ARTICLES:

Reiji Yoshimura, Nobuyuki Yanagihara, Takeshi Terao, Yasuhito Uezono, Yumiko Toyohira, Susumu Ueno, Kazuhiko Abe, and Futoshi Izumi

Carbamazepine-Induced Up-regulation of Voltage-dependent Na⁺ Channels in Bovine Adrenal Medullary Cells in Culture
J Pharmacol Exp Ther 1998 287: 441-447. [Abstract] [Full Text] [PDF]  

Lawrence W. Fitzgerald, John P. Patterson, Deborah S. Conklin, Robert Horlick, and Brian L. Largent

Pharmacological and Biochemical Characterization of a Recombinant Human Galanin GALR1 Receptor: Agonist Character of Chimeric Galanin Peptides
J Pharmacol Exp Ther 1998 287: 448-456. [Abstract] [Full Text] [PDF]  

Ryosei Kawai, Diane Mathew, Chiaki Tanaka, and Malcolm Rowland

Physiologically Based Pharmacokinetics of Cyclosporine A: Extension to Tissue Distribution Kinetics in Rats and Scale-up to Human
J Pharmacol Exp Ther 1998 287: 457-468. [Abstract] [Full Text] [PDF]  

René Anand, Mark E. Nelson, Volodymyr Gerzanich, Gregg B. Wells, and Jon Lindstrom

Determinants of Channel Gating Located in the N-Terminal Extracellular Domain of Nicotinic 7 Receptor
J Pharmacol Exp Ther 1998 287: 469-479. [Abstract] [Full Text] [PDF]  

Shiling Hu, Shuya Wang, Joyce Gibson, and Timothy A. Gilbertson

Inhibition of Delayed Rectifier K⁺ Channels by Dexfenfluramine (Redux)
J Pharmacol Exp Ther 1998 287: 480-486. [Abstract] [Full Text] [PDF]  

Alexander F. Hoffman, Carl R. Lupica, and Greg A. Gerhardt

Dopamine Transporter Activity in the Substantia Nigra and Striatum Assessed by High-Speed Chronoamperometric Recordings in Brain Slices
J Pharmacol Exp Ther 1998 287: 487-496. [Abstract] [Full Text] [PDF]  

D. Fulton, J. C. Mcgiff, and J. Quilley

Pharmacological Evaluation of an Epoxide as the Putative Hyperpolarizing Factor Mediating the Nitric Oxide-Independent Vasodilator Effect of Bradykinin in the Rat Heart
J Pharmacol Exp Ther 1998 287: 497-503. [Abstract] [Full Text] [PDF]  

Hidenori Takada, Masaki Otagiri, and Yorishige Imamura

20-Hydroxysteroid Dehydrogenase Catalyzes Ketone-Reduction of Acetohexamide, an Oral Antidiabetic Drug, in Liver Microsomes of Adult Male Rats
J Pharmacol Exp Ther 1998 287: 504-507. [Abstract] [Full Text] [PDF]  

Nika Adham, John M. Zgombick, Jonathan Bard, and Theresa A. Branchek

Functional Characterization of the Recombinant Human 5-Hydroxytryptamine_7(a) Receptor Isoform Coupled to Adenylate Cyclase Stimulation
J Pharmacol Exp Ther 1998 287: 508-514. [Abstract] [Full Text] [PDF]  

Hui-Yun Wu and Y. James Kang

Inhibition of Buthionine Sulfoximine-Enhanced Doxorubicin Toxicity in Metallothionein Overexpressing Transgenic Mouse Heart
J Pharmacol Exp Ther 1998 287: 515-520. [Abstract] [Full Text] [PDF]  

Vera Ralevic, Gillian Knight, and Geoffrey Burnstock

Effects of Hibernation and Arousal from Hibernation on Mesenteric Arterial Responses of the Golden Hamster
J Pharmacol Exp Ther 1998 287: 521-526. [Abstract] [Full Text] [PDF]  

Gao-Lin Liu, Theodore A. Christopher, Bernard L. Lopez, Feng Gao, Yaping Guo, Erhe Gao, Karlheinz Knuettel, Martin Feelisch, and Xin L. Ma

SP/W-5186, A Cysteine-Containing Nitric Oxide Donor, Attenuates Postischemic Myocardial Injury
J Pharmacol Exp Ther 1998 287: 527-537. [Abstract] [Full Text] [PDF]  

Liza Leventhal, Robert M. Silva, Grace C. Rossi, Gavril W. Pasternak, and Richard J. Bodnar

Morphine-6-Glucuronide-Induced Hyperphagia: Characterization of Opioid Action By Selective Antagonists and Antisense Mapping in Rats
J Pharmacol Exp Ther 1998 287: 538-544. [Abstract] [Full Text] [PDF]  

Cuiping Chen and Gary M. Pollack

Altered Disposition and Antinociception of [D-Penicillamine^2,5] Enkephalin in mdr1a-Gene-Deficient Mice
J Pharmacol Exp Ther 1998 287: 545-552. [Abstract] [Full Text] [PDF]  

Tushar G. Kokate, Shun-Ichi Yamaguchi, Lewis K. Pannell, Umamaheswari Rajamani, David M. Carroll, Andrew B. Grossman, and Michael A. Rogawski

Lack of Anticonvulsant Tolerance to the Neuroactive Steroid Pregnanolone in Mice
J Pharmacol Exp Ther 1998 287: 553-558. [Abstract] [Full Text] [PDF]  

Masayasu Takahashi, Jian Wei Ni, Sachiko Kawasaki-Yatsugi, Takashi Toya, Chikako Ichiki, Shin-Ichi Yatsugi, Kazuo Koshiya, Masao Shimizu-Sasamata, and Tokio Yamaguchi

Neuroprotective Efficacy of YM872, an -Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptor Antagonist, after Permanent Middle Cerebral Artery Occlusion in Rats
J Pharmacol Exp Ther 1998 287: 559-566. [Abstract] [Full Text] [PDF]  

Duncan J. Campbell, Frank Anastasopoulos, Ann-Maree Duncan, Gail M. James, Athena Kladis, and Todd A. Briscoe

Effects of Neutral Endopeptidase Inhibition and Combined Angiotensin Converting Enzyme and Neutral Endopeptidase Inhibition on Angiotensin and Bradykinin Peptides in Rats
J Pharmacol Exp Ther 1998 287: 567-577. [Abstract] [Full Text] [PDF]  

Louise Cullen, Linda Kelly, Shane O. Connor, and Desmond J. Fitzgerald

Selective Cyclooxygenase-2 Inhibition by Nimesulide in Man
J Pharmacol Exp Ther 1998 287: 578-582. [Abstract] [Full Text] [PDF]  

Larry C. Wienkers, Rick C. Steenwyk, Michael J. Hauer, Joseph C. Fleishaker, and Paul G. Pearson

Biotransformation of Tirilazad in Human: 3. Tirilazad A-Ring Reduction by Human Liver Microsomal 5-Reductase Type 1 and Type 2
J Pharmacol Exp Ther 1998 287: 583-590. [Abstract] [Full Text] [PDF]  

Joseph C. Fleishaker, Paul G. Pearson, Larry C. Wienkers, Laura K. Pearson, Theresa A. Moore, and Gary R. Peters

Biotransformation of Tirilazad in Human: 4. Effect of Finasteride on Tirilazad Clearance and Reduced Metabolite Formation
J Pharmacol Exp Ther 1998 287: 591-597. [Abstract] [Full Text] [PDF]  

Mario D. Aceto, Susan M. Scates, Raj K. Razdan, and Billy R. Martin

Anandamide, an Endogenous Cannabinoid, Has a Very Low Physical Dependence Potential
J Pharmacol Exp Ther 1998 287: 598-605. [Abstract] [Full Text] [PDF]  

Elaine H. Shen, Janet Dorow, Richard Harland, Sue Burkhart-Kasch, and Tamara J. Phillips

Seizure Sensitivity and GABAergic Modulation of Ethanol Sensitivity in Selectively Bred FAST and SLOW Mouse Lines
J Pharmacol Exp Ther 1998 287: 606-615. [Abstract] [Full Text] [PDF]  

Joel W. Proksch, W. Brooks Gentry, and S. Michael Owens

Pharmacokinetic Mechanisms for Obtaining High Renal Coelimination of Phencyclidine and a Monoclonal Antiphencyclidine Antigen-Binding Fragment of Immunoglobulin G in the Rat
J Pharmacol Exp Ther 1998 287: 616-624. [Abstract] [Full Text] [PDF]  

Ann E. Remmers, Mary J. Clark, Xiang Yang Liu, and Fedor Medzihradsky

Delta Opioid Receptor Down-Regulation Is Independent of Functional G Protein yet Is Dependent on Agonist Efficacy
J Pharmacol Exp Ther 1998 287: 625-632. [Abstract] [Full Text] [PDF]  

Yasuhito Arakida, Kiyomi Suwa, Keiko Ohga, Masaki Yokota, Keiji Miyata, Toshimitsu Yamada, and Kazuo Honda

In Vitro Pharmacologic Profile of YM158, a New Dual Antagonist for LTD₄ and TXA₂ receptors
J Pharmacol Exp Ther 1998 287: 633-639. [Abstract] [Full Text] [PDF]  

Steven W. Kerr, Rebecca Yu, Carol D. Stearns, Nancy A. Haynes, and Raymond J. Winquist

Characterization of the Polymorphonuclear Leukocyte-Induced Vasoconstriction in Isolated Human Umbilical Veins
J Pharmacol Exp Ther 1998 287: 640-647. [Abstract] [Full Text] [PDF]  

Ying Lu, Sharon Grady, Michael J. Marks, Marina Picciotto, Jean-Pierre Changeux, and Allan C. Collins

Pharmacological Characterization of Nicotinic Receptor-stimulated GABA Release From Mouse Brain Synaptosomes
J Pharmacol Exp Ther 1998 287: 648-657. [Abstract] [Full Text] [PDF]  

X. Ligneau, J.-S. Lin, G. Vanni-Mercier, M. Jouvet, J. L. Muir, C. R. Ganellin, H. Stark, S. Elz, W. Schunack, and J.-C. Schwartz

Neurochemical and Behavioral Effects of Ciproxifan, A Potent Histamine H₃-Receptor Antagonist
J Pharmacol Exp Ther 1998 287: 658-666. [Abstract] [Full Text] [PDF]  

Jyrki P. Kukkonen, Annika Renvaktar, Ramin Shariatmadari, and Karl E. O. Åkerman

Ligand- and Subtype-Selective Coupling of Human Alpha-2 Adrenoceptors to Ca⁺⁺ elevation in Chinese Hamster Ovary Cells
J Pharmacol Exp Ther 1998 287: 667-671. [Abstract] [Full Text] [PDF]  

Yumiko Matsuo, Ikuko Yano, Tatsuya Ito, Yukiya Hashimoto, and Ken-Ichi Inui

Transport of Quinolone Antibacterial Drugs in a Kidney Epithelial Cell Line, LLC-PK₁
J Pharmacol Exp Ther 1998 287: 672-678. [Abstract] [Full Text] [PDF]  

Shin Yoshino, Motoyasu Ohsawa, and Masaru Sagai

Diesel Exhaust Particles Block Induction of Oral Tolerance in Mice
J Pharmacol Exp Ther 1998 287: 679-683. [Abstract] [Full Text] [PDF]  

Wiyada Akarawut, Chun-Jung Lin, and David E. Smith

Noncompetitive Inhibition of Glycylsarcosine Transport by Quinapril in Rabbit Renal Brush Border Membrane Vesicles: Effect on High-Affinity Peptide Transporter
J Pharmacol Exp Ther 1998 287: 684-690. [Abstract] [Full Text] [PDF]  

Osamu Yamamoto, Hiromichi Niida, Koyuki Tajima, Yoshiaki Shirouchi, Yousuke Kyotani, Fusao Ueda, Masahiro Kise, and Kiyoshi Kimura

Effect of YNS-15P, a New Alpha-2 Adrenoceptor Antagonist, on Stress-Stimulated Colonic Propulsion in Rats
J Pharmacol Exp Ther 1998 287: 691-696. [Abstract] [Full Text] [PDF]  

Cory D. Griffiths, Dominic P. Geraghty, Tristram P.D. Eldershaw, and Eric Q. Colquhoun

Acute and Chronic Effects of Capsaicin in Perfused Rat Muscle: The Role of Tachykinins and Calcitonin Gene-Related Peptide
J Pharmacol Exp Ther 1998 287: 697-704. [Abstract] [Full Text] [PDF]  

Don E. Griswold, Edward F. Webb, Alison M. Badger, Peter D. Gorycki, Patricia A. Levandoski, Mary A. Barnette, Marilyn Grous, Siegfried Christensen, and Theodore J. Torphy

SB 207499 (Ariflo), a Second Generation Phosphodiesterase 4 Inhibitor, Reduces Tumor Necrosis Factor  and Interleukin-4 Production in vivo
J Pharmacol Exp Ther 1998 287: 705-711. [Abstract] [Full Text] [PDF]  

Toshiyuki Tanaka, Akiyoshi Mizumoto, Erito Mochiki, Hideki Suzuki, Zen Itoh, and Satoshi Omura

Effects of EM574 and Cisapride on Gastric Contractile and Emptying Activity in Normal and Drug-Induced Gastroparesis in Dogs
J Pharmacol Exp Ther 1998 287: 712-719. [Abstract] [Full Text] [PDF]  

Daniel S. Fletcher, Mari Rios Candelore, Danica Grujic, Bradford B. Lowell, Silvi Luell, Vedrana S. Susulic, and D. Euan Macintyre

Beta-3 Adrenergic Receptor Agonists Cause an Increase in Gastrointestinal Transit Time in Wild-type Mice, But Not in Mice Lacking the Beta-3 Adrenergic Receptor
J Pharmacol Exp Ther 1998 287: 720-724. [Abstract] [Full Text] [PDF]  

Akiko Matsui, Hirotami Matsuo, Hitomi Takanaga, Shigeki Sasaki, Minoru Maeda, and Yasufumi Sawada

Prediction of Catalepsies Induced by Amiodarone, Aprindine and Procaine: Similarity in Conformation of Diethylaminoethyl Side Chain
J Pharmacol Exp Ther 1998 287: 725-732. [Abstract] [Full Text] [PDF]  

Subramaniam Apparsundaram, Aurelio Galli, Louis J. DeFelice, H. Criss Hartzell, and Randy D. Blakely

Acute Regulation of Norepinephrine Transport: I. Protein Kinase C-Linked Muscarinic Receptors Influence Transport Capacity and Transporter Density in SK-N-SH Cells
J Pharmacol Exp Ther 1998 287: 733-743. [Abstract] [Full Text] [PDF]  

Subramaniam Apparsundaram, Sally Schroeter, Elena Giovanetti, and Randy D. Blakely

Acute Regulation of Norepinephrine Transport: II. PKC-Modulated Surface Expression of Human Norepinephrine Transporter Proteins
J Pharmacol Exp Ther 1998 287: 744-751. [Abstract] [Full Text] [PDF]  

Tai-Jun Zhao, Ming Li, Ted H. Chiu, and Howard C. Rosenberg

Decreased Benzodiazepine Binding with Little Effect on -Aminobutyric Acid Binding in Rat Brain After Treatment with Antisense Oligodeoxynucleotide to the -Aminobutyric Acid_A Receptor Gamma-2 Subunit
J Pharmacol Exp Ther 1998 287: 752-759. [Abstract] [Full Text] [PDF]  

Catherine E. Adams and Karen E. Stevens

Inhibition of Nitric Oxide Synthase Disrupts Inhibitory Gating of Auditory Responses in Rat Hippocampus
J Pharmacol Exp Ther 1998 287: 760-765. [Abstract] [Full Text] [PDF]  

Pradeep K. Banerjee, Richard W. Olsen, Niranjala J. K. Tillakaratne, Simon Brailowsky, Allan J. Tobin, and O. Carter Snead III

Absence Seizures Decrease Steroid Modulation of t-[³⁵S]Butylbicyclophosphorothionate Binding in Thalamic Relay Nuclei
J Pharmacol Exp Ther 1998 287: 766-772. [Abstract] [Full Text] [PDF]  

Takiko Oguro, Moyuru Hayashi, Shigeo Nakajo, Satoshi Numazawa, and Takemi Yoshida

The Expression of Heme Oxygenase-1 Gene Responded to Oxidative Stress Produced by Phorone, a Glutathione Depletor, in the Rat Liver; The Relevance to Activation of c-Jun N-Terminal Kinase
J Pharmacol Exp Ther 1998 287: 773-778. [Abstract] [Full Text] [PDF]  

Nan Chiang, Tomoko Takano, Clary B. Clish, Nicos A. Petasis, Hsin-Hsiung Tai, and Charles N. Serhan

Aspirin-Triggered 15-epi-Lipoxin A₄ (ATL) Generation by Human Leukocytes and Murine Peritonitis Exudates: Development of a Specific 15-epi-LXA₄ ELISA
J Pharmacol Exp Ther 1998 287: 779-790. [Abstract] [Full Text] [PDF]  

Haruhiro Okuda, Kenichiro Ogura, Atsushi Kato, Hiroaki Takubo, and Tadashi Watabe

A Possible Mechanism of Eighteen Patient Deaths Caused by Interactions of Sorivudine, a New Antiviral Drug, with Oral 5-Fluorouracil Prodrugs
J Pharmacol Exp Ther 1998 287: 791-799. [Abstract] [Full Text] [PDF]  

Yumiko Urakami, Masahiro Okuda, Satohiro Masuda, Hideyuki Saito, and Ken-Ichi Inui

Functional Characteristics and Membrane Localization of Rat Multispecific Organic Cation Transporters, OCT1 and OCT2, Mediating Tubular Secretion of Cationic Drugs
J Pharmacol Exp Ther 1998 287: 800-805. [Abstract] [Full Text] [PDF]  

Andreas Vogt, Robert L. Rice, Catherine E. Settineri, Fumiaki Yokokawa, Shiho Yokokawa, Peter Wipf, and John S. Lazo

Disruption of Insulin-Like Growth Factor-1 Signaling and Down-Regulation of Cdc2 by SC-9, a Novel Small Molecule Antisignaling Agent Identified in a Targeted Array Library
J Pharmacol Exp Ther 1998 287: 806-813. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction for vol. 285, p. 1246
J Pharmacol Exp Ther 1998 287: 814. [Full Text] [PDF]  

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