THE 1998 ASPET OTTO KRAYER AWARD LECTURE:

Theodore A. Slotkin

Fetal Nicotine or Cocaine Exposure: Which One is Worse?
J Pharmacol Exp Ther 1998 285: 931-945. [Abstract] [Full Text] [PDF]  

ANALGESIA AND DRUGS OF ABUSE:

Jenny L. Wiley, David R. Compton, Dong Dai, Julia A. H. Lainton, Michelle Phillips, John W. Huffman, and Billy R. Martin

Structure-Activity Relationships of Indole- and Pyrrole-Derived Cannabinoids
J Pharmacol Exp Ther 1998 285: 995-1004. [Abstract] [Full Text] [PDF]  

David M. Dirig, Peter C. Isakson, and Tony L. Yaksh

Effect of COX-1 and COX-2 Inhibition on Induction and Maintenance of Carrageenan-Evoked Thermal Hyperalgesia in Rats
J Pharmacol Exp Ther 1998 285: 1031-1038. [Abstract] [Full Text] [PDF]  

J. Shane Hardin, William D. Wessinger, Joel W. Proksch, and S. Michael Owens

Pharmacodynamics of a Monoclonal Antiphencyclidine Fab with Broad Selectivity for Phencyclidine-Like Drugs¹
J Pharmacol Exp Ther 1998 285: 1113-1122. [Abstract] [Full Text] [PDF]  

Stacie A. Cook, John A. Lowe, and Billy R. Martin

CB1 Receptor Antagonist Precipitates Withdrawal in Mice Exposed to ⁹-Tetrahydrocannabinol
J Pharmacol Exp Ther 1998 285: 1150-1156. [Abstract] [Full Text] [PDF]  

Gregg D. Smith and Maree T. Smith

The Excitatory Behavioral and Antianalgesic Pharmacology of Normorphine-3-glucuronide after Intracerebroventricular Administration to Rats
J Pharmacol Exp Ther 1998 285: 1157-1162. [Abstract] [Full Text] [PDF]  

Li He and Nancy M. Lee

Delta Opioid Receptor Enhancement of Mu Opioid Receptor-Induced Antinociception in Spinal Cord
J Pharmacol Exp Ther 1998 285: 1181-1186. [Abstract] [Full Text] [PDF]  

Raymond C. Pitts, Richard M. Allen, Ellen A. Walker, and Linda A. Dykstra

Clocinnamox Antagonism of the Antinociceptive Effects of Mu Opioids in Squirrel Monkeys
J Pharmacol Exp Ther 1998 285: 1197-1206. [Abstract] [Full Text] [PDF]  

George Bot, Allan D. Blake, Shuixing Li, and Terry Reisine

Fentanyl and its Analogs Desensitize the Cloned Mu Opioid Receptor
J Pharmacol Exp Ther 1998 285: 1207-1218. [Abstract] [Full Text] [PDF]  

Mark J. Field, Scott McCleary, Philip Boden, Nirmala Suman-Chauhan, John Hughes, and Lakhbir Singh

Involvement of the Central Tachykinin NK₁ Receptor during Maintenance of Mechanical Hypersensitivity Induced by Diabetes in the Rat
J Pharmacol Exp Ther 1998 285: 1226-1232. [Abstract] [Full Text] [PDF]  

Edward J. Wagner, Oline K. Rønnekleiv, and Martin J. Kelly

Protein Kinase A Maintains Cellular Tolerance to Mu Opioid Receptor Agonists in Hypothalamic Neurosecretory Cells with Chronic Morphine Treatment: Convergence on a Common Pathway with Estrogen in Modulating Mu Opioid Receptor/Effector Coupling
J Pharmacol Exp Ther 1998 285: 1266-1273. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

Matthew V. Sennitt, Alberto J. Kaumann, Peter Molenaar, Lee J. Beeley, Paul W. Young, John Kelly, Helen Chapman, Sian M. Henson, John M. Berge, David K. Dean, Nikesh R. Kotecha, Helen K. A. Morgan, Harshad K. Rami, Robert W. Ward, Mervyn Thompson, Shelagh Wilson, Stephen A. Smith, Michael A. Cawthorne, Michael J. Stock, and Jonathan R. S. Arch

The Contribution of Classical (_1/2-) and Atypical -Adrenoceptors to the Stimulation of Human White Adipocyte Lipolysis and Right Atrial Appendage Contraction by Novel ₃-Adrenoceptor Agonists of Differing Selectivities
J Pharmacol Exp Ther 1998 285: 1084-1095. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Andrea Vaccari, Luca Ferraro, Pierluigi Saba, Stefania Ruiu, Ignazia Mocci, Tiziana Antonelli, and Sergio Tanganelli

Differential Mechanisms in the Effects of Disulfiram and Diethyldithiocarbamate Intoxication on Striatal Release and Vesicular Transport of Glutamate
J Pharmacol Exp Ther 1998 285: 961-967. [Abstract] [Full Text] [PDF]  

Hugh M. Marston, Keith Finlayson, Takuya Maemoto, Henry J. Olverman, Atsushi Akahane, John Sharkey, and Steven P. Butcher

Pharmacological Characterization of a Simple Behavioral Response Mediated Selectively by Central Adenosine A₁ Receptors, Using In Vivo and In Vitro Techniques
J Pharmacol Exp Ther 1998 285: 1023-1030. [Abstract] [Full Text] [PDF]  

M. Foster Olive, Wesley F. Seidel, and Dale M. Edgar

Compensatory Sleep Responses to Wakefulness Induced by the Dopamine Autoreceptor Antagonist ()DS121
J Pharmacol Exp Ther 1998 285: 1073-1083. [Abstract] [Full Text] [PDF]  

S. Stevens Negus, Michael B. Gatch, and Nancy K. Mello

Discriminative Stimulus Effects of a Cocaine/Heroin "Speedball" Combination in Rhesus Monkeys
J Pharmacol Exp Ther 1998 285: 1123-1136. [Abstract] [Full Text] [PDF]  

Jennifer W. Tidey and and Jack Bergman

Drug Discrimination in Methamphetamine-Trained Monkeys: Agonist and Antagonist Effects of Dopaminergic Drugs
J Pharmacol Exp Ther 1998 285: 1163-1174. [Abstract] [Full Text] [PDF]  

Maria Grazia Giovannini, Ilaria Ceccarelli, Beatrice Molinari, Marco Cecchi, Joseph Goldfarb, and Patrizio Blandina

Serotonergic Modulation of Acetylcholine Release from Cortex of Freely Moving Rats
J Pharmacol Exp Ther 1998 285: 1219-1225. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Rachel M. Priest, Thomas P. Robertson, Richard M. Leach, and Jeremy P. T. Ward

Membrane Potential-Dependent and -Independent Vasodilation in Small Pulmonary Arteries from Chronically Hypoxic Rats
J Pharmacol Exp Ther 1998 285: 975-982. [Abstract] [Full Text] [PDF]  

Kenneth S. Kilgore, Keith B. Naylor, Elaine J. Tanhehco, James L. Park, Erin A. Booth, Ruth A. Washington, and Benedict R. Lucchesi

The Semisynthetic Polysaccharide Pentosan Polysulfate Prevents Complement-Mediated Myocardial Injury in the Rabbit Perfused Heart
J Pharmacol Exp Ther 1998 285: 987-994. [Abstract] [Full Text] [PDF]  

Fatimunnisa Qadri, Thomas Waldmann, Achim Wolf, Susanne Höhle, Wolfgang Rascher, and Thomas Unger

Differential Contribution of Angiotensinergic and Cholinergic Receptors in the Hypothalamic Paraventricular Nucleus to Osmotically Induced AVP Release
J Pharmacol Exp Ther 1998 285: 1012-1018. [Abstract] [Full Text] [PDF]  

Motoki Hara, Peter Danilo Jr., and Michael R. Rosen

Effects of Gonadal Steroids on Ventricular Repolarization and on the Response to E4031
J Pharmacol Exp Ther 1998 285: 1068-1072. [Abstract] [Full Text] [PDF]  

Arpad Tosaki, Nilanjana Maulik, Gary T. Elliott, Ingolf E. Blasig, Richard M. Engelman, and Dipak K. Das

Preconditioning of Rat Heart with Monophosphoryl Lipid A: A Role for Nitric Oxide
J Pharmacol Exp Ther 1998 285: 1274-1279. [Abstract] [Full Text] [PDF]  

Yoshiyuki Muranaka, Yasundo Yamasaki, Yoshihisa Nozawa, Hiroshi Terakawa, Yasutaka Tanahashi, Nobuyuki Oda, Atsushi Satoh, Tetsuji Asao, Hidekazu Miyake, and Naosuke Matsuura

TAS-301, an Inhibitor of Smooth Muscle Cell Migration and Proliferation, Inhibits Intimal Thickening after Balloon Injury to Rat Carotid Arteries
J Pharmacol Exp Ther 1998 285: 1280-1286. [Abstract] [Full Text] [PDF]  

Rodney A. Bednar, S. Lee Gaul, Terence G. Hamill, Melissa S. Egbertson, Jules A. Shafer, George D. Hartman, Robert J. Gould, and Bohumil Bednar

Identification of Low Molecular Weight GP IIb/IIIa Antagonists That Bind Preferentially to Activated Platelets
J Pharmacol Exp Ther 1998 285: 1317-1326. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

B. F. King, S. S. Wildman, A. Townsend-Nicholson, and G. Burnstock

Antagonism of an Adenosine/ATP Receptor in Follicular Xenopus Oocytes
J Pharmacol Exp Ther 1998 285: 1005-1011. [Abstract] [Full Text] [PDF]  

William F. Hopkins

Toxin and Subunit Specificity of Blocking Affinity of Three Peptide Toxins for Heteromultimeric, Voltage-Gated Potassium Channels Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 1998 285: 1051-1060. [Abstract] [Full Text] [PDF]  

Matthew W. Hill, P. Amruta Reddy, Douglas F. Covey, and Steven M. Rothman

Inhibition of Voltage-Dependent Sodium Channels by the Anticonvulsant -Aminobutyric Acid Type A Receptor Modulator, 3-Benzyl-3-Ethyl-2-Piperidinone
J Pharmacol Exp Ther 1998 285: 1303-1309. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Raymond Paul, Sandra Silve, Nathalie De Nys, Pascal-Henry Dupuy, Christine Labit-Le Bouteiller, Jorge Rosenfeld, Pascual Ferrara, Gérard Le Fur, Pierre Casellas, and Gérard Loison

Both the Immunosuppressant SR31747 and the Antiestrogen Tamoxifen Bind to an Emopamil-Insensitive Site of Mammalian 8-7 Sterol Isomerase
J Pharmacol Exp Ther 1998 285: 1296-1302. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Oliver Yoa-Pu Hu, Hung-Shang Tang, Hsien-Yuan Lane, Wen-Ho Chang, and Teh-Min Hu

Novel Single-Point Plasma or Saliva Dextromethorphan Method for Determining CYP2D6 Activity
J Pharmacol Exp Ther 1998 285: 955-960. [Abstract] [Full Text] [PDF]  

Kazuya Matsuura, Akira Hara, Makiko Kato, Yoshihiro Deyashiki, Yoshiyuki Miyabe, Syuhei Ishikura, Tadashi Sugiyama, and Yoshihiro Katagiri

Activation of Human Liver 3-Hydroxysteroid Dehydrogenase by Clofibrate Derivatives
J Pharmacol Exp Ther 1998 285: 1096-1103. [Abstract] [Full Text] [PDF]  

Alfonso Lampen, Yuanchao Zhang, Ina Hackbarth, Leslie Z. Benet, Karl-Fr. Sewing, and Uwe Christians

Metabolism and Transport of the Macrolide Immunosuppressant Sirolimus in the Small Intestine
J Pharmacol Exp Ther 1998 285: 1104-1112. [Abstract] [Full Text] [PDF]  

Masanori Takagi, Yoko Taki, Toshiyasu Sakane, Tanekazu Nadai, Hitoshi Sezaki, Naoto Oku, and Shinji Yamashita

A New Interpretation of Salicylic Acid Transport across the Lipid Bilayer: Implications of pH-Dependent but not Carrier-Mediated Absorption from the Gastrointestinal Tract
J Pharmacol Exp Ther 1998 285: 1175-1180. [Abstract] [Full Text] [PDF]  

Hiroyuki Kusuhara, Hiroshi Suzuki, Mikihiko Naito, Takashi Tsuruo, and Yuichi Sugiyama

Characterization of Efflux Transport of Organic Anions in a Mouse Brain Capillary Endothelial Cell Line
J Pharmacol Exp Ther 1998 285: 1260-1265. [Abstract] [Full Text] [PDF]  

Jun Gu, Qing-Yu Zhang, Mary Beth Genter, Thomas W. Lipinskas, Masahiko Negishi, Daniel W. Nebert, and Xinxin Ding

Purification and Characterization of Heterologously Expressed Mouse CYP2A5 and CYP2G1: Role in Metabolic Activation of Acetaminophen and 2,6-Dichlorobenzonitrile in Mouse Olfactory Mucosal Microsomes
J Pharmacol Exp Ther 1998 285: 1287-1295. [Abstract] [Full Text] [PDF]  

Pnina K. Powell, Imre Wolf, Rongyu Jin, and Jerome M. Lasker

Metabolism of Arachidonic Acid to 20-Hydroxy-5,8,11,14-eicosatetraenoic Acid by P450 Enzymes in Human Liver: Involvement of CYP4F2 and CYP4A11
J Pharmacol Exp Ther 1998 285: 1327-1336. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Manuela Marcoli, Guido Maura, Massimo Tortarolo, and Maurizio Raiteri

Trazodone is a Potent Agonist at 5-HT_2C Receptors Mediating Inhibition of the N-Methyl-D-Aspartate/Nitric Oxide/Cyclic GMP Pathway in Rat Cerebellum
J Pharmacol Exp Ther 1998 285: 983-986. [Abstract] [Full Text] [PDF]  

Eckart Krupp and Wolfgang Löscher

Anticonvulsant Drug Effects in the Direct Cortical Ramp-Stimulation Model in Rats: Comparison with Conventional Seizure Models
J Pharmacol Exp Ther 1998 285: 1137-1149. [Abstract] [Full Text] [PDF]  

Genoveva Davidkova, Long-Wu Zhou, Mark Morabito, Sui-Po Zhang, and Benjamin Weiss

D₂ Dopamine Antisense RNA Expression Vector, Unlike Haloperidol, Produces Long-term Inhibition of D₂ Dopamine-Mediated Behaviors without Causing Up-regulation of D₂ Dopamine Receptors
J Pharmacol Exp Ther 1998 285: 1187-1196. [Abstract] [Full Text] [PDF]  

Isabel J. M. Beresford, Christopher Browning, Sarah J. Starkey, Jason Brown, Steven M. Foord, Josephine Coughlan, Peter C. North, Margarita L. Dubocovich, and Russell M. Hagan

GR196429: A Nonindolic Agonist at High-Affinity Melatonin Receptors
J Pharmacol Exp Ther 1998 285: 1239-1245. [Abstract] [Full Text] [PDF]  

J. B. Daunais, S. L. Hart, H. R. Smith, S. R. Letchworth, H. M. L. Davies, T. Sexton, B.A. Bennett, S. R. Childers, and L. J. Porrino

Long-Acting Blockade of Biogenic Amine Transporters in Rat Brain by Administration of the Potent Novel Tropane 2-Propanoyl-3-(2-Naphthyl)-Tropane
J Pharmacol Exp Ther 1998 285: 1246-1254. [Abstract] [Full Text] [PDF]  

M. Foster Olive and Nigel T. Maidment

Opioid Regulation of Pallidal Enkephalin Release: Bimodal Effects of Locally Administered Mu and Delta Opioid Agonists in Freely Moving Rats
J Pharmacol Exp Ther 1998 285: 1310-1316. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

H. J. Showell, M. J. Conklyn, R. Alpert, G. P. Hingorani, K. F. Wright, M. A. Smith, E. Stam, E. D. Salter, D. N. Scampoli, S. Meltzer, L. A. Reiter, K. Koch, A. D. Piscopio, S. R. Cortina, A. Lopez-Anaya, E. R. Pettipher, A. J. Milici, and R. J. Griffiths

The Preclinical Pharmacological Profile of the Potent and Selective Leukotriene B₄ Antagonist CP-195543
J Pharmacol Exp Ther 1998 285: 946-954. [Abstract] [Full Text] [PDF]  

Lorraine Mcmurdo, Alan H. Stephenson, Joseph J. Baldassare, Randy S. Sprague, and Andrew J. Lonigro

Biosynthesis of Sulfidopeptide Leukotrienes Via the Transfer of Leukotriene A₄ from Polymorphonuclear Cells to Bovine Retinal Pericytes
J Pharmacol Exp Ther 1998 285: 1255-1259. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Mi Hyun Kim, Sun-Hee Kim, Hyun Sook Kim, Jai Won Chang, Yoo Sun Hong, Hae Won Kim, and Chun Sik Park

Regulation of Renin Secretion Through Reversible Phosphorylation of Myosin by Myosin Light Chain Kinase and Protein Phosphatase Type 1
J Pharmacol Exp Ther 1998 285: 968-974. [Abstract] [Full Text] [PDF]  

Richard M. Edwards, Elwood J. Stack, and Walter Trizna

Interaction of L-Arginine Analogs with L-Arginine Uptake in Rat Renal Brush Border Membrane Vesicles
J Pharmacol Exp Ther 1998 285: 1019-1022. [Abstract] [Full Text] [PDF]  

Th. Hauet, G. Bauza, J. M. Goujon, J. C. Caritez, M. Carretier, M. Eugene, and J. P. Tillement

Effects of Trimetazidine on Lipid Peroxidation and Phosphorus Metabolites during Cold Storage and Reperfusion of Isolated Perfused Rat Kidneys
J Pharmacol Exp Ther 1998 285: 1061-1067. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Lawrence H. Lash, David A. Putt, and Rudolfs K. Zalups

Role of Extracellular Thiols in Accumulation and Distribution of Inorganic Mercury in Rat Renal Proximal and Distal Tubular Cells
J Pharmacol Exp Ther 1998 285: 1039-1050. [Abstract] [Full Text] [PDF]  

Aron D. Ross, Indranil Dey, Nathan Janes, and Yedy Israel

Effect of Antithyroid Drugs on Hydroxyl Radical Formation and -1-Proteinase Inhibitor Inactivation by Neutrophils: Therapeutic Implications
J Pharmacol Exp Ther 1998 285: 1233-1238. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction for vol. 283, p. 704
J Pharmacol Exp Ther 1998 285: 1336. [Full Text] [PDF]  

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