 294: 61-72. [Abstract] [Full Text] [PDF]  

Chung-Ren Jan and Ching-Jiunn Tseng

MK-886, a Leukotriene Biosynthesis Inhibitor, as an Activator of Ca²⁺ Mobilization in Madin-Darby Canine Kidney (MDCK) Cells
J Pharmacol Exp Ther 2000 294: 96-102. [Abstract] [Full Text] [PDF]  

Yogesh Dwivedi and Ghanshyam N. Pandey

Adrenal Glucocorticoids Modulate [³H]Cyclic AMP Binding to Protein Kinase A (PKA), Cyclic AMP-Dependent PKA Activity, and Protein Levels of Selective Regulatory and Catalytic Subunit Isoforms of PKA in Rat Brain
J Pharmacol Exp Ther 2000 294: 103-116. [Abstract] [Full Text] [PDF]  

Zhao-Hui Song and Miao Zhong

CB1 Cannabinoid Receptor-Mediated Cell Migration
J Pharmacol Exp Ther 2000 294: 204-209. [Abstract] [Full Text] [PDF]  

George J. Trachte

Depletion of Natriuretic Peptide C Receptors Eliminates Inhibitory Effects of C-Type Natriuretic Peptide on Evoked Neurotransmitter Efflux
J Pharmacol Exp Ther 2000 294: 210-215. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Roberto Gambari, Giordana Feriotto, Cristina Rutigliano, Nicoletta Bianchi, and Carlo Mischiati

Biospecific Interaction Analysis (BIA) of Low-Molecular Weight DNA-Binding Drugs
J Pharmacol Exp Ther 2000 294: 370-377. [Abstract] [Full Text] [PDF]  

Denggao Yao, Shaohong Ding, Brian Burchell, C. Roland Wolf, and Thomas Friedberg

Detoxication of Vinca Alkaloids by Human P450 CYP3A4-Mediated Metabolism: Implications for the Development of Drug Resistance
J Pharmacol Exp Ther 2000 294: 387-395. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Se-Ne Huang and Peter W. Swaan

Involvement of a Receptor-Mediated Component in Cellular Translocation of Riboflavin
J Pharmacol Exp Ther 2000 294: 117-125. [Abstract] [Full Text] [PDF]  

Edwin E. Daniel, Jennifer Jury, Anne Marie Salapatek, Tim Bowes, Annette Lam, Shoba Thomas, Michelle Ramnarain, Vicky Nguyen, and Valerie Mistry

Nitric Oxide from Enteric Nerves Acts by a Different Mechanism from Myogenic Nitric Oxide in Canine Lower Esophageal Sphincter
J Pharmacol Exp Ther 2000 294: 270-279. [Abstract] [Full Text] [PDF]  

David A. Schneider, Mike Perrone, and James J. Galligan

Nicotinic Acetylcholine Receptors at Sites of Neurotransmitter Release to the Guinea Pig Intestinal Circular Muscle
J Pharmacol Exp Ther 2000 294: 363-369. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Keiji Wada, Emiko Fujii, Hiroyasu Ishida, Toshimasa Yoshioka, and Takamura Muraki

Effect of Lipoteichoic Acid on Dermal Vascular Permeability in Mice
J Pharmacol Exp Ther 2000 294: 280-286. [Abstract] [Full Text] [PDF]  

Natalie Serkova, Bernard Hausen, Gerald J. Berry, Wolfgang Jacobsen, Leslie Z. Benet, Randall E. Morris, and Uwe Christians

Tissue Distribution and Clinical Monitoring of the Novel Macrolide Immunosuppressant SDZ-RAD and Its Metabolites in Monkey Lung Transplant Recipients: Interaction with Cyclosporine
J Pharmacol Exp Ther 2000 294: 323-332. [Abstract] [Full Text] [PDF]  

Juan J. Moreno

Resveratrol Modulates Arachidonic Acid Release, Prostaglandin Synthesis, and 3T6 Fibroblast Growth
J Pharmacol Exp Ther 2000 294: 333-338. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Yolanda Hoyo, John C. McGrath, and Elisabet Vila

Evidence for Y1-Receptor-Mediated Facilitatory, Modulatory Cotransmission by NPY in the Rat Anococcygeus Muscle
J Pharmacol Exp Ther 2000 294: 38-44. [Abstract] [Full Text] [PDF]  

Markus Storvik, Anni-Maija Lindén, Outi Kontkanen, Merja Lakso, Eero Castrén, and Garry Wong

Induction of cAMP Response Element Modulator (CREM) and Inducible cAMP Early Repressor (ICER) Expression in Rat Brain by Uncompetitive N-Methyl-D-aspartate Receptor Antagonists
J Pharmacol Exp Ther 2000 294: 52-60. [Abstract] [Full Text] [PDF]  

Shao-yu Chen and Kathleen K. Sulik

Iron-Mediated Free Radical Injury in Ethanol-Exposed Mouse Neural Crest Cells
J Pharmacol Exp Ther 2000 294: 134-140. [Abstract] [Full Text] [PDF]  

Michael R. Brandt and Charles P. France

Chronic l--Acetylmethadol (LAAM) in Rhesus Monkeys: Tolerance and Cross-Tolerance to the Antinociceptive, Ventilatory, and Rate-Decreasing Effects of Opioids
J Pharmacol Exp Ther 2000 294: 168-178. [Abstract] [Full Text] [PDF]  

Luigia Trabace, Tommaso Cassano, Luca Steardo, Claudio Pietra, Gino Villetti, Keith M. Kendrick, and Vincenzo Cuomo

Biochemical and Neurobehavioral Profile of CHF2819, a Novel, Orally Active Acetylcholinesterase Inhibitor for Alzheimer's Disease
J Pharmacol Exp Ther 2000 294: 187-194. [Abstract] [Full Text] [PDF]  

Virginia L. Pulito, Xiaobing Li, Sally S. Varga, Linda S. Mulcahy, Kerry S. Clark, Sheridan A. Halbert, Allen B. Reitz, William V. Murray, and Linda K. Jolliffe

An Investigation of the Uroselective Properties of Four Novel _1a-Adrenergic Receptor Subtype-Selective Antagonists
J Pharmacol Exp Ther 2000 294: 224-229. [Abstract] [Full Text] [PDF]  

John R. Mantsch, Stefan D. Schlussman, Ann Ho, and Mary Jeanne Kreek

Effects of Cocaine Self-Administration on Plasma Corticosterone and Prolactin in Rats
J Pharmacol Exp Ther 2000 294: 239-247. [Abstract] [Full Text] [PDF]  

Limin Mao and John Q. Wang

Microinjection of Nociceptin (Orphanin FQ) into Nucleus Tractus Solitarii Elevates Blood Pressure and Heart Rate in Both Anesthetized and Conscious Rats
J Pharmacol Exp Ther 2000 294: 255-262. [Abstract] [Full Text] [PDF]  

Cheng Wang, Joel A. Kaufmann, Monica G. Sanchez-Ross, and Kenneth M. Johnson

Mechanisms of N-Methyl-D-aspartate-Induced Apoptosis in Phencyclidine-Treated Cultured Forebrain Neurons
J Pharmacol Exp Ther 2000 294: 287-295. [Abstract] [Full Text] [PDF]  

Florence Serres, Nancy A. Muma, Daní K. Raap, Francisca Garcia, George Battaglia, and Louis D. Van de Kar

Coadministration of 5-Hydroxytryptamine_1A Antagonist WAY-100635 Prevents Fluoxetine-Induced Desensitization of Postsynaptic 5-Hydroxytryptamine_1A Receptors in Hypothalamus
J Pharmacol Exp Ther 2000 294: 296-301. [Abstract] [Full Text] [PDF]  

Ernô Sántha, Beáta Sperlágh, Tibor Zelles, Gabriella Zsilla, Péter T. Tóth, Balázs Lendvai, Mária Baranyi, and E. Sylvester Vizi

Multiple Cellular Mechanisms Mediate the Effect of Lobeline on the Release of Norepinephrine
J Pharmacol Exp Ther 2000 294: 302-307. [Abstract] [Full Text] [PDF]  

Thomas J. Feuerstein, Boris Huber, Jan Vetter, Heike Aranda, Vera Van Velthoven, and Norbert Limberger

Characterization of the ₂-Adrenoceptor Subtype, Which Functions as ₂-Autoreceptor in Human Neocortex
J Pharmacol Exp Ther 2000 294: 356-362. [Abstract] [Full Text] [PDF]  

Anthony J. Williams, Jitendra R. Dave, James B. Phillips, Yu Lin, R. Tyler McCabe, and Frank C. Tortella

Neuroprotective Efficacy and Therapeutic Window of the High-Affinity N-Methyl-D-aspartate Antagonist Conantokin-G: In Vitro (Primary Cerebellar Neurons) and In Vivo (Rat Model of Transient Focal Brain Ischemia) Studies
J Pharmacol Exp Ther 2000 294: 378-386. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Ignazio Grattagliano, Gianluigi Vendemiale, Veronika B. Deiss, Edith Junker, and Bernhard H. Lauterburg

Effect of Oral and Intravenous S,N-Diacetylcysteine Monoethyl Ester on Circulating and Hepatic Sulfhydryls in the Rat
J Pharmacol Exp Ther 2000 294: 155-159. [Abstract] [Full Text] [PDF]  

Milagros Galisteo, Mary Rissel, Odile Sergent, Martine Chevanne, Josiane Cillard, André Guillouzo, and Dominique Lagadic-Gossmann

Hepatotoxicity of Tacrine: Occurrence of Membrane Fluidity Alterations without Involvement of Lipid Peroxidation
J Pharmacol Exp Ther 2000 294: 160-167. [Abstract] [Full Text] [PDF]  

Shana L. Morrell, James A. Fuchs, and Jordan L. Holtzman

Effect of Methoxychlor Administration to Male Rats on Hepatic, Microsomal Iodothyronine 5'-Deiodinase, Form I
J Pharmacol Exp Ther 2000 294: 308-312. [Abstract] [Full Text] [PDF]  

ASPET MEETING REPORT:

Helmut Steinberg

Meeting Report of the ASPET-Ray Fuller Symposium: Insulin Resistance in Diabetes and Hypertension: Syndrome X and Beyond
J Pharmacol Exp Ther 2000 294: 402-406. [Full Text] [PDF]  

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