ANALGESIA AND DRUGS OF ABUSE:

Yuri Kolesnikov, Subash Jain, Roger Wilson, and Gavril W. Pasternak

Lack of Morphine and Enkephalin Tolerance in 129/SvEv Mice: Evidence for a NMDA Receptor Defect
J Pharmacol Exp Ther 1998 284: 455-459. [Abstract] [Full Text] [PDF]  

Laura M. Harrison, Abba J. Kastin, and James E. Zadina

Tyr-W-MIF-1 Attenuates Down-Regulation of Opiate Receptors in SH-SY5Y Human Neuroblastoma Cells
J Pharmacol Exp Ther 1998 284: 611-617. [Abstract] [Full Text] [PDF]  

David P. D. Woldbye, Kristian Klemp, and Torsten M. Madsen

Neuropeptide Y Attenuates Naloxone-Precipitated Morphine Withdrawal via Y5-like Receptors
J Pharmacol Exp Ther 1998 284: 633-636. [Abstract] [Full Text] [PDF]  

Stuart A. Dunbar and Istvan J. Pulai

Repetitive Opioid Abstinence Causes Progressive Hyperalgesia Sensitive to N-Methyl-D-aspartate Receptor Blockade in the Rat
J Pharmacol Exp Ther 1998 284: 678-686. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Wolfgang Löscher, Dagmar Hönack, and Chris Rundfeldt

Antiepileptogenic Effects of the Novel Anticonvulsant Levetiracetam (ucb L059) in the Kindling Model of Temporal Lobe Epilepsy
J Pharmacol Exp Ther 1998 284: 474-479. [Abstract] [Full Text] [PDF]  

Peter Clausing, Glenn D. Newport, and John F. Bowyer

Fenfluramine and Norfenfluramine Levels in Brain Microdialysate, Brain Tissue and Plasma of Rats Administered Doses of d-Fenfluramine Known to Deplete 5-Hydroxytryptamine Levels in Brain
J Pharmacol Exp Ther 1998 284: 618-624. [Abstract] [Full Text] [PDF]  

David R. Helton, Joseph P. Tizzano, James A. Monn, Darryle D. Schoepp, and Mary Jeanne Kallman

Anxiolytic and Side-Effect Profile of LY354740: A Potent, Highly Selective, Orally Active Agonist for Group II Metabotropic Glutamate Receptors
J Pharmacol Exp Ther 1998 284: 651-660. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Hiromu Kawasaki, Makoto Takenaga, Hiroaki Araki, Kojirou Futagami, and Yutaka Gomita

Angiotensin Inhibits Neurotransmission of Calcitonin Gene-Related Peptide-Containing Vasodilator Nerves in Mesenteric Artery of Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 1998 284: 508-515. [Abstract] [Full Text] [PDF]  

Zhenguo Liu, M. Audrey Rudd, Jane E. Freedman, and Joseph Loscalzo

S-Transnitrosation Reactions Are Involved in the Metabolic Fate and Biological Actions of Nitric Oxide
J Pharmacol Exp Ther 1998 284: 526-534. [Abstract] [Full Text] [PDF]  

Giuseppe Alloatti, Claudia Penna, Maria Pia Gallo, Renzo C. Levi, Ezio Bombardelli, and Giovanni Appendino

Differential Effects of Paclitaxel and Derivatives on Guinea Pig Isolated Heart and Papillary Muscle
J Pharmacol Exp Ther 1998 284: 561-567. [Abstract] [Full Text] [PDF]  

Eugene Patterson, Lianmin Ma, Bela Szabo, Casey P. Robinson, and Udho Thadani

Ovariectomy and Estrogen-Induced Alterations in Myocardial Contractility in Female Rabbits: Role of the L-Type Calcium Channel
J Pharmacol Exp Ther 1998 284: 586-591. [Abstract] [Full Text] [PDF]  

Kishor M. Wasan, Manisha Ramaswamy, Wesley Wong, and P. Haydn Pritchard

Lipid Transfer Protein I Facilitated Transfer of Cyclosporine from Low- to High-Density Lipoproteins is Only Partially Dependent on its Cholesteryl Ester Transfer Activity
J Pharmacol Exp Ther 1998 284: 599-605. [Abstract] [Full Text] [PDF]  

Lifan Zhao and Randall L. Tackett

Oxidized Low-Density Lipoprotein Inhibits Acetylcholine-Induced Vasorelaxation and Increases 5-HT-Induced Vasoconstriction in Isolated Human Saphenous Vein
J Pharmacol Exp Ther 1998 284: 637-643. [Abstract] [Full Text] [PDF]  

Peter Baluk, Natasha W. Fine, Holly A. Thomas, Edward T. Wei, and Donald M. Mcdonald

Anti-inflammatory Mystixin Peptides Inhibit Plasma Leakage Without Blocking Endothelial Gap Formation
J Pharmacol Exp Ther 1998 284: 693-699. [Abstract] [Full Text] [PDF]  

W. Zhang, L. Edvinsson, and Tony J-F. Lee

Mechanism of Nicotine-Induced Relaxation in the Porcine Basilar Artery
J Pharmacol Exp Ther 1998 284: 790-797. [Abstract] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Ildiko Kovacs, Henry I. Yamamura, Sue L. Waite, Eva V. Varga, and William R. Roeske

Pharmacological Comparison of the Cloned Human and Rat M2 Muscarinic Receptor Genes Expressed in the Murine Fibroblast (B82) Cell Line
J Pharmacol Exp Ther 1998 284: 500-507. [Abstract] [Full Text] [PDF]  

G. Jeglitsch, K. Rein, D. G. Baden, and D. J. Adams

Brevetoxin-3 (PbTx-3) and Its Derivatives Modulate Single Tetrodotoxin-Sensitive Sodium Channels in Rat Sensory Neurons
J Pharmacol Exp Ther 1998 284: 516-525. [Abstract] [Full Text] [PDF]  

Ying Ruan, Hong Kan, Jean-Hugues Parmentier, Soghra Fatima, Lee F. Allen, and Kafait U. Malik

Alpha-1A Adrenergic Receptor Stimulation with Phenylephrine Promotes Arachidonic Acid Release by Activation of Phospholipase D in Rat-1 Fibroblasts: Inhibition by Protein Kinase A
J Pharmacol Exp Ther 1998 284: 576-585. [Abstract] [Full Text] [PDF]  

Lihjen Sun, Louis H. Philipson, and Richard J. Miller

Regulation of K⁺ and Ca⁺⁺ Channels by a Family of Neuropeptide Y Receptors
J Pharmacol Exp Ther 1998 284: 625-632. [Abstract] [Full Text] [PDF]  

Murielle Rinaldi-Carmona, Francis Barth, José Millan, Jean-Marie Derocq, Pierre Casellas, Christian Congy, Didier Oustric, Martine Sarran, Monsif Bouaboula, Bernard Calandra, Marielle Portier, David Shire, Jean-Claude Brelière, and Gérard Le Fur

SR 144528, the First Potent and Selective Antagonist of the CB2 Cannabinoid Receptor
J Pharmacol Exp Ther 1998 284: 644-650. [Abstract] [Full Text] [PDF]  

Sherry L. Purkerson and Lincoln T. Potter

Use of Antimuscarinic Toxins To Facilitate Studies of Striatal m4 Muscarinic Receptors
J Pharmacol Exp Ther 1998 284: 707-713. [Abstract] [Full Text] [PDF]  

Paul W. Young, Derek R. Buckle, Barrie C. C. Cantello, Helen Chapman, John C. Clapham, Paul J. Coyle, David Haigh, Richard M. Hindley, Julie C. Holder, Howard Kallender, Alison J. Latter, Kenneth W. M. Lawrie, Danuta Mossakowska, Gregory J. Murphy, Lynne Roxbee Cox, and Stephen A. Smith

Identification of High-Affinity Binding Sites for the Insulin Sensitizer Rosiglitazone (BRL-49653) in Rodent and Human Adipocytes Using a Radioiodinated Ligand for Peroxisomal Proliferator-Activated Receptor
J Pharmacol Exp Ther 1998 284: 751-759. [Abstract] [Full Text] [PDF]  

Douglas W. Sapp and Hermes H. Yeh

Ethanol-GABA_A Receptor Interactions: A Comparison between Cell Lines and Cerebellar Purkinje Cells
J Pharmacol Exp Ther 1998 284: 768-776. [Abstract] [Full Text] [PDF]  

Kenneth A. Stauderman, L. Scott Mahaffy, Michael Akong, Gönül Veliçelebi, Laura E. Chavez-Noriega, James H. Crona, Edwin C. Johnson, Kathryn J. Elliott, Alison Gillespie, Richard T. Reid, Pamala Adams, Michael M. Harpold, and Janis Corey-Naeve

Characterization of Human Recombinant Neuronal Nicotinic Acetylcholine Receptor Subunit Combinations 24, 34 and 44 Stably Expressed in HEK293 Cells
J Pharmacol Exp Ther 1998 284: 777-789. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Masahiko Kurokawa, Toyoharu Hozumi, Purusotam Basnet, Michio Nakano, Shigetoshi Kadota, Tuneo Namba, Takashi Kawana, and Kimiyasu Shiraki

Purification and Characterization of Eugeniin as an Anti-herpesvirus Compound from Geum japonicum and Syzygium aromaticum
J Pharmacol Exp Ther 1998 284: 728-735. [Abstract] [Full Text] [PDF]  

DEVELOPMENTAL PHARMACOLOGY:

John A. Ring, Hany Ghabrial, Michael S. Ching, Arthur Shulkes, Richard A. Smallwood, and Denis J. Morgan

Propranolol Elimination by Right and Left Fetal Liver: Studies in the Intact Isolated Perfused Fetal Sheep Liver
J Pharmacol Exp Ther 1998 284: 535-541. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Katsunori Nakamura, Tsuyoshi Yokoi, Takao Kodama, Kazuaki Inoue, Kazuo Nagashima, Noriaki Shimada, Toshiaki Shimizu, and Tetsuya Kamataki

Oxidation of Histamine H1 Antagonist Mequitazine is Catalyzed by Cytochrome P450 2D6 in Human Liver Microsomes
J Pharmacol Exp Ther 1998 284: 437-442. [Abstract] [Full Text] [PDF]  

O. E. Della Paschoa, J. W. Mandema, R. A. Voskuyl, and M. Danhof

Pharmacokinetic-Pharmacodynamic Modeling of the Anticonvulsant and Electroencephalogram Effects of Phenytoin in Rats
J Pharmacol Exp Ther 1998 284: 460-466. [Abstract] [Full Text] [PDF]  

Wanping Geng, Andreas J. Schwab, Tohru Horie, Carl A. Goresky, and K. Sandy Pang

Hepatic Uptake of Bromosulfophthalein-Glutathione in Perfused Eisai Hyperbilirubinemic Mutant Rat Liver: A Multiple-Indicator Dilution Study
J Pharmacol Exp Ther 1998 284: 480-492. [Abstract] [Full Text] [PDF]  

Marc Levine, Eva Y. W. Law, Stelvio M. Bandiera, Thomas K. H. Chang, and Gail D. Bellward

In Vivo Cimetidine Inhibits Hepatic CYP2C6 and CYP2C11 but Not CYP1A1 in Adult Male Rats^,
J Pharmacol Exp Ther 1998 284: 493-499. [Abstract] [Full Text] [PDF]  

Hiroyuki Sasabe, Yukio Kato, Akira Tsuji, and Yuichi Sugiyama

Stereoselective Hepatobiliary Transport of the Quinolone Antibiotic Grepafloxacin and Its Glucuronide in the Rat
J Pharmacol Exp Ther 1998 284: 661-668. [Abstract] [Full Text] [PDF]  

M. Teresa Donato, M. José Gómez-Lechón, Ramiro Jover, Toshikazu Nakamura, and José V. Castell

Human Hepatocyte Growth Factor Down-regulates the Expression of Cytochrome P450 Isozymes in Human Hepatocytes in Primary Culture
J Pharmacol Exp Ther 1998 284: 760-767. [Abstract] [Full Text] [PDF]  

ENDOCRINE PHARMACOLOGY:

Marcos R. Difalco, Line Dufresne, and Luis Fernando Congote

Efficacy of an Insulin-Like Growth Factor-Interleukin-3 Fusion Protein in Reversing the Hematopoietic Toxicity Associated with Azidothymidine in Mice
J Pharmacol Exp Ther 1998 284: 449-454. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

Cormac T. Taylor, Steven J. Lisco, Christopher S. Awtrey, and Sean P. Colgan

Hypoxia Inhibits Cyclic Nucleotide-Stimulated Epithelial Ion Transport: Role for Nucleotide Cyclases as Oxygen Sensors
J Pharmacol Exp Ther 1998 284: 568-575. [Abstract] [Full Text] [PDF]  

Satoshi Aiko, John Fuseler, and Matthew B. Grisham

Effects of Nitric Oxide Synthase Inhibition or Sulfasalazine on the Spontaneous Colitis Observed in HLA-B27 Transgenic Rats
J Pharmacol Exp Ther 1998 284: 722-727. [Abstract] [Full Text] [PDF]  

Pascal Nicole, Kai Du, Alain Couvineau, and Marc Laburthe

Site-Directed Mutagenesis of Human Vasoactive Intestinal Peptide Receptor Subtypes VIP1 and VIP2: Evidence for Difference in the Structure-Function Relationship
J Pharmacol Exp Ther 1998 284: 744-750. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

Jeffrey R. Jackson, Brian Bolognese, Leonard Hillegass, Shouki Kassis, Jerry Adams, Don E. Griswold, and James D. Winkler

Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models
J Pharmacol Exp Ther 1998 284: 687-692. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Masayasu Takahashi, Jian Wei Ni, Sachiko Kawasaki-Yatsugi, Takashi Toya, Sin-Ichi Yatsugi, Masao Shimizu-Sasamata, Kazuo Koshiya, Jun-Ichi Shishikura, Shuichi Sakamoto, and Tokio Yamaguchi

YM872, a Novel Selective -Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Antagonist, Reduces Brain Damage after Permanent Focal Cerebral Ischemia in Cats
J Pharmacol Exp Ther 1998 284: 467-473. [Abstract] [Full Text] [PDF]  

Russell A. Wilke, Shyue-Fang Hsu, and Meyer B. Jackson

Dopamine D₄ Receptor Mediated Inhibition of Potassium Current in Neurohypophysial Nerve Terminals
J Pharmacol Exp Ther 1998 284: 542-548. [Abstract] [Full Text] [PDF]  

David T. Ault, Julie M. Radeff, and Linda L. Werling

Modulation of [³H]Dopamine Release from Rat Nucleus Accumbens by Neuropeptide Y May Involve a Sigma₁-like Receptor
J Pharmacol Exp Ther 1998 284: 553-560. [Abstract] [Full Text] [PDF]  

L. Kantor and M. E. Gnegy

Protein Kinase C Inhibitors Block Amphetamine-Mediated Dopamine Release in Rat Striatal Slices
J Pharmacol Exp Ther 1998 284: 592-598. [Abstract] [Full Text] [PDF]  

Catherine Mytilineou, Efthimia Kototos Leonardi, Pheona Radcliffe, Esa H. Heinonen, Shan-Kuo Han, Peter Werner, Gerald Cohen, and C. Warren Olanow

Deprenyl and Desmethylselegiline Protect Mesencephalic Neurons from Toxicity Induced by Glutathione Depletion
J Pharmacol Exp Ther 1998 284: 700-706. [Abstract] [Full Text] [PDF]  

Lauren P. Shearman and Jerrold S. Meyer

Norepinephrine Transporters in Rat Placenta Labeled with [³H]Nisoxetine
J Pharmacol Exp Ther 1998 284: 736-743. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Daniel S. Fletcher, W. Richard Widmer, Silvi Luell, Amy Christen, Chad Orevillo, Shrenik Shah, and Denise Visco

Therapeutic Administration of a Selective Inhibitor of Nitric Oxide Synthase Does Not Ameliorate the Chronic Inflammation and Tissue Damage Associated with Adjuvant-Induced Arthritis in Rats
J Pharmacol Exp Ther 1998 284: 714-721. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

Randy S. Sprague, Alan H. Stephenson, Lorraine Mcmurdo, and Andrew J. Lonigro

Nitric Oxide Opposes Phorbol Ester-Induced Increases in Pulmonary Microvascular Permeability in Dogs
J Pharmacol Exp Ther 1998 284: 443-448. [Abstract] [Full Text] [PDF]  

Isabelle Gorenne, Carlos Labat, Jean-Pierre Gascard, Xavier Norel, Nabila Nashashibi, and Charles Brink

Leukotriene D₄ Contractions in Human Airways are Blocked by SK&F 96365, an Inhibitor of Receptor-Mediated Calcium Entry
J Pharmacol Exp Ther 1998 284: 549-552. [Abstract] [Full Text] [PDF]  

Douglas W. P. Hay, Mark A. Luttmann, Mark A. Pullen, and Ponnal Nambi

Functional and Binding Characterization of Endothelin Receptors in Human Bronchus: Evidence for a Novel Endothelin B Receptor Subtype?
J Pharmacol Exp Ther 1998 284: 669-677. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Laura Trumper, Liliana A. Monasterolo, and M. Mónica Elías

Probenecid Protects against In Vivo Acetaminophen-Induced Nephrotoxicity in Male Wistar Rats
J Pharmacol Exp Ther 1998 284: 606-610. [Abstract] [Full Text] [PDF]  

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