EDITORIALS:

S. J. Enna

Editorial
J Pharmacol Exp Ther 2000 292: 1-2. [Full Text] [PDF]  

PERSPECTIVES IN PHARMACOLOGY:

Norman G. Bowery and S. J. Enna

-Aminobutyric Acid_B Receptors: First of the Functional Metabotropic Heterodimers
J Pharmacol Exp Ther 2000 292: 2-7. [Abstract] [Full Text] [PDF]  

ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION:

Rosanne M. Crooke, Mark J. Graham, Michael J. Martin, Kristina M. Lemonidis, Tad Wyrzykiewiecz, and Lendell L. Cummins

Metabolism of Antisense Oligonucleotides in Rat Liver Homogenates
J Pharmacol Exp Ther 2000 292: 140-149. [Abstract] [Full Text] [PDF]  

Yo Kawakubo, Hans F. Merk, Tlaytmas Al Masaoudi, Sonja Sieben, and Brunhilde Blömeke

N-Acetylation of Paraphenylenediamine in Human Skin and Keratinocytes
J Pharmacol Exp Ther 2000 292: 150-155. [Abstract] [Full Text] [PDF]  

Arun K. Agrawal and Bernard H. Shapiro

Differential Expression of Gender-Dependent Hepatic Isoforms of Cytochrome P-450 by Pulse Signals in the Circulating Masculine Episodic Growth Hormone Profile of the Rat
J Pharmacol Exp Ther 2000 292: 228-237. [Abstract] [Full Text] [PDF]  

Tomoko Hirohashi, Hiroshi Suzuki, Xiao-Yan Chu, Ikumi Tamai, Akira Tsuji, and Yuichi Sugiyama

Function and Expression of Multidrug Resistance-Associated Protein Family in Human Colon Adenocarcinoma Cells (Caco-2)
J Pharmacol Exp Ther 2000 292: 265-270. [Abstract] [Full Text] [PDF]  

Jerome H. Hochman, Masato Chiba, Joy Nishime, Masayo Yamazaki, and Jiunn H. Lin

Influence of P-Glycoprotein on the Transport and Metabolism of Indinavir in Caco-2 Cells Expressing Cytochrome P-450 3A4
J Pharmacol Exp Ther 2000 292: 310-318. [Abstract] [Full Text] [PDF]  

Sharon O'Byrne, Cheerag Shirodaria, Timothy Millar, Cliff Stevens, David Blake, and Nigel Benjamin

Inhibition of Platelet Aggregation with Glyceryl Trinitrate and Xanthine Oxidoreductase
J Pharmacol Exp Ther 2000 292: 326-330. [Abstract] [Full Text] [PDF]  

Howard J. Lim, Dana Masin, Natashia L. McIntosh, Thomas D. Madden, and Marcel B. Bally

Role of Drug Release and Liposome-Mediated Drug Delivery in Governing the Therapeutic Activity of Liposomal Mitoxantrone Used to Treat Human A431 and LS180 Solid Tumors
J Pharmacol Exp Ther 2000 292: 337-345. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR:

Kenneth S. Bauer, Kelly J. Cude, Shannon C. Dixon, Erwin A. Kruger, and William D. Figg

Carboxyamido-triazole Inhibits Angiogenesis by Blocking the Calcium-Mediated Nitric-Oxide Synthase-Vascular Endothelial Growth Factor Pathway
J Pharmacol Exp Ther 2000 292: 31-37. [Abstract] [Full Text] [PDF]  

Takashi Shindo, Yusuke Katayama, Yoshiyuki Horio, and Yoshihisa Kurachi

MCC-134, a Novel Vascular Relaxing Agent, Is an Inverse Agonist for the Pancreatic-Type ATP-Sensitive K⁺ Channel
J Pharmacol Exp Ther 2000 292: 131-135. [Abstract] [Full Text] [PDF]  

Sheng-Nan Wu, Hui-Fang Li, and Yi-Ching Lo

Characterization of Tetrandrine-Induced Inhibition of Large-Conductance Calcium-Activated Potassium Channels in a Human Endothelial Cell Line (HUV-EC-C)
J Pharmacol Exp Ther 2000 292: 188-195. [Abstract] [Full Text] [PDF]  

Xiaoping Xu, Seth J. Rials, Ying Wu, Tengxian Liu, Roger A. Marinchak, and Peter R. Kowey

Effects of Captopril Treatment of Renovascular Hypertension on -Adrenergic Modulation of L-Type Ca²⁺ Current
J Pharmacol Exp Ther 2000 292: 196-200. [Abstract] [Full Text] [PDF]  

Elaine J. Tanhehco, Koji Yasojima, Patrick L. McGeer, and Benedict R. Lucchesi

Acute Cocaine Exposure Up-Regulates Complement Expression in Rabbit Heart
J Pharmacol Exp Ther 2000 292: 201-208. [Abstract] [Full Text] [PDF]  

Ping Li, Masayo Fukuhara, Debra I. Diz, Carlos M. Ferrario, and K. Bridget Brosnihan

Novel Angiotensin II AT₁ Receptor Antagonist Irbesartan Prevents Thromboxane A₂-Induced Vasoconstriction in Canine Coronary Arteries and Human Platelet Aggregation
J Pharmacol Exp Ther 2000 292: 238-246. [Abstract] [Full Text] [PDF]  

Ponnal Nambi, Hsiao-Ling Wu, Diana Ye, Alison Gagnon, and Nabil Elshourbagy

Characterization of a Novel Porcine Endothelin_B Receptor Splice Variant
J Pharmacol Exp Ther 2000 292: 247-253. [Abstract] [Full Text] [PDF]  

William J. Crumb, Jr.

Loratadine Blockade of K⁺ Channels in Human Heart: Comparison with Terfenadine under Physiological Conditions
J Pharmacol Exp Ther 2000 292: 261-264. [Abstract] [Full Text] [PDF]  

Kyung-Soo Kim, Sandeep Kumar, William H. Simmons, and Nancy J. Brown

Inhibition of Aminopeptidase P Potentiates Wheal Response to Bradykinin in Angiotensin-Converting Enzyme Inhibitor-Treated Humans
J Pharmacol Exp Ther 2000 292: 295-298. [Abstract] [Full Text] [PDF]  

Pancras C. Wong, Mimi L. Quan, Earl J., Crain, Carol A. Watson, Ruth R. Wexler, and Robert M. Knabb

Nonpeptide Factor Xa Inhibitors: I. Studies with SF303 and SK549, a New Class of Potent Antithrombotics
J Pharmacol Exp Ther 2000 292: 351-357. [Abstract] [Full Text] [PDF]  

Richard M. White, Carlos O. Rivera, and Cathy A. Davison

Nitric Oxide-Dependent and -Independent Mechanisms Account for Gender Differences in Vasodilation to Acetylcholine
J Pharmacol Exp Ther 2000 292: 375-380. [Abstract] [Full Text] [PDF]  

Anne M. Gillis, Heather J. Mathison, Elzbieta Kulisz, and Wanda M. Lester

Dispersion of Ventricular Repolarization and Ventricular Fibrillation in Left Ventricular Hypertrophy: Influence of Selective Potassium Channel Blockers
J Pharmacol Exp Ther 2000 292: 381-386. [Abstract] [Full Text] [PDF]  

Yoshikazu Maeda, Uichi Ikeda, Ken-ichi Oya, Masahisa Shimpo, Shuichi Ueno, Koji Okada, Toshikazu Saito, Hiroyuki Mano, Keiya Ozawa, and Kazuyuki Shimada

Endogenously Generated Nitric Oxide by Nitric-Oxide Synthase Gene Transfer Inhibits Cellular Proliferation
J Pharmacol Exp Ther 2000 292: 387-393. [Abstract] [Full Text] [PDF]  

Frank Aimond, Lionel Beck, Patrick Gautier, Ouafiya K. Chérif, Jean-Marc Davy, Paco Lorente, Dino Nisato, and Guy Vassort

Cellular and In Vivo Electrophysiological Effects of Dronedarone in Normal and Postmyocardial Infarcted Rats
J Pharmacol Exp Ther 2000 292: 415-424. [Abstract] [Full Text] [PDF]  

Kylie M. Burrell, Peter Molenaar, Peter J. Dawson, and Alberto J. Kaumann

Contractile and Arrhythmic Effects of Endothelin Receptor Agonists in Human Heart In Vitro: Blockade with SB 209670
J Pharmacol Exp Ther 2000 292: 449-459. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR:

Yuhui Xiao, Jiale He, Raymond D. Gilbert, and Lubo Zhang

Cocaine Induces Apoptosis in Fetal Myocardial Cells through a Mitochondria-Dependent Pathway
J Pharmacol Exp Ther 2000 292: 8-14. [Abstract] [Full Text] [PDF]  

Juan Carlos Gomora, Lin Xu, Judith A. Enyeart, and John J. Enyeart

Effect of Mibefradil on Voltage-Dependent Gating and Kinetics of T-Type Ca²⁺ Channels in Cortisol-Secreting Cells
J Pharmacol Exp Ther 2000 292: 96-103. [Abstract] [Full Text] [PDF]  

Ahmed Chahdi, Paul F. Fraundorfer, and Michael A. Beaven

Compound 48/80 Activates Mast Cell Phospholipase D via Heterotrimeric GTP-Binding Proteins
J Pharmacol Exp Ther 2000 292: 122-130. [Abstract] [Full Text] [PDF]  

Norbert Wilke, Michael W. Sganga, Gregory G. Gayer, Kwei-Perng Hsieh, and Michael F. Miles

Characterization of Promoter Elements Mediating Ethanol Regulation of hsc70 Gene Transcription
J Pharmacol Exp Ther 2000 292: 173-180. [Abstract] [Full Text] [PDF]  

Chung-Ren Jan and Ching-Jiunn Tseng

W-7 Induces [Ca²⁺]_i Increases in Madin-Darby Canine Kidney (MDCK) Cells
J Pharmacol Exp Ther 2000 292: 358-365. [Abstract] [Full Text] [PDF]  

MeeRa Hong, Lyanne Schlichter, and Reina Bendayan

A Na⁺-Dependent Nucleoside Transporter in Microglia
J Pharmacol Exp Ther 2000 292: 366-374. [Abstract] [Full Text] [PDF]  

James E. Porter and Dianne M. Perez

Influence of a Lysine 331 Counterion on the pK_a of Aspartic Acid 125: Evidence for a Salt-Bridge Interaction and Role in _1b-Adrenergic Receptor Activation
J Pharmacol Exp Ther 2000 292: 440-448. [Abstract] [Full Text] [PDF]  

ENDOCRINE AND REPRODUCTIVE:

Makoto Murakami, Yoshitaka Tomiyama, Kohichi Hayakawa, Masuo Akahane, Yukiyoshi Ajisawa, Young-Chol Park, Norio Ohnishi, Takahide Sugiyama, and Takashi Kurita

Effects of -Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs
J Pharmacol Exp Ther 2000 292: 67-75. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL:

Gunther Hartmann, Christoph Bidlingmaier, Britta Siegmund, Stefan Albrich, Johannes Schulze, Katharina Tschoep, Andreas Eigler, Hans Anton Lehr, and Stefan Endres

Specific Type IV Phosphodiesterase Inhibitor Rolipram Mitigates Experimental Colitis in Mice
J Pharmacol Exp Ther 2000 292: 22-30. [Abstract] [Full Text] [PDF]  

Robert W. Wilmott, Joseph A. Kitzmiller, Csaba Szabó, Garry J. Southan, and Andrew L. Salzman

Mercaptoethylguanidine Inhibits the Inflammatory Response in a Murine Model of Chronic Infection with Pseudomonas aeruginosa
J Pharmacol Exp Ther 2000 292: 88-95. [Abstract] [Full Text] [PDF]  

Jai Youl Ro, Byung Chul Lee, Ji Young Kim, Yean Jun Chung, Myung Hee Chung, Seung Kee Lee, Tae Hyung Jo, Kyung Hwan Kim, and Young In Park

Inhibitory Mechanism of Aloe Single Component (Alprogen) on Mediator Release in Guinea Pig Lung Mast Cells Activated with Specific Antigen-Antibody Reactions
J Pharmacol Exp Ther 2000 292: 114-121. [Abstract] [Full Text] [PDF]  

Thierry Hauet, Herve Baumert, Imed Ben Amor, Helene Gibelin, Claude Tallineau, Michel Eugene, Jean Paul Tillement, and Michel Carretier

Pharmacological Limitation of Damage to Renal Medulla after Cold Storage and Transplantation by Trimetazidine
J Pharmacol Exp Ther 2000 292: 254-260. [Abstract] [Full Text] [PDF]  

Craig M. Schramm

-Adrenergic Relaxation of Rabbit Tracheal Smooth Muscle: A Receptor Deficit That Improves with Corticosteroid Administration
J Pharmacol Exp Ther 2000 292: 280-287. [Abstract] [Full Text] [PDF]  

Takahiro Hirano, Yoshitaka Yamamura, Shigeki Nakamura, Toshiyuki Onogawa, and Toyoki Mori

Effects of the V₂-Receptor Antagonist OPC-41061 and the Loop Diuretic Furosemide Alone and in Combination in Rats
J Pharmacol Exp Ther 2000 292: 288-294. [Abstract] [Full Text] [PDF]  

Karen E. Pedersen, Carl K. Buckner, Sonya N. Meeker, and Bradley J. Undem

Pharmacological Examination of the Neurokinin-1 Receptor Mediating Relaxation of Human Intralobar Pulmonary Artery
J Pharmacol Exp Ther 2000 292: 319-325. [Abstract] [Full Text] [PDF]  

Yasumasa Gotoh, Hiroshi Suzuki, Setsuo Kinoshita, Tomoko Hirohashi, Yukio Kato, and Yuichi Sugiyama

Involvement of an Organic Anion Transporter (Canalicular Multispecific Organic Anion Transporter/Multidrug Resistance-Associated Protein 2) in Gastrointestinal Secretion of Glutathione Conjugates in Rats
J Pharmacol Exp Ther 2000 292: 433-439. [Abstract] [Full Text] [PDF]  

INFLAMMATION AND IMMUNOPHARMACOLOGY:

Hiroshi Nakase, Kazuichi Okazaki, Yasuhiko Tabata, Suguru Uose, Masaya Ohana, Kazushige Uchida, Yumi Matsushima, Chiharu Kawanami, Chikashi Oshima, Yoshito Ikada, and Tsutomu Chiba

Development of an Oral Drug Delivery System Targeting Immune-Regulating Cells in Experimental Inflammatory Bowel Disease: A New Therapeutic Strategy
J Pharmacol Exp Ther 2000 292: 15-21. [Abstract] [Full Text] [PDF]  

Angela Ianaro, Armando Ialenti, Pasquale Maffia, Lidia Sautebin, Laura Rombolà, Rosa Carnuccio, Teresa Iuvone, Fulvio D'Acquisto, and Massimo Di Rosa

Anti-Inflammatory Activity of Macrolide Antibiotics
J Pharmacol Exp Ther 2000 292: 156-163. [Abstract] [Full Text] [PDF]  

Glenn Dorsam, Mohiuddin M. Taher, Kristoffer C. Valerie, Nancy B. Kuemmerle, James C. Chan, and Richard C. Franson

Diphenyleneiodium Chloride Blocks Inflammatory Cytokine-Induced Up-Regulation of Group IIA Phospholipase A₂ in Rat Mesangial Cells
J Pharmacol Exp Ther 2000 292: 271-279. [Abstract] [Full Text] [PDF]  

Darakhshanda Shehnaz, Brian Torres, Maria A. Balboa, and Paul A. Insel

Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a Putative P2Y₁ Receptor Antagonist, Blocks Signaling at a Site Distal to the Receptor in Madin-Darby Canine Kidney-D₁ Cells
J Pharmacol Exp Ther 2000 292: 346-350. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Mark J. Millan, Alain Gobert, Adrian Newman-Tancredi, Françoise Lejeune, Didier Cussac, Jean-Michel Rivet, Valérie Audinot, Agnès Adhumeau, Mauricette Brocco, Jean-Paul Nicolas, Jean A. Boutin, Nicole Despaux, and Jean-Louis Peglion

S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at ₁- and ₂-Adrenergic Receptors: I. Receptorial, Neurochemical, and Electrophysiological Profile
J Pharmacol Exp Ther 2000 292: 38-53. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Mauricette Brocco, Jean-Michel Rivet, Valérie Audinot, Adrian Newman-Tancredi, Lisa Maiofiss, Sophie Queriaux, Nicole Despaux, Jean-Louis Peglion, and Anne Dekeyne

S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at ₁- and ₂-Adrenergic Receptors: II. Functional Profile and a Multiparametric Comparison with Haloperidol, Clozapine, and 11 Other Antipsychotic Agents
J Pharmacol Exp Ther 2000 292: 54-66. [Abstract] [Full Text] [PDF]  

Gerard J. Marek, Rebecca A. Wright, Darryle D. Schoepp, James A. Monn, and George K. Aghajanian

Physiological Antagonism between 5-Hydroxytryptamine_2A and Group II Metabotropic Glutamate Receptors in Prefrontal Cortex
J Pharmacol Exp Ther 2000 292: 76-87. [Abstract] [Full Text] [PDF]  

Michael S. Cousins, Georgetta Vosmer, David H. Overstreet, and Lewis S. Seiden

Rats Selectively Bred for Responsiveness to 5-Hydroxytryptamine_1A Receptor Stimulation: Differences in Differential Reinforcement of Low Rate 72-Second Performance and Response to Serotonergic Drugs
J Pharmacol Exp Ther 2000 292: 104-113. [Abstract] [Full Text] [PDF]  

Zhao-Hui Song and Carole-Anne Slowey

Involvement of Cannabinoid Receptors in the Intraocular Pressure-Lowering Effects of WIN55212-2
J Pharmacol Exp Ther 2000 292: 136-139. [Abstract] [Full Text] [PDF]  

Gilboé L. Mendes, Adair R. S. Santos, Angela Malheiros, Valdir Cechinel Filho, Rosendo A. Yunes, and João B. Calixto

Assessment of Mechanisms Involved in Antinociception Caused by Sesquiterpene Polygodial
J Pharmacol Exp Ther 2000 292: 164-172. [Abstract] [Full Text] [PDF]  

Mayumi Yamano, Hidenobu Yuki, Syuhei Yasuda, and Keiji Miyata

Corticotropin-Releasing Hormone₁ Receptors Mediate Consensus Interferon- YM643-Induced Depression-Like Behavior in Mice
J Pharmacol Exp Ther 2000 292: 181-187. [Abstract] [Full Text] [PDF]  

Eva V. Varga, Dagmar Stropova, Tae Kim, Man Wang, William R. Roeske, and Henry I. Yamamura

Coupling of Human -Opioid Receptor to Retinal Rod Transducin in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 2000 292: 209-214. [Abstract] [Full Text] [PDF]  

Lawrence D. Snell, David J. Claffey, James A. Ruth, C. Fernando Valenzuela, Rita Cardoso, Zejun Wang, Simon R. Levinson, William A. Sather, Anna V. Williamson, Nan C. Ingersoll, Larissa Ovchinnikova, Sanjiv V. Bhave, Paula L. Hoffman, and Boris Tabakoff

Novel Structure Having Antagonist Actions at Both the Glycine Site of the N-Methyl-D-Aspartate Receptor and Neuronal Voltage-Sensitive Sodium Channels: Biochemical, Electrophysiological, and Behavioral Characterization
J Pharmacol Exp Ther 2000 292: 215-227. [Abstract] [Full Text] [PDF]  

Waltraud Binder, John Carmody, and Judith Walker

Effect of Gender on Anti-Inflammatory and Analgesic Actions of Two -Opioids
J Pharmacol Exp Ther 2000 292: 303-309. [Abstract] [Full Text] [PDF]  

Hiroyuki Nakano, Toshiaki Minami, Kohji Abe, Tohko Arai, Miwa Tokumura, Nobuhiro Ibii, Emiko Okuda-Ashitaka, Hidemaro Mori, and Seiji Ito

Effect of Intrathecal Nocistatin on the Formalin-Induced Pain in Mice Versus That of Nociceptin/Orphanin FQ
J Pharmacol Exp Ther 2000 292: 331-336. [Abstract] [Full Text] [PDF]  

Deborah A. Finn, Edward J. Gallaher, and John C. Crabbe

Differential Change in Neuroactive Steroid Sensitivity during Ethanol Withdrawal
J Pharmacol Exp Ther 2000 292: 394-405. [Abstract] [Full Text] [PDF]  

Chad J. Swanson and Peter W. Kalivas

Regulation of Locomotor Activity by Metabotropic Glutamate Receptors in the Nucleus Accumbens and Ventral Tegmental Area
J Pharmacol Exp Ther 2000 292: 406-414. [Abstract] [Full Text] [PDF]  

H. Steve White, R. Tyler McCabe, Heather Armstrong, Sean D. Donevan, Lourdes J. Cruz, Fe C. Abogadie, Josep Torres, Jean E. Rivier, Ingo Paarmann, Michael Hollmann, and Baldomero M. Olivera

In Vitro and In Vivo Characterization of Conantokin-R, a Selective Nmda Receptor Antagonist Isolated from the Venom of the Fish-Hunting Snail Conus radiatus¹
J Pharmacol Exp Ther 2000 292: 425-432. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Tomoki Kimura, Isami Fujita, Norio Itoh, Norio Muto, Tsuyoshi Nakanishi, Kyoko Takahashi, Junichi Azuma, and Keiichi Tanaka

Metallothionein Acts as a Cytoprotectant against Doxorubicin Toxicity
J Pharmacol Exp Ther 2000 292: 299-302. [Abstract] [Full Text] [PDF]  

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