PERSPECTIVES IN PHARMACOLOGY:

G. Kenneth Lloyd and Michael Williams

Neuronal Nicotinic Acetylcholine Receptors as Novel Drug Targets
J Pharmacol Exp Ther 2000 292: 461-467. [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Madeline Butler, Rosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Marilee Lougheed, Susan F. Murray, Donna Witchell, Urs Steinbrecher, and C. Frank Bennett

Phosphorothioate Oligodeoxynucleotides Distribute Similarly in Class A Scavenger Receptor Knockout and Wild-Type Mice
J Pharmacol Exp Ther 2000 292: 489-496. [Abstract] [Full Text] [PDF]  

Hirokazu Kouzuki, Hiroshi Suzuki, Bruno Stieger, Peter J. Meier, and Yuichi Sugiyama

Characterization of the Transport Properties of Organic Anion Transporting Polypeptide 1 (oatp1) and Na⁺/Taurocholate Cotransporting Polypeptide (Ntcp): Comparative Studies on the Inhibitory Effect of their Possible Substrates in Hepatocytes and cDNA-Transfected COS-7 Cells
J Pharmacol Exp Ther 2000 292: 505-511. [Abstract] [Full Text] [PDF]  

Michael D. Perloff, Lisa L. von Moltke, Michael H. Court, Tsutomu Kotegawa, Richard I. Shader, and David J. Greenblatt

Midazolam and Triazolam Biotransformation in Mouse and Human Liver Microsomes: Relative Contribution of CYP3A and CYP2C Isoforms
J Pharmacol Exp Ther 2000 292: 618-628. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Agnès Bénardeau, Jacques Weissenburger, Luc Hondeghem, and Eric A. Ertel

Effects of the T-Type Ca²⁺ Channel Blocker Mibefradil on Repolarization of Guinea Pig, Rabbit, Dog, Monkey, and Human Cardiac Tissue
J Pharmacol Exp Ther 2000 292: 561-575. [Abstract] [Full Text] [PDF]  

Astrid Parenti, Sandra Filippi, Sandra Amerini, Harris J. Granger, Alessandro Fazzini, and Fabrizio Ledda

Inositol Phosphate Metabolism and Nitric-Oxide Synthase Activity in Endothelial Cells Are Involved in the Vasorelaxant Activity of Nebivolol
J Pharmacol Exp Ther 2000 292: 698-703. [Abstract] [Full Text] [PDF]  

Chih-Ming Leo Tseng, Mohammad A. Tabrizi-Fard, and Ho-Leung Fung

Differential Sensitivity among Nitric Oxide Donors toward ODQ-Mediated Inhibition of Vascular Relaxation
J Pharmacol Exp Ther 2000 292: 737-742. [Abstract] [Full Text] [PDF]  

Curtis K. Kost, Jr., William A. Herzer, Barbara R. Rominski, Zaichuan Mi, and Edwin K. Jackson

Diuretic Response to Adenosine A₁ Receptor Blockade in Normotensive and Spontaneously Hypertensive Rats: Role of Pertussis Toxin-Sensitive G-Proteins
J Pharmacol Exp Ther 2000 292: 752-760. [Abstract] [Full Text] [PDF]  

Yuichi Hattori, Naoyuki Matsuda, Atsushi Sato, Satoko Watanuki, Hiroshi Tomioka, Hisao Kawasaki, and Morio Kanno

Predominant Contribution of the G Protein-Mediated Mechanism to NaF-Induced Vascular Contractions in Diabetic Rats: Association with an Increased Level of G_q Expression
J Pharmacol Exp Ther 2000 292: 761-768. [Abstract] [Full Text] [PDF]  

Roger J. Laham, Mehrdad Rezaee, Mark Post, Debborah Novicki, Frank W. Sellke, Justin D. Pearlman, Michael Simons, and David Hung

Intrapericardial Delivery of Fibroblast Growth Factor-2 Induces Neovascularization in a Porcine Model of Chronic Myocardial Ischemia
J Pharmacol Exp Ther 2000 292: 795-802. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Andreas Vogt, Angela S. Wang, Candace S. Johnson, James P. Fabisiak, Peter Wipf, and John S. Lazo

In Vivo Antitumor Activity and Induction of Insulin-Like Growth Factor-1-Resistant Apoptosis by SC-9
J Pharmacol Exp Ther 2000 292: 530-537. [Abstract] [Full Text] [PDF]  

Yaoxian Ding and Nosratola D. Vaziri

Nifedipine and Diltiazem but Not Verapamil Up-Regulate Endothelial Nitric-Oxide Synthase Expression
J Pharmacol Exp Ther 2000 292: 606-609. [Abstract] [Full Text] [PDF]  

Hervé Le Stunff, Lien Dokhac, and Simone Harbon

The Roles of Protein Kinase C and Tyrosine Kinases in Mediating Endothelin-1-Stimulated Phospholipase D Activity in Rat Myometrium: Differential Inhibition by Ceramides and Cyclic AMP
J Pharmacol Exp Ther 2000 292: 629-637. [Abstract] [Full Text] [PDF]  

Petrus J. Pauwels, Stéphanie Tardif, Thierry Wurch, and Francis C. Colpaert

Facilitation of Constitutive _2A-Adrenoceptor Activity by Both Single Amino Acid Mutation (Thr³⁷³Lys) and G_o Protein Coexpression: Evidence for Inverse Agonism
J Pharmacol Exp Ther 2000 292: 654-663. [Abstract] [Full Text] [PDF]  

Wang-Ni Tian, Duane D. Miller, and Richard C. Deth

Bidirectional Allosteric Effects of Agonists and GTP at _2A/D-Adrenoceptors
J Pharmacol Exp Ther 2000 292: 664-671. [Abstract] [Full Text] [PDF]  

Emanuel Meller, Hua Li, Kenneth D. Carr, and Jacob M. Hiller

5-Hydroxytryptamine_1A Receptor-Stimulated [³⁵S]GTPS Binding in Rat Brain: Absence of Regional Differences in Coupling Efficiency
J Pharmacol Exp Ther 2000 292: 684-691. [Abstract] [Full Text] [PDF]  

Atsuko Suzuki, Kimihiro Matsunaga, Heejae Shin, Jioji Tabudrav, Yoshikazu Shizuri, and Yasushi Ohizumi

Bisprasin, a Novel Ca²⁺ Releaser with Caffeine-Like Properties from a Marine Sponge, Dysidea spp., Acts on Ca²⁺-Induced Ca²⁺ Release Channels of Skeletal Muscle Sarcoplasmic Reticulum
J Pharmacol Exp Ther 2000 292: 725-730. [Abstract] [Full Text] [PDF]  

Ashvani K. Singh, Daniel C. Devor, Aaron C. Gerlach, Margaret Gondor, Joseph M. Pilewski, and Robert J. Bridges

Stimulation of Cl Secretion by Chlorzoxazone
J Pharmacol Exp Ther 2000 292: 778-787. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Thierry Voisin, Mathieu Goumain, Anne-Marie Lorinet, Jean-José Maoret, and Marc Laburthe

Functional and Molecular Properties of the Human Recombinant Y4 Receptor: Resistance to Agonist-Promoted Desensitization
J Pharmacol Exp Ther 2000 292: 638-646. [Abstract] [Full Text] [PDF]  

Céline Méhats, Gisèle Tanguy, Brigitte Paris, Brigitte Robert, Nadja Pernin, Françoise Ferré, and Marie-Josèphe Leroy

Pregnancy Induces a Modulation of the cAMP Phosphodiesterase 4-Conformers Ratio in Human Myometrium: Consequences for the Utero-Relaxant Effect of PDE4-Selective Inhibitors
J Pharmacol Exp Ther 2000 292: 817-823. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Ralph Theo Schermuly, Axel Roehl, Norbert Weissmann, Hossein Ardeschir Ghofrani, Christian Schudt, Herrmann Tenor, Friedrich Grimminger, Werner Seeger, and Dieter Walmrath

Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange
J Pharmacol Exp Ther 2000 292: 512-520. [Abstract] [Full Text] [PDF]  

Shuichi Tsuruoka, Koh-ichi Sugimoto, Shigeaki Muto, Kazuo Nomiyama, Akio Fujimura, and Masashi Imai

Acute Effect of Cadmium-Metallothionein on Glucose and Amino Acid Transport across the Apical Membrane of the Rabbit Proximal Tubule Perfused In Vitro
J Pharmacol Exp Ther 2000 292: 769-777. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Scott Henry, Kim Stecker, Doug Brooks, David Monteith, Boyd Conklin, and C. Frank Bennett

Chemically Modified Oligonucleotides Exhibit Decreased Immune Stimulation in Mice
J Pharmacol Exp Ther 2000 292: 468-479. [Abstract] [Full Text] [PDF]  

Sandra K. Klimuk, Sean C. Semple, Patrick N. Nahirney, Michelle C. Mullen, C. Frank Bennett, Peter Scherrer, and Michael J. Hope

Enhanced Anti-Inflammatory Activity of a Liposomal Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide in an Acute Model of Contact Hypersensitivity
J Pharmacol Exp Ther 2000 292: 480-488. [Abstract] [Full Text] [PDF]  

Sung Su Yea, Kyu-Hwan Yang, and Norbert E. Kaminski

Role of Nuclear Factor of Activated T-Cells and Activator Protein-1 in the Inhibition of Interleukin-2 Gene Transcription by Cannabinol in EL4 T-Cells
J Pharmacol Exp Ther 2000 292: 597-605. [Abstract] [Full Text] [PDF]  

Elisabeth Boichot, John L. Wallace, Noëlla Germain, Marianne Corbel, Claire Lugnier, Vincent Lagente, and Jean-Jacques Bourguignon

Anti-Inflammatory Activities of a New Series of Selective Phosphodiesterase 4 Inhibitors Derived from 9-Benzyladenine
J Pharmacol Exp Ther 2000 292: 647-653. [Abstract] [Full Text] [PDF]  

Lisa J. Benincosa, Fung-Sing Chow, Leeann P. Tobia, Deborah C. Kwok, Charles B. Davis, and William J. Jusko

Pharmacokinetics and Pharmacodynamics of a Humanized Monoclonal Antibody to Factor IX in Cynomolgus Monkeys
J Pharmacol Exp Ther 2000 292: 810-816. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Sam Wang, Qing Cheng, Sundeep Malik, and Jay Yang

Interleukin-1 Inhibits -Aminobutyric Acid Type A (GABA_A) Receptor Current in Cultured Hippocampal Neurons
J Pharmacol Exp Ther 2000 292: 497-504. [Abstract] [Full Text] [PDF]  

Leonard L. Howell, Paul W. Czoty, Michael J. Kuhar, and F. Ivy Carrol

Comparative Behavioral Pharmacology of Cocaine and the Selective Dopamine Uptake Inhibitor RTI-113 in the Squirrel Monkey
J Pharmacol Exp Ther 2000 292: 521-529. [Abstract] [Full Text] [PDF]  

Ann E. Friedrich and Gerald F. Gebhart

Effects of Spinal Cholecystokinin Receptor Antagonists on Morphine Antinociception in a Model of Visceral Pain in the Rat
J Pharmacol Exp Ther 2000 292: 538-544. [Abstract] [Full Text] [PDF]  

Sabine M. Hölter, Wojciech Danysz, and Rainer Spanagel

Novel Uncompetitive N-Methyl-D-Aspartate (NMDA)-Receptor Antagonist MRZ 2/579 Suppresses Ethanol Intake in Long-Term Ethanol-Experienced Rats and Generalizes to Ethanol Cue in Drug Discrimination Procedure
J Pharmacol Exp Ther 2000 292: 545-552. [Abstract] [Full Text] [PDF]  

Leon F. Tseng, Minoru Narita, Chiaki Suganuma, Hirokazu Mizoguchi, Masahiro Ohsawa, Hiroshi Nagase, and John P. Kampine

Differential Antinociceptive Effects of Endomorphin-1 and Endomorphin-2 in the Mouse
J Pharmacol Exp Ther 2000 292: 576-583. [Abstract] [Full Text] [PDF]  

Adam C. Bartolomeo, Herman Morris, Jerry J. Buccafusco, Nancy Kille, Sharon Rosenzweig-Lipson, Morris G. Husbands, Annmarie L. Sabb, Magid Abou-Gharbia, John A. Moyer, and Carl A. Boast

The Preclinical Pharmacological Profile of WAY-132983, a Potent M1 Preferring Agonist
J Pharmacol Exp Ther 2000 292: 584-596. [Abstract] [Full Text] [PDF]  

Richard De La Garza, II and Kathryn A. Cunningham

The Effects of the 5-Hydroxytryptamine_1A Agonist 8-Hydroxy-2-(di-n-propylamino)tetralin on Spontaneous Activity, Cocaine-Induced Hyperactivity and Behavioral Sensitization: A Microanalysis of Locomotor Activity
J Pharmacol Exp Ther 2000 292: 610-617. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Alain Gobert, Karin Bervoets, Jean-Michel Rivet, Sylvie Veiga, and Mauricette Brocco

Induction of Spontaneous Tail-Flicks in Rats by Blockade of Transmission at N-Methyl-D-Aspartate Receptors: Roles of Multiple Monoaminergic Receptors in Relation to the Actions of Antipsychotic Agents
J Pharmacol Exp Ther 2000 292: 672-683. [Abstract] [Full Text] [PDF]  

Daniel S. Auld, Jamie C. Day, Françoise Mennicken, and Rémi Quirion

Pharmacological Characterization of Endogenous Acetylcholine Release from Primary Septal Cultures
J Pharmacol Exp Ther 2000 292: 692-697. [Abstract] [Full Text] [PDF]  

Niaz Sahibzada, Manuel Ferreira, Adam M. Wasserman, Angelo M. Taveira-DaSilva, and Richard A. Gillis

Reversal of Morphine-Induced Apnea in the Anesthetized Rat by Drugs that Activate 5-Hydroxytryptamine_1A Receptors
J Pharmacol Exp Ther 2000 292: 704-713. [Abstract] [Full Text] [PDF]  

Martin Goulet and Bertha K. Madras

D₁ Dopamine Receptor Agonists Are More Effective in Alleviating Advanced than Mild Parkinsonism in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys
J Pharmacol Exp Ther 2000 292: 714-724. [Abstract] [Full Text] [PDF]  

Sandra Oerther and Sven Ahlenius

Atypical Antipsychotics and Dopamine D₁ Receptor Agonism: An In Vivo Experimental Study Using Core Temperature Measurements in the Rat
J Pharmacol Exp Ther 2000 292: 731-736. [Abstract] [Full Text] [PDF]  

Megumi Kaneko, Christine Mestre, Edgard H. Sánchez, and Donna L. Hammond

Intrathecally Administered Gabapentin Inhibits Formalin-Evoked Nociception and the Expression of Fos-Like Immunoreactivity in the Spinal Cord of the Rat
J Pharmacol Exp Ther 2000 292: 743-751. [Abstract] [Full Text] [PDF]  

José A. Morón, Virgili Pérez, Manel Pastó, José Miguel Lizcano, and Mercedes Unzeta

FA-70, A Novel Selective and Irreversible Monoamine Oxidase-A Inhibitor: Effect on Monoamine Metabolism in Mouse Cerebral Cortex
J Pharmacol Exp Ther 2000 292: 788-794. [Abstract] [Full Text] [PDF]  

Charles J. Kotzer, Douglas W. P. Hay, Giulio Dondio, Giuseppe Giardina, Paola Petrillo, and David C. Underwood

The Antitussive Activity of -Opioid Receptor Stimulation in Guinea Pigs
J Pharmacol Exp Ther 2000 292: 803-809. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Bhagavatula Moorthy, Kristen M. Parker, Charles V. Smith, John R. Bend, and Stephen E. Welty

Potentiation of Oxygen-Induced Lung Injury in Rats by the Mechanism-Based Cytochrome P-450 Inhibitor, 1-Aminobenzotriazole
J Pharmacol Exp Ther 2000 292: 553-560. [Abstract] [Full Text] [PDF]  

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