PERSPECTIVES IN PHARMACOLOGY:

Najwa N. Izzat, Mitchell E. Deshazer, and David S. Loose-Mitchell

New Molecular Targets for Cholesterol-Lowering Therapy
J Pharmacol Exp Ther 2000 293: 315-320. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach, and David J. Greenblatt

Microsomal Binding of Amitriptyline: Effect on Estimation of Enzyme Kinetic Parameters In Vitro
J Pharmacol Exp Ther 2000 293: 343-350. [Abstract] [Full Text] [PDF]  

Christiane Pauli-Magnus, Oliver von Richter, Oliver Burk, Anja Ziegler, Thomas Mettang, Michel Eichelbaum, and Martin F. Fromm

Characterization of the Major Metabolites of Verapamil as Substrates and Inhibitors of P-glycoprotein
J Pharmacol Exp Ther 2000 293: 376-382. [Abstract] [Full Text] [PDF]  

Eve M. Taylor, Deborah A. Otero, William A. Banks, and John S. O'Brien

Designing Stable Blood-Brain Barrier-Permeable Prosaptide Peptides for Treatment of Central Nervous System Neurodegeneration
J Pharmacol Exp Ther 2000 293: 403-409. [Abstract] [Full Text] [PDF]  

David J. Greenblatt, Jerold S. Harmatz, Lisa L. von Moltke, C. Eugene Wright, Anna Liza B. Durol, Lisa M. Harrel-Joseph, and Richard I. Shader

Comparative Kinetics and Response to the Benzodiazepine Agonists Triazolam and Zolpidem: Evaluation of Sex-Dependent Differences
J Pharmacol Exp Ther 2000 293: 435-443. [Abstract] [Full Text] [PDF]  

Keith W. Ward, Robin Griffiths, Mark A. Levy, and Brian R. Smith

Evaluation of the Use of Accelerated Infusions for the Determination of Pharmacokinetic Linearity
J Pharmacol Exp Ther 2000 293: 468-479. [Abstract] [Full Text] [PDF]  

Douglas W. Loe, Roger G. Deeley, and Susan P. C. Cole

Verapamil Stimulates Glutathione Transport by the 190-kDa Multidrug Resistance Protein 1 (MRP1)
J Pharmacol Exp Ther 2000 293: 530-538. [Abstract] [Full Text] [PDF]  

Tammy L. Domanski, You-Ai He, Greg R. Harlow, and James R. Halpert

Dual Role of Human Cytochrome P450 3A4 Residue Phe-304 in Substrate Specificity and Cooperativity
J Pharmacol Exp Ther 2000 293: 585-591. [Abstract] [Full Text] [PDF]  

Brian S. Cummings, Jerome M. Lasker, and Lawrence H. Lash

Expression of Glutathione-Dependent Enzymes and Cytochrome P450s in Freshly Isolated and Primary Cultures of Proximal Tubular Cells from Human Kidney
J Pharmacol Exp Ther 2000 293: 677-685. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Emmanuel N. Mbaku, Lubo Zhang, Sue P. Duckles, and John Buchholz

Nitric-Oxide Synthase-Containing Nerves Facilitate Adrenergic Transmitter Release in Sheep Middle Cerebral Arteries
J Pharmacol Exp Ther 2000 293: 397-402. [Abstract] [Full Text] [PDF]  

Ge-Xin Wang, Xiao-Bo Zhou, and Michael Korth

Effects of Mitoxantrone on Excitation-Contraction Coupling in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 2000 293: 501-508. [Abstract] [Full Text] [PDF]  

Jodan D. Ratz, John J. McGuire, Diane J. Anderson, and Brian M. Bennett

Effects of the Flavoprotein Inhibitor, Diphenyleneiodonium Sulfate, on Ex Vivo Organic Nitrate Tolerance in the Rat
J Pharmacol Exp Ther 2000 293: 569-577. [Abstract] [Full Text] [PDF]  

Hong-Yu Li, Jin-Song Bian, Yiu Wa Kwan, and Tak Ming Wong

Enhanced Responses to 17-Estradiol in Rat Hearts Treated with Isoproterenol: Involvement of a Cyclic AMP-Dependent Pathway
J Pharmacol Exp Ther 2000 293: 592-598. [Abstract] [Full Text] [PDF]  

Chris L. Kapicka, Stephen C. Montamat, Ramagopal V. Mudumbi, Shelley M. Jacks, Richard D. Olson, and Robert E. Vestal

Effects of Cyclopentyladenosine on Isoproterenol Response in Adult and Senescent Cardiac Tissue from Fischer 344 Rats
J Pharmacol Exp Ther 2000 293: 599-606. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Roland G. W. Staal, Kelly A. Hogan, Chang-Lin Liang, Dwight C. German, and Patricia K. Sonsalla

In Vitro Studies of Striatal Vesicles Containing the Vesicular Monoamine Transporter (VMAT2): Rat versus Mouse Differences in Sequestration of 1-Methyl-4-phenylpyridinium
J Pharmacol Exp Ther 2000 293: 329-335. [Abstract] [Full Text] [PDF]  

Roland G. W. Staal and Patricia K. Sonsalla

Inhibition of Brain Vesicular Monoamine Transporter (VMAT2) Enhances 1-Methyl-4-phenylpyridinium Neurotoxicity In Vivo in Rat Striata
J Pharmacol Exp Ther 2000 293: 336-342. [Abstract] [Full Text] [PDF]  

Ganesan L. Kamatchi, Shveta N. Tiwari, Marcel E. Durieux, and Carl Lynch, III

Effects of Volatile Anesthetics on the Direct and Indirect Protein Kinase C-Mediated Enhancement of 1E-Type Ca²⁺ Current in Xenopus Oocytes
J Pharmacol Exp Ther 2000 293: 360-369. [Abstract] [Full Text] [PDF]  

Sandra J. Hewett, Tracy F. Uliasz, Aniruddha S. Vidwans, and James A. Hewett

Cyclooxygenase-2 Contributes to N-Methyl-D-aspartate-Mediated Neuronal Cell Death in Primary Cortical Cell Culture
J Pharmacol Exp Ther 2000 293: 417-425. [Abstract] [Full Text] [PDF]  

Ana Lucia Marques Ventura and David R. Sibley

Altered Regulation of the D₁ Dopamine Receptor in Mutant Chinese Hamster Ovary Cells Deficient in Cyclic AMP-Dependent Protein Kinase Activity
J Pharmacol Exp Ther 2000 293: 426-434. [Abstract] [Full Text] [PDF]  

Jinshyun R. Wu-Wong, William J. Chiou, and Jiahong Wang

Extracellular Signal-Regulated Kinases Are Involved in the Antiapoptotic Effect of Endothelin-1
J Pharmacol Exp Ther 2000 293: 514-521. [Abstract] [Full Text] [PDF]  

David R. Linden, Melissa J. Chell, Esam E. El-Fakahany, and Virginia S. Seybold

Neurokinin₃ Receptors Couple to the Activation of Neuronal Nitric-Oxide Synthase in Stably Transfected Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 2000 293: 559-568. [Abstract] [Full Text] [PDF]  

Bok Hee Choi, Jin-Sung Choi, Seong-Whan Jeong, Sang June Hahn, Shin Hee Yoon, Yang-Hyeok Jo, and Myung-Suk Kim

Direct Block by Bisindolylmaleimide of Rat Kv1.5 Expressed in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 2000 293: 634-640. [Abstract] [Full Text] [PDF]  

Patrício Soares-da-Silva and Maria Paula Serrão

Outward Transfer of Dopamine Precursor L-3,4-Dihydroxyphenylalanine (L-dopa) by Native and Human P-glycoprotein in LLC-PK₁ and LLC-GA5 Col300 Renal Cells
J Pharmacol Exp Ther 2000 293: 697-704. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY:

Jan S. Moreb, Chalesea Maccow, Mark Schweder, and Jaima Hecomovich

Expression of Antisense RNA to Aldehyde Dehydrogenase Class-1 Sensitizes Tumor Cells to 4-Hydroperoxycyclophosphamide In Vitro
J Pharmacol Exp Ther 2000 293: 390-396. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Stefan Dhein, Stefan Hochreuther, Christian aus dem Spring, Klaus Bollig, Christine Hufnagel, and Manfred Raschack

Long-Term Effects of the Endothelin_A Receptor Antagonist LU 135252 and the Angiotensin-Converting Enzyme Inhibitor Trandolapril on Diabetic Angiopathy and Nephropathy in a Chronic Type I Diabetes Mellitus Rat Model
J Pharmacol Exp Ther 2000 293: 351-359. [Abstract] [Full Text] [PDF]  

Shiling Hu, Shuya Wang, Barbara Fanelli, Philip A. Bell, Beth E. Dunning, Sabine Geisse, Rita Schmitz, and Brian R. Boettcher

Pancreatic -Cell K_ATP Channel Activity and Membrane-Binding Studies with Nateglinide: A Comparison with Sulfonylureas and Repaglinide
J Pharmacol Exp Ther 2000 293: 444-452. [Abstract] [Full Text] [PDF]  

Clemens Fürnsinn, Barbara Brunmair, Susanne Neschen, Michael Roden, and Werner Waldhäusl

Troglitazone Directly Inhibits CO₂ Production from Glucose and Palmitate in Isolated Rat Skeletal Muscle
J Pharmacol Exp Ther 2000 293: 487-493. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Wallace K. MacNaughton and Kelly Cushing

Role of Constitutive Cyclooxygenase-2 in Prostaglandin-Dependent Secretion in Mouse Colon In Vitro
J Pharmacol Exp Ther 2000 293: 539-544. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Najam A. Sharif, Julie Y. Crider, Shouxi X. Xu, and Gary W. Williams

Affinities, Selectivities, Potencies, and Intrinsic Activities of Natural and Synthetic Prostanoids Using Endogenous Receptors: Focus on DP Class Prostanoids
J Pharmacol Exp Ther 2000 293: 321-328. [Abstract] [Full Text] [PDF]  

Shu Hashimoto, Yasuhiro Gon, Ken Matsumoto, Shuichiro Maruoka, Ikuko Takeshita, Shinichi Hayashi, Yasukiyo Asai, Yoshito Asai, Itsuro Jibiki, Tatsuya Machino, and Takashi Horie

Selective Inhibitor of p38 Mitogen-Activated Protein Kinase Inhibits Lipopolysaccharide-Induced Interleukin-8 Expression in Human Pulmonary Vascular Endothelial Cells
J Pharmacol Exp Ther 2000 293: 370-375. [Abstract] [Full Text] [PDF]  

Masayuki Hojo, Masaru Suzuki, Karim Maghni, Qutayba Hamid, William S. Powell, and James G. Martin

Role of Cysteinyl Leukotrienes in CD4⁺ T Cell-Driven Late Allergic Airway Responses
J Pharmacol Exp Ther 2000 293: 410-416. [Abstract] [Full Text] [PDF]  

Cuyue Tang, Magang Shou, Qin Mei, Thomas H. Rushmore, and A. David Rodrigues

Major Role of Human Liver Microsomal Cytochrome P450 2C9 (CYP2C9) in the Oxidative Metabolism of Celecoxib, a Novel Cyclooxygenase-II Inhibitor
J Pharmacol Exp Ther 2000 293: 453-459. [Abstract] [Full Text] [PDF]  

Nader G. Abraham, Shanlong Jiang, Liming Yang, Barbara A. Zand, Michal Laniado-Schwartzman, Jackleen Marji, George S. Drummond, and Attallah Kappas

Adenoviral Vector-Mediated Transfer of Human Heme Oxygenase in Rats Decreases Renal Heme-Dependent Arachidonic Acid Epoxygenase Activity
J Pharmacol Exp Ther 2000 293: 494-500. [Abstract] [Full Text] [PDF]  

Esther Castaño, Ramon Bartrons, and Joan Gil

Inhibition of Cyclooxygenase-2 Decreases DNA Synthesis Induced by Platelet-Derived Growth Factor in Swiss 3T3 Fibroblasts
J Pharmacol Exp Ther 2000 293: 509-513. [Abstract] [Full Text] [PDF]  

Soo Peang Khor, Kyle McCarthy, Michelle DuPont, Kristin Murray, and Gregg Timony

Pharmacokinetics, Pharmacodynamics, Allometry, and Dose Selection of rPSGL-Ig for Phase I Trial
J Pharmacol Exp Ther 2000 293: 618-624. [Abstract] [Full Text] [PDF]  

Luis Gómez-Cambronero, Bruno Camps, José García de la Asunción, Miguel Cerdá, Antonio Pellín, Federico V. Pallardó, Julio Calvete, Jacob H. Sweiry, Giovanni E. Mann, José Viña, and Juan Sastre

Pentoxifylline Ameliorates Cerulein-Induced Pancreatitis in Rats: Role of Glutathione and Nitric Oxide
J Pharmacol Exp Ther 2000 293: 670-676. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

E. Bradshaw Bunney, Sarah B. Appel, and Mark S. Brodie

Cocaine Potentiates Ethanol-Induced Excitation of Dopaminergic Reward Neurons in the Ventral Tegmental Area
J Pharmacol Exp Ther 2000 293: 383-389. [Abstract] [Full Text] [PDF]  

Richard Sullivan, Anne Chateauneuf, Nathalie Coulombe, Lee F. Kolakowski, Jr., Michael P. Johnson, Terence E. Hebert, Nathalie Ethier, Michel Belley, Kathleen Metters, Mark Abramovitz, Gary P. O'Neill, and Gordon Y. K. Ng

Coexpression of Full-Length -Aminobutyric Acid_B (GABA_B) Receptors with Truncated Receptors and Metabotropic Glutamate Receptor 4 Supports the GABA_B Heterodimer as the Functional Receptor
J Pharmacol Exp Ther 2000 293: 460-467. [Abstract] [Full Text] [PDF]  

Kari R. Hoyt, Beth Ann McLaughlin, Donald S. Higgins, Jr., and Ian J. Reynolds

Inhibition of Glutamate-Induced Mitochondrial Depolarization by Tamoxifen in Cultured Neurons
J Pharmacol Exp Ther 2000 293: 480-486. [Abstract] [Full Text] [PDF]  

Michiko Oka, Yoshinori Itoh, and Yojiro Ukai

Preferential Inhibition by a Novel Na⁺/Ca²⁺ Channel Blocker NS-7 of Severe to Mild Hypoxic Injury in Rat Cerebrocortical Slices: A Possible Involvement of a Highly Voltage-Dependent Blockade of Ca²⁺ Channel
J Pharmacol Exp Ther 2000 293: 522-529. [Abstract] [Full Text] [PDF]  

Kathleen M. K. Boje and Sukwinder Singh Lakhman

Nitric Oxide Redox Species Exert Differential Permeability Effects on the Blood-Brain Barrier
J Pharmacol Exp Ther 2000 293: 545-550. [Abstract] [Full Text] [PDF]  

Charlotte A. Dayer, Scott Baron, Kim E. Light, and Galen R. Wenger

Effects of Ethanol on Working Memory and Attention in Pigeons
J Pharmacol Exp Ther 2000 293: 551-558. [Abstract] [Full Text] [PDF]  

Maria Luisa Laorden, Gregorio Fuertes, Ana González-Cuello, and Maria Victoria Milanés

Changes in Catecholaminergic Pathways Innervating Paraventricular Nucleus and Pituitary-Adrenal Axis Response during Morphine Dependence: Implication of ₁- and ₂-Adrenoceptors
J Pharmacol Exp Ther 2000 293: 578-584. [Abstract] [Full Text] [PDF]  

Bin Liu, Lina Du, and Jau-Shyong Hong

Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation
J Pharmacol Exp Ther 2000 293: 607-617. [Abstract] [Full Text] [PDF]  

Saejeong Kim, Robert Westphalen, Brian Callahan, George Hatzidimitriou, Jie Yuan, and George A. Ricaurte

Toward Development of an In Vitro Model of Methamphetamine-Induced Dopamine Nerve Terminal Toxicity
J Pharmacol Exp Ther 2000 293: 625-633. [Abstract] [Full Text] [PDF]  

Marta Valle, María J. Garrido, Juan M. Pavón, Rosario Calvo, and Iñaki F. Trocóniz

Pharmacokinetic-Pharmacodynamic Modeling of the Antinociceptive Effects of Main Active Metabolites of Tramadol, (+)-O-Desmethyltramadol and ()-O-Desmethyltramadol, in Rats
J Pharmacol Exp Ther 2000 293: 646-653. [Abstract] [Full Text] [PDF]  

Zhiguo Nie, Samuel G. Madamba, and George R. Siggins

Ethanol Enhances -Aminobutyric Acid Responses in a Subpopulation of Nucleus Accumbens Neurons: Role of Metabotropic Glutamate Receptors
J Pharmacol Exp Ther 2000 293: 654-661. [Abstract] [Full Text] [PDF]  

Makoto Inoue and Hiroshi Ueda

Protein Kinase C-Mediated Acute Tolerance to Peripheral µ-Opioid Analgesia in the Bradykinin-Nociception Test in Mice
J Pharmacol Exp Ther 2000 293: 662-669. [Abstract] [Full Text] [PDF]  

Sharon R. Letchworth, Hilary R. Smith, Linda J. Porrino, Barbara A. Bennett, Huw M. L. Davies, Tammy Sexton, and Steven R. Childers

Characterization of a Tropane Radioligand, [³H]2-Propanoyl-3-(4-tolyl) Tropane ([³H]PTT), for Dopamine Transport Sites in Rat Brain
J Pharmacol Exp Ther 2000 293: 686-696. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Peta J. Harvey, Jill E. Gready, Zhanli Yin, David G. Le Couteur, and Allan J. McLean

Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats
J Pharmacol Exp Ther 2000 293: 641-645. [Abstract] [Full Text] [PDF]  

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