ARTICLES:

Andrea Vaccari, Pierluigi Saba, Ignazia Mocci, and Stefania Ruiu

Dithiocarbamate Pesticides Affect Glutamate Transport in Brain Synaptic Vesicles
J Pharmacol Exp Ther 1999 288: 1-5. [Abstract] [Full Text] [PDF]  

Nobuo Katsube, Katsuyoshi Sunaga, Hideki Aishita, De-Maw Chuang, and Ryoichi Ishitani

ONO-1603, a Potential Antidementia Drug, Delays Age-Induced Apoptosis and Suppresses Overexpression of Glyceraldehyde-3-Phosphate Dehydrogenase in Cultured Central Nervous System Neurons
J Pharmacol Exp Ther 1999 288: 6-13. [Abstract] [Full Text] [PDF]  

Nora D. Volkow, Gene-Jack Wang, Joanna S. Fowler, S. John Gatley, Jean Logan, Yu-Shin Ding, Stephen L. Dewey, Robert Hitzemann, Andrew N. Gifford, and Naomi R. Pappas

Blockade of Striatal Dopamine Transporters by Intravenous Methylphenidate Is Not Sufficient to Induce Self-Reports of "High"
J Pharmacol Exp Ther 1999 288: 14-20. [Abstract] [Full Text] [PDF]  

Sean Ekins, Gianpaolo Bravi, Barbara J. Ring, Todd A. Gillespie, Jennifer S. Gillespie, Mark Vandenbranden, Steven A. Wrighton, and James H. Wikel

Three-Dimensional Quantitative Structure Activity Relationship Analyses of Substrates for CYP2B6
J Pharmacol Exp Ther 1999 288: 21-29. [Abstract] [Full Text] [PDF]  

Gilles Martin, Riszard Przewlocki, and George R. Siggins

Chronic Morphine Treatment Selectively Augments Metabotropic Glutamate Receptor-Induced Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Neurotransmission in Nucleus Accumbens
J Pharmacol Exp Ther 1999 288: 30-35. [Abstract] [Full Text] [PDF]  

Oliver Vögler, Patrick Krummenerl, Martina Schmidt, Karl H. Jakobs, and Chris J. Van Koppen

RhoA-Sensitive Trafficking of Muscarinic Acetylcholine Receptors
J Pharmacol Exp Ther 1999 288: 36-42. [Abstract] [Full Text] [PDF]  

Hiroichi Nagai, Yoshifumi Ueda, Hiroyuki Tanaka, Yousuke Hirano, Nobuaki Nakamura, Naoki Inagaki, Kiyoshi Takatsu, and Kenji Kawada

Effect of Overproduction of Interleukin 5 on Dinitrofluorobenzene-Induced Allergic Cutaneous Response in Mice
J Pharmacol Exp Ther 1999 288: 43-50. [Abstract] [Full Text] [PDF]  

C. Ju and J. P. Uetrecht

Detection of 2-Hydroxyiminostilbene in the Urine of Patients Taking Carbamazepine and Its Oxidation to a Reactive Iminoquinone Intermediate
J Pharmacol Exp Ther 1999 288: 51-56. [Abstract] [Full Text] [PDF]  

Kokichi Suzuki, Hiroshi Susaki, Satoshi Okuno, and Yuichi Sugiyama

Renal Drug Targeting Using a Vector "Alkylglycoside"
J Pharmacol Exp Ther 1999 288: 57-64. [Abstract] [Full Text] [PDF]  

Roque Bort, Xavier Ponsoda, Ramiro Jover, M. José Gómez-Lechón, and José V. Castell

Diclofenac Toxicity to Hepatocytes: A Role for Drug Metabolism in Cell Toxicity
J Pharmacol Exp Ther 1999 288: 65-72. [Abstract] [Full Text] [PDF]  

Kyong-Tai Kim, Se-Young Choi, and Tae-Ju Park

Neomycin Inhibits Catecholamine Secretion by Blocking Nicotinic Acetylcholine Receptors in Bovine Adrenal Chromaffin Cells
J Pharmacol Exp Ther 1999 288: 73-80. [Abstract] [Full Text] [PDF]  

Eitan Gur, Bernard Lerer, and Michael E. Newman

Chronic Clomipramine and Triiodothyronine Increase Serotonin Levels in Rat Frontal Cortex In Vivo: Relationship to Serotonin Autoreceptor Activity
J Pharmacol Exp Ther 1999 288: 81-87. [Abstract] [Full Text] [PDF]  

John D. Fryer and Ronald J. Lukas

Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine
J Pharmacol Exp Ther 1999 288: 88-92. [Abstract] [Full Text] [PDF]  

J.-G. Jin, A. E. Foxx-Orenstein, and J. R. Grider

Propulsion in Guinea Pig Colon Induced by 5-Hydroxytryptamine (HT) via 5-HT₄ and 5-HT₃ Receptors
J Pharmacol Exp Ther 1999 288: 93-97. [Abstract] [Full Text] [PDF]  

D. K. Raap, S. Evans, F. Garcia, Q. Li, N. A. Muma, W. A. Wolf, G. Battaglia, and L. D. Van De Kar

Daily Injections of Fluoxetine Induce Dose-Dependent Desensitization of Hypothalamic 5-HT_1A Receptors: Reductions in Neuroendocrine Responses to 8-OH-DPAT and in Levels of G_z and G_i Proteins
J Pharmacol Exp Ther 1999 288: 98-106. [Abstract] [Full Text] [PDF]  

Zenaide M. N. Quezado, William D. Hoffman, Steven M. Banks, Robert L. Danner, Peter Q. Eichacker, Gregory M. Susla, and Charles Natanson

Increasing Doses of Pentoxifylline as a Continuous Infusion in Canine Septic Shock
J Pharmacol Exp Ther 1999 288: 107-113. [Abstract] [Full Text] [PDF]  

N. S. Postma, D. J. A. Crommelin, W. M. C. Eling, and J. Zuidema

Treatment with Liposome-Bound Recombinant Human Tumor Necrosis Factor- Suppresses Parasitemia and Protects against Plasmodium berghei k173-Induced Experimental Cerebral Malaria in Mice
J Pharmacol Exp Ther 1999 288: 114-120. [Abstract] [Full Text] [PDF]  

Gene C. Palmer, Robert J. Murray, Carrie L. Cramer, Mary L. Stagnitto, Marilyn K. Knowles, Lou R. Freedman, Mark S. Eismann, Nik Mahmood, Mike Balestra, Alfonso R. Borrelli, Thomas J. Hudzik, and Dennis J. McCarthy

[S]-AR-R 15896ARA Novel Anticonvulsant: Acute Safety, Pharmacokinetic and Pharmacodynamic Properties
J Pharmacol Exp Ther 1999 288: 121-132. [Abstract] [Full Text] [PDF]  

Chi Dae Kim, Hyun Hee Kim, and Ki Whan Hong

Inhibitory Effect of Rebamipide on the Neutrophil Adherence Stimulated by Conditioned Media from Helicobacter pylori-Infected Gastric Epithelial Cells
J Pharmacol Exp Ther 1999 288: 133-138. [Abstract] [Full Text] [PDF]  

Paul Ernsberger, Tatsuya Ishizuka, Sha Liu, Craig J. Farrell, David Bedol, Richard J. Koletsky, and Jacob E. Friedman

Mechanisms of Antihyperglycemic Effects of Moxonidine in the Obese Spontaneously Hypertensive Koletsky Rat (SHROB)
J Pharmacol Exp Ther 1999 288: 139-147. [Abstract] [Full Text] [PDF]  

A. M. Low, H. Lu-Chao, J. C. P. Loke, C. Y. Kwan, and E. E. Daniel

Insights Into the Unusual Alpha Adrenoceptor Subtype in Dog Saphenous Vein Using Phenoxybenzamine
J Pharmacol Exp Ther 1999 288: 148-156. [Abstract] [Full Text] [PDF]  

Christopher M. Waters, Michael J. Avram, Tom C. Krejcie, and Thomas K. Henthorn

Uptake of Fentanyl in Pulmonary Endothelium
J Pharmacol Exp Ther 1999 288: 157-163. [Abstract] [Full Text] [PDF]  

Maria C. Olianas, Angela Ingianni, Carlo Maullu, Abdu Adem, Evert Karlsson, and Pierluigi Onali

Selectivity Profile of Muscarinic Toxin 3 in Functional Assays of Cloned and Native Receptors
J Pharmacol Exp Ther 1999 288: 164-170. [Abstract] [Full Text] [PDF]  

A. Collett, N. B. Higgs, E. Sims, M. Rowland, and and G. Warhurst

Modulation of the Permeability of H₂ Receptor Antagonists Cimetidine and Ranitidine by P-Glycoprotein in Rat Intestine and the Human Colonic Cell Line Caco-2
J Pharmacol Exp Ther 1999 288: 171-178. [Abstract] [Full Text] [PDF]  

María J. Garrido, Marta Valle, Rosario Calvo, and Iñaki F. Trocóniz

Altered Plasma and Brain Disposition and Pharmacodynamics of Methadone in Abstinent Rats
J Pharmacol Exp Ther 1999 288: 179-187. [Abstract] [Full Text] [PDF]  

Hendrée E. Jones, Bridgette E. Garrett, and Roland R. Griffiths

Subjective and Physiological Effects of Intravenous Nicotine and Cocaine in Cigarette Smoking Cocaine Abusers
J Pharmacol Exp Ther 1999 288: 188-197. [Abstract] [Full Text] [PDF]  

Masashi Homma, Hiroshi Suzuki, Hiroyuki Kusuhara, Mikihiko Naito, Takashi Tsuruo, and Yuichi Sugiyama

High-Affinity Efflux Transport System for Glutathione Conjugates on the Luminal Membrane of a Mouse Brain Capillary Endothelial Cell Line (MBEC4)
J Pharmacol Exp Ther 1999 288: 198-203. [Abstract] [Full Text] [PDF]  

G. A. R. Mealing, T. H. Lanthorn, C. L. Murray, D. L. Small, and P. Morley

Differences in Degree of Trapping of Low-Affinity Uncompetitive N-Methyl-D-aspartic Acid Receptor Antagonists with Similar Kinetics of Block
J Pharmacol Exp Ther 1999 288: 204-210. [Abstract] [Full Text] [PDF]  

Yun Wang, Ronald K. Freund, and Michael R. Palmer

Potentiation of Ethanol Effects in Cerebellum by Activation of Endogenous Noradrenergic Inputs
J Pharmacol Exp Ther 1999 288: 211-220. [Abstract] [Full Text] [PDF]  

William A. Hewlett, Bakula L. Trivedi, Zhang-Jin Zhang, Tomas de Paulis, Dennis E. Schmidt, David M. Lovinger, M. Sib Ansari, and Michael H. Ebert

Characterization of (S)-Des-4-amino-3-[¹²⁵I]iodozacopride ([¹²⁵I]DAIZAC), a Selective High-Affinity Radioligand for 5-Hydroxytryptamine₃ Receptors
J Pharmacol Exp Ther 1999 288: 221-231. [Abstract] [Full Text] [PDF]  

Lisa Y. Yung, Sushma A. Joshi, Robbie Y.K. Chan, Joy S.C. Chan, Gang Pei, and Yung H. Wong

G_L1 (G₁₄) Couples the Opioid Receptor-Like₁ Receptor to Stimulation of Phospholipase C
J Pharmacol Exp Ther 1999 288: 232-238. [Abstract] [Full Text] [PDF]  

Sushanta Chakder and Satish Rattan

Mechanisms and Sites of Action of Endothelins 1 and 2 on the Opossum Internal Anal Sphincter Smooth Muscle Tone In Vitro
J Pharmacol Exp Ther 1999 288: 239-246. [Abstract] [Full Text] [PDF]  

Nissar A. Darmani and Bashir Ahmad

Long-Term Sequential Determination of Behavioral Ontogeny of 5-HT_1A and 5-HT₂ Receptor Functions in the Rat
J Pharmacol Exp Ther 1999 288: 247-253. [Abstract] [Full Text] [PDF]  

Blair U. Bradford, Nobuyuki Enomoto, Kenichi Ikejima, Michelle L. Rose, Heidi K. Bojes, Donald T. Forman, and Ronald G. Thurman

Peroxisomes Are Involved in the Swift Increase in Alcohol Metabolism
J Pharmacol Exp Ther 1999 288: 254-259. [Abstract] [Full Text] [PDF]  

M. J. Kreek, J. Schluger, L. Borg, M. Gunduz, and A. Ho

Dynorphin A_1-13 Causes Elevation of Serum Levels of Prolactin Through an Opioid Receptor Mechanism in Humans: Gender Differences and Implications for Modulation of Dopaminergic Tone in the Treatment of Addictions
J Pharmacol Exp Ther 1999 288: 260-269. [Abstract] [Full Text] [PDF]  

Qiong Wang, Michael Cwik, Catherine J. Wright, Francesca Cunningham, and Dale A. Pelligrino

The In Vivo Unidirectional Conversion of Nitro-D-arginine to Nitro-L-arginine
J Pharmacol Exp Ther 1999 288: 270-273. [Abstract] [Full Text] [PDF]  

Scott E. Hemby, Conchita Co, Steven I. Dworkin, and James E. Smith

Synergistic Elevations in Nucleus Accumbens Extracellular Dopamine Concentrations during Self-Administration of Cocaine/Heroin Combinations (Speedball) in Rats
J Pharmacol Exp Ther 1999 288: 274-280. [Abstract] [Full Text] [PDF]  

R. J. Kok, F. Grijpstra, R. B. Walthuis, F. Moolenaar, D. de Zeeuw, and D. K. F. Meijer

Specific Delivery of Captopril to the Kidney with the Prodrug Captopril-Lysozyme
J Pharmacol Exp Ther 1999 288: 281-285. [Abstract] [Full Text] [PDF]  

William T. Jackson, Larry L. Froelich, Robert J. Boyd, James P. Schrementi, David L. Saussy Jr., Richard M. Schultz, J. Scott Sawyer, Michael J. Sofia, David K. Herron, Theodore Goodson Jr., David W. Snyder, Penni A. Pechous, Stephen M. Spaethe, Carlos R. Roman, and Jerome H. Fleisch

Pharmacologic Actions of the Second-Generation Leukotriene B₄ Receptor Antagonist LY293111: In Vitro Studies
J Pharmacol Exp Ther 1999 288: 286-294. [Abstract] [Full Text] [PDF]  

Zaichuan Mi and Edwin K. Jackson

Effects of - and -Adrenoceptor Blockade on Purine Secretion Induced by Sympathetic Nerve Stimulation in the Rat Kidney
J Pharmacol Exp Ther 1999 288: 295-301. [Abstract] [Full Text] [PDF]  

Jonathan L. Katz, Sari Izenwasser, Richard H. Kline, Andrew C. Allen, and Amy Hauck Newman

Novel 3-Diphenylmethoxytropane Analogs: Selective Dopamine Uptake Inhibitors with Behavioral Effects Distinct from Those of Cocaine
J Pharmacol Exp Ther 1999 288: 302-315. [Abstract] [Full Text] [PDF]  

Peggy Bowman, Heimo Haikala, and Richard J. Paul

Levosimendan, a Calcium Sensitizer in Cardiac Muscle, Induces Relaxation in Coronary Smooth Muscle Through Calcium Desensitization
J Pharmacol Exp Ther 1999 288: 316-325. [Abstract] [Full Text] [PDF]  

Pat Wheelan, Joseph A. Hankin, Bahri Bilir, Denis Guenette, and Robert C. Murphy

Metabolic Transformations of Leukotriene B₄ in Primary Cultures of Human Hepatocytes
J Pharmacol Exp Ther 1999 288: 326-334. [Abstract] [Full Text] [PDF]  

P. J. Winsauer, F. H. Rodriguez, A. E. Cha, and J. M. Moerschbaecher

Full and Partial 5-HT_1A Receptor Agonists Disrupt Learning and Performance in Rats
J Pharmacol Exp Ther 1999 288: 335-347. [Abstract] [Full Text] [PDF]  

Stephan Döppenschmitt, Peter Langguth, Carl Gunnar Regårdh, Tommy B. Andersson, Constanze Hilgendorf, and Hildegard Spahn-Langguth

Characterization of Binding Properties to Human P-Glycoprotein: Development of a [³H]Verapamil Radioligand-Binding Assay
J Pharmacol Exp Ther 1999 288: 348-357. [Abstract] [Full Text] [PDF]  

Atsufumi Kawabata, Mahmoud Saifeddine, Bahjat Al-Ani, Lorraine Leblond, and Morley D. Hollenberg

Evaluation of Proteinase-Activated Receptor-1 (PAR₁) Agonists and Antagonists Using a Cultured Cell Receptor Desensitization Assay: Activation of PAR₂ by PAR₁-Targeted Ligands
J Pharmacol Exp Ther 1999 288: 358-370. [Abstract] [Full Text] [PDF]  

Yvonne S. Lin, Cindy Nguyen, Jose-Luis Mendoza, Enrique Escandon, David Fei, Y. Gloria Meng, and Nishit B. Modi

Preclinical Pharmacokinetics, Interspecies Scaling, and Tissue Distribution of a Humanized Monoclonal Antibody against Vascular Endothelial Growth Factor
J Pharmacol Exp Ther 1999 288: 371-378. [Abstract] [Full Text] [PDF]  

Liesl C. Strachan, Richard J. Lewis, and Graham M. Nicholson

Differential Actions of Pacific Ciguatoxin-1 on Sodium Channel Subtypes in Mammalian Sensory Neurons
J Pharmacol Exp Ther 1999 288: 379-388. [Abstract] [Full Text] [PDF]  

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