ARTICLES:

William W. Fleming

1999 Torald Sollman Award Lecture: Cellular Adaptation: Journey from Smooth Muscle Cells to Neurons
J Pharmacol Exp Ther 1999 291: 925-931. [Abstract] [Full Text] [PDF]  

Elizabeth I. Tietz, Xu J. Zeng, Shanyi Chen, Scott M. Lilly, Howard C. Rosenberg, and Peter Kometiani

Antagonist-Induced Reversal of Functional and Structural Measures of Hippocampal Benzodiazepine Tolerance
J Pharmacol Exp Ther 1999 291: 932-942. [Abstract] [Full Text] [PDF]  

Christiane Mourre, Marina N. Chernova, Marie-France Martin-Eauclaire, Richard Bessone, Guy Jacquet, Maurice Gola, Seth. L. Alper, and Marcel Crest

Distribution in Rat Brain of Binding Sites of Kaliotoxin, a Blocker of Kv1.1 and Kv1.3 -Subunits
J Pharmacol Exp Ther 1999 291: 943-952. [Abstract] [Full Text] [PDF]  

Gloria M. Su, Rachel M. Sefton, and Michael Murray

Down-Regulation of Rat Hepatic Microsomal Cytochromes P-450 in Microvesicular Steatosis Induced by Orotic Acid
J Pharmacol Exp Ther 1999 291: 953-959. [Abstract] [Full Text] [PDF]  

Ana M. Castejon, Ximena Paez, Luis Hernandez, and Luigi X. Cubeddu

Use of Intravenous Microdialysis to Monitor Changes in Serotonin Release and Metabolism Induced by Cisplatin in Cancer Patients: Comparative Effects of Granisetron and Ondansetron
J Pharmacol Exp Ther 1999 291: 960-966. [Abstract] [Full Text] [PDF]  

Rajiv Kumar, Ronald W. Joyner, Padmini Komalavilas, and Thomas M. Lincoln

Analysis of Expression of cGMP-Dependent Protein Kinase in Rabbit Heart Cells
J Pharmacol Exp Ther 1999 291: 967-975. [Abstract] [Full Text] [PDF]  

Masaaki Ito, Yutaka Hirata, Hideshi Nakamura, and Yasushi Ohizumi

Xestoquinone, Isolated from Sea Sponge, Causes Ca²⁺ Release through Sulfhydryl Modification from Skeletal Muscle Sarcoplasmic Reticulum
J Pharmacol Exp Ther 1999 291: 976-981. [Abstract] [Full Text] [PDF]  

Christophe Junot, Laurence Nicolet, Eric Ezan, Marie-Francoise Gonzales, Joel Menard, and Michel Azizi

Effect of Angiotensin-Converting Enzyme Inhibition on Plasma, Urine, and Tissue Concentrations of Hemoregulatory Peptide Acetyl-Ser-Asp-Lys-Pro in Rats
J Pharmacol Exp Ther 1999 291: 982-987. [Abstract] [Full Text] [PDF]  

Akira Nishiyama, Akira Miyatake, Yasuharu Aki, Toshiki Fukui, Matlubur Rahman, Shoji Kimura, and Youichi Abe

Adenosine A₁ Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction
J Pharmacol Exp Ther 1999 291: 988-993. [Abstract] [Full Text] [PDF]  

Shigeto Yamada, Mutsuo Harano, Naoko Annoh, and Masatoshi Tanaka

Dopamine D₃ Receptors Modulate Evoked Dopamine Release from Slices of Rat Nucleus Accumbens Via Muscarinic Receptors, But Not from the Striatum
J Pharmacol Exp Ther 1999 291: 994-998. [Abstract] [Full Text] [PDF]  

Qian Li, Christine Wichems, Armin Heils, Louis D. Van de Kar, Klaus-Peter Lesch, and Dennis L. Murphy

Reduction of 5-Hydroxytryptamine (5-HT)_1A-Mediated Temperature and Neuroendocrine Responses and 5-HT_1A Binding Sites in 5-HT Transporter Knockout Mice
J Pharmacol Exp Ther 1999 291: 999-1007. [Abstract] [Full Text] [PDF]  

Yong-Xiang Wang, S. Scott Bowersox, Mark Pettus, and Da Gao

Antinociceptive Properties of Fenfluramine, a Serotonin Reuptake Inhibitor, in a Rat Model of Neuropathy
J Pharmacol Exp Ther 1999 291: 1008-1016. [Abstract] [Full Text] [PDF]  

L. Fenart, A. Casanova, B. Dehouck, C. Duhem, S. Slupek, R. Cecchelli, and D. Betbeder

Evaluation of Effect of Charge and Lipid Coating on Ability of 60-nm Nanoparticles to Cross an In Vitro Model of the Blood-Brain Barrier
J Pharmacol Exp Ther 1999 291: 1017-1022. [Abstract] [Full Text] [PDF]  

Salvatore Guarini, Carla Bazzani, Maria Michela Cainazzo, Chiara Mioni, Giuseppe Ferrazza, Anna Valeria Vergoni, Helgi B. Schiöth, Jarl E. S. Wikberg, and Alfio Bertolini

Evidence That Melanocortin 4 Receptor Mediates Hemorrhagic Shock Reversal Caused by Melanocortin Peptides
J Pharmacol Exp Ther 1999 291: 1023-1027. [Abstract] [Full Text] [PDF]  

Frederick Jia-Pei Miao and Jon D. Levine

Neural and Endocrine Mechanisms Mediating Noxious Stimulus-Induced Inhibition of Bradykinin Plasma Extravasation in the Rat
J Pharmacol Exp Ther 1999 291: 1028-1037. [Abstract] [Full Text] [PDF]  

Jiang-Yong Min, Steffen Sandmann, Achim Meissner, Thomas Unger, and Ruediger Simon

Differential Effects of Mibefradil, Verapamil, and Amlodipine on Myocardial Function and Intracellular Ca²⁺ Handling in Rats with Chronic Myocardial Infarction
J Pharmacol Exp Ther 1999 291: 1038-1044. [Abstract] [Full Text] [PDF]  

Roger A. Gallegos, Rong-Sheng Lee, José R. Criado, Steven J. Henriksen, and Scott C. Steffensen

Adaptive Responses of -Aminobutyric Acid Neurons in the Ventral Tegmental Area to Chronic Ethanol
J Pharmacol Exp Ther 1999 291: 1045-1053. [Abstract] [Full Text] [PDF]  

Hugh E. Criswell, Thomas J. McCown, Zhen Ming, Robert A. Mueller, and George R. Breese

Interactive Role for Neurosteroids in Ethanol Enhancement of -Aminobutyric Acid-Gated Currents from Dissociated Substantia Nigra Reticulata Neurons
J Pharmacol Exp Ther 1999 291: 1054-1059. [Abstract] [Full Text] [PDF]  

P. Zia-Amirhosseini, E. Minthorn, L. J. Benincosa, T. K. Hart, C. S. Hottenstein, L. A. P. Tobia, and C. B. Davis

Pharmacokinetics and Pharmacodynamics of SB-240563, a Humanized Monoclonal Antibody Directed to Human Interleukin-5, in Monkeys
J Pharmacol Exp Ther 1999 291: 1060-1067. [Abstract] [Full Text] [PDF]  

Wei Tang, Ralph A. Stearns, Gloria Y. Kwei, Susan A. Iliff, Randall R. Miller, Marjorie A. Egan, Nathan X. Yu, Dennis C. Dean, Sanjeev Kumar, Magang Shou, Jiunn H. Lin, and Thomas A. Baillie

Interaction of Diclofenac and Quinidine in Monkeys: Stimulation of Diclofenac Metabolism
J Pharmacol Exp Ther 1999 291: 1068-1074. [Abstract] [Full Text] [PDF]  

A. Banan, S. Choudhary, Y. Zhang, J. Z. Fields, and A. Keshavarzian

Ethanol-Induced Barrier Dysfunction and Its Prevention by Growth Factors in Human Intestinal Monolayers: Evidence for Oxidative and Cytoskeletal Mechanisms
J Pharmacol Exp Ther 1999 291: 1075-1085. [Abstract] [Full Text] [PDF]  

Pierre Moine and Jean Xavier Mazoit

Streptococcus pneumoniae Pneumonia in Mice: Optimal Amoxicillin Dosing Predicted from a Pharmacokinetic-Pharmacodynamic Model
J Pharmacol Exp Ther 1999 291: 1086-1092. [Abstract] [Full Text] [PDF]  

J. R. Traynor, L. Guo, A. Coop, J. W. Lewis, and J. H. Woods

Ring-Constrained Orvinols as Analogs of Buprenorphine: Differences in Opioid Activity Related to Configuration of C₂₀ Hydroxyl Group
J Pharmacol Exp Ther 1999 291: 1093-1099. [Abstract] [Full Text] [PDF]  

Jan F. Gummert, Markus J. Barten, Steve W. Sherwood, Teun van Gelder, and Randall E. Morris

Pharmacodynamics of Immunosuppression by Mycophenolic Acid: Inhibition of Both Lymphocyte Proliferation and Activation Correlates with Pharmacokinetics
J Pharmacol Exp Ther 1999 291: 1100-1112. [Abstract] [Full Text] [PDF]  

M. C. Holden Ko, Mark D. Johnson, Eduardo R. Butelman, Kurt J. Willmont, Henry I. Mosberg, and James H. Woods

Intracisternal Nor-Binaltorphimine Distinguishes Central and Peripheral -Opioid Antinociception in Rhesus Monkeys
J Pharmacol Exp Ther 1999 291: 1113-1120. [Abstract] [Full Text] [PDF]  

Kimihiro Matsunaga, Keigo Nakatani, Masahiro Murakami, Katsumi Yamaguchi, and Yasushi Ohizumi

Powerful Activation of Skeletal Muscle Actomyosin ATPase by Goniodomin A Is Highly Sensitive to Troponin/Tropomyosin Complex
J Pharmacol Exp Ther 1999 291: 1121-1126. [Abstract] [Full Text] [PDF]  

Ying Lu, Michael J. Marks, and Allan C. Collins

Desensitization of Nicotinic Agonist-Induced [³H]-Aminobutyric Acid Release from Mouse Brain Synaptosomes Is Produced by Subactivating Concentrations of Agonists
J Pharmacol Exp Ther 1999 291: 1127-1134. [Abstract] [Full Text] [PDF]  

Karen Alexander, Wende Niforatos, Bruce Bianchi, Edward C. Burgard, Kevin J. Lynch, Elizabeth A. Kowaluk, Michael F. Jarvis, and Tim van Biesen

Allosteric Modulation and Accelerated Resensitization of Human P2X₃ Receptors by Cibacron Blue
J Pharmacol Exp Ther 1999 291: 1135-1142. [Abstract] [Full Text] [PDF]  

Evangelos D. Michelakis, E. Kenneth Weir, Daniel P. Nelson, Helen L. Reeve, Simona Tolarova, and Stephen L. Archer

Dexfenfluramine Elevates Systemic Blood Pressure by Inhibiting Potassium Currents in Vascular Smooth Muscle Cells
J Pharmacol Exp Ther 1999 291: 1143-1149. [Abstract] [Full Text] [PDF]  

Richard W. Lambrecht, Otto S. Gildemeister, Joyce A. Pepe, Kristina D. Tortorelli, Alyssa Williams, and Herbert L. Bonkovsky

Effects of Antidepressants and Benzodiazepine-Type Anxiolytic Agents on Hepatic Porphyrin Accumulation in Primary Cultures of Chick Embryo Liver Cells
J Pharmacol Exp Ther 1999 291: 1150-1155. [Abstract] [Full Text] [PDF]  

Amy C. Herring and Norbert E. Kaminski

Cannabinol-Mediated Inhibition of Nuclear Factor-B, cAMP Response Element-Binding Protein, and Interleukin-2 Secretion by Activated Thymocytes
J Pharmacol Exp Ther 1999 291: 1156-1163. [Abstract] [Full Text] [PDF]  

David J. J. Waugh, Robert J. Gaivin, Derek S. Damron, Paul A. Murray, and Dianne M. Perez

Binding, Partial Agonism, and Potentiation of ₁-Adrenergic Receptor Function by Benzodiazepines: A Potential Site of Allosteric Modulation
J Pharmacol Exp Ther 1999 291: 1164-1171. [Abstract] [Full Text] [PDF]  

Susanne Keffel, Martina Schmidt, Angela Bischoff, and Martin C. Michel

Neuropeptide-Y Stimulation of Extracellular Signal-Regulated Kinases in Human Erythroleukemia Cells
J Pharmacol Exp Ther 1999 291: 1172-1178. [Abstract] [Full Text] [PDF]  

A. Banes, J. A. Florian, and S. W. Watts

Mechanisms of 5-Hydroxytryptamine_2A Receptor Activation of the Mitogen-Activated Protein Kinase Pathway in Vascular Smooth Muscle
J Pharmacol Exp Ther 1999 291: 1179-1187. [Abstract] [Full Text] [PDF]  

A. M. Mamoon, J. Smith, R. C. Baker, and J. M. Farley

Activation of Protein Kinase A Increases Phospholipase D Activity and Inhibits Phospholipase D Activation by Acetylcholine in Tracheal Smooth Muscle
J Pharmacol Exp Ther 1999 291: 1188-1195. [Abstract] [Full Text] [PDF]  

Neal L. Benowitz, Eliseo J. Perez-Stable, Irving Fong, Gunnard Modin, Brenda Herrera, and Peyton Jacob, III

Ethnic Differences in N-Glucuronidation of Nicotine and Cotinine
J Pharmacol Exp Ther 1999 291: 1196-1203. [Abstract] [Full Text] [PDF]  

Richard B. Kim, Brenda Leake, Mirjana Cvetkovic, Mark M. Roden, Jessica Nadeau, Andrew Walubo, and Grant R. Wilkinson

Modulation by Drugs of Human Hepatic Sodium-Dependent Bile Acid Transporter (Sodium Taurocholate Cotransporting Polypeptide) Activity
J Pharmacol Exp Ther 1999 291: 1204-1209. [Abstract] [Full Text] [PDF]  

Rommel G. Tirona, Eugene Tan, Galina Meier, and K. Sandy Pang

Uptake and Glutathione Conjugation of Ethacrynic Acid and Efflux of the Glutathione Adduct by Periportal and Perivenous Rat Hepatocytes
J Pharmacol Exp Ther 1999 291: 1210-1219. [Abstract] [Full Text] [PDF]  

Gilles J. Rivière, Kelly A. Byrnes, W. Brooks Gentry, and S. Michael Owens

Spontaneous Locomotor Activity and Pharmacokinetics of Intravenous Methamphetamine and Its Metabolite Amphetamine in the Rat
J Pharmacol Exp Ther 1999 291: 1220-1226. [Abstract] [Full Text] [PDF]  

Junji Ichikawa and Herbert Y. Meltzer

R(+)-8-OH-DPAT, a Serotonin_1A Receptor Agonist, Potentiated S()-Sulpiride-Induced Dopamine Release in Rat Medial Prefrontal Cortex and Nucleus Accumbens But Not Striatum
J Pharmacol Exp Ther 1999 291: 1227-1232. [Abstract] [Full Text] [PDF]  

James K. Rowlett, Roger D. Spealman, and Snjezana Lelas

Discriminative Stimulus Effects of Zolpidem in Squirrel Monkeys: Comparison with Conventional Benzodiazepines and Sedative-Hypnotics
J Pharmacol Exp Ther 1999 291: 1233-1241. [Abstract] [Full Text] [PDF]  

Rajash K. Handa, Joseph W. Harding, and Steven M. Simasko

Characterization and Function of the Bovine Kidney Epithelial Angiotensin Receptor Subtype 4 Using Angiotensin IV and Divalinal Angiotensin IV as Receptor Ligands
J Pharmacol Exp Ther 1999 291: 1242-1249. [Abstract] [Full Text] [PDF]  

Yuji Odagaki, Nobuyuki Nishi, Shin Nakagawa, and Tsukasa Koyama

Activation of G Proteins by Neuropeptide Y and -Aminobutyric Acid_B Receptor Agonists in Rat Cerebral Cortical Membranes through Distinct Modes of Action
J Pharmacol Exp Ther 1999 291: 1250-1256. [Abstract] [Full Text] [PDF]  

Brandi J. Smith and Warren K. Bickel

Flumazenil Discrimination by Humans under a Two-Response and a Novel-Response Procedure
J Pharmacol Exp Ther 1999 291: 1257-1268. [Abstract] [Full Text] [PDF]  

Emiko L. Kreklau, Chandrika Kurpad, David A. Williams, and Leonard C. Erickson

Prolonged Inhibition of O⁶-Methylguanine DNA Methyltransferase in Human Tumor Cells by O⁶-Benzylguanine In Vitro and In Vivo
J Pharmacol Exp Ther 1999 291: 1269-1275. [Abstract] [Full Text] [PDF]  

Atsumi Nitta, Megumi Ito, Hidefumi Fukumitsu, Makoto Ohmiya, Hisanori Ito, Ayako Sometani, Hiroshi Nomoto, Yoshiko Furukawa, and Shoei Furukawa

4-Methylcatechol Increases Brain-Derived Neurotrophic Factor Content and mRNA Expression in Cultured Brain Cells and in Rat Brain In Vivo
J Pharmacol Exp Ther 1999 291: 1276-1283. [Abstract] [Full Text] [PDF]  

M. I. Damaj, W. Glassco, M. Dukat, and B. R. Martin

Pharmacological Characterization of Nicotine-Induced Seizures in Mice
J Pharmacol Exp Ther 1999 291: 1284-1291. [Abstract] [Full Text] [PDF]  

Ester Alvino, Rita Pepponi, Elena Pagani, Pedro Miguel Lacal, Corrado Nunziata, Enzo Bonmassar, and Stefania D'Atri

O⁶-Benzylguanine Enhances the In Vitro Immunotoxic Activity of Temozolomide on Natural or Antigen-Dependent Immunity
J Pharmacol Exp Ther 1999 291: 1292-1300. [Abstract] [Full Text] [PDF]  

Fatih M. Uckun, Kelly Bellomy, Karen O'Neill, Yoav Messinger, Trista Johnson, and Chun-Lin Chen

Toxicity, Biological Activity, and Pharmacokinetics of TXU (Anti-CD7)-Pokeweed Antiviral Protein in Chimpanzees and Adult Patients Infected with Human Immunodeficiency Virus
J Pharmacol Exp Ther 1999 291: 1301-1307. [Abstract] [Full Text] [PDF]  

Tom C. Krejcie, Thomas K. Henthorn, W. Brooks Gentry, Claus U. Niemann, Cheri Enders-Klein, Colin A. Shanks, and Michael J. Avram

Modifications of Blood Volume Alter the Disposition of Markers of Blood Volume, Extracellular Fluid, and Total Body Water
J Pharmacol Exp Ther 1999 291: 1308-1316. [Abstract] [Full Text] [PDF]  

Kimberly E. Vanover, Dale M. Edgar, Wesley F. Seidel, Derk J. Hogenkamp, David B. Fick, Nancy C. Lan, Kelvin W. Gee, and Richard B. Carter

Response-Rate Suppression in Operant Paradigm as Predictor of Soporific Potency in Rats and Identification of Three Novel Sedative-Hypnotic Neuroactive Steroids
J Pharmacol Exp Ther 1999 291: 1317-1323. [Abstract] [Full Text] [PDF]  

Min Jiang, Wen Dun, Jing-Song Fan, and Gea-Ny Tseng

Use-Dependent `Agonist' Effect of Azimilide on the HERG Channel
J Pharmacol Exp Ther 1999 291: 1324-1336. [Abstract] [Full Text] [PDF]  

Lori Manzel, Lucjan Strekowski, Fyaz M. D. Ismail, Jerry C. Smith, and Donald E. Macfarlane

Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by 4-Aminoquinolines and Other Weak Bases: Mechanistic Studies
J Pharmacol Exp Ther 1999 291: 1337-1347. [Abstract] [Full Text] [PDF]  

Miechelle L. O'Brien, Bojana Vulevic, Seema Freer, Jonathan Boyd, Hongxie Shen, and Kenneth D. Tew

Glutathione Peptidomimetic Drug Modulator of Multidrug Resistance-Associated Protein
J Pharmacol Exp Ther 1999 291: 1348-1355. [Abstract] [Full Text] [PDF]  

Timothy P. Reilly, Rodger D. MacArthur, Marti J. Farrough, Lawrence R. Crane, Patrick M. Woster, and Craig K. Svensson

Is Hydroxylamine-Induced Cytotoxicity a Valid Marker for Hypersensitivity Reactions to Sulfamethoxazole in Human Immunodeficiency Virus-Infected Individuals?
J Pharmacol Exp Ther 1999 291: 1356-1364. [Abstract] [Full Text] [PDF]  

Simone Sbrenna, Matteo Marti, Michele Morari, Girolamo Calo, Remo Guerrini, Lorenzo Beani, and Clementina Bianchi

L-Glutamate and -Aminobutyric Acid Efflux from Rat Cerebrocortical Synaptosomes: Modulation by - and µ- but Not - and Opioid Receptor Like-1 Receptors
J Pharmacol Exp Ther 1999 291: 1365-1371. [Abstract] [Full Text] [PDF]  

Shiling Hu, Shuya Wang, and Beth E. Dunning

Tissue Selectivity of Antidiabetic Agent Nateglinide: Study on Cardiovascular and -Cell K_ATP Channels
J Pharmacol Exp Ther 1999 291: 1372-1379. [Abstract] [Full Text] [PDF]  

Alison M. Badger, Simon M. Blake, Robert A. Dodds, Don E. Griswold, Barbara A. Swift, David J. Rieman, George B. Stroup, Sandra J. Hoffman, and Maxine Gowen

Idoxifene, a Novel Selective Estrogen Receptor Modulator, Is Effective in a Rat Model of Adjuvant-Induced Arthritis
J Pharmacol Exp Ther 1999 291: 1380-1386. [Abstract] [Full Text] [PDF]  

Michael Vasko and Jerry Gebhart

ASPET Meeting Report: Meeting Report for the ASPET-Ray Fuller Symposium: Cellular Mechanisms and Novel Strategies for Pain Control
J Pharmacol Exp Ther 1999 291: 1387-1388. [Full Text] [PDF]  

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