ARTICLES:

Masahiko Sato, Charles H. Turner, Tongyu Wang, M. Dee Adrian, Ellen Rowley, and Henry U. Bryant

LY353381.HCl: A Novel Raloxifene Analog with Improved SERM Potency and Efficacy In Vivo
J Pharmacol Exp Ther 1998 287: 1-7. [Abstract] [Full Text] [PDF]  

Diego Gonzalez-Ramirez, Miguel Zuniga-Charles, Antonio Narro-Juarez, Yolanda Molina-Recio, Katherine M. Hurlbut, Richard C. Dart, and H. Vasken Aposhian

DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride
J Pharmacol Exp Ther 1998 287: 8-12. [Abstract] [Full Text] [PDF]  

Christoph Sauvant, Stefan Silbernagl, and Michael Gekle

Exposure to Ochratoxin A Impairs Organic Anion Transport in Proximal-Tubule-Derived Opossum Kidney Cells
J Pharmacol Exp Ther 1998 287: 13-20. [Abstract] [Full Text] [PDF]  

E. A. van Schaick, K. P. Zuideveld, H. E. Tukker, M. W. E. Langemeijer, A. P. Ijzerman, and M. Danhof

Metabolic and Cardiovascular Effects of the Adenosine A₁ Receptor Agonist N⁶-(p-Sulfophenyl)Adenosine in Diabetic Zucker Rats: Influence of the Disease on the Selectivity of Action
J Pharmacol Exp Ther 1998 287: 21-30. [Abstract] [Full Text] [PDF]  

Guohua Ding, Kohji Naora, Sadao Nagasako, Hidenari Hirano, and Kikuo Iwamoto

Excretion of Ofloxacin into Saliva in Rats with Renal Failure
J Pharmacol Exp Ther 1998 287: 31-36. [Abstract] [Full Text] [PDF]  

Hitoshi Ishizuka, Kumiko Konno, Hideo Naganuma, Kenji Nishimura, Hirokazu Kouzuki, Hiroshi Suzuki, Bruno Stieger, Peter J. Meier, and Yuichi Sugiyama

Transport of Temocaprilat into Rat Hepatocytes: Role of Organic Anion Transporting Polypeptide
J Pharmacol Exp Ther 1998 287: 37-42. [Abstract] [Full Text] [PDF]  

R. L. McLeod, R. Aslanian, M. del Prado, R. Duffy, R. W. Egan, W. Kreutner, R. McQuade, and J. A. Hey

Sch 50971, an Orally Active Histamine H₃ Receptor Agonist, Inhibits Central Neurogenic Vascular Inflammation and Produces Sedation in the Guinea Pig
J Pharmacol Exp Ther 1998 287: 43-50. [Abstract] [Full Text] [PDF]  

Giuseppe Di Giovanni, Michele Di Mascio, Vincenzo Di Matteo, and Ennio Esposito

Effects of Acute and Repeated Administration of Amisulpride, a Dopamine D₂/D₃ Receptor Antagonist, on the Electrical Activity of Midbrain Dopaminergic Neurons
J Pharmacol Exp Ther 1998 287: 51-57. [Abstract] [Full Text] [PDF]  

Marco Giorgetti, Javaid I. Javaid, John M. Davis, Erminio Costa, Alessandro Guidotti, Sarah B. Appel, and Mark S. Brodie

Imidazenil, a Positive Allosteric GABA_A Receptor Modulator, Inhibits the Effects of Cocaine on Locomotor Activity and Extracellular Dopamine in the Nucleus Accumbens Shell Without Tolerance Liability
J Pharmacol Exp Ther 1998 287: 58-66. [Abstract] [Full Text] [PDF]  

L. Edward Clemens, Ramona G. Almirez, Karine A. Baudouin, Ronald P. Mischak, Elliott B. Grossbard, and Andrew A. Protter

Pharmacokinetics and Biological Actions of Subcutaneously Administered Human Brain Natriuretic Peptide
J Pharmacol Exp Ther 1998 287: 67-71. [Abstract] [Full Text] [PDF]  

John R. Mantsch, David Saphier, and Nick E. Goeders

Corticosterone Facilitates the Acquisition of Cocaine Self-Administration in Rats: Opposite Effects of the Type II Glucocorticoid Receptor Agonist Dexamethasone
J Pharmacol Exp Ther 1998 287: 72-80. [Abstract] [Full Text] [PDF]  

Angel L. Cogolludo, Francisco Perez-Vizcaino, and Juan Tamargo

Antagonism by Class I Antiarrhythmic Drugs of Levcromakalim-Induced Relaxation in Isolated Rat Aorta
J Pharmacol Exp Ther 1998 287: 81-86. [Abstract] [Full Text] [PDF]  

Mark P. Thomas, Daniel T. Monaghan, and Richard A. Morrisett

Evidence for a Causative Role of N-Methyl-D-aspartate Receptors in an In Vitro Model of Alcohol Withdrawal Hyperexcitability
J Pharmacol Exp Ther 1998 287: 87-97. [Abstract] [Full Text] [PDF]  

Anne Marie F. Salapatek, Annette Lam, and Edwin E. Daniel

Calcium Source Diversity in Canine Lower Esophageal Sphincter Muscle
J Pharmacol Exp Ther 1998 287: 98-106. [Abstract] [Full Text] [PDF]  

Bryan K. Yamamoto and Wenjun Zhu

The Effects of Methamphetamine on the Production of Free Radicals and Oxidative Stress
J Pharmacol Exp Ther 1998 287: 107-114. [Abstract] [Full Text] [PDF]  

Itsuko Ishii, Noriko Yokoyama, Mamoru Yanagimachi, Naoya Ashikawa, Masayuki Hata, Shigeru Murakami, Yumiko Asami, Nobuhiro Morisaki, Yasushi Saito, Shigeru Ohmori, and Mitsukazu Kitada

Stimulation of Cholesterol Release from Rabbit Foam Cells by the Action of a New Inhibitor for Acyl CoA:Cholesterol Acyltransferase (ACAT), HL-004
J Pharmacol Exp Ther 1998 287: 115-121. [Abstract] [Full Text] [PDF]  

Donald R. Gehlert, Laura Dreshfield, Frank Tinsley, Mark J. Benvenga, Scott Gleason, Ray W. Fuller, David T. Wong, and Susan K. Hemrick-Luecke

The Selective Norepinephrine Reuptake Inhibitor, LY368975, Reduces Food Consumption in Animal Models of Feeding
J Pharmacol Exp Ther 1998 287: 122-127. [Abstract] [Full Text] [PDF]  

Jun Lu, Dana J. Philpott, Paul R. Saunders, Mary H. Perdue, Ping-Chang Yang, and Derek M. McKay

Epithelial Ion Transport and Barrier Abnormalities Evoked by Superantigen-Activated Immune Cells Are Inhibited by Interleukin-10 but Not Interleukin-4
J Pharmacol Exp Ther 1998 287: 128-136. [Abstract] [Full Text] [PDF]  

Stefania Meini, Alessandro Lecci, Paola Cucchi, Rose-Marie Catalioto, Marco Criscuoli, and Carlo A. Maggi

Inflammation Modifies the Role of Cyclooxygenases in the Contractile Responses of the Rat Detrusor Smooth Muscle to Kinin Agonists
J Pharmacol Exp Ther 1998 287: 137-143. [Abstract] [Full Text] [PDF]  

Dong-Keun Song, Hong-Won Suh, Sung-Oh Huh, Jun-Sub Jung, Bong-Moo Ihn, Ihn-Geun Choi, and Yung-Hi Kim

Central GABA_A and GABA_B Receptor Modulation of Basal and Stress-Induced Plasma Interleukin-6 Levels in Mice
J Pharmacol Exp Ther 1998 287: 144-149. [Abstract] [Full Text] [PDF]  

Jessica Fiedler, Pat Wheelan, Peter M. Henson, and Robert C. Murphy

Exogenous Leukotriene B₄ (LTB₄) Inhibits Human Neutrophil Generation of LTB₄ from Endogenous Arachidonic Acid During Opsonized Zymosan Phagocytosis
J Pharmacol Exp Ther 1998 287: 150-156. [Abstract] [Full Text] [PDF]  

Mark G. Obukowicz, Dean J. Welsch, William J. Salsgiver, Cynthia L. Martin-Berger, Kevin S. Chinn, Kevin L. Duffin, Amiram Raz, and Philip Needleman

Novel, Selective 6 or 5 Fatty Acid Desaturase Inhibitors as Antiinflammatory Agents in Mice
J Pharmacol Exp Ther 1998 287: 157-166. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Adrian Newman-Tancredi, Mauricette Brocco, Alain Gobert, Françoise Lejeune, Valérie Audinot, Jean-Michel Rivet, Rudy Schreiber, Anne Dekeyne, Michael Spedding, Jean-Paul Nicolas, and Jean-Louis Peglion

S 18126 ({2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl}), a Potent, Selective and Competitive Antagonist at Dopamine D₄ Receptors: An In Vitro and In Vivo Comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2,3b]pyridine) and Raclopride
J Pharmacol Exp Ther 1998 287: 167-186. [Abstract] [Full Text] [PDF]  

Valérie Audinot, Adrian Newman-Tancredi, Alain Gobert, Jean-Michel Rivet, Mauricette Brocco, Françoise Lejeune, Laurence Gluck, Isabelle Desposte, Karin Bervoets, Anne Dekeyne, and Mark J. Millan

A Comparative In Vitro and In Vivo Pharmacological Characterization of the Novel Dopamine D₃ Receptor Antagonists (+)-S 14297, Nafadotride, GR 103,691 and U 99194
J Pharmacol Exp Ther 1998 287: 187-197. [Abstract] [Full Text] [PDF]  

Jon E. Hawkinson, Manuel Acosta-Burruel, Kevin C. Yang, Derk J. Hogenkamp, Jie-Sheng Chen, Nancy C. Lan, John A. Drewe, Edward R. Whittemore, Richard M. Woodward, Richard B. Carter, and Ravindra B. Upasani

Substituted 3-Phenylethynyl Derivatives of 3-Hydroxy-5-pregnan-20-one: Remarkably Potent Neuroactive Steroid Modulators of -Aminobutyric Acid_A Receptors
J Pharmacol Exp Ther 1998 287: 198-207. [Abstract] [Full Text] [PDF]  

Yasuhiro Masubuchi, Haruka Saito, and Toshiharu Horie

Structural Requirements for the Hepatotoxicity of Nonsteroidal Anti-inflammatory Drugs in Isolated Rat Hepatocytes
J Pharmacol Exp Ther 1998 287: 208-213. [Abstract] [Full Text] [PDF]  

Hiromi Sugawara and Masao Endoh

A Novel Cardiotonic Agent SCH00013 Acts as a Ca⁺⁺ Sensitizer with No Chronotropic Activity in Mammalian Cardiac Muscle
J Pharmacol Exp Ther 1998 287: 214-222. [Abstract] [Full Text] [PDF]  

Rupa Mokkapatti, Subhash J. Vyas, Guillermo G. Romero, Zaichuan Mi, Tomoo Inoue, Raghvendra K. Dubey, Delbert G. Gillespie, Amy K. Stout, and Edwin K. Jackson

Modulation by Angiotensin II of Isoproterenol-Induced cAMP Production in Preglomerular Microvascular Smooth Muscle Cells from Normotensive and Genetically Hypertensive Rats
J Pharmacol Exp Ther 1998 287: 223-231. [Abstract] [Full Text] [PDF]  

K. A. Sluka

Blockade of N- and P/Q-Type Calcium Channels Reduces the Secondary Heat Hyperalgesia Induced by Acute Inflammation
J Pharmacol Exp Ther 1998 287: 232-237. [Abstract] [Full Text] [PDF]  

Sena F. Sezen, Velga A. Kenigs, and Daniel R. Kapusta

Renal Excretory Responses Produced by the Delta Opioid Agonist, BW373U86, in Conscious Rats
J Pharmacol Exp Ther 1998 287: 238-245. [Abstract] [Full Text] [PDF]  

Yuanchao Zhang, Yunsheng Hsieh, Takashi Izumi, Emil T. Lin, and Leslie Z. Benet

Effects of Ketoconazole on the Intestinal Metabolism, Transport and Oral Bioavailability of K02, a Novel Vinylsulfone Peptidomimetic Cysteine Protease Inhibitor and a P450 3A, P-Glycoprotein Dual Substrate, in Male Sprague-Dawley Rats
J Pharmacol Exp Ther 1998 287: 246-252. [Abstract] [Full Text] [PDF]  

Richard M. Hann, Oné R. Pagán, Liza Gregory, Tomas Jácome, Abimael D. Rodríguez, P. A. Ferchmin, Ruiliang Lu, and Vesna A. Eterovic

Characterization of Cembranoid Interaction with the Nicotinic Acetylcholine Receptor
J Pharmacol Exp Ther 1998 287: 253-260. [Abstract] [Full Text] [PDF]  

Theresa E. Madden and Steven W. Johnson

Gamma-Hydroxybutyrate is a GABA_B Receptor Agonist that Increases a Potassium Conductance in Rat Ventral Tegmental Dopamine Neurons
J Pharmacol Exp Ther 1998 287: 261-265. [Abstract] [Full Text] [PDF]  

W. Koek, J.-F. Patoiseau, M.-B. Assié, C. Cosi, M. S. Kleven, E. Dupont-Passelaigue, E. Carilla-Durand, C. Palmier, J.-P. Valentin, G. John, P. J. Pauwels, J.-P. Tarayre, and F. C. Colpaert

F 11440, a Potent, Selective, High Efficacy 5-HT_1A Receptor Agonist with Marked Anxiolytic and Antidepressant Potential
J Pharmacol Exp Ther 1998 287: 266-283. [Abstract] [Full Text] [PDF]  

J. C. Froehlich, N. E. Badia-Elder, R. W. Zink, D. E. McCullough, and P. S. Portoghese

Contribution of the Opioid System to Alcohol Aversion and Alcohol Drinking Behavior
J Pharmacol Exp Ther 1998 287: 284-292. [Abstract] [Full Text] [PDF]  

Manabu Nishio, Yoshizumi Habuchi, Hideo Tanaka, Junichiro Morikawa, Taku Yamamoto, and Kei Kashima

Blockage by Terfenadine of the Adenosine Triphosphate (ATP)-Sensitive K⁺ Current in Rabbit Ventricular Myocytes
J Pharmacol Exp Ther 1998 287: 293-300. [Abstract] [Full Text] [PDF]  

C.A. Lesch, R.B. Gilbertsen, Y. Song, R.D. Dyer, D. Schrier, E.R. Kraus, B. Sanchez, and A. Guglietta

Effects of Novel Anti-Inflammatory Compounds on Healing of Acetic Acid-Induced Gastric Ulcer in Rats
J Pharmacol Exp Ther 1998 287: 301-306. [Abstract] [Full Text] [PDF]  

Xinzhu Pang, Nicholas Alexacos, Richard Letourneau, Dimitri Seretakis, Wei Gao, William Boucher, David E. Cochrane, and Theoharis C. Theoharides

A Neurotensin Receptor Antagonist Inhibits Acute Immobilization Stress-Induced Cardiac Mast Cell Degranulation, a Corticotropin-Releasing Hormone-Dependent Process
J Pharmacol Exp Ther 1998 287: 307-314. [Abstract] [Full Text] [PDF]  

John L. Tonkinson, Lillian L. Habeck, John E. Toth, Laurane G. Mendelsohn, Jesse Bewley, Katherine A. Shackelford, Susan B. Gates, James Ray, and Victor J. Chen

The Antiproliferative and Cell Cycle Effects of 5,6,7,8-Tetrahydro-N⁵,N¹⁰-Carbonylfolic Acid, an Inhibitor of Methylenetetrahydrofolate Dehydrogenase, Are Potentiated by Hypoxanthine
J Pharmacol Exp Ther 1998 287: 315-321. [Abstract] [Full Text] [PDF]  

Li-I Tsao, Bruce Ladenheim, Anne M. Andrews, Chuang C. Chiueh, Jean Lud Cadet, and Tsung-Ping Su

Delta Opioid Peptide [D-Ala²,D-leu⁵]Enkephalin Blocks the Long-term Loss of Dopamine Transporters Induced by Multiple Administrations of Methamphetamine: Involvement of Opioid Receptors and Reactive Oxygen Species
J Pharmacol Exp Ther 1998 287: 322-331. [Abstract] [Full Text] [PDF]  

Hailing Zhang, Bing Zhu, Jian-An Yao, and Gea-Ny Tseng

Differential Effects of S6 Mutations on Binding of Quinidine and 4-Aminopyridine to Rat Isoform of Kv1.4: Common Site but Different Factors in Determining Blockers' Binding Affinity
J Pharmacol Exp Ther 1998 287: 332-343. [Abstract] [Full Text] [PDF]  

Bambang Wispriyono, Masato Matsuoka, Hideki Igisu, and Koji Matsuno

Protection from Cadmium Cytotoxicity by N-Acetylcysteine in LLC-PK₁ Cells
J Pharmacol Exp Ther 1998 287: 344-351. [Abstract] [Full Text] [PDF]  

Marion B. Sewer and Edward T. Morgan

Down-Regulation of the Expression of Three Major Rat Liver Cytochrome P450S by Endotoxin In Vivo Occurs Independently of Nitric Oxide Production
J Pharmacol Exp Ther 1998 287: 352-358. [Abstract] [Full Text] [PDF]  

Jan Oberdoerster, Angela R. Kamer, and Richard A. Rabin

Differential Effect of Ethanol on PC12 Cell Death
J Pharmacol Exp Ther 1998 287: 359-365. [Abstract] [Full Text] [PDF]  

Richard R. Ryan, H. Christian Weber, Samuel A. Mantey, Wei Hou, Mary E. Hilburger, Tapas K. Pradhan, David H. Coy, and Robert T. Jensen

Pharmacology and Intracellular Signaling Mechanisms of the Native Human Orphan Receptor BRS-3 in Lung Cancer Cells
J Pharmacol Exp Ther 1998 287: 366-380. [Abstract] [Full Text] [PDF]  

Richard L. Voorman, Stephen M. Maio, N. Ann Payne, Zhiyang Zhao, Kenneth A. Koeplinger, and Xiaohong Wang

Microsomal Metabolism of Delavirdine: Evidence for Mechanism-Based Inactivation of Human Cytochrome P450 3A
J Pharmacol Exp Ther 1998 287: 381-388. [Abstract] [Full Text] [PDF]  

María Isolde Rudolph, Claudia Oviedo, Edgardo Vega, Lorena Martínez, Karin Reinicke, María Villar, and Leonor Villán

Oxytocin Inhibits the Uptake of Serotonin into Uterine Mast Cells
J Pharmacol Exp Ther 1998 287: 389-394. [Abstract] [Full Text] [PDF]  

Erwin Duizer, Cees Van Der Wulp, Carolien H. M. Versantvoort, and John P. Groten

Absorption Enhancement, Structural Changes in Tight Junctions and Cytotoxicity Caused by Palmitoyl Carnitine in Caco-2 and IEC-18 Cells
J Pharmacol Exp Ther 1998 287: 395-402. [Abstract] [Full Text] [PDF]  

Kohei Takada, Kimihiro Yamashita, Yasuko Sakurai-Yamashita, Kazuto Shigematsu, Yoshinori Hamada, Kohshiro Hioki, and Kohtaro Taniyama

Participation of Nitric Oxide in the Mucosal Injury of Rat Intestine Induced by Ischemia-Reperfusion
J Pharmacol Exp Ther 1998 287: 403-407. [Abstract] [Full Text] [PDF]  

Makiya Nishikawa, Shigeo Takemura, Yoshinobu Takakura, and Mitsuru Hashida

Targeted Delivery of Plasmid DNA to Hepatocytes In Vivo: Optimization of the Pharmacokinetics of Plasmid DNA/Galactosylated Poly(L-Lysine) Complexes by Controlling their Physicochemical Properties
J Pharmacol Exp Ther 1998 287: 408-415. [Abstract] [Full Text] [PDF]  

Jian-Hua Zhang, Jeffery W. Stobb, Jodie M. Hanesworth, Michael F. Sardinia, and Joseph W. Harding

Characterization and Purification of the Bovine Adrenal Angiotensin IV Receptor (AT₄) Using [¹²⁵I]Benzoylphenylalanine-Angiotensin IV as a Specific Photolabel
J Pharmacol Exp Ther 1998 287: 416-424. [Abstract] [Full Text] [PDF]  

Luc Levesque and Stanley T. Crooke

Depletion of Protein Kinase C- by Antisense Oligonucleotides Alters Beta-Adrenergic Function and Reverses the Phorbol Ester-Induced Reduction of Isoproterenol-Induced Adenosine 3'-5'-Cyclic Monophosphate Accumulation in Murine Swiss 3T3 Fibroblasts.
J Pharmacol Exp Ther 1998 287: 425-434. [Abstract] [Full Text] [PDF]  

Kevin D. Macklin, Arno D. J. Maus, Edna F. R. Pereira, Edson X. Albuquerque, and Bianca M. Conti-Fine

Human Vascular Endothelial Cells Express Functional Nicotinic Acetylcholine Receptors
J Pharmacol Exp Ther 1998 287: 435-439. [Abstract] [Full Text] [PDF]  

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