ARTICLES:

Linda P. Dwoskin, Lihong Teng, Susan T. Buxton, and Peter A. Crooks

(S)-()-Cotinine, the Major Brain Metabolite of Nicotine, Stimulates Nicotinic Receptors to Evoke [³H]Dopamine Release from Rat Striatal Slices in a Calcium-Dependent Manner
J Pharmacol Exp Ther 1999 288: 905-911. [Abstract] [Full Text] [PDF]  

Hideo Tanaka and Kenji Mizojiri

Drug-Protein Binding and Blood-Brain Barrier Permeability
J Pharmacol Exp Ther 1999 288: 912-918. [Abstract] [Full Text] [PDF]  

Eiichiro Hatta, Ryushi Maruyama, Stuart J. Marshall, Michiaki Imamura, and Roberto Levi

Bradykinin Promotes Ischemic Norepinephrine Release in Guinea Pig and Human Hearts
J Pharmacol Exp Ther 1999 288: 919-927. [Abstract] [Full Text] [PDF]  

Li J. Yu, Pernille Drewes, Katja Gustafsson, Etienne G. C. Brain, Jodi E. D. Hecht, and David J. Waxman

In Vivo Modulation of Alternative Pathways of P-450-Catalyzed Cyclophosphamide Metabolism: Impact on Pharmacokinetics and Antitumor Activity
J Pharmacol Exp Ther 1999 288: 928-937. [Abstract] [Full Text] [PDF]  

Guang-Wu Wang and Y. James Kang

Inhibition of Doxorubicin Toxicity in Cultured Neonatal Mouse Cardiomyocytes with Elevated Metallothionein Levels
J Pharmacol Exp Ther 1999 288: 938-944. [Abstract] [Full Text] [PDF]  

Graham W. Warren, Samuel M. Poloyac, Devin S. Gary, Mark P. Mattson, and Robert A. Blouin

Hepatic Cytochrome P-450 Expression in Tumor Necrosis Factor- Receptor (p55/p75) Knockout Mice After Endotoxin Administration
J Pharmacol Exp Ther 1999 288: 945-950. [Abstract] [Full Text] [PDF]  

Timothy P. Reilly, Patrick M. Woster, and Craig K. Svensson

Methemoglobin Formation by Hydroxylamine Metabolites of Sulfamethoxazole and Dapsone: Implications for Differences in Adverse Drug Reactions
J Pharmacol Exp Ther 1999 288: 951-959. [Abstract] [Full Text] [PDF]  

S. Taverna, G. Sancini, M. Mantegazza, S. Franceschetti, and G. Avanzini

Inhibition of Transient and Persistent Na⁺ Current Fractions by the New Anticonvulsant Topiramate
J Pharmacol Exp Ther 1999 288: 960-968. [Abstract] [Full Text] [PDF]  

Rennolds S. Ostrom and Frederick J. Ehlert

Comparison of Functional Antagonism Between Isoproterenol and M₂ Muscarinic Receptors in Guinea Pig Ileum and Trachea
J Pharmacol Exp Ther 1999 288: 969-976. [Abstract] [Full Text] [PDF]  

Xiang-Qun Hu, Shumei Yang, William J. Pearce, Lawrence D. Longo, and Lubo Zhang

Effect of Chronic Hypoxia on Alpha-1 Adrenoceptor-Mediated Inositol 1,4,5-Trisphosphate Signaling in Ovine Uterine Artery
J Pharmacol Exp Ther 1999 288: 977-983. [Abstract] [Full Text] [PDF]  

Wolfgang Löscher, Holger Lehmann, Hans-Jürgen Teschendorf, Martin Traut, and Gerhard Gross

Inhibition of Monoamine Oxidase Type A, but Not Type B, Is an Effective Means of Inducing Anticonvulsant Activity in the Kindling Model of Epilepsy
J Pharmacol Exp Ther 1999 288: 984-992. [Abstract] [Full Text] [PDF]  

Varanuj Chatsudthipong, Promsuk Jutabha, Kristen K. Evans, and William H. Dantzler

Effects of Inhibitors and Substitutes for Chloride in Lumen on p-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubules
J Pharmacol Exp Ther 1999 288: 993-1001. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Mauricette Brocco, Alain Gobert, Rudy Schreiber, and Anne Dekeyne

S-16924 [(R)-2-{1-[2-(2,3-Dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl}-1-(4-fluorophenyl)-ethanone], a Novel, Potential Antipsychotic with Marked Serotonin_1A Agonist Properties: III. Anxiolytic Actions in Comparison with Clozapine and Haloperidol
J Pharmacol Exp Ther 1999 288: 1002-1014. [Abstract] [Full Text] [PDF]  

Yukun Yuan and William D. Atchison

Comparative Effects of Methylmercury on Parallel-Fiber and Climbing-Fiber Responses of Rat Cerebellar Slices
J Pharmacol Exp Ther 1999 288: 1015-1025. [Abstract] [Full Text] [PDF]  

Hui-Lin Pan, James C. Eisenach, and Shao-Rui Chen

Gabapentin Suppresses Ectopic Nerve Discharges and Reverses Allodynia in Neuropathic Rats
J Pharmacol Exp Ther 1999 288: 1026-1030. [Abstract] [Full Text] [PDF]  

Tomio Okamura, Kazuhide Ayajiki, Masami Uchiyama, Masami Uehara, and Noboru Toda

Neurogenic Vasodilatation of Canine Isolated Small Labial Arteries
J Pharmacol Exp Ther 1999 288: 1031-1036. [Abstract] [Full Text] [PDF]  

Françoise Berlioz, Stéphanie Julien, Annick Tsocas, Jacques Chariot, Claude Carbon, Robert Farinotti, and Claude Rozé

Neural Modulation of Cephalexin Intestinal Absorption Through the Di- and Tripeptide Brush Border Transporter of Rat Jejunum In Vivo
J Pharmacol Exp Ther 1999 288: 1037-1044. [Abstract] [Full Text] [PDF]  

Francesca Crema, Chiara Modini, Tiziano Croci, Michel Langlois, and Fabrizio de Ponti

Intestinal Prokinesia by Two Esters of 4-Amino-5-Chloro-2-Methoxybenzoic Acid: Involvement of 5-Hydroxytryptamine-4 Receptors and Dissociation from Cardiac Effects In Vivo
J Pharmacol Exp Ther 1999 288: 1045-1052. [Abstract] [Full Text] [PDF]  

Maciej Gasior, Mohammed Shoaib, Sevil Yasar, Maria Jaszyna, and Steven R. Goldberg

Acquisition of Nicotine Discrimination and Discriminative Stimulus Effects of Nicotine in Rats Chronically Exposed to Caffeine
J Pharmacol Exp Ther 1999 288: 1053-1073. [Abstract] [Full Text] [PDF]  

P. Ferrari, M. Ferrandi, G. Tripodi, L. Torielli, G. Padoani, E. Minotti, P. Melloni, and G. Bianchi

PST 2238: A New Antihypertensive Compound that Modulates Na,K-ATPase in Genetic Hypertension
J Pharmacol Exp Ther 1999 288: 1074-1083. [Abstract] [Full Text] [PDF]  

Andrea Teschemacher and Horst Lemoine

Kinetic Analysis of Drug-Receptor Interactions of Long-Acting ₂ Sympathomimetics in Isolated Receptor Membranes: Evidence against Prolonged Effects of Salmeterol and Formoterol on Receptor-Coupled Adenylyl Cyclase
J Pharmacol Exp Ther 1999 288: 1084-1092. [Abstract] [Full Text] [PDF]  

Lilijana Sprah, Marko Zivin, and Dusan Sket

Ergoline Derivative LEK-8829-Induced Turning Behavior in Rats with Unilateral Striatal Ibotenic Acid Lesions: Interaction with Bromocriptine
J Pharmacol Exp Ther 1999 288: 1093-1100. [Abstract] [Full Text] [PDF]  

Michael A. Saunders, Maria G. Belvisi, Guiseppe Cirino, P. J. Barnes, Timothy D. Warner, and Jane A. Mitchell

Mechanisms of Prostaglandin E₂ Release by Intact Cells Expressing Cyclooxygenase-2: Evidence for a `Two-Component' Model
J Pharmacol Exp Ther 1999 288: 1101-1106. [Abstract] [Full Text] [PDF]  

Carolyn A. Fairbanks and George L. Wilcox

Spinal Antinociceptive Synergism between Morphine and Clonidine Persists in Mice Made Acutely or Chronically Tolerant to Morphine
J Pharmacol Exp Ther 1999 288: 1107-1116. [Abstract] [Full Text] [PDF]  

David W. Snyder, Nicholas J. Bach, Robert D. Dillard, Susan E. Draheim, Donald G. Carlson, Niles Fox, Neal W. Roehm, Christopher T. Armstrong, Chan H. Chang, Lawrence W. Hartley, Lea M. Johnson, Carlos R. Roman, Amy C. Smith, Min Song, and Jerome H. Fleisch

Pharmacology of LY315920/S-5920, [ [3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A₂ Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI
J Pharmacol Exp Ther 1999 288: 1117-1124. [Abstract] [Full Text] [PDF]  

S. F. de Boer, M. Lesourd, E. Mocaer, and J. M. Koolhaas

Selective Antiaggressive Effects of Alnespirone in Resident-Intruder Test Are Mediated via 5-Hydroxytryptamine_1A Receptors: A Comparative Pharmacological Study with 8-Hydroxy-2-Dipropylaminotetralin, Ipsapirone, Buspirone, Eltoprazine, and WAY-100635
J Pharmacol Exp Ther 1999 288: 1125-1133. [Abstract] [Full Text] [PDF]  

H. Kevin Happe, David B. Bylund, and L. Charles Murrin

Alpha-2 Adrenergic Receptor Functional Coupling to G Proteins in Rat Brain During Postnatal Development
J Pharmacol Exp Ther 1999 288: 1134-1142. [Abstract] [Full Text] [PDF]  

James L. Ellis, Dean Harman, Javier Gonzalez, Michael L. Spera, Ronggang Liu, T. Y. Shen, Donna M. Wypij, and Fangming Zuo

Development of Muscarinic Analgesics Derived from Epibatidine: Role of the M₄ Receptor Subtype
J Pharmacol Exp Ther 1999 288: 1143-1150. [Abstract] [Full Text] [PDF]  

P. Salvati, R. Maj, C. Caccia, M. A. Cervini, M. G. Fornaretto, E. Lamberti, P. Pevarello, G. A. Skeen, H. S. White, H. H. Wolf, L. Faravelli, M. Mazzanti, E. Mancinelli, M. Varasi, and R. G. Fariello

Biochemical and Electrophysiological Studies on the Mechanism of Action of PNU-151774E, A Novel Antiepileptic Compound
J Pharmacol Exp Ther 1999 288: 1151-1159. [Abstract] [Full Text] [PDF]  

Scot C. Westwood and Glen R. Hanson

Effects of Stimulants of Abuse on Extrapyramidal and Limbic Neuropeptide Y Systems
J Pharmacol Exp Ther 1999 288: 1160-1166. [Abstract] [Full Text] [PDF]  

Minako Kaburaki, Hideo Yabana, Hisayoshi Doi, Koichi Nagata, Hiroshi Narita, and Sakae Murata

The Mechanism of the Increasing Action of TA-993, a New 1,5-Benzothiazepine Derivative, on Limb Blood Flow in Anesthetized Dogs: Selective Suppression of Sympathetic Nerve Activity
J Pharmacol Exp Ther 1999 288: 1167-1173. [Abstract] [Full Text] [PDF]  

Bengt Särnstrand, Anne-Helene Jansson, Giedre Matuseviciene, Annika Scheynius, Stefan Pierrou, and Håkan Bergstrand

N,N'-Diacetyl-L-cystinethe Disulfide Dimer of N-acetylcysteineIs a Potent Modulator of Contact Sensitivity/Delayed Type Hypersensitivity Reactions in Rodents
J Pharmacol Exp Ther 1999 288: 1174-1184. [Abstract] [Full Text] [PDF]  

James R. Hammond, Stephanie Lee, and Peter J. Ferguson

[³H]Gemcitabine Uptake by Nucleoside Transporters in a Human Head and Neck Squamous Carcinoma Cell Line
J Pharmacol Exp Ther 1999 288: 1185-1191. [Abstract] [Full Text] [PDF]  

Lei Zhang, Wenche Gorset, Mark J. Dresser, and Kathleen M. Giacomini

The Interaction of n-Tetraalkylammonium Compounds with a Human Organic Cation Transporter, hOCT1
J Pharmacol Exp Ther 1999 288: 1192-1198. [Abstract] [Full Text] [PDF]  

C. Fernando Valenzuela and Rita A. Cardoso

Acute Effects of Ethanol on Kainate Receptors with Different Subunit Compositions
J Pharmacol Exp Ther 1999 288: 1199-1206. [Abstract] [Full Text] [PDF]  

Pierre Gressens, Leslie Besse, Patrick Robberecht, Illana Gozes, Mati Fridkin, and Philippe Evrard

Neuroprotection of the Developing Brain by Systemic Administration of Vasoactive Intestinal Peptide Derivatives
J Pharmacol Exp Ther 1999 288: 1207-1213. [Abstract] [Full Text] [PDF]  

Katsuya Onishi, Michiya Ohno, William C. Little, and Che-Ping Cheng

Endogenous Endothelin-1 Depresses Left Ventricular Systolic and Diastolic Performance in Congestive Heart Failure
J Pharmacol Exp Ther 1999 288: 1214-1222. [Abstract] [Full Text] [PDF]  

Amanda D. Smith and Friedbert Weiss

Ethanol Exposure Differentially Alters Central Monoamine Neurotransmission in Alcohol-Preferring versus -Nonpreferring Rats
J Pharmacol Exp Ther 1999 288: 1223-1228. [Abstract] [Full Text] [PDF]  

Tomoo Inoue, Zaichuan Mi, Delbert G. Gillespie, Raghvendra K. Dubey, and Edwin K. Jackson

Angiotensin Receptor Subtype 1 Mediates Angiotensin II Enhancement of Isoproterenol-Induced Cyclic AMP Production in Preglomerular Microvascular Smooth Muscle Cells
J Pharmacol Exp Ther 1999 288: 1229-1234. [Abstract] [Full Text] [PDF]  

Nuria A. Callejas, Antonio Castrillo, Lisardo Boscá, and Paloma Martín-Sanz

Inhibition of Prostaglandin Synthesis Up-Regulates Cyclooxygenase-2 Induced by Lipopolysaccharide and Peroxisomal Proliferators
J Pharmacol Exp Ther 1999 288: 1235-1241. [Abstract] [Full Text] [PDF]  

Kenichi Kato, A. Mark Evans, and Roland Z. Kozlowski

Relaxation of Endothelin-1-Induced Pulmonary Arterial Constriction by Niflumic Acid and NPPB: Mechanism(s) Independent of Chloride Channel Block
J Pharmacol Exp Ther 1999 288: 1242-1250. [Abstract] [Full Text] [PDF]  

John R. Cashman, Yeng N. Xiong, Lifen Xu, and Aaron Janowsky

N-Oxygenation of Amphetamine and Methamphetamine by the Human Flavin-Containing Monooxygenase (Form 3): Role in Bioactivation and Detoxication
J Pharmacol Exp Ther 1999 288: 1251-1260. [Abstract] [Full Text] [PDF]  

Benoit Drolet, Frédérick Vincent, Jimmy Rail, Mohamed Chahine, Dominic Deschênes, Sylvie Nadeau, Majed Khalifa, Bettina A. Hamelin, and Jacques Turgeon

Thioridazine Lengthens Repolarization of Cardiac Ventricular Myocytes by Blocking the Delayed Rectifier Potassium Current
J Pharmacol Exp Ther 1999 288: 1261-1268. [Abstract] [Full Text] [PDF]  

Keith W. Easterling and Stephen G. Holtzman

Discriminative Stimulus Effects of Naltrexone After a Single Dose of Morphine in the Rat
J Pharmacol Exp Ther 1999 288: 1269-1277. [Abstract] [Full Text] [PDF]  

Wilfred Lieberthal, Robert Fuhro, Jane E. Freedman, George Toolan, Joseph Loscalzo, and C. Robert Valeri

O-Raffinose Cross-Linking Markedly Reduces Systemic and Renal Vasoconstrictor Effects of Unmodified Human Hemoglobin
J Pharmacol Exp Ther 1999 288: 1278-1287. [Abstract] [Full Text] [PDF]  

Mary-Frances Jett, Chakk S. Ramesha, Carl D. Brown, Sophie Chiu, Caroline Emmett, Tatyana Voronin, Thomas Sun, Counde O'Yang, John C. Hunter, Richard M. Eglen, and Randolph M. Johnson

Characterization of the Analgesic and Anti-Inflammatory Activities of Ketorolac and Its Enantiomers in the Rat
J Pharmacol Exp Ther 1999 288: 1288-1297. [Abstract] [Full Text] [PDF]  

J. M. Witkin, N. Savtchenko, M. Mashkovsky, M. Beekman, P. Munzar, M. Gasior, S. R. Goldberg, J. T. Ungard, J. Kim, T. Shippenberg, and V. Chefer

Behavioral, Toxic, and Neurochemical Effects of Sydnocarb, a Novel Psychomotor Stimulant: Comparisons with Methamphetamine
J Pharmacol Exp Ther 1999 288: 1298-1310. [Abstract] [Full Text] [PDF]  

Deanne L. Heath and Robert Vink

Optimization of Magnesium Therapy after Severe Diffuse Axonal Brain Injury in Rats
J Pharmacol Exp Ther 1999 288: 1311-1316. [Abstract] [Full Text] [PDF]  

Geri A. Sawada, Craig L. Barsuhn, Barry S. Lutzke, Michael E. Houghton, Guy E. Padbury, Norman F. H. Ho, and Thomas J. Raub

Increased Lipophilicity and Subsequent Cell Partitioning Decrease Passive Transcellular Diffusion of Novel, Highly Lipophilic Antioxidants
J Pharmacol Exp Ther 1999 288: 1317-1326. [Abstract] [Full Text] [PDF]  

Geri A. Sawada, Lawrence R. Williams, Barry S. Lutzke, and Thomas J. Raub

Novel, Highly Lipophilic Antioxidants Readily Diffuse Across the Blood-Brain Barrier and Access Intracellular Sites
J Pharmacol Exp Ther 1999 288: 1327-1333. [Abstract] [Full Text] [PDF]  

Meleik A. Hebert, Gaynor A. Larson, Nancy R. Zahniser, and Greg A. Gerhardt

Age-Related Reductions in [³H]WIN 35,428 Binding to the Dopamine Transporter in Nigrostriatal and Mesolimbic Brain Regions of the Fischer 344 Rat
J Pharmacol Exp Ther 1999 288: 1334-1339. [Abstract] [Full Text] [PDF]  

Anumantha G. Kanthasamy, Richard J. Yun, Bang Nguyen, and Daniel D. Truong

Effect of Riluzole on the Neurological and Neuropathological Changes in an Animal Model of Cardiac Arrest-Induced Movement Disorder
J Pharmacol Exp Ther 1999 288: 1340-1348. [Abstract] [Full Text] [PDF]  

Leena K. Singh, William Boucher, Xinzhu Pang, Richard Letourneau, Dimitri Seretakis, Marlon Green, and Theoharis C. Theoharides

Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin-Releasing Hormone Receptors
J Pharmacol Exp Ther 1999 288: 1349-1356. [Abstract] [Full Text] [PDF]  

Yaakov Waksman, John M. Olson, Steven J. Carlisle, and Guy A. Cabral

The Central Cannabinoid Receptor (CB1) Mediates Inhibition of Nitric Oxide Production by Rat Microglial Cells
J Pharmacol Exp Ther 1999 288: 1357-1366. [Abstract] [Full Text] [PDF]  

Masayuki Takeda, Kenji Obara, Takaki Mizusawa, Yoshihiko Tomita, Kei Arai, Toshiki Tsutsui, Akihiko Hatano, Kota Takahashi, and Shintaro Nomura

Evidence for ₃-Adrenoceptor Subtypes in Relaxation of the Human Urinary Bladder Detrusor: Analysis by Molecular Biological and Pharmacological Methods
J Pharmacol Exp Ther 1999 288: 1367-1373. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.