ARTICLES:

Jin-Sung Choi, Sang June Hahn, Duck-Joo Rhie, Shin-Hee Yoon, Yang-Hyeok Jo, and Myung-Suk Kim

Mechanism of Fluoxetine Block of Cloned Voltage-Activated Potassium Channel Kv1.3
J Pharmacol Exp Ther 1999 291: 1-6. [Abstract] [Full Text] [PDF]  

Tenna Juul Jensen and Ove A. Nedergaard

Modulation of Norepinephrine Release from Sympathetic Neurons of the Rabbit Aorta by Prejunctional Prostanoid Receptors
J Pharmacol Exp Ther 1999 291: 7-11. [Abstract] [Full Text] [PDF]  

Pilar Sánchez-Blázquez, Marta Rodríguez-Díaz, Isabel DeAntonio, and Javier Garzón

Endomorphin-1 and Endomorphin-2 Show Differences in Their Activation of µ Opioid Receptor-Regulated G Proteins in Supraspinal Antinociception in Mice
J Pharmacol Exp Ther 1999 291: 12-18. [Abstract] [Full Text] [PDF]  

David S. Segal and Ronald Kuczenski

Escalating Dose-Binge Treatment with Methylphenidate: Role of Serotonin in the Emergent Behavioral Profile
J Pharmacol Exp Ther 1999 291: 19-30. [Abstract] [Full Text] [PDF]  

Esam Z. Dajani, Kenneth R. Larsen, John Taylor, Noura E. Dajani, Thomas G. Shahwan, Stephen D. Neeleman, Mark S. Taylor, Merril T. Dayton, and G. Nabi Mir

1',1'-Dimethylheptyl--8-tetrahydrocannabinol-11-oic Acid: A Novel, Orally Effective Cannabinoid with Analgesic and Anti-inflammatory Properties
J Pharmacol Exp Ther 1999 291: 31-38. [Abstract] [Full Text] [PDF]  

G. M. Gilad and V. H. Gilad

Novel Polyamine Derivatives as Neuroprotective Agents
J Pharmacol Exp Ther 1999 291: 39-43. [Abstract] [Full Text] [PDF]  

Jason G. Murphy and Raouf A. Khalil

Decreased [Ca²⁺]_i during Inhibition of Coronary Smooth Muscle Contraction by 17-Estradiol, Progesterone, and Testosterone
J Pharmacol Exp Ther 1999 291: 44-52. [Abstract] [Full Text] [PDF]  

Ken-Ichi Hosoya, Hideo Ueda, Kwang-Jin Kim, and Vincent H. L. Lee

Nucleotide Stimulation of Cl Secretion in the Pigmented Rabbit Conjunctiva
J Pharmacol Exp Ther 1999 291: 53-59. [Abstract] [Full Text] [PDF]  

S. Stevens Negus, Michael R. Brandt, and Nancy K. Mello

Effects of the Long-Acting Monoamine Reuptake Inhibitor Indatraline on Cocaine Self-Administration in Rhesus Monkeys
J Pharmacol Exp Ther 1999 291: 60-69. [Abstract] [Full Text] [PDF]  

Catherine Coirault, Olivier Langeron, Francine Lambert, François-Xavier Blanc, Guy Lerebours, Nancy Claude, Bruno Riou, Denis Chemla, and Yves Lecarpentier

Impaired Skeletal Muscle Performance in the Early Stage of Cardiac Pressure Overload in Rabbits: Beneficial Effects of Angiotensin-Converting Enzyme Inhibition
J Pharmacol Exp Ther 1999 291: 70-75. [Abstract] [Full Text] [PDF]  

Bradley T. Andresen, Delbert G. Gillespie, Zaichuan Mi, Raghvendra K. Dubey, and Edwin K. Jackson

Role of Adenosine A₁ Receptors in Modulating Extracellular Adenosine Levels
J Pharmacol Exp Ther 1999 291: 76-80. [Abstract] [Full Text] [PDF]  

Katsuyoshi Akiyama, Masachiyo Hora, Satoshi Tatemichi, Naoyuki Masuda, Syunji Nakamura, Ryoichi Yamagishi, and Makio Kitazawa

KMD-3213, a Uroselective and Long-Acting _1a-Adrenoceptor Antagonist, Tested in a Novel Rat Model
J Pharmacol Exp Ther 1999 291: 81-91. [Abstract] [Full Text] [PDF]  

James J. Galligan

Nerve Terminal Nicotinic Cholinergic Receptors on Excitatory Motoneurons in the Myenteric Plexus of Guinea Pig Intestine
J Pharmacol Exp Ther 1999 291: 92-98. [Abstract] [Full Text] [PDF]  

Gene G. Kinney, Patricia Patino, Yvan Mermet-Bouvier, John E. Starrett, Jr, and Valentin K. Gribkoff

Cognition-Enhancing Drugs Increase Stimulated Hippocampal  Rhythm Amplitude in the Urethane-Anesthetized Rat
J Pharmacol Exp Ther 1999 291: 99-106. [Abstract] [Full Text] [PDF]  

Se-Young Choi and Kyong-Tai Kim

Capsaicin Inhibits Phospholipase C-Mediated Ca²⁺ Increase by Blocking Thapsigargin-Sensitive Store-Operated Ca²⁺ Entry in PC12 Cells
J Pharmacol Exp Ther 1999 291: 107-114. [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, William A. Herzer, Zaichuan Mi, Subhash J. Vyas, and Curtis K. Kost, Jr

Low-Dose Angiotensin II Reduces Urinary Cyclic AMP Excretion in Spontaneously Hypertensive, But Not Normotensive, Rats: Independence from Hypertension and Renal Hemodynamic Effects of Angiotensin
J Pharmacol Exp Ther 1999 291: 115-123. [Abstract] [Full Text] [PDF]  

Zuoning Han, David L. Boyle, Karlfried R. Aupperle, Brydon Bennett, Anthony M. Manning, and Gary S. Firestein

Jun N-Terminal Kinase in Rheumatoid Arthritis
J Pharmacol Exp Ther 1999 291: 124-130. [Abstract] [Full Text] [PDF]  

Wolfgang Jacobsen, Gabriele Kirchner, Katrin Hallensleben, Laviero Mancinelli, Michael Deters, Ingelore Hackbarth, Karen Baner, Leslie Z. Benet, Karl-Friedrich Sewing, and Uwe Christians

Small Intestinal Metabolism of the 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitor Lovastatin and Comparison with Pravastatin
J Pharmacol Exp Ther 1999 291: 131-139. [Abstract] [Full Text] [PDF]  

H. Yamamura, N. Nagano, M. Hirano, K. Muraki, M. Watanabe, and Y. Imaizumi

Activation of Ca²⁺-Dependent K⁺ Current by Nordihydroguaiaretic Acid in Porcine Coronary Arterial Smooth Muscle Cells
J Pharmacol Exp Ther 1999 291: 140-146. [Abstract] [Full Text] [PDF]  

Jessica E. van Montfoort, Bruno Hagenbuch, Karin E. Fattinger, Michael Müller, Geny M. M. Groothuis, Dirk K. F. Meijer, and Peter J. Meier

Polyspecific Organic Anion Transporting Polypeptides Mediate Hepatic Uptake of Amphipathic Type II Organic Cations
J Pharmacol Exp Ther 1999 291: 147-152. [Abstract] [Full Text] [PDF]  

Cornelis J. J. G. Bol, John P. W. Vogelaar, and Jaap W. Mandema

Anesthetic Profile of Dexmedetomidine Identified by Stimulus-Response and Continuous Measurements in Rats
J Pharmacol Exp Ther 1999 291: 153-160. [Abstract] [Full Text] [PDF]  

Jayne Cartmell, James A. Monn, and Darryle D. Schoepp

The Metabotropic Glutamate 2/3 Receptor Agonists LY354740 and LY379268 Selectively Attenuate Phencyclidine versus d-Amphetamine Motor Behaviors in Rats
J Pharmacol Exp Ther 1999 291: 161-170. [Abstract] [Full Text] [PDF]  

Mitsutoshi Kimura and Masahiko Ogihara

Stimulation by Transforming Growth Factor- of DNA Synthesis and Proliferation of Adult Rat Hepatocytes in Primary Cultures: Modulation by - and -Adrenoceptor Agonists
J Pharmacol Exp Ther 1999 291: 171-180. [Abstract] [Full Text] [PDF]  

Motohiro Kitamura, Shinichi Sugamoto, Shoji Kawauchi, Shinichi Kato, and Koji Takeuchi

Modulation by Endogenous Nitric Oxide of Acid Secretion Induced by Gastric Distention in Rats: Enhancement by Nitric Oxide Synthase Inhibitor
J Pharmacol Exp Ther 1999 291: 181-187. [Abstract] [Full Text] [PDF]  

Lise A. Eliot and Fakhreddin Jamali

Pharmacokinetics and Pharmacodynamics of Nifedipine in Untreated and Atorvastatin-Treated Hyperlipidemic Rats
J Pharmacol Exp Ther 1999 291: 188-193. [Abstract] [Full Text] [PDF]  

Michael John Mihm, Christen Marie Coyle, Liang Jing, and John Anthony Bauer

Vascular Peroxynitrite Formation during Organic Nitrate Tolerance
J Pharmacol Exp Ther 1999 291: 194-198. [Abstract] [Full Text] [PDF]  

Peter Gozzi, Ingrid Påhlman, Lena Palmér, Alvar Grönberg, and and Stefan Persson

Pharmacokinetic-Pharmacodynamic Modeling of the Immunomodulating Agent Susalimod and Experimentally Induced Tumor Necrosis Factor- Levels in the Mouse
J Pharmacol Exp Ther 1999 291: 199-203. [Abstract] [Full Text] [PDF]  

Yong-Hae Han, Yukio Kato, and Yuichi Sugiyama

Nonlinear Disposition Kinetics of a Novel Antifolate, MX-68, in Rats
J Pharmacol Exp Ther 1999 291: 204-212. [Abstract] [Full Text] [PDF]  

Maurice G. Emery, Carole Jubert, Kenneth E. Thummel, and Evan D. Kharasch

Duration of Cytochrome P-450 2E1 (CYP2E1) Inhibition and Estimation of Functional CYP2E1 Enzyme Half-Life after Single-Dose Disulfiram Administration in Humans
J Pharmacol Exp Ther 1999 291: 213-219. [Abstract] [Full Text] [PDF]  

Casimir A. Fornal, Francisco J. Martin, Christine W. Metzler, and Barry L. Jacobs

Pindolol, a Putative 5-Hydroxytryptamine_1A Antagonist, Does Not Reverse the Inhibition of Serotonergic Neuronal Activity Induced by Fluoxetine in Awake Cats: Comparison to WAY-100635
J Pharmacol Exp Ther 1999 291: 220-228. [Abstract] [Full Text] [PDF]  

Casimir A. Fornal, Francisco J. Martin, Christine W. Metzler, and Barry L. Jacobs

Pindolol Suppresses Serotonergic Neuronal Activity and Does Not Block the Inhibition of Serotonergic Neurons Produced by 8-Hydroxy-2-(di-n-propylamino)tetralin in Awake Cats
J Pharmacol Exp Ther 1999 291: 229-238. [Abstract] [Full Text] [PDF]  

Patrik Munzar, Michael D. Laufert, Scott W. Kutkat, Jana Nováková, and Steven R. Goldberg

Effects of Various Serotonin Agonists, Antagonists, and Uptake Inhibitors on the Discriminative Stimulus Effects of Methamphetamine in Rats
J Pharmacol Exp Ther 1999 291: 239-250. [Abstract] [Full Text] [PDF]  

Roberto Maggio, Pascaline Barbier, Antonella Colelli, Federica Salvadori, Graziella Demontis, and Giovanni U. Corsini

G Protein-Linked Receptors: Pharmacological Evidence for the Formation of Heterodimers
J Pharmacol Exp Ther 1999 291: 251-257. [Abstract] [Full Text] [PDF]  

Amruthesh C. Shivachar and Douglas C. Eikenburg

Differential Effects of Epinephrine and Norepinephrine on cAMP Response and G_i3 Protein Expression in Cultured Sympathetic Neurons
J Pharmacol Exp Ther 1999 291: 258-264. [Abstract] [Full Text] [PDF]  

Jonathan L. Katz, Theresa A. Kopajtic, Krista A. Myers, Robert J. Mitkus, and Michael Chider

Behavioral Effects of Cocaine: Interactions with D1 Dopaminergic Antagonists and Agonists in Mice and Squirrel Monkeys
J Pharmacol Exp Ther 1999 291: 265-279. [Abstract] [Full Text] [PDF]  

Majed Khalifa, Pascal Daleau, and and Jacques Turgeon

Mechanism of Sodium Channel Block by Venlafaxine in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 1999 291: 280-284. [Abstract] [Full Text] [PDF]  

Scott C. Harvey and Phil Skolnick

Polyamine-Like Actions of Aminoglycosides at Recombinant N-Methyl-D-Aspartate Receptors
J Pharmacol Exp Ther 1999 291: 285-291. [Abstract] [Full Text] [PDF]  

W. George Lai, Nasir Zahid, and Jack P. Uetrecht

Metabolism of Trimethoprim to a Reactive Iminoquinone Methide by Activated Human Neutrophils and Hepatic Microsomes
J Pharmacol Exp Ther 1999 291: 292-299. [Abstract] [Full Text] [PDF]  

Lance R. McMahon and Kathryn A. Cunningham

Antagonism of 5-Hydroxytryptamine₄ Receptors Attenuates Hyperactivity Induced by Cocaine: Putative Role for 5-Hydroxytryptamine₄ Receptors in the Nucleus Accumbens Shell
J Pharmacol Exp Ther 1999 291: 300-307. [Abstract] [Full Text] [PDF]  

Makoto Inoue, Ichiro Shimohira, Akira Yoshida, Andreas Zimmer, Hiroshi Takeshima, Tsukasa Sakurada, and Hiroshi Ueda

Dose-Related Opposite Modulation by Nociceptin/Orphanin FQ of Substance P Nociception in the Nociceptors and Spinal Cord
J Pharmacol Exp Ther 1999 291: 308-313. [Abstract] [Full Text] [PDF]  

Young Jin Kang, Young Soo Lee, Goun Woo Lee, Duck Hyung Lee, Jae Chun Ryu, Hye Sook Yun-Choi, and Ki Churl Chang

Inhibition of Activation of Nuclear Factor B Is Responsible for Inhibition of Inducible Nitric Oxide Synthase Expression by Higenamine, an Active Component of Aconite Root
J Pharmacol Exp Ther 1999 291: 314-320. [Abstract] [Full Text] [PDF]  

Odile Barou, Marie-Hélène Lafage-Proust, Catherine Martel, Thierry Thomas, Fabrice Tirode, Norbert Laroche, Alain Barbier, Christian Alexandre, and Laurence Vico

Bisphosphonate Effects in Rat Unloaded Hindlimb Bone Loss Model: Three-Dimensional Microcomputed Tomographic, Histomorphometric, and Densitometric Analyses
J Pharmacol Exp Ther 1999 291: 321-328. [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, William A. Herzer, Subhash J. Vyas, and Curtis K. Kost, Jr

Angiotensin II-Induced Renal Vasoconstriction in Genetic Hypertension
J Pharmacol Exp Ther 1999 291: 329-334. [Abstract] [Full Text] [PDF]  

Shunichi Shimizu and Richard J. Paul

Hypoxia and Alkalinization Inhibit Endothelium-Derived Nitric Oxide But Not Endothelium-Derived Hyperpolarizing Factor Responses in Porcine Coronary Artery
J Pharmacol Exp Ther 1999 291: 335-344. [Abstract] [Full Text] [PDF]  

Tadahito Shimada, Naomi Watanabe, Yukio Ohtsuka, Motoya Endoh, Kazuo Kojima, Hideyuki Hiraishi, and Akira Terano

Polaprezinc Down-Regulates Proinflammatory Cytokine-Induced Nuclear Factor-B Activiation and Interleukin-8 Expression in Gastric Epithelial Cells
J Pharmacol Exp Ther 1999 291: 345-352. [Abstract] [Full Text] [PDF]  

S. Barak Caine, S. Stevens Negus, Nancy K. Mello, and Jack Bergman

Effects of Dopamine D_1-like and D_2-like Agonists in Rats that Self-Administer Cocaine
J Pharmacol Exp Ther 1999 291: 353-360. [Abstract] [Full Text] [PDF]  

Pradeep K. Banerjee, Richard W. Olsen, and O. Carter Snead, III

Zinc Inhibition of -Aminobutyric Acid_A Receptor Function Is Decreased in the Cerebral Cortex during Pilocarpine-Induced Status Epilepticus
J Pharmacol Exp Ther 1999 291: 361-366. [Abstract] [Full Text] [PDF]  

S. N. Iyer, G. Gurujeyalakshmi, and S. N. Giri

Effects of Pirfenidone on Transforming Growth Factor- Gene Expression at the Transcriptional Level in Bleomycin Hamster Model of Lung Fibrosis
J Pharmacol Exp Ther 1999 291: 367-373. [Abstract] [Full Text] [PDF]  

Jin Zhai, Michael D. Gershon, John H. Walsh, Helen C. Wong, and Annette L. Kirchgessner

Inward Currents in Neurons from Newborn Guinea Pig Intestine: Mediation by 5-Hydroxytryptamine Type 3 Receptors
J Pharmacol Exp Ther 1999 291: 374-382. [Abstract] [Full Text] [PDF]  

Julius D. Militante and John B. Lombardini

Stimulatory Effect of Taurine on Calcium Ion Uptake in Rod Outer Segments of the Rat Retina Is Independent of Taurine Uptake
J Pharmacol Exp Ther 1999 291: 383-389. [Abstract] [Full Text] [PDF]  

M. I. Damaj, W. Glassco, M. D. Aceto, and B. R. Martin

Antinociceptive and Pharmacological Effects of Metanicotine, a Selective Nicotinic Agonist
J Pharmacol Exp Ther 1999 291: 390-398. [Abstract] [Full Text] [PDF]  

Frank C. Tortella, Paul Britton, Anthony Williams, Xi Chung May Lu, and Amy H. Newman

Neuroprotection (Focal Ischemia) and Neurotoxicity (Electroencephalographic) Studies in Rats with AHN649, a 3-Amino Analog of Dextromethorphan and Low-Affinity N-Methyl-D-Aspartate Antagonist
J Pharmacol Exp Ther 1999 291: 399-408. [Abstract] [Full Text] [PDF]  

Nora D. Volkow, Gene-Jack Wang, Joanna S. Fowler, Jean Logan, S. John Gatley, Cristopher Wong, Robert Hitzemann, and Naomi R. Pappas

Reinforcing Effects of Psychostimulants in Humans Are Associated with Increases in Brain Dopamine and Occupancy of D₂ Receptors
J Pharmacol Exp Ther 1999 291: 409-415. [Abstract] [Full Text] [PDF]  

Frank A. D. T. G. Wagener, Jean-Louis da Silva, Tim Farley, Theo de Witte, Attallah Kappas, and Nader G. Abraham

Differential Effects of Heme Oxygenase Isoforms on Heme Mediation of Endothelial Intracellular Adhesion Molecule 1 Expression
J Pharmacol Exp Ther 1999 291: 416-423. [Abstract] [Full Text] [PDF]  

Sean Ekins, Gianpaolo Bravi, James H. Wikel, and Steven A. Wrighton

Three-Dimensional-Quantitative Structure Activity Relationship Analysis of Cytochrome P-450 3A4 Substrates
J Pharmacol Exp Ther 1999 291: 424-433. [Abstract] [Full Text] [PDF]  

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