ARTICLES:

Rosalin H. Arends, Takahiko G. Hayashi, Thomas J. Luger, and Danny D. Shen

Cotreatment with Racemic Fenfluramine Inhibits the Development of Tolerance to Morphine Analgesia in Rats
J Pharmacol Exp Ther 1998 286: 585-592. [Abstract] [Full Text] [PDF]  

Subhas C. Ganguli, Chan-Guk Park, Martin H. Holtmann, Elizabeth M. Hadac, Terry P. Kenakin, and Laurence J. Miller

Protean Effects of a Natural Peptide Agonist of the G Protein-Coupled Secretin Receptor Demonstrated by Receptor Mutagenesis
J Pharmacol Exp Ther 1998 286: 593-598. [Abstract] [Full Text] [PDF]  

Ji-Ming Ye and Eric Q. Colquhoun

Changes in Functional Expression of Alpha-1 Adrenoceptors in Hindlimb Vascular Bed of Spontaneously Hypertensive Rats and their Effects on Oxygen Consumption
J Pharmacol Exp Ther 1998 286: 599-606. [Abstract] [Full Text] [PDF]  

G. Faintrenie and A. Géloën

Alpha-1 Adrenergic Stimulation of Glucose Uptake in Rat White Adipocytes
J Pharmacol Exp Ther 1998 286: 607-610. [Abstract] [Full Text] [PDF]  

G. J. Smits, M. McVey, B. F. Cox, M. H. Perrone, and K. L. Clark

Cardioprotective Effects of the Novel Adenosine A₁/A₂ Receptor Agonist AMP 579 in a Porcine Model of Myocardial Infarction
J Pharmacol Exp Ther 1998 286: 611-618. [Abstract] [Full Text] [PDF]  

Grace A. Stafford, Robert E. Oswald, Antonio Figl, Bruce N. Cohen, and Gregory A. Weiland

Two Domains of the Beta Subunit of Neuronal Nicotinic Acetylcholine Receptors Contribute to the Affinity of Substance P
J Pharmacol Exp Ther 1998 286: 619-626. [Abstract] [Full Text] [PDF]  

Jessica C. Brimecombe, Michael J. Gallagher, David R. Lynch, and Elias Aizenman

An NR2B Point Mutation Affecting Haloperidol and CP101,606 Sensitivity of Single Recombinant N-Methyl-D-Aspartate Receptors
J Pharmacol Exp Ther 1998 286: 627-634. [Abstract] [Full Text] [PDF]  

Marjorie Gondré and George J. Christ

Endothelin-1-Induced Alterations in Phenylephrine-Induced Contractile Responses Are Largely Additive in Physiologically Diverse Rabbit Vasculature
J Pharmacol Exp Ther 1998 286: 635-642. [Abstract] [Full Text] [PDF]  

Tomoko Hoshino, Rikako Yamauchi, Kohei Kikkawa, Hideo Yabana, and Sakae Murata

Pharmacological Profile of T-0201, a Highly Potent and Orally Active Endothelin Receptor Antagonist
J Pharmacol Exp Ther 1998 286: 643-649. [Abstract] [Full Text] [PDF]  

Eliot H. Ohlstein, Ponnal Nambi, Douglas W. P. Hay, Miklos Gellai, David P. Brooks, Juan Luengo, Jia-Ning Xiang, and John D. Elliott

Nonpeptide Endothelin Receptor Antagonists. XI. Pharmacological Characterization of SB 234551, a High-Affinity and Selective Nonpeptide ET_A Receptor Antagonist
J Pharmacol Exp Ther 1998 286: 650-656. [Abstract] [Full Text] [PDF]  

Max Reinshagen, Günther Flämig, Sabine Ernst, Irmlind Geerling, Helen Wong, John H. Walsh, Viktor E. Eysselein, and Guido Adler

Calcitonin Gene-Related Peptide Mediates the Protective Effect of Sensory Nerves in a Model of Colonic Injury
J Pharmacol Exp Ther 1998 286: 657-661. [Abstract] [Full Text] [PDF]  

Elizabeth J. Kelso, J. Paul Spiers, Barbara J. McDermott, C. Norman Scholfield, and Bernard Silke

Receptor-Mediated Effects of Endothelin on the L-Type Ca⁺⁺ Current in Ventricular Cardiomyocytes
J Pharmacol Exp Ther 1998 286: 662-669. [Abstract] [Full Text] [PDF]  

P. Hoffmann, A. Bernat, P. Savi, and J. M. Herbert

Prevention of Thrombosis and Enhancement of Thrombolysis in Rabbits by SR 121787, a Glycoprotein II/III Antagonist
J Pharmacol Exp Ther 1998 286: 670-675. [Abstract] [Full Text] [PDF]  

Kenji Takami, Hideyuki Saito, Masahiro Okuda, Mikihisa Takano, and Ken-Ichi Inui

Distinct Characteristics of Transcellular Transport between Nicotine and Tetraethylammonium in LLC-PK₁ Cells
J Pharmacol Exp Ther 1998 286: 676-680. [Abstract] [Full Text] [PDF]  

Masashi Arimitsu, Minori Mitsui-Saito, Koichi Sato, Hiroshi Ozaki, Yoshihisa Koga, and Hideaki Karaki

Mechanism of Relaxant Effect of Clonidine in Isolated Bovine Tracheal Smooth Muscle
J Pharmacol Exp Ther 1998 286: 681-687. [Abstract] [Full Text] [PDF]  

Gwenaelle Le Pen, Dominique Duterte-Boucher, and Jean Costentin

Sensitization to the Rewarding Effects of the Specific Dopamine Uptake Inhibitor GBR12783
J Pharmacol Exp Ther 1998 286: 688-696. [Abstract] [Full Text] [PDF]  

Jeffrey A. Vivian, Shiroh Kishioka, Eduardo R. Butelman, Jillian Broadbear, Katherine O. Lee, and James H. Woods

Analgesic, Respiratory and Heart Rate Effects of Cannabinoid and Opioid Agonists in Rhesus Monkeys: Antagonist Effects of SR 141716A
J Pharmacol Exp Ther 1998 286: 697-703. [Abstract] [Full Text] [PDF]  

Angela Bischoff, Volker Limmroth, and Martin C. Michel

Indomethacin Inhibits the Natriuretic Effects of Neuropeptide Y in Anesthetized Rats
J Pharmacol Exp Ther 1998 286: 704-708. [Abstract] [Full Text] [PDF]  

Michael E. Schnee and Barry S. Brown

Selectivity of Linopirdine (DuP 996), a Neurotransmitter Release Enhancer, in Blocking Voltage-Dependent and Calcium-Activated Potassium Currents in Hippocampal Neurons
J Pharmacol Exp Ther 1998 286: 709-717. [Abstract] [Full Text] [PDF]  

Lisa Cassis, Amy Laughter, Mike Fettinger, Scott Akers, Robert Speth, Gerome Burke, Victoria King, and Linda Dwoskin

Cold Exposure Regulates the Renin-Angiotensin System
J Pharmacol Exp Ther 1998 286: 718-726. [Abstract] [Full Text] [PDF]  

Robert Dumaine, Mary-Louise Roy, and Arthur M. Brown

Blockade of HERG and Kv1.5 by Ketoconazole
J Pharmacol Exp Ther 1998 286: 727-735. [Abstract] [Full Text] [PDF]  

Chun-Su Yuan, Dong Liu, and Anoja S. Attele

GABAergic Effects on Nucleus Tractus Solitarius Neurons Receiving Gastric Vagal Inputs
J Pharmacol Exp Ther 1998 286: 736-741. [Abstract] [Full Text] [PDF]  

Mercedes Balcells-Olivero, Michael S. Cousins, and Lewis S. Seiden

Holtzman and Harlan Sprague-Dawley Rats: Differences in DRL 72-Sec Performance and 8-Hydroxy-Di-Propylamino Tetralin-Induced Hypothermia
J Pharmacol Exp Ther 1998 286: 742-752. [Abstract] [Full Text] [PDF]  

Pierluigi Onali and Maria C. Olianas

Identification and Characterization of Muscarinic Receptors Potentiating the Stimulation of Adenylyl Cyclase Activity by Corticotropin-Releasing Hormone in Membranes of Rat Frontal Cortex
J Pharmacol Exp Ther 1998 286: 753-759. [Abstract] [Full Text] [PDF]  

Geng-Hua Yi, Daniel Burkhoff, Hui Zhang, Shu-Ming Zhu, Donna Zwas, and Jie Wang

Hemodynamic Effects of a Calcium Channel Promoter, BAY y 5959, are Preserved after Chronic Administration in Ischemic Heart Failure in Conscious Dogs
J Pharmacol Exp Ther 1998 286: 760-766. [Abstract] [Full Text] [PDF]  

Hirohisa Takano, Heung-Bin Lim, Yuichi Miyabara, Takamichi Ichinose, Toshikazu Yoshikawa, and Masaru Sagai

Oral Administration of L-Arginine Potentiates Allergen-Induced Airway Inflammation and Expression of Interleukin-5 in Mice
J Pharmacol Exp Ther 1998 286: 767-771. [Abstract] [Full Text] [PDF]  

Jorge M. S. Pascual, Andrew McKenzie, James R. Yankaskas, John R. Falck, and Darryl C. Zeldin

Epoxygenase Metabolites of Arachidonic Acid Affect Electrophysiologic Properties of Rat Tracheal Epithelial Cells¹
J Pharmacol Exp Ther 1998 286: 772-779. [Abstract] [Full Text] [PDF]  

Masahiro Ohsawa, Hiroshi Nagase, and Junzo Kamei

Role of Intracellular Calcium in Modification of Mu and Delta Opioid Receptor-Mediated Antinociception by Diabetes in Mice
J Pharmacol Exp Ther 1998 286: 780-787. [Abstract] [Full Text] [PDF]  

David Rampe, Michael K. Murawsky, Jessica Grau, and Eric W. Lewis

The Antipsychotic Agent Sertindole is a High Affinity Antagonist of the Human Cardiac Potassium Channel HERG
J Pharmacol Exp Ther 1998 286: 788-793. [Abstract] [Full Text] [PDF]  

D. A. Cory-Slechta, D. J. O'Mara, and B. J. Brockel

Nucleus Accumbens Dopaminergic Medication of Fixed Interval Schedule-Controlled Behavior and Its Modulation by Low-Level Lead Exposure
J Pharmacol Exp Ther 1998 286: 794-805. [Abstract] [Full Text] [PDF]  

Robert D. Lasley and Robert M. Mentzer Jr.

Dose-Dependent Effects of Adenosine on Interstitial Fluid Adenosine and Postischemic Function in the Isolated Rat Heart
J Pharmacol Exp Ther 1998 286: 806-811. [Abstract] [Full Text] [PDF]  

Nancy K. Mello and S. Stevens Negus

Effects of Kappa Opioid Agonists on Cocaine- and Food-Maintained Responding by Rhesus Monkeys
J Pharmacol Exp Ther 1998 286: 812-824. [Abstract] [Full Text] [PDF]  

Lei Ke, Cynthia M. Eisenhour, Merouane Bencherif, and Ronald J. Lukas

Effects of Chronic Nicotine Treatment on Expression of Diverse Nicotinic Acetylcholine Receptor Subtypes. I. Dose- and Time-Dependent Effects of Nicotine Treatment
J Pharmacol Exp Ther 1998 286: 825-840. [Abstract] [Full Text] [PDF]  

Ming Yang, Jens Reese, Susanna Cotecchia, and Martin C. Michel

Murine Alpha₁-Adrenoceptor Subtypes. I. Radioligand Binding Studies
J Pharmacol Exp Ther 1998 286: 841-847. [Abstract] [Full Text] [PDF]  

A. William Tank, Cheryl A. Osterhout, and Carol R. Sterling

Regulation of Tyrosine Hydroxylase Activity by Muscarinic Agonists in Rat Adrenal Medulla
J Pharmacol Exp Ther 1998 286: 848-854. [Abstract] [Full Text] [PDF]  

Hermann Ammer and Rüdiger Schulz

Adenylyl Cyclase Supersensitivity in Opioid-Withdrawn NG108-15 Hybrid Cells Requires G_s but Is Not Mediated by the G_s Subunit
J Pharmacol Exp Ther 1998 286: 855-862. [Abstract] [Full Text] [PDF]  

Toyokazu Hiranuma, Ken Kitamura, Takao Taniguchi, Masayuki Kanai, Yoshiharu Arai, Kayoko Iwao, and Tetsuo Oka

Protection against Dynorphin-(1-8) Hydrolysis in Membrane Preparations by the Combination of Amastatin, Captopril and Phosphoramidon
J Pharmacol Exp Ther 1998 286: 863-869. [Abstract] [Full Text] [PDF]  

N. Fernández, M. J. Diez, M. T. Terán, J. J. García, A. P. Calle, and M. Sierra

Influence of Two Commercial Fibers in the Pharmacokinetics of Ethinylestradiol in Rabbits
J Pharmacol Exp Ther 1998 286: 870-874. [Abstract] [Full Text] [PDF]  

Bruce Nock, Theodore J. Cicero, and Michele Wich

Chronic Exposure to Morphine Decreases Physiologically Active Corticosterone in Both Male and Female Rats but by Different Mechanisms
J Pharmacol Exp Ther 1998 286: 875-882. [Abstract] [Full Text] [PDF]  

Piyarat Govitrapong, Tunda Suttitum, Naiphinich Kotchabhakdi, and Thongchai Uneklabh

Alterations of Immune Functions in Heroin Addicts and Heroin Withdrawal Subjects
J Pharmacol Exp Ther 1998 286: 883-889. [Abstract] [Full Text] [PDF]  

Takeo Kitazawa, Tetsuya Terasaki, Hiroshi Suzuki, Atsuyuki Kakee, and Yuichi Sugiyama

Efflux of Taurocholic Acid Across the Blood-Brain Barrier: Interaction with Cyclic Peptides
J Pharmacol Exp Ther 1998 286: 890-895. [Abstract] [Full Text] [PDF]  

Erika Albrecht, Nelya N. Samovilova, Stephan Oswald, Ingo Baeger, and Hartmut Berger

Nociceptin (Orphanin FQ): High-Affinity and High-Capacity Binding Site Coupled to Low-Potency Stimulation of Guanylyl-5'-O-(-thio)-triphosphate Binding in Rat Brain Membranes
J Pharmacol Exp Ther 1998 286: 896-902. [Abstract] [Full Text] [PDF]  

Jean-François Desaphy, Annamaria De Luca, Sabata Pierno, Paola Imbrici, and Diana Conte Camerino

Partial Recovery of Skeletal Muscle Sodium Channel Properties in Aged Rats Chronically Treated with Growth Hormone or the GH-Secretagogue Hexarelin
J Pharmacol Exp Ther 1998 286: 903-912. [Abstract] [Full Text] [PDF]  

J. R. Martin, M. Bös, F. Jenck, J.-L. Moreau, V. Mutel, A. J. Sleight, J. Wichmann, J. S. Andrews, H. H. G. Berendsen, C. L. E. Broekkamp, G. S. F. Ruigt, C. Köhler, and A. M. L. van Delft

5-HT_2C Receptor Agonists: Pharmacological Characteristics and Therapeutic Potential
J Pharmacol Exp Ther 1998 286: 913-924. [Abstract] [Full Text] [PDF]  

Jogarao V.S. Gobburu, Christopher Tenhoor, Mark C. Rogge, Donald E. Frazier Jr., David Thomas, Chris Benjamin, Donna M. Hess, and William J. Jusko

Pharmacokinetics/Dynamics of 5c8, a Monoclonal Antibody to CD154 (CD40 Ligand) Suppression of an Immune Response in Monkeys
J Pharmacol Exp Ther 1998 286: 925-930. [Abstract] [Full Text] [PDF]  

Jason E. Nowak, Ricardo Gomez-Flores, Silvia N. Calderon, Kenner C. Rice, and Richard J. Weber

Rat Natural Killer Cell, T Cell and Macrophage Functions after Intracerebroventricular Injection of SNC 80
J Pharmacol Exp Ther 1998 286: 931-937. [Abstract] [Full Text] [PDF]  

S. Dikalov, B. Fink, M. Skatchkov, D. Stalleicken, and E. Bassenge

Formation of Reactive Oxygen Species by Pentaerithrityltetranitrate and Glyceryl Trinitrate In Vitro and Development of Nitrate Tolerance
J Pharmacol Exp Ther 1998 286: 938-944. [Abstract] [Full Text] [PDF]  

Natalie P. Murphy, Domenico Pratico, and Desmond J. Fitzgerald

Functional Relevance of the Expression of Ligand-Induced Binding Sites in the Response to Platelet GP IIb/IIIa Antagonists In Vivo.
J Pharmacol Exp Ther 1998 286: 945-951. [Abstract] [Full Text] [PDF]  

Hema J. Patel, Mark A. Giembycz, Joelle E. Keeling, Peter J. Barnes, and Maria G. Belvisi

Inhibition of Cholinergic Neurotransmission in Guinea Pig Trachea by NS1619, a Putative Activator of Large-Conductance, Calcium-Activated Potassium Channels
J Pharmacol Exp Ther 1998 286: 952-958. [Abstract] [Full Text] [PDF]  

Senshang Lin, Li-Lan H. Chen, and Yie W. Chien

Comparative Pharmacokinetic and Pharmacodynamic Studies of Human Insulin and Analogues in Chronic Diabetic Yucatan Minipigs
J Pharmacol Exp Ther 1998 286: 959-966. [Abstract] [Full Text] [PDF]  

Lynette C. Daws, Glenn M. Toney, Greg A. Gerhardt, and Alan Frazer

In Vivo Chronoamperometric Measures of Extracellular Serotonin Clearance in Rat Dorsal Hippocampus: Contribution of Serotonin and Norepinephrine Transporters
J Pharmacol Exp Ther 1998 286: 967-976. [Abstract] [Full Text] [PDF]  

Toshikatsu Shimizu, Takayuki Kuroda, Minoru Ikeda, Satoshi Hata, and Masafumi Fujimoto

Potential Contribution of Endothelin to Renal Abnormalities in Glycerol-Induced Acute Renal Failure in Rats
J Pharmacol Exp Ther 1998 286: 977-983. [Abstract] [Full Text] [PDF]  

C. J. Daly, C. M. Milligan, G. Milligan, J. F. Mackenzie, and J. C. Mcgrath

Cellular Localization and Pharmacological Characterization of Functioning Alpha-1 Adrenoceptors by Fluorescent Ligand Binding and Image Analysis Reveals Identical Binding Properties of Clustered and Diffuse Populations of Receptors
J Pharmacol Exp Ther 1998 286: 984-990. [Abstract] [Full Text] [PDF]  

R. Tyler McCabe, R. Duane Sofia, Richard T. Layer, Kevin A. Leiner, Richard L. M. Faull, Neelam Narang, and James K. Wamsley

Felbamate Increases [³H]Glycine Binding in Rat Brain and Sections of Human Postmortem Brain
J Pharmacol Exp Ther 1998 286: 991-999. [Abstract] [Full Text] [PDF]  

Li Zhou, Qin Zhang, Christoph Stein, and Michael Schäfer

Contribution of Opioid Receptors on Primary Afferent Versus Sympathetic Neurons to Peripheral Opioid Analgesia
J Pharmacol Exp Ther 1998 286: 1000-1006. [Abstract] [Full Text] [PDF]  

Ira E. Goldberg, Grace C. Rossi, Sharon R. Letchworth, John P. Mathis, Jennifer Ryan-Moro, Liza Leventhal, Wendy Su, David Emmel, Elizabeth A. Bolan, and Gavril W. Pasternak

Pharmacological characterization of Endomorphin-1 and Endomorphin-2 in Mouse Brain
J Pharmacol Exp Ther 1998 286: 1007-1013. [Abstract] [Full Text] [PDF]  

Ming Yin, Kenichi Ikejima, Gavin E. Arteel, Vitor Seabra, Blair U. Bradford, Hiroshi Kono, Ivan Rusyn, and Ronald G. Thurman

Glycine Accelerates Recovery from Alcohol-Induced Liver Injury
J Pharmacol Exp Ther 1998 286: 1014-1019. [Abstract] [Full Text] [PDF]  

Ruth Luthi-Carter, Amy K. Barczak, Henry Speno, and Joseph T. Coyle

Molecular Characterization of Human Brain N-Acetylated -Linked Acidic Dipeptidase (NAALADase)
J Pharmacol Exp Ther 1998 286: 1020-1025. [Abstract] [Full Text] [PDF]  

Marie T. Walsh, John F. Foley, and B. Therese Kinsella

Characterization of the Role of N-Linked Glycosylation on the Cell Signaling and Expression of the Human Thromboxane A₂ Receptor Alpha and Beta Isoforms
J Pharmacol Exp Ther 1998 286: 1026-1036. [Abstract] [Full Text] [PDF]  

Kazushige Takahashi, Nobuhiko Nakamura, Tomohiro Terada, Tomonobu Okano, Takahiro Futami, Hideyuki Saito, and Ken-Ichi Inui

Interaction of -Lactam Antibiotics with H⁺/Peptide Cotransporters in Rat Renal Brush-Border Membranes
J Pharmacol Exp Ther 1998 286: 1037-1042. [Abstract] [Full Text] [PDF]  

Hirokazu Kouzuki, Hiroshi Suzuki, Kousei Ito, Rui Ohashi, and Yuichi Sugiyama

Contribution of Sodium Taurocholate Co-Transporting Polypeptide to the Uptake of Its Possible Substrates Into Rat Hepatocytes
J Pharmacol Exp Ther 1998 286: 1043-1050. [Abstract] [Full Text] [PDF]  

Ravi B. Marala and S. Jamal Mustafa

Immunological Characterization of Adenosine A_2A Receptors in Human and Porcine Cardiovascular Tissues
J Pharmacol Exp Ther 1998 286: 1051-1057. [Abstract] [Full Text] [PDF]  

Virginia A. Boundy, Jingshan Chen, and Eric J. Nestler

Regulation of cAMP-Dependent Protein Kinase Subunit Expression in CATH.a and SH-SY5Y Cells
J Pharmacol Exp Ther 1998 286: 1058-1065. [Abstract] [Full Text] [PDF]  

Christopher L. Morton and Philip M. Potter

Rhabdomyosarcoma-Specific Expression of the Herpes Simplex Virus Thymidine Kinase Gene Confers Sensitivity to Ganciclovir
J Pharmacol Exp Ther 1998 286: 1066-1073. [Abstract] [Full Text] [PDF]  

John F. Bowyer, Lynn T. Frame, Peter Clausing, Kumi Nagamoto-Combs, Cheryl A. Osterhout, Carol R. Sterling, and A. William Tank

Long-term Effects of Amphetamine Neurotoxicity on Tyrosine Hydroxylase mRNA and Protein in Aged Rats
J Pharmacol Exp Ther 1998 286: 1074-1085. [Abstract] [Full Text] [PDF]  

K. N. Browning, Z. L. Zheng, D. L. Kreulen, and R. A. Travagli

Effects of Nitric Oxide in Cultured Prevertebral Sympathetic Ganglion Neurons
J Pharmacol Exp Ther 1998 286: 1086-1093. [Abstract] [Full Text] [PDF]  

N. A. Sharif, S. X. Xu, G. W. Williams, J. Y. Crider, B. W. Griffin, and T. L. Davis

Pharmacology of [³H]Prostaglandin E₁/[³H]Prostaglandin E₂ and [³H]Prostaglandin F₂ Binding to EP₃ and FP Prostaglandin Receptor Binding Sites in Bovine Corpus Luteum: Characterization and Correlation with Functional Data
J Pharmacol Exp Ther 1998 286: 1094-1102. [Abstract] [Full Text] [PDF]  

Weigang Zhu, Herman Friedman, and Thomas W. Klein

⁹-Tetrahydrocannabinol Induces Apoptosis in Macrophages and Lymphocytes: Involvement of Bcl-2 and Caspase-1
J Pharmacol Exp Ther 1998 286: 1103-1109. [Abstract] [Full Text] [PDF]  

Graham S. Baldwin, Vincent J. Murphy, Zhiyu Yang, and Takashi Hashimoto

Binding of Nonsteroidal Antiinflammatory Drugs to the -Subunit of the Trifunctional Protein of Long Chain Fatty Acid Oxidation
J Pharmacol Exp Ther 1998 286: 1110-1114. [Abstract] [Full Text] [PDF]  

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