PERSPECTIVES IN PHARMACOLOGY:

Joseph W. Kable, L. Charles Murrin, and David B. Bylund

In Vivo Gene Modification Elucidates Subtype-Specific Functions of ₂-Adrenergic Receptors
J Pharmacol Exp Ther 2000 293: 1-7. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Hitomi Takanaga, Ayako Ohnishi, Shiho Yamada, Hirotami Matsuo, Satoshi Morimoto, Yukihiro Shoyama, Hisakazu Ohtani, and Yasufumi Sawada

Polymethoxylated Flavones in Orange Juice Are Inhibitors of P-glycoprotein but Not Cytochrome P450 3A4
J Pharmacol Exp Ther 2000 293: 230-236. [Abstract] [Full Text] [PDF]  

Sharon A. Chen, Ronald J. Sawchuk, Richard C. Brundage, Christopher Horvath, H. Vincent Mendenhall, Robert A. Gunther, and Rene A. Braeckman

Plasma and Lymph Pharmacokinetics of Recombinant Human Interleukin-2 and Polyethylene Glycol-Modified Interleukin-2 in Pigs
J Pharmacol Exp Ther 2000 293: 248-259. [Abstract] [Full Text] [PDF]  

Shanmugam Muthian, Kasem Nithipatikom, William B. Campbell, and Cecilia J. Hillard

Synthesis and Characterization of a Fluorescent Substrate for the N-Arachidonoylethanolamine (Anandamide) Transmembrane Carrier
J Pharmacol Exp Ther 2000 293: 289-295. [Abstract] [Full Text] [PDF]  

Paul Stoppie, Marcel Borgers, Peter Borghgraef, Lieve Dillen, Jan Goossens, Gerard Sanz, Heidi Szel, Carl Van Hove, Greta Van Nyen, Geert Nobels, Hugo Vanden Bossche, Marc Venet, Gustaaf Willemsens, and Jean Van Wauwe

R115866 Inhibits All-trans-Retinoic Acid Metabolism and Exerts Retinoidal Effects in Rodents
J Pharmacol Exp Ther 2000 293: 304-312. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Rana M. Temsah, Chadwyn Dyck, Thomas Netticadan, Donald Chapman, Vijayan Elimban, and Naranjan S. Dhalla

Effect of -Adrenoceptor Blockers on Sarcoplasmic Reticular Function and Gene Expression in the Ischemic-Reperfused Heart
J Pharmacol Exp Ther 2000 293: 15-23. [Abstract] [Full Text] [PDF]  

Edith-Clara Garcia-Cohen, Jesus Marin, Luis D. Diez-Picazo, Ana B. Baena, Mercedes Salaices, and M. Angeles Rodriguez-Martinez

Oxidative Stress Induced by tert-Butyl Hydroperoxide Causes Vasoconstriction in the Aorta from Hypertensive and Aged Rats: Role of Cyclooxygenase-2 Isoform
J Pharmacol Exp Ther 2000 293: 75-81. [Abstract] [Full Text] [PDF]  

Yi Zhang and Donald B. Hoover

Signaling Mechanisms for Muscarinic Receptor-Mediated Coronary Vasoconstriction in Isolated Rat Hearts
J Pharmacol Exp Ther 2000 293: 96-106. [Abstract] [Full Text] [PDF]  

Hidetsuna Kitamura, Mitsuhiro Yokoyama, Hozuka Akita, Kenji Matsushita, Yoshihisa Kurachi, and Mitsuhiko Yamada

Tertiapin Potently and Selectively Blocks Muscarinic K⁺ Channels in Rabbit Cardiac Myocytes
J Pharmacol Exp Ther 2000 293: 196-205. [Abstract] [Full Text] [PDF]  

Luke T. Krebs, Jodie M. Hanesworth, Michael F. Sardinia, Robert C. Speth, John W. Wright, and Joseph W. Harding

A Novel Angiotensin Analog with Subnanomolar Affinity for Angiotensin-Converting Enzyme
J Pharmacol Exp Ther 2000 293: 260-267. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Daniela M. Zisterer, Giuseppe Campiani, Vito Nacci, and D. Clive Williams

Pyrrolo-1,5-benzoxazepines Induce Apoptosis in HL-60, Jurkat, and Hut-78 Cells: A New Class of Apoptotic Agents
J Pharmacol Exp Ther 2000 293: 48-59. [Abstract] [Full Text] [PDF]  

Mubarack M. Muthalif, Jean-Hugues Parmentier, Ibrahim F. Benter, Nour Karzoun, Aftab Ahmed, Zinat Khandekar, Mohamed Z. Adl, Sylvain Bourgoin, and Kafait U. Malik

Ras/Mitogen-Activated Protein Kinase Mediates Norepinephrine-Induced Phospholipase D Activation in Rabbit Aortic Smooth Muscle Cells by a Phosphorylation-Dependent Mechanism
J Pharmacol Exp Ther 2000 293: 268-274. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Sibylle Grub, Elke Persohn, Wolfgang E. Trommer, and Armin Wolf

Induction of Apoptosis by the O-Hydroxyethyl-D(Ser)⁸-cyclosporine A Derivative SDZ IMM 125 in Rat Hepatocytes
J Pharmacol Exp Ther 2000 293: 24-32. [Abstract] [Full Text] [PDF]  

Kalina Venkova, S. Terence Dunn, Adekunle M. Adesina, and Beverley Greenwood-Van Meerveld

Neuromuscular Dysfunction in the Jejunum and Colon of Human Leukocyte Antigen B27 Transgenic Rats
J Pharmacol Exp Ther 2000 293: 60-66. [Abstract] [Full Text] [PDF]  

Gopalakrishnan Gurujeyalakshmi, Yingjin Wang, and Shri N. Giri

Taurine and Niacin Block Lung Injury and Fibrosis by Down-Regulating Bleomycin-Induced Activation of Transcription Nuclear Factor-B in Mice
J Pharmacol Exp Ther 2000 293: 82-90. [Abstract] [Full Text] [PDF]  

Kerry J. Rhoden, Alicia M. Dodson, and Betty Ky

Stimulation of the Na⁺-K⁺ Pump in Cultured Guinea Pig Airway Smooth Muscle Cells by Serotonin
J Pharmacol Exp Ther 2000 293: 107-112. [Abstract] [Full Text] [PDF]  

Mariusz T. Skowronski, Yasuko Ishikawa, and Hajime Ishida

Enhancement by Epinephrine of Benzylpenicillin Transport in Rat Small Intestine
J Pharmacol Exp Ther 2000 293: 128-135. [Abstract] [Full Text] [PDF]  

Zbigniew K. Krowicki and Pamela J. Hornby

Substance P in the Dorsal Motor Nucleus of the Vagus Evokes Gastric Motor Inhibition via Neurokinin 1 Receptor in Rat
J Pharmacol Exp Ther 2000 293: 214-221. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Amarnath Sharma, Charles B. Davis, Lee Ann P. Tobia, Deborah C. Kwok, Marcella G. Tucci, Elizabeth R. Gore, Danuta J. Herzyk, and Timothy K. Hart

Comparative Pharmacodynamics of Keliximab and Clenoliximab in Transgenic Mice Bearing Human CD4
J Pharmacol Exp Ther 2000 293: 33-41. [Abstract] [Full Text] [PDF]  

Sidney R. Smith, Carol Terminelli, and Georgetta Denhardt

Effects of Cannabinoid Receptor Agonist and Antagonist Ligands on Production of Inflammatory Cytokines and Anti-Inflammatory Interleukin-10 in Endotoxemic Mice
J Pharmacol Exp Ther 2000 293: 136-150. [Abstract] [Full Text] [PDF]  

Roma Kalra, Shashi P. Singh, Susan M. Savage, Gregory L. Finch, and Mohan L. Sopori

Effects of Cigarette Smoke on Immune Response: Chronic Exposure to Cigarette Smoke Impairs Antigen-Mediated Signaling in T Cells and Depletes IP3-Sensitive Ca²⁺ Stores
J Pharmacol Exp Ther 2000 293: 166-171. [Abstract] [Full Text] [PDF]  

Kouya Yamaki, Takayuki Yonezawa, and Kazuo Ohuchi

Signal Transduction Cascade in Staurosporine-Induced Prostaglandin E₂ Production by Rat Peritoneal Macrophages
J Pharmacol Exp Ther 2000 293: 206-213. [Abstract] [Full Text] [PDF]  

Christine Boulos, Houli Jiang, and Michael Balazy

Diffusion of Peroxynitrite into the Human Platelet Inhibits Cyclooxygenase via Nitration of Tyrosine Residues
J Pharmacol Exp Ther 2000 293: 222-229. [Abstract] [Full Text] [PDF]  

David C. Underwood, Ruth R. Osborn, Charles J. Kotzer, Jerry L. Adams, John C. Lee, Edward F. Webb, Donald C. Carpenter, Steven Bochnowicz, Heath C. Thomas, Douglas W. P. Hay, and Don E. Griswold

SB 239063, a Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence
J Pharmacol Exp Ther 2000 293: 281-288. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Gary E. Duncan, Seiya Miyamoto, Jeremy N. Leipzig, and Jeffrey A. Lieberman

Comparison of the Effects of Clozapine, Risperidone, and Olanzapine on Ketamine-Induced Alterations in Regional Brain Metabolism
J Pharmacol Exp Ther 2000 293: 8-14. [Abstract] [Full Text] [PDF]  

Manuela Marcoli, Simona Scarrone, Guido Maura, Giambattista Bonanno, and Maurizio Raiteri

A Subtype of the -Aminobutyric Acid_B Receptor Regulates Cholinergic Twitch Response in the Guinea Pig Ileum
J Pharmacol Exp Ther 2000 293: 42-47. [Abstract] [Full Text] [PDF]  

Jerry A. Stitzel, Melissa Jimenez, Michael J. Marks, Theresa Tritto, and Allan C. Collins

Potential Role of the 4 and 6 Nicotinic Receptor Subunits in Regulating Nicotine-Induced Seizures
J Pharmacol Exp Ther 2000 293: 67-74. [Abstract] [Full Text] [PDF]  

Carolina O. Jaliffa, Francisco Firpo Lacoste, Diego Weinberg Llomovatte, María I. Keller Sarmiento, and Ruth E. Rosenstein

Dopamine Decreases Melatonin Content in Golden Hamster Retina
J Pharmacol Exp Ther 2000 293: 91-95. [Abstract] [Full Text] [PDF]  

Hong Bing Deng, Wei Guang, and Jia Bei Wang

Selected Cysteine Residues in Transmembrane Domains of µ-Opioid Receptor Are Critical for Effects of Sulfhydryl Reagents
J Pharmacol Exp Ther 2000 293: 113-120. [Abstract] [Full Text] [PDF]  

Ming He and Toni S. Shippenberg

Strain Differences in Basal and Cocaine-Evoked Dopamine Dynamics in Mouse Striatum
J Pharmacol Exp Ther 2000 293: 121-127. [Abstract] [Full Text] [PDF]  

Edward J. Bilsky, Xinhua Qian, Victor J. Hruby, and Frank Porreca

Antinociceptive Activity of [-Methyl-2',6'-dimethyltyrosine¹]-Substituted Cyclic [D-Pen²,D-Pen⁵]Enkephalin and [D-Ala²,Asp⁴]Deltorphin Analogs
J Pharmacol Exp Ther 2000 293: 151-158. [Abstract] [Full Text] [PDF]  

Feng Chen and Andrew J. Lawrence

Effect of Chronic Ethanol and Withdrawal on the µ-Opioid Receptor- and 5-Hydroxytryptamine_1A Receptor-Stimulated Binding of [³⁵S]Guanosine-5'-O-(3-thio)triphosphate in the Fawn-Hooded Rat Brain: A Quantitative Autoradiography Study
J Pharmacol Exp Ther 2000 293: 159-165. [Abstract] [Full Text] [PDF]  

Victor Mendoza-Fernández, R. David Andrew, and Carlos Barajas-López

ATP Inhibits Glutamate Synaptic Release by Acting at P2Y Receptors in Pyramidal Neurons of Hippocampal Slices
J Pharmacol Exp Ther 2000 293: 172-179. [Abstract] [Full Text] [PDF]  

Heather S. Hain, John C. Crabbe, Susan E. Bergeson, and John K. Belknap

Cocaine-Induced Seizure Thresholds: Quantitative Trait Loci Detection and Mapping in Two Populations Derived from the C57BL/6 and DBA/2 Mouse Strains
J Pharmacol Exp Ther 2000 293: 180-187. [Abstract] [Full Text] [PDF]  

V. Gene Erwin, Vaughn M. Gehle, and Richard A. Deitrich

Selectively Bred Lines of Mice Show Response and Drug Specificity for Genetic Regulation of Acute Functional Tolerance to Ethanol and Pentobarbital
J Pharmacol Exp Ther 2000 293: 188-195. [Abstract] [Full Text] [PDF]  

Ahmed Hasbi, Stéphane Allouche, François Sichel, Laura Stanasila, Dominique Massotte, Gérard Landemore, Jocelyne Polastron, and Philippe Jauzac

Internalization and Recycling of -Opioid Receptor Are Dependent on a Phosphorylation-Dephosphorylation Mechanism
J Pharmacol Exp Ther 2000 293: 237-247. [Abstract] [Full Text] [PDF]  

Douglas A. Schober, Susan L. Gackenheimer, Mark L. Heiman, and Donald R. Gehlert

Pharmacological Characterization of ¹²⁵I-1229U91 Binding to Y1 and Y4 Neuropeptide Y/Peptide YY Receptors
J Pharmacol Exp Ther 2000 293: 275-280. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Hiroshi Kono, Ivan Rusyn, Blair U. Bradford, Henry D. Connor, Ronald P. Mason, and Ronald G. Thurman

Allopurinol Prevents Early Alcohol-Induced Liver Injury in Rats
J Pharmacol Exp Ther 2000 293: 296-303. [Abstract] [Full Text] [PDF]  

ERRATA:

J Pharmacol Exp Ther 2000 293: 313. [Full Text] [PDF]  

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