ANALGESIA AND DRUGS OF ABUSE:

Yong-Fu Xiao and James P. Morgan

Cocaine Blockade of the Acetylcholine-Activated Muscarinic K⁺ Channel in Ferret Cardiac Myocytes
J Pharmacol Exp Ther 1998 284: 10-18. [Abstract] [Full Text] [PDF]  

Zheng-Xiong Xi, Scott A. Fuller, and Elliot A. Stein

Dopamine Release in the Nucleus Accumbens during Heroin Self-Administration Is Modulated by Kappa Opioid Receptors: An In Vivo Fast-Cyclic Voltammetry Study
J Pharmacol Exp Ther 1998 284: 151-161. [Abstract] [Full Text] [PDF]  

Jimmy Y. Xu, Kevin P. Hill, and Jean M. Bidlack

The Nitric Oxide/Cyclic GMP System at the Supraspinal Site Is Involved in the Development of Acute Morphine Antinociceptive Tolerance^,
J Pharmacol Exp Ther 1998 284: 196-201. [Abstract] [Full Text] [PDF]  

George Bot, Allan D. Blake, Shuixing Li, and Terry Reisine

Mutagenesis of the Mouse Delta Opioid Receptor Converts ()-Buprenorphine from a Partial Agonist to an Antagonist
J Pharmacol Exp Ther 1998 284: 283-290. [Abstract] [Full Text] [PDF]  

Christian C. Felder, Kelly E. Joyce, Eileen M. Briley, Michelle Glass, Kenneth P. Mackie, Kennan J. Fahey, George J. Cullinan, David C. Hunden, Douglas W. Johnson, Michael O. Chaney, Gary A. Koppel, and Michael Brownstein

LY320135, a Novel Cannabinoid CB1 Receptor Antagonist, Unmasks Coupling of the CB1 Receptor to Stimulation of cAMP Accumulation
J Pharmacol Exp Ther 1998 284: 291-297. [Abstract] [Full Text] [PDF]  

Donna L. Hammond, Huilan Wang, Nora Nakashima, and Allan I. Basbaum

Differential Effects of Intrathecally Administered Delta and Mu Opioid Receptor Agonists on Formalin-Evoked Nociception and on the Expression of Fos-like Immunoreactivity in the Spinal Cord of the Rat
J Pharmacol Exp Ther 1998 284: 378-387. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

Gregory W. Sawyer and Frederick J. Ehlert

Contractile Roles of the M₂ and M₃ Muscarinic Receptors in the Guinea Pig Colon
J Pharmacol Exp Ther 1998 284: 269-277. [Abstract] [Full Text] [PDF]  

José Melena, Juan Santafé, and José Segarra

The Effect of Topical Diltiazem on the Intraocular Pressure in Betamethasone-Induced Ocular Hypertensive Rabbits
J Pharmacol Exp Ther 1998 284: 278-282. [Abstract] [Full Text] [PDF]  

Frank R. M. Stassen, Roel G. H. T. Maas, Paul M. H. Schiffers, Ger M. J. Janssen, and Jo G. R. De Mey

A Positive and Reversible Relationship Between Adrenergic Nerves and Alpha-1A Adrenoceptors in Rat Arteries
J Pharmacol Exp Ther 1998 284: 399-405. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Susan A. Vanecek, William D. Essman, Duncan P. Taylor, and James H. Woods

Discriminative Stimulus Characteristics of BMY 14802 in the Pigeon
J Pharmacol Exp Ther 1998 284: 1-9. [Abstract] [Full Text] [PDF]  

Ezio Tirelli, Beth Geter-Douglass, and Jeffrey M. Witkin

-Aminobutyric Acid_A Agonists Differentially Augment Gnawing Induced by Indirect-Acting Dopamine Agonists in C57BL/6J Mice
J Pharmacol Exp Ther 1998 284: 116-124. [Abstract] [Full Text] [PDF]  

Mark S. Kleven and Wouter Koek

Discriminative Stimulus Effects of 8-Hydroxy-2-(di-n-propylamino)tetralin in Pigeons and Rats: Species Similarities and Differences
J Pharmacol Exp Ther 1998 284: 238-249. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Teruhisa Ichihashi, Mariko Izawa, Kenji Miyata, Takuji Mizui, Koichiro Hirano, and Yasushi Takagishi

Mechanism of Hypocholesterolemic Action of S-8921 in Rats: S-8921 Inhibits Ileal Bile Acid Absorption
J Pharmacol Exp Ther 1998 284: 43-50. [Abstract] [Full Text] [PDF]  

Lev Protas, Jian-Bing Shen, and Achilles J. Pappano

Carbachol Increases Contractions and Intracellular Ca⁺⁺ Transients in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 1998 284: 66-74. [Abstract] [Full Text] [PDF]  

Renhui Yang, Stuart Bunting, Annie Ko, Bruce A. Keyt, Nishit B. Modi, Thomas F. Zioncheck, Napoleone Ferrara, and Hongkui Jin

Substantially Attenuated Hemodynamic Responses to Escherichia coli-Derived Vascular Endothelial Growth Factor Given by Intravenous Infusion Compared with Bolus Injection
J Pharmacol Exp Ther 1998 284: 103-110. [Abstract] [Full Text] [PDF]  

Nobuya Matsuoka, Hiroyuki Arakawa, Hiroshi Kodama, and Isamu Yamaguchi

Characterization of Stress-Induced Sudden Death in Cardiomyopathic Hamsters
J Pharmacol Exp Ther 1998 284: 125-135. [Abstract] [Full Text] [PDF]  

John Wharton, Kevin Morgan, Richard A. D. Rutherford, John D. Catravas, Adrian Chester, Bruce F. Whitehead, Marc R. De Leval, Magdi H. Yacoub, and Julia M. Polak

Differential Distribution of Angiotensin AT₂ Receptors in the Normal and Failing Human Heart
J Pharmacol Exp Ther 1998 284: 323-336. [Abstract] [Full Text] [PDF]  

Jennifer A. Florian and Stephanie W. Watts

Integration of Mitogen-Activated Protein Kinase Kinase Activation in Vascular 5-Hydroxytryptamine_2A Receptor Signal Transduction
J Pharmacol Exp Ther 1998 284: 346-355. [Abstract] [Full Text] [PDF]  

Kenneth S. Kilgore, Elaine J. Tanhehco, James L. Park, Keith B. Naylor, Mark B. Anderson, and Benedict R. Lucchesi

Reduction of Myocardial Infarct Size In Vivo by Carbohydrate-Based Glycomimetics
J Pharmacol Exp Ther 1998 284: 427-435. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

David F. Gray, Anastasia S. Mihailidou, Peter S. Hansen, Kerrie A. Buhagiar, Nerida L. Bewick, Helge H. Rasmussen, and David W. Whalley

Amiodarone Inhibits the Na⁺-K⁺ Pump in Rabbit Cardiac Myocytes after Acute and Chronic Treatment
J Pharmacol Exp Ther 1998 284: 75-82. [Abstract] [Full Text] [PDF]  

J. L. Weiner, A. V. Buhler, V. J. Whatley, R. A. Harris, and T. V. Dunwiddie

Colchicine Is a Competitive Antagonist at Human Recombinant -Aminobutyric Acid_A Receptors
J Pharmacol Exp Ther 1998 284: 95-102. [Abstract] [Full Text] [PDF]  

Joseph J. Pancrazio, Ganesan L. Kamatchi, Amy K. Roscoe, and Carl Lynch III

Inhibition of Neuronal Na⁺ Channels by Antidepressant Drugs
J Pharmacol Exp Ther 1998 284: 208-214. [Abstract] [Full Text] [PDF]  

Alejandro M. Dopico, Vellareddy Anantharam, and Steven N. Treistman

Ethanol Increases the Activity of Ca⁺⁺-Dependent K⁺ (mslo) Channels: Functional Interaction with Cytosolic Ca⁺⁺ 
J Pharmacol Exp Ther 1998 284: 258-268. [Abstract] [Full Text] [PDF]  

Mubarack M. Muthalif, Ibrahim F. Benter, Mohammad R. Uddin, Jason L. Harper, and Kafait U. Malik

Signal Transduction Mechanisms Involved in Angiotensin-(1-7)-Stimulated Arachidonic Acid Release and Prostanoid Synthesis in Rabbit Aortic Smooth Muscle Cells
J Pharmacol Exp Ther 1998 284: 388-398. [Abstract] [Full Text] [PDF]  

DEVELOPMENTAL PHARMACOLOGY:

Andrew M. Luks, Maurice S. Zwass, Ronald C. Brown, Marie Lau, Gopal Chari, and Dennis M. Fisher

Opioid-Induced Analgesia in Neonatal Dogs: Pharmacodynamic Differences between Morphine and Fentanyl
J Pharmacol Exp Ther 1998 284: 136-141. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Hazel H. Szeto, James F. Clapp, Dominic M. Desiderio, Peter W. Schiller, Olga O. Grigoriants, Yi Soong, Dunli Wu, Niculina Olariu, Jih-Lie Tseng, and Robert Becklin

In Vivo Disposition of Dermorphin Analog (DALDA) in Nonpregnant and Pregnant Sheep
J Pharmacol Exp Ther 1998 284: 61-65. [Abstract] [Full Text] [PDF]  

Ira Bergman, Gilbert J. Burckart, Clifford R. Pohl, Raman Venkataramanan, Mamdouha A. Barmada, Judith A. Griffin, and Nai-Kong V. Cheung

Pharmacokinetics of IgG and IgM Anti-Ganglioside Antibodies in Rats and Monkeys after Intrathecal Administration
J Pharmacol Exp Ther 1998 284: 111-115. [Abstract] [Full Text] [PDF]  

B. Tuk, V. M. M. Herben, J. W. Mandema, and M. Danhof

Relevance of Arteriovenous Concentration Differences in Pharmacokinetic-Pharmacodynamic Modeling of Midazolam
J Pharmacol Exp Ther 1998 284: 202-207. [Abstract] [Full Text] [PDF]  

Ronald J. Ferguson, Sonia M.F. De Morais, Simone Benhamou, Christine Bouchardy, Joyce Blaisdell, Gordon Ibeanu, Grant R. Wilkinson, Troy C. Sarich, James M. Wright, Pierre Dayer, and Joyce A. Goldstein

A New Genetic Defect in Human CYP2C19: Mutation of the Initiation Codon Is Responsible for Poor Metabolism of S-Mephenytoin
J Pharmacol Exp Ther 1998 284: 356-361. [Abstract] [Full Text] [PDF]  

ENDOCRINE PHARMACOLOGY:

T. Österman, L. Laurén, P. Kuurtamo, R. Hannuniemi, P. Isaksson, K. Kippo, Z. Peng, H. K. Väänänen, and R. Sellman

The Effect of Orally Administered Clodronate on Bone Mineral Density and Bone Geometry in Ovariectomized Rats
J Pharmacol Exp Ther 1998 284: 312-316. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

Satoru Takahashi and Susumu Okabe

Roles of Extracellular Ca⁺⁺ and Calmodulin in Roxatidine-Stimulated Secretion and Synthesis of Mucus by Cultured Rabbit Gastric Mucosal Cells
J Pharmacol Exp Ther 1998 284: 37-42. [Abstract] [Full Text] [PDF]  

Tuulikki Lindmark, Yukitaka Kimura, and Per Artursson

Absorption Enhancement through Intracellular Regulation of Tight Junction Permeability by Medium Chain Fatty Acids in Caco-2 Cells
J Pharmacol Exp Ther 1998 284: 362-369. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

Charles I. Ezeamuzie and Mary Al-Hage

Differential Effects of Salbutamol and Salmeterol on Human Eosinophil Responses
J Pharmacol Exp Ther 1998 284: 25-31. [Abstract] [Full Text] [PDF]  

Daniel H. Albert, Peter E. Malo, Paul Tapang, Thomas K. Shaughnessy, Douglas W. Morgan, Craig D. Wegner, Michael L. Curtin, George S. Sheppard, Lianhong Xu, Steven K. Davidsen, James B. Summers, and George W. Carter

The Role of Platelet-Activating Factor (PAF) and the Efficacy of ABT-491, a Highly Potent and Selective PAF Antagonist, in Experimental Allergic Rhinitis
J Pharmacol Exp Ther 1998 284: 83-88. [Abstract] [Full Text] [PDF]  

Norihito Matsumoto, Yoshiya Aze, Akira Akimoto, and Tsuneo Fujita

ONO-4007, an Antitumor Lipid A Analog, Induces Tumor Necrosis Factor- Production by Human Monocytes Only under Primed State: Different Effects of ONO-4007 and Lipopolysaccharide on Cytokine Production
J Pharmacol Exp Ther 1998 284: 189-195. [Abstract] [Full Text] [PDF]  

Tracey A. Ignatowski and Jean M. Bidlack

Detection of Kappa Opioid Receptors on Mouse Thymocyte Phenotypic Subpopulations as Assessed by Flow Cytometry
J Pharmacol Exp Ther 1998 284: 298-306. [Abstract] [Full Text] [PDF]  

Mary S. Barnette, Siegfried B. Christensen, David M. Essayan, Marilyn Grous, Uma Prabhakar, Julia A. Rush, Anne Kagey-Sobotka, and Theodore J. Torphy

SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In Vitro Anti-inflammatory Actions
J Pharmacol Exp Ther 1998 284: 420-426. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Tina K. Machu, S. John Mihic, and J. E. Dildy-Mayfield

Selective Actions of a Detergent on Ligand-Gated Ion Channels Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 1998 284: 32-36. [Abstract] [Full Text] [PDF]  

Baojian Yu and Patricia Shinnick-Gallagher

Corticotropin-Releasing Factor Increases Dihydropyridine- and Neurotoxin-Resistant Calcium Currents in Neurons of the Central Amygdala
J Pharmacol Exp Ther 1998 284: 170-179. [Abstract] [Full Text] [PDF]  

R. Adron Harris, C. Fernando Valenzuela, Susan Brozowski, Luminita Chuang, Karen Hadingham, and Paul J. Whiting

Adaptation of -Aminobutyric Acid Type A Receptors to Alcohol Exposure: Studies with Stably Transfected Cells
J Pharmacol Exp Ther 1998 284: 180-188. [Abstract] [Full Text] [PDF]  

Keith Baker, Catherine Bucay Marcus, Karl Huffman, Henry Kruk, Bernard Malfroy, and Susan R. Doctrow

Synthetic Combined Superoxide Dismutase/Catalase Mimetics Are Protective as a Delayed Treatment in a Rat Stroke Model: A Key Role for Reactive Oxygen Species in Ischemic Brain Injury
J Pharmacol Exp Ther 1998 284: 215-221. [Abstract] [Full Text] [PDF]  

Ilan Lampl, Peter Schwindt, and Wayne Crill

Reduction of Cortical Pyramidal Neuron Excitability by the Action of Phenytoin on Persistent Na⁺ Current
J Pharmacol Exp Ther 1998 284: 228-237. [Abstract] [Full Text] [PDF]  

Andrea M. Allan, Hua Wu, Linda L. Paxton, and Daniel D. Savage

Prenatal Ethanol Exposure Alters the Modulation of the -Aminobutyric Acid_A Receptor-Gated Chloride Ion Channel in Adult Rat Offspring
J Pharmacol Exp Ther 1998 284: 250-257. [Abstract] [Full Text] [PDF]  

Edward F. Domino and Lisong Ni

Trihexyphenidyl Interactions with the Dopamine D₁-Selective Receptor Agonist SKF-82958 and the D₂-Selective Receptor Agonist N-0923 in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Hemiparkinsonian Monkeys
J Pharmacol Exp Ther 1998 284: 307-311. [Abstract] [Full Text] [PDF]  

Jeong-Hoon Kim and Paul Vezina

Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens Contribute to Amphetamine-Induced Locomotion
J Pharmacol Exp Ther 1998 284: 317-322. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Johan Bylund, Tina Kunz, Karin Valmsen, and Ernst H. Oliw

Cytochromes P450 with Bisallylic Hydroxylation Activity on Arachidonic and Linoleic Acids Studied with Human Recombinant Enzymes and with Human and Rat Liver Microsomes
J Pharmacol Exp Ther 1998 284: 51-60. [Abstract] [Full Text] [PDF]  

Stuart L. Bursten, David Federighi, Jeffrey Wald, Brent Meengs, William Spickler, and Edward Nudelman

Lisofylline Causes Rapid and Prolonged Suppression of Serum Levels of Free Fatty Acids
J Pharmacol Exp Ther 1998 284: 337-345. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

David C. Thompson and Ralph J. Altiere

Differential Susceptibility of Tracheal Contraction to Nonadrenergic Noncholinergic Relaxation
J Pharmacol Exp Ther 1998 284: 19-24. [Abstract] [Full Text] [PDF]  

Kazuhiko Fujii, Hirotsugu Kohrogi, Hajime Iwagoe, Junji Hamamoto, Naomi Hirata, Eisuke Goto, Osamu Kawano, Kazuteru Wada, Shinsuke Yamagata, and Masayuki Ando

Novel Phosphodiesterase 4 Inhibitor T-440 Reverses and Prevents Human Bronchial Contraction Induced by Allergen
J Pharmacol Exp Ther 1998 284: 162-169. [Abstract] [Full Text] [PDF]  

Tracey E. Lawrence, Lyndell L. Millecchia, and Jeffrey S. Fedan

Fluticasone Propionate and Pentamidine Isethionate Reduce Airway Hyperreactivity, Pulmonary Eosinophilia and Pulmonary Dendritic Cell Response in a Guinea Pig Model of Asthma
J Pharmacol Exp Ther 1998 284: 222-227. [Abstract] [Full Text] [PDF]  

Brendan J. Canning, Axel Fischer, and Bradley J. Undem

Pharmacological Analysis of the Tachykinin Receptors that Mediate Activation of Nonadrenergic, Noncholinergic Relaxant Nerves that Innervate Guinea Pig Trachealis
J Pharmacol Exp Ther 1998 284: 370-377. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

William C. Zamboni, Peter J. Houghton, Randall K. Johnson, Jeff L. Hulstein, William R. Crom, Pam J. Cheshire, Suzan K. Hanna, Lois B. Richmond, Xiaolong Luo, and Clinton F. Stewart

Probenecid Alters Topotecan Systemic and Renal Disposition by Inhibiting Renal Tubular Secretion
J Pharmacol Exp Ther 1998 284: 89-94. [Abstract] [Full Text] [PDF]  

Sophie Potdevin, Françoise Courjault-Gautier, Bertrand Monegier Du Sorbier, Pierre Ripoche, and Hervé J. Toutain

Role of Protein Thiols in Inhibition of Sodium-Coupled Glucose Uptake by Cisplatin in Renal Brush-Border Membrane Vesicles
J Pharmacol Exp Ther 1998 284: 142-150. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

S. M. Hossein Sadrzadeh and Amin A. Nanji

The 21-Aminosteroid 16-Desmethyl Tirilazad Mesylate Prevents Necroinflammatory Changes in Experimental Alcoholic Liver Disease
J Pharmacol Exp Ther 1998 284: 406-412. [Abstract] [Full Text] [PDF]  

Florence M. Ndikum-Moffor, Trenton R. Schoeb, and Stephen M. Roberts

Liver Toxicity from Norcocaine Nitroxide, an N-Oxidative Metabolite of Cocaine
J Pharmacol Exp Ther 1998 284: 413-419. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction for vol. 282, p. 1064
J Pharmacol Exp Ther 1998 284: 435. [Full Text] [PDF]  

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