ARTICLES:

Katrin Palm, Kristina Luthman, Jenny Ros, Johan Gråsjö, and Per Artursson

Effect of Molecular Charge on Intestinal Epithelial Drug Transport: pH-Dependent Transport of Cationic Drugs
J Pharmacol Exp Ther 1999 291: 435-443. [Abstract] [Full Text] [PDF]  

Heather S. Hain, John K. Belknap, and Jeffrey S. Mogil

Pharmacogenetic Evidence for the Involvement of 5-Hydroxytryptamine (Serotonin)-1B Receptors in the Mediation of Morphine Antinociceptive Sensitivity
J Pharmacol Exp Ther 1999 291: 444-449. [Abstract] [Full Text] [PDF]  

Harald Hofer, Guan-min Ho, Meinrad Peterlik, Milan R. Uskokovic, Jae Kyoo Lee, M. Christina White, Gary H. Posner, and Heide S. Cross

Biological Effects of 1-Hydroxy- and 1-(Hydroxymethyl)-Vitamin D Compounds Relevant for Potential Colorectal Cancer Therapy
J Pharmacol Exp Ther 1999 291: 450-455. [Abstract] [Full Text] [PDF]  

Neil C. E. Smith and Roberto Levi

LLC-PK₁ Cells Stably Expressing the Human Norepinephrine Transporter: A Functional Model of Carrier-Mediated Norepinephrine Release in Protracted Myocardial Ischemia
J Pharmacol Exp Ther 1999 291: 456-463. [Abstract] [Full Text] [PDF]  

Taiji Furukawa, Takeshi Yamakawa, Takayuki Midera, Toshio Sagawa, Yasuo Mori, and Toshihide Nukada

Selectivities of Dihydropyridine Derivatives in Blocking Ca²⁺ Channel Subtypes Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 1999 291: 464-473. [Abstract] [Full Text] [PDF]  

Klaus J. Wirth, Björn Rosenstein, Jörg Uhde, Heinrich C. Englert, Andreas E. Busch, and Bernward A. Schölkens

ATP-Sensitive Potassium Channel Blocker HMR 1883 Reduces Mortality and Ischemia-Associated Electrocardiographic Changes in Pigs with Coronary Occlusion
J Pharmacol Exp Ther 1999 291: 474-481. [Abstract] [Full Text] [PDF]  

Marc N. Potenza, Stephen J. Gold, Alison Roby-Shemkowitz, Michael R. Lerner, and Eric J. Nestler

Effects of Regulators of G Protein-Signaling Proteins on the Functional Response of the µ-Opioid Receptor in a Melanophore-Based Assay
J Pharmacol Exp Ther 1999 291: 482-491. [Abstract] [Full Text] [PDF]  

Lawrence H. Lash, David A. Putt, and Rudolfs K. Zalups

Influence of Exogenous Thiols on Inorganic Mercury-Induced Injury in Renal Proximal and Distal Tubular Cells from Normal and Uninephrectomized Rats
J Pharmacol Exp Ther 1999 291: 492-502. [Abstract] [Full Text] [PDF]  

J. L. Zeiders, F. J. Seidler, and T. A. Slotkin

Agonist-Induced Sensitization of -Adrenoceptor Signaling in Neonatal Rat Heart: Expression and Catalytic Activity of Adenylyl Cyclase
J Pharmacol Exp Ther 1999 291: 503-510. [Abstract] [Full Text] [PDF]  

R. John MacLeod, P. Lembessis, J. R. Hamilton, and William S. Powell

5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates Isotonic Volume Reduction of Guinea Pig Jejunal Crypt Epithelial Cells
J Pharmacol Exp Ther 1999 291: 511-516. [Abstract] [Full Text] [PDF]  

Shaoheng He, Marianna D. A. Gaça, Alan R. McEuen, and Andrew F. Walls

Inhibitors of Chymase as Mast Cell-Stabilizing Agents: Contribution of Chymase in the Activation of Human Mast Cells
J Pharmacol Exp Ther 1999 291: 517-523. [Abstract] [Full Text] [PDF]  

Jennifer Case and Cathy A. Davison

Estrogen Alters Relative Contributions of Nitric Oxide and Cyclooxygenase Products to Endothelium-Dependent Vasodilation
J Pharmacol Exp Ther 1999 291: 524-530. [Abstract] [Full Text] [PDF]  

Elena H. Chartoff, Raymond P. Ward, and Daniel M. Dorsa

Role of Adenosine and N-Methyl-D-aspartate Receptors in Mediating Haloperidol-Induced Gene Expression and Catalepsy
J Pharmacol Exp Ther 1999 291: 531-537. [Abstract] [Full Text] [PDF]  

Peter Dobelis, James E. Madl, James A. Pfister, Gary D. Manners, and John P. Walrond

Effects of Delphinium Alkaloids on Neuromuscular Transmission
J Pharmacol Exp Ther 1999 291: 538-546. [Abstract] [Full Text] [PDF]  

Metin Bagli, Richard Süverkrüp, Ralph Quadflieg, Gereon Höflich, Siegfried Kasper, Hans-Jürgen Möller, Michael Langer, Uwe Barlage, and Marie Luise Rao

Pharmacokinetic-Pharmacodynamic Modeling of Tolerance to the Prolactin-Secreting Effect of Chlorprothixene after Different Modes of Drug Administration
J Pharmacol Exp Ther 1999 291: 547-554. [Abstract] [Full Text] [PDF]  

Carlotta E. Groves and Mark N. Morales

Chlorotrifluoroethylcysteine Interaction with Rabbit Proximal Tubule Cell Basolateral Membrane Organic Anion Transport and Apical Membrane Amino Acid Transport
J Pharmacol Exp Ther 1999 291: 555-561. [Abstract] [Full Text] [PDF]  

Yulong Li, Toshiaki Sato, and Makoto Arita

Bepridil Blunts the Shortening of Action Potential Duration Caused by Metabolic Inhibition via Blockade of ATP-Sensitive K⁺ Channels and Na⁺-Activated K⁺ Channels
J Pharmacol Exp Ther 1999 291: 562-568. [Abstract] [Full Text] [PDF]  

John Smeda, Sudesh Vasdev, and Shelley R. King

Effect of Poststroke Captopril Treatment on Mortality Associated with Hemorrhagic Stroke in Stroke-Prone Rats
J Pharmacol Exp Ther 1999 291: 569-575. [Abstract] [Full Text] [PDF]  

Marianna E. Jung, Cleatus J. Wallis, Michael B. Gatch, and Harbans Lal

Sex Differences in the Pentylenetetrazol-Like Stimulus Induced by Ethanol Withdrawal
J Pharmacol Exp Ther 1999 291: 576-582. [Abstract] [Full Text] [PDF]  

Laurent Loufrani, Daniel Henrion, Dominique Chansel, Raymond Ardaillou, and Bernard I. Levy

Functional Evidence for an Angiotensin IV Receptor in Rat Resistance Arteries
J Pharmacol Exp Ther 1999 291: 583-588. [Abstract] [Full Text] [PDF]  

Nobuyuki Ohte, Che-Ping Cheng, Makoto Suzuki, and William C. Little

Effects of Atrial Natriuretic Peptide on Left Ventricular Performance in Conscious Dogs Before and After Pacing-Induced Heart Failure
J Pharmacol Exp Ther 1999 291: 589-595. [Abstract] [Full Text] [PDF]  

Ronald L. George, Xiang Wu, Wei Huang, You-Jun Fei, Frederick H. Leibach, and Vadivel Ganapathy

Molecular Cloning and Functional Characterization of a Polyspecific Organic Anion Transporter from Caenorhabditis elegans
J Pharmacol Exp Ther 1999 291: 596-603. [Abstract] [Full Text] [PDF]  

Kensuke Orito, Takashi Imaizumi, Kenji Yoshida, Hiroyuki Fujiki, Masami Kishi, Shuji Teramoto, Michinori Tanaka, Hiroshi Shimizu, Michiaki Tominaga, Yukio Kimura, Junichi Kambayashi, and Toyoki Mori

Mechanisms of Action of OPC-28326, a Selective Hindlimb Vasodilator
J Pharmacol Exp Ther 1999 291: 604-611. [Abstract] [Full Text] [PDF]  

Michael W. Lark, George B. Stroup, Shing Mei Hwang, Ian E. James, David J. Rieman, Fred H. Drake, Jeremy N. Bradbeer, Ashwini Mathur, Karl F. Erhard, Kenneth A. Newlander, Stephen T. Ross, Kevin L. Salyers, Brian R. Smith, William H. Miller, William F. Huffman, and Maxine Gowen

Design and Characterization of Orally Active Arg-Gly-Asp Peptidomimetic Vitronectin Receptor Antagonist SB 265123 for Prevention of Bone Loss in Osteoporosis
J Pharmacol Exp Ther 1999 291: 612-617. [Abstract] [Full Text] [PDF]  

Sean D. McAllister, Graeme Griffin, Leslie S. Satin, and Mary E. Abood

Cannabinoid Receptors Can Activate and Inhibit G Protein-Coupled Inwardly Rectifying Potassium Channels in a Xenopus Oocyte Expression System
J Pharmacol Exp Ther 1999 291: 618-626. [Abstract] [Full Text] [PDF]  

Isabelle Dumont, Xin Hou, Pierre Hardy, Krishna G. Peri, Martin Beauchamp, Taline Najarian, Stéphane Molotchnikoff, Daya R. Varma, and Sylvain Chemtob

Developmental Regulation of Endothelial Nitric Oxide Synthase in Cerebral Vessels of Newborn Pig by Prostaglandin E₂
J Pharmacol Exp Ther 1999 291: 627-633. [Abstract] [Full Text] [PDF]  

Satoru Takahashi, Norihiro Kobayashi, and Susumu Okabe

Regulation by Endogenous Interleukin-1 of mRNA Expression of Healing-Related Factors in Gastric Ulcers in Rats
J Pharmacol Exp Ther 1999 291: 634-641. [Abstract] [Full Text] [PDF]  

Titti Martinsson, Tryggve Ljung, Carlos Rubio, and Per M. Hellström

Beneficial Effects of Ropivacaine in Rat Experimental Colitis
J Pharmacol Exp Ther 1999 291: 642-647. [Abstract] [Full Text] [PDF]  

Sylvie Chalon, Lucette Garreau, Patrick Emond, Luc Zimmer, Marie-Paule Vilar, Jean-Claude Besnard, and Denis Guilloteau

Pharmacological Characterization of (E)-N-(3-iodoprop-2-enyl)-2-Carbomethoxy-3-(4'-methylphenyl)nortropane as a Selective and Potent Inhibitor of the Neuronal Dopamine Transporter
J Pharmacol Exp Ther 1999 291: 648-654. [Abstract] [Full Text] [PDF]  

Travis W. Hein, Luiz Belardinelli, and Lih Kuo

Adenosine A_2A Receptors Mediate Coronary Microvascular Dilation to Adenosine: Role of Nitric Oxide and ATP-Sensitive Potassium Channels
J Pharmacol Exp Ther 1999 291: 655-664. [Abstract] [Full Text] [PDF]  

William A. Banks

Characterization of Interleukin-1 Binding to Mouse Brain Endothelial Cells
J Pharmacol Exp Ther 1999 291: 665-670. [Abstract] [Full Text] [PDF]  

E. E. Daniel, R. Dale Brown, Y. F. Wang, A. M. Low, H. Lu-Chao, and C.-Y. Kwan

-Adrenoceptors in Canine Mesenteric Artery Are Predominantly 1A Subtype: Pharmacological and Immunochemical Evidence
J Pharmacol Exp Ther 1999 291: 671-679. [Abstract] [Full Text] [PDF]  

Scott A. Wadsworth, Druie E. Cavender, Scott A. Beers, Praful Lalan, Peter H. Schafer, Elizabeth A. Malloy, Wei Wu, Bohumila Fahmy, Gilbert C. Olini, Janet E. Davis, J. Lee Pellegrino-Gensey, Michael P. Wachter, and John J. Siekierka

RWJ 67657, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase
J Pharmacol Exp Ther 1999 291: 680-687. [Abstract] [Full Text] [PDF]  

Yogesh Dwivedi and Ghanshyam N. Pandey

Effects of Treatment with Haloperidol, Chlorpromazine, and Clozapine on Protein Kinase C (PKC) and Phosphoinositide-Specific Phospholipase C (PI-PLC) Activity and on mRNA and Protein Expression of PKC and PLC Isozymes in Rat Brain
J Pharmacol Exp Ther 1999 291: 688-704. [Abstract] [Full Text] [PDF]  

Kyoko Sawada, Tomohiro Terada, Hideyuki Saito, Yukiya Hashimoto, and Ken-Ichi Inui

Recognition of L-Amino Acid Ester Compounds by Rat Peptide Transporters PEPT1 and PEPT2
J Pharmacol Exp Ther 1999 291: 705-709. [Abstract] [Full Text] [PDF]  

Kouichi Tanonaka, Taku Taguchi, Miki Koshimizu, Tsuyoshi Ando, Tomohiro Morinaka, Tomoya Yogo, Fusako Konishi, and Satoshi Takeo

Role of an ATP-Sensitive Potassium Channel Opener, YM934, in Mitochondrial Energy Production in Ischemic/Reperfused Heart
J Pharmacol Exp Ther 1999 291: 710-716. [Abstract] [Full Text] [PDF]  

Lars Börjesson, Svante Nordgren, and Dick S. Delbro

K⁺-Induced Neurogenic Relaxation of Rat Distal Colon
J Pharmacol Exp Ther 1999 291: 717-724. [Abstract] [Full Text] [PDF]  

Leslie D. Napier, Sandra C. Roerig, Darice A. Yoshishige, Barbara A. Barron, and James L. Caffrey

Canine Cardiac Muscarinic Receptors, G Proteins, and Adenylate Cyclase after Long-Term Morphine
J Pharmacol Exp Ther 1999 291: 725-732. [Abstract] [Full Text] [PDF]  

B. C. Yang, D. S. Zander, and J. L. Mehta

Hypoxia-Reoxygenation-Induced Apoptosis in Cultured Adult Rat Myocytes and the Protective Effect of Platelets and Transforming Growth Factor-₁
J Pharmacol Exp Ther 1999 291: 733-738. [Abstract] [Full Text] [PDF]  

Vincent A. Pollack, Douglas M. Savage, Deborah A. Baker, Konstantinos E. Tsaparikos, Donald E. Sloan, James D. Moyer, Elsa G. Barbacci, Leslie R. Pustilnik, Teresa A. Smolarek, John A. Davis, Madhur P. Vaidya, Lee D. Arnold, John L. Doty, Kenneth K. Iwata, and Michael J. Morin

Inhibition of Epidermal Growth Factor Receptor-Associated Tyrosine Phosphorylation in Human Carcinomas with CP-358,774: Dynamics of Receptor Inhibition In Situ and Antitumor Effects in Athymic Mice
J Pharmacol Exp Ther 1999 291: 739-748. [Abstract] [Full Text] [PDF]  

Qin Mei, Cuyue Tang, Carol Assang, Yuh Lin, Donald Slaughter, A. David Rodrigues, Thomas A. Baillie, Thomas H. Rushmore, and Magang Shou

Role of a Potent Inhibitory Monoclonal Antibody to Cytochrome P-450 3A4 in Assessment of Human Drug Metabolism
J Pharmacol Exp Ther 1999 291: 749-759. [Abstract] [Full Text] [PDF]  

Qingbo Tang, Ronnie Gandhoke, Andrew Burritt, Victor J. Hruby, Frank Porreca, and Josephine Lai

High-Affinity Interaction of (des-Tyrosyl)Dynorphin A(2-17) with NMDA Receptors
J Pharmacol Exp Ther 1999 291: 760-765. [Abstract] [Full Text] [PDF]  

Qiangrong Liang, Edward C. Carlson, Anthony J. Borgerding, and Paul N. Epstein

A Transgenic Model of Acetaldehyde Overproduction Accelerates Alcohol Cardiomyopathy
J Pharmacol Exp Ther 1999 291: 766-772. [Abstract] [Full Text] [PDF]  

Shijie Sun, Max Harry Weil, Wanchun Tang, Heitor P. Povoas, and Earl Mason

Combined Effects of Buffer and Adrenergic Agents on Postresuscitation Myocardial Function
J Pharmacol Exp Ther 1999 291: 773-777. [Abstract] [Full Text] [PDF]  

Rikiya Ohashi, Ikumi Tamai, Hikaru Yabuuchi, Jun-Ichi Nezu, Asuka Oku, Yoshimichi Sai, Miyuki Shimane, and Akira Tsuji

Na⁺-Dependent Carnitine Transport by Organic Cation Transporter (OCTN2): Its Pharmacological and Toxicological Relevance
J Pharmacol Exp Ther 1999 291: 778-784. [Abstract] [Full Text] [PDF]  

Jessica C. Brimecombe, William K. Potthoff, and Elias Aizenman

A Critical Role of the N-Methyl-D-aspartate (NMDA) Receptor Subunit (NR) 2A in the Expression of Redox Sensitivity of NR1/NR2A Recombinant NMDA Receptors
J Pharmacol Exp Ther 1999 291: 785-792. [Abstract] [Full Text] [PDF]  

Rainer Büscher, Volker Herrmann, Kevin M. Ring, Mala T. Kailasam, Daniel T. O'Connor, Robert J. Parmer, and Paul A. Insel

Variability in Phenylephrine Response and Essential Hypertension: A Search for Human _1B-Adrenergic Receptor Polymorphisms
J Pharmacol Exp Ther 1999 291: 793-798. [Abstract] [Full Text] [PDF]  

James H. McElmurray, III, Rupak Mukherjee, R. Brent New, Angela C. Sampson, Mary K. King, Jennifer W. Hendrick, Aron Goldberg, Thomas J. Peterson, Hussein Hallak, Michael R. Zile, and Francis G. Spinale

Angiotensin-Converting Enzyme and Matrix Metalloproteinase Inhibition with Developing Heart Failure: Comparative Effects on Left Ventricular Function and Geometry
J Pharmacol Exp Ther 1999 291: 799-811. [Abstract] [Full Text] [PDF]  

Roy D. Schwarz, Michael J. Callahan, Linda L. Coughenour, Melvin R. Dickerson, Jack J. Kinsora, William J. Lipinski, Charlotte A. Raby, Carolyn J. Spencer, and Haile Tecle

Milameline (CI-979/RU35926): A Muscarinic Receptor Agonist with Cognition-Activating Properties: Biochemical and In Vivo Characterization
J Pharmacol Exp Ther 1999 291: 812-822. [Abstract] [Full Text] [PDF]  

Mohammad A. Khoyi, Lisa G. Gregory, Andrew D. Smith, Kathleen D. Keef, and David P. Westfall

An Unusual Ca²⁺ Entry Pathway Activated by Protein Kinase C in Dog Splenic Artery
J Pharmacol Exp Ther 1999 291: 823-828. [Abstract] [Full Text] [PDF]  

You-Yi Zhang, Kai-Ming Xu, and Chide Han

₁-Adrenoceptor Subtypes Mediating Inotropic Responses in Rat Heart
J Pharmacol Exp Ther 1999 291: 829-836. [Abstract] [Full Text] [PDF]  

Chen-ni Chin, James W. Murphy, John W. Huffman, and Debra A. Kendall

The Third Transmembrane Helix of the Cannabinoid Receptor Plays a Role in the Selectivity of Aminoalkylindoles for CB2, Peripheral Cannabinoid Receptor
J Pharmacol Exp Ther 1999 291: 837-844. [Abstract] [Full Text] [PDF]  

Robert G. Tsushima, James E. Kelly, Joseph J. Salata, Kristine N. Liberty, and J. Andrew Wasserstrom

Modification of Cardiac Na⁺ Current by RWJ 24517 and Its Enantiomers in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 1999 291: 845-855. [Abstract] [Full Text] [PDF]  

Hiroyuki Inoue, Kay Castagnoli, Cornelis Van der Schyf, Stéphane Mabic, Kazuo Igarashi, and Neal Castagnoli, Jr

Species-Dependent Differences in Monoamine Oxidase A and B-Catalyzed Oxidation of Various C4 Substituted 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives
J Pharmacol Exp Ther 1999 291: 856-864. [Abstract] [Full Text] [PDF]  

Yolanda Gutiérrez-Puente, Ana M. Tari, Clifton Stephens, Michael Rosenblum, Reyes Tamez Guerra, and Gabriel Lopez-Berestein

Safety, Pharmacokinetics, and Tissue Distribution of Liposomal P-Ethoxy Antisense Oligonucleotides Targeted to Bcl-2
J Pharmacol Exp Ther 1999 291: 865-869. [Abstract] [Full Text] [PDF]  

Brenda J. Kitchen, Asher Moser, Elizabeth Lowe, Frank M. Balis, Brigitte Widemann, Lawrence Anderson, John Strong, Susan M. Blaney, Stacey L. Berg, Michelle O'Brien, and Peter C. Adamson

Thioguanine Administered as a Continuous Intravenous Infusion to Pediatric Patients Is Metabolized to the Novel Metabolite 8-Hydroxy-Thioguanine
J Pharmacol Exp Ther 1999 291: 870-874. [Abstract] [Full Text] [PDF]  

Anish A. Konkar, Sandeep S. Vansal, Gamal Shams, Paul F. Fraundorfer, Wei-Ping Zheng, Victor I. Nikulin, Joseph De Los Angeles, Richard H. Fertel, Duane D. Miller, and Dennis R. Feller

-Adrenoceptor Subtype Activities of Trimetoquinol Derivatives: Biochemical Studies on Human -Adrenoceptors Expressed in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 1999 291: 875-883. [Abstract] [Full Text] [PDF]  

Lidia Serova, Emil Danailov, Firas Chamas, and Esther L. Sabban

Nicotine Infusion Modulates Immobilization Stress-Triggered Induction of Gene Expression of Rat Catecholamine Biosynthetic Enzymes
J Pharmacol Exp Ther 1999 291: 884-892. [Abstract] [Full Text] [PDF]  

Jian Mu, Shou-yuan Zhuang, M. Todd Kirby, Robert E. Hampson, and Sam A. Deadwyler

Cannabinoid Receptors Differentially Modulate Potassium A and D Currents in Hippocampal Neurons in Culture
J Pharmacol Exp Ther 1999 291: 893-902. [Abstract] [Full Text] [PDF]  

Steven W. Kerr, Walter W. Wolyniec, Zoran Filipovic, Suzanne G. Nodop, Frank Braza, Raymond J. Winquist, and Thomas C. Noonan

Repeated Measurement of Intestinal Permeability as an Assessment of Colitis Severity in HLA-B27 Transgenic Rats
J Pharmacol Exp Ther 1999 291: 903-910. [Abstract] [Full Text] [PDF]  

Mahin D. Maines, Vulapali S. Raju, and Nariman Panahian

Spin Trap (N-t-butyl--phenylnitrone)-Mediated Suprainduction of Heme Oxygenase-1 in Kidney Ischemia/Reperfusion Model: Role of the Oxygenase in Protection against Oxidative Injury
J Pharmacol Exp Ther 1999 291: 911-919. [Abstract] [Full Text] [PDF]  

Asad Junaid, Li Cui, S. Brian Penner, and Donald D. Smyth

Regulation of Aquaporin-2 Expression by the ₂-Adrenoceptor Agonist Clonidine in the Rat
J Pharmacol Exp Ther 1999 291: 920-923. [Abstract] [Full Text] [PDF]  

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