BEHAVIORAL PHARMACOLOGY:

Beth Geter-Douglass, Jonathan L. Katz, Ken Alling, Jane B. Acri, and Jeffrey M. Witkin

Characterization of Unconditioned Behavioral Effects of Dopamine D₃/D₂ Receptor Agonists
J Pharmacol Exp Ther 1997 283: 7-15. [Abstract] [Full Text] [PDF]  

Michael R. Weed, Ian A. Paul, Linda P. Dwoskin, Susan E. Moore, and William L. Woolverton

The Relationship between Reinforcing Effects and in Vitro Effects of D1 Agonists in Monkeys
J Pharmacol Exp Ther 1997 283: 29-38. [Abstract] [Full Text] [PDF]  

Magí Farré, Rafael De La Torre, María L. González, María T. Terán, Pere N. Roset, Esther Menoyo, and Jordi Camí

Cocaine and Alcohol Interactions in Humans: Neuroendocrine Effects and Cocaethylene Metabolism
J Pharmacol Exp Ther 1997 283: 164-176. [Abstract] [Full Text] [PDF]  

J. X. Cai and A. F. T. Arnsten

Dose-Dependent Effects of the Dopamine D1 Receptor Agonists A77636 or SKF81297 On Spatial Working Memory in Aged Monkeys
J Pharmacol Exp Ther 1997 283: 183-189. [Abstract] [Full Text] [PDF]  

Leonard L. Howell and Alyson M. Landrum

Effects of Chronic Caffeine Administration on Respiration and Schedule-Controlled Behavior in Rhesus Monkeys
J Pharmacol Exp Ther 1997 283: 190-199. [Abstract] [Full Text] [PDF]  

Kathleen M. Kantak, Melissa A. Edwards, Kristin M. Wilcox, and Erica Kitchel

Discriminative Stimulus Effects of Magnesium Chloride: Substitution Studies with Monoamine Uptake Inhibitors and N-Methyl-D-Aspartate Antagonists
J Pharmacol Exp Ther 1997 283: 200-206. [Abstract] [Full Text] [PDF]  

Wallace B. Pickworth, Reginald V. Fant, and Jack E. Henningfield

Inhibition of Prostaglandin Synthesis and Effects of Ethanol and Pentobarbital in Humans
J Pharmacol Exp Ther 1997 283: 274-280. [Abstract] [Full Text] [PDF]  

Jeffrey Cohn and Robert C. Macphail

Chlorpyrifos Produces Selective Learning Deficits in Rats Working Under a Schedule of Repeated Acquisition and Performance
J Pharmacol Exp Ther 1997 283: 312-320. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

J. P. Hérault, A. Bernat, A. M. Pflieger, J. C. Lormeau, and J. M. Herbert

Comparative Effects of Two Direct and Indirect Factor Xa Inhibitors on Free and Clot-Bound Prothrombinase
J Pharmacol Exp Ther 1997 283: 16-22. [Abstract] [Full Text] [PDF]  

Sam S. Rebello, Howard S. Blank, William E. Rote, George P. Vlasuk, and Benedict R. Lucchesi

Antithrombotic Efficacy of a Recombinant Nematode Anticoagulant Peptide (rNAP5) in Canine Models of Thrombosis after Single Subcutaneous Administration
J Pharmacol Exp Ther 1997 283: 91-99. [Abstract] [Full Text] [PDF]  

Galen M. Pieper and Wolfgang Siebeneich

Use of a Nitronyl Nitroxide to Discriminate the Contribution of Nitric Oxide Radical in Endothelium-Dependent Relaxation of Control and Diabetic Blood Vessels
J Pharmacol Exp Ther 1997 283: 138-147. [Abstract] [Full Text] [PDF]  

Céline Fiset, Benoit Drolet, Bettina A. Hamelin, and Jacques Turgeon

Block of I_Ks by the Diuretic Agent Indapamide Modulates Cardiac Electrophysiological Effects of the Class III Antiarrhythmic Drug dl-Sotalol
J Pharmacol Exp Ther 1997 283: 148-156. [Abstract] [Full Text] [PDF]  

Margaret Van Heek, Constance F. France, Douglas S. Compton, Robbie L. Mcleod, Nathan P. Yumibe, Kevin B. Alton, Edmund J. Sybertz, and Harry R. Davis, Jr.

In Vivo Metabolism-Based Discovery of a Potent Cholesterol Absorption Inhibitor, SCH58235, in the Rat and Rhesus Monkey through the Identification of the Active Metabolites of SCH48461
J Pharmacol Exp Ther 1997 283: 157-163. [Abstract] [Full Text] [PDF]  

Robert H. G. Schwinger, Klara Brixius, Udo Bavendiek, Susanne Hoischen, Jochen Müller-Ehmsen, Birgit Bölck, and Erland Erdmann

Effect of Cyclopiazonic Acid on the Force-Frequency Relationship in Human Nonfailing  Myocardium
J Pharmacol Exp Ther 1997 283: 286-292. [Abstract] [Full Text] [PDF]  

David A. Cox and Marlene L. Cohen

Relationship between Phospholipase D Activation and Endothelial Vasomotor Dysfunction in Rabbit Aorta
J Pharmacol Exp Ther 1997 283: 305-311. [Abstract] [Full Text] [PDF]  

Terry C. Major and Joan A. Keiser

Inhibition of Cell Growth: Effects of the Tyrosine Kinase Inhibitor CGP 53716
J Pharmacol Exp Ther 1997 283: 402-410. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Donald J. Wolff, Douglas S. Gauld, Matthew J. Neulander, and Garry Southan

Inactivation of Nitric Oxide Synthase by Substituted Aminoguanidines and Aminoisothioureas
J Pharmacol Exp Ther 1997 283: 265-273. [Abstract] [Full Text] [PDF]  

Hisashi Yokoshiki, Yasuhiro Katsube, Masanori Sunagawa, and Nicholas Sperelakis

The Novel Calcium Sensitizer Levosimendan Activates the ATP-Sensitive K⁺ Channel in Rat Ventricular Cells
J Pharmacol Exp Ther 1997 283: 375-383. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Satoru Koyanagi, Shigehiro Ohdo, Eiji Yukawa, and Shun Higuchi

Chronopharmacological Study of Interferon- in Mice
J Pharmacol Exp Ther 1997 283: 259-264. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

R. Scott Obach, James G. Baxter, Theodore E. Liston, B. Michael Silber, Barry C. Jones, Fiona Macintyre, David J. Rance, and Philip Wastall

The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
J Pharmacol Exp Ther 1997 283: 46-58. [Abstract] [Full Text] [PDF]  

Yuji Mano, Hiroshi Suzuki, Tetsuya Terasaki, Toshiro Iwahashi, Ken-Ichi Ono, Mikihiko Naito, Takashi Tsuruo, and Yuichi Sugiyama

Kinetic Analysis of the Disposition of MRK16, an Anti-P-glycoprotein Monoclonal Antibody, in Tumors: Comparison Between in Vitro and in Vivo Disposition
J Pharmacol Exp Ther 1997 283: 391-401. [Abstract] [Full Text] [PDF]  

ENDOCRINE PHARMACOLOGY:

Roshanak Rahimian, Ismail Laher, Gregory Dube, and Cornelis van Breemen

Estrogen and Selective Estrogen Receptor Modulator LY117018 Enhance Release of Nitric Oxide in Rat Aorta
J Pharmacol Exp Ther 1997 283: 116-122. [Abstract] [Full Text] [PDF]  

Hui-Xin Zhuang, Laura Wuarin, Zhi-Jian Fei, and Douglas N. Ishii

Insulin-Like Growth Factor (IGF) Gene Expression Is Reduced in Neural Tissues and Liver from Rats with Non-Insulin-Dependent Diabetes Mellitus, and IGF Treatment Ameliorates Diabetic Neuropathy
J Pharmacol Exp Ther 1997 283: 366-374. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

E. Ekblad and F. Sundler

Motor Responses in Rat Ileum Evoked by Nitric Oxide Donors vs. Field Stimulation: Modulation by Pituitary Adenylate Cyclase-Activating Peptide, Forskolin and Guanylate Cyclase Inhibitors
J Pharmacol Exp Ther 1997 283: 23-28. [Abstract] [Full Text] [PDF]  

Ikumi Tamai, Ayaka Saheki, Ryoichi Saitoh, Yoshimichi Sai, Ichimaro Yamada, and Akira Tsuji

Nonlinear Intestinal Absorption of 5-Hydroxytryptamine Receptor Antagonist Caused by Absorptive and Secretory Transporters
J Pharmacol Exp Ther 1997 283: 108-115. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

Stephen J. Getting, Roderick J. Flower, Luca Parente, Rinaldo de Médicis, André Lussier, Barry A. Woliztky, Marco A. Martins, and Mauro Perretti

Molecular Determinants of Monosodium Urate Crystal-Induced Murine Peritonitis: A Role for Endogenous Mast Cells and a Distinct Requirement for Endothelial-Derived Selectins
J Pharmacol Exp Ther 1997 283: 123-130. [Abstract] [Full Text] [PDF]  

Hiroichi Nagai, Hidetaka Hiyama, Akihiko Matsuo, Yoshifumi Ueda, Naoki Inagaki, and Kenji Kawada

FK-506 and Cyclosporin A Potentiate the IgE Antibody Production by Contact Sensitization with Hapten in Mice
J Pharmacol Exp Ther 1997 283: 321-327. [Abstract] [Full Text] [PDF]  

Osamu Kaminuma, Akio Mori, Koji Ogawa, Kazuteru Wada, Hideo Kikkawa, Kazauaki Naito, Matsunobu Suko, and Hirokazu Okudaira

Two Differential Effects of Cyclic Adenosine 3,5-Monophosphate on IL-5 Production by Antigen-Specific Human T Cell Line
J Pharmacol Exp Ther 1997 283: 345-349. [Abstract] [Full Text] [PDF]  

Laurent Vernhet, Jean-Yves Petit, and François Lang

An Anti-Inflammatory Benzamide Derivative Inhibits the Protein Kinase C (PKC)-Dependent Pathway of ERK2 Phosphorylation in Murine Macrophages
J Pharmacol Exp Ther 1997 283: 358-365. [Abstract] [Full Text] [PDF]  

Henry M. Sarau, Julia A. Rush, James J. Foley, Mary E. Brawner, Dulcie B. Schmidt, John R. White, and Mary S. Barnette

Characterization of Functional Chemokine Receptors (CCR1 and CCR2) on EoL-3 Cells: A Model System to Examine the Role of Chemokines in Cell Function
J Pharmacol Exp Ther 1997 283: 411-418. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Anna Pittaluga, Daniella Vaccari, and Maurizio Raiteri

The "Kynurenate Test," a Biochemical Assay for Putative Cognition Enhancers
J Pharmacol Exp Ther 1997 283: 82-90. [Abstract] [Full Text] [PDF]  

Francesco Fornai, Maria Grazia Alessandrì, Maria Tilde Torracca, Lucia Bassi, and Giovanni Umberto Corsini

Effects of Noradrenergic Lesions on MPTP/MPP⁺ Kinetics and MPTP-Induced Nigrostriatal Dopamine Depletions
J Pharmacol Exp Ther 1997 283: 100-107. [Abstract] [Full Text] [PDF]  

Lars Johansson, Daniel Sohn, Seth-Olof Thorberg, David M. Jackson, Diana Kelder, Lars-Gunnar Larsson, Lucy Rényi, Svante B. Ross, Carin Wallsten, Håkan Eriksson, Ping-Sheng Hu, Eva Jerning, Nina Mohell, and Anita Westlind-Danielsson

The Pharmacological Characterization of a Novel Selective 5-Hydroxytryptamine_1A Receptor Antagonist, NAD-299
J Pharmacol Exp Ther 1997 283: 216-225. [Abstract] [Full Text] [PDF]  

V. L. Arvanov, X. Liang, J. Schwartz, S. Grossman, and R. Y. Wang

Clozapine and Haloperidol Modulate N-Methyl-D-aspartate- and Non-N-Methyl-D-aspartate Receptor-Mediated Neurotransmission in Rat Prefrontal Cortical Neurons In Vitro
J Pharmacol Exp Ther 1997 283: 226-234. [Abstract] [Full Text] [PDF]  

James P. Sullivan, Diana Donnelly-Roberts, Clark A. Briggs, David J. Anderson, Murali Gopalakrishnan, Iris C. Xue, Marietta Piattoni-Kaplan, Eduardo Molinari, Jeffrey E. Campbell, David G. Mckenna, David E. Gunn, Nan-Horng Lin, Keith B. Ryther, Yun He, Mark W. Holladay, Susan Wonnacott, Michael Williams, and Stephen P. Arneric

ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A Potent and Selective Cholinergic Channel Modulator with Neuroprotective Properties
J Pharmacol Exp Ther 1997 283: 235-246. [Abstract] [Full Text] [PDF]  

Michael W. Decker, Anthony W. Bannon, Peter Curzon, Karen L. Gunther, Jorge D. Brioni, Mark W. Holladay, Nan-Horng Lin, Yihong Li, Jerome F. Daanen, Jerry J. Buccafusco, Mark A. Prendergast, William J. Jackson, and Stephen P. Arneric

ABT-089 [2-Methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A Novel Cholinergic Channel Modulator with Effects on Cognitive Performance in Rats and Monkeys
J Pharmacol Exp Ther 1997 283: 247-258. [Abstract] [Full Text] [PDF]  

Annette E. Fleckenstein, Diana G. Wilkins, James W. Gibb, and Glen R. Hanson

Interaction Between Hyperthermia and Oxygen Radical Formation in the 5-Hydroxytryptaminergic Response to a Single Methamphetamine Administration
J Pharmacol Exp Ther 1997 283: 281-285. [Abstract] [Full Text] [PDF]  

Akira Kato, Atsushi Fukunari, Yoko Sakai, and Tohru Nakajima

Prevention of Amyloid-Like Deposition by a Selective Prolyl Endopeptidase Inhibitor, Y-29794, in Senescence-Accelerated Mouse
J Pharmacol Exp Ther 1997 283: 328-335. [Abstract] [Full Text] [PDF]  

R. F. Tyndale, S. V. Bhave, E. Hoffmann, P. L. Hoffman, B. Tabakoff, A. J. Tobin, and R. W. Olsen

Pentobarbital Decreases the -Aminobutyric Acid_A Receptor Subunit gamma-2 Long/Short mRNA Ratio by a Mechanism Distinct from Receptor Occupation
J Pharmacol Exp Ther 1997 283: 350-357. [Abstract] [Full Text] [PDF]  

Mohammad H. Jalilian Tehrani and Eugene M. Barnes, Jr.

Sequestration of -Aminobutyric Acid_A Receptors on Clathrin-Coated Vesicles During Chronic Benzodiazepine Administration In Vivo
J Pharmacol Exp Ther 1997 283: 384-390. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Titti Martinsson, Takaharu Oda, Eva Fernvik, Karin Roempke, Carl-Johan Dalsgaard, and Erik Svensjö

Ropivacaine Inhibits Leukocyte Rolling, Adhesion and CD11b/CD18 Expression
J Pharmacol Exp Ther 1997 283: 59-65. [Abstract] [Full Text] [PDF]  

Annmarie Dellipizzi, Michael L. Pucci, Aimi Y. Mosny, Katie Deseyn, and Alberto Nasjletti

Contribution of Constrictor Prostanoids to the Calcium-Dependent Basal Tone in the Aorta from Rats with Aortic Coarctation-Induced Hypertension: Relationship to Nitric Oxide
J Pharmacol Exp Ther 1997 283: 75-81. [Abstract] [Full Text] [PDF]  

Robert F. Spurney and Thomas M. Coffman

The C-Terminus of the Thromboxane Receptor Contributes to Coupling and Desensitization in a Mouse Mesangial Cell Line
J Pharmacol Exp Ther 1997 283: 207-215. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

W. S. Fred Wong, Diana S. K. Koh, Alan H. M. Koh, W. L. Ting, and Peter T. H. Wong

Effects of Tyrosine Kinase Inhibitors on Antigen Challenge of Guinea Pig Lung In Vitro
J Pharmacol Exp Ther 1997 283: 131-137. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Cindy Woodland, Zul Verjee, Esther Giesbrecht, Gideon Koren, and Shinya Ito

The Digoxin-Propafenone Interaction: Characterization of a Mechanism Using Renal Tubular Cell Monolayers
J Pharmacol Exp Ther 1997 283: 39-45. [Abstract] [Full Text] [PDF]  

Edwin K. Jackson, Zaichuan Mi, Delbert G. Gillespie, and Raghvendra K. Dubey

Metabolism of cAMP to Adenosine in the Renal Vasculature
J Pharmacol Exp Ther 1997 283: 177-182. [Abstract] [Full Text] [PDF]  

Jose C. Rodriguez-Perez, Antonio Losada, Aranzazu Anabitarte, Juan Cabrera, Javier Llobet, Leocadia Palop, and Celia Plaza

Effects of the Novel Multiple-Action Agent Carvedilol on Severe Nephrosclerosis in Renal Ablated Rats
J Pharmacol Exp Ther 1997 283: 336-344. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Rolf Gebhardt, Gerhard Beckers, Frank Gaunitz, Wolfram Haupt, Dirk Jonitza, Sabine Klein, and Ludger Scheja

Treatment of Cirrhotic Rats with L-Ornithine-L-Aspartate Enhances Urea Synthesis and Lowers Serum Ammonia Levels
J Pharmacol Exp Ther 1997 283: 1-6. [Abstract] [Full Text] [PDF]  

Andrea Guidarelli, Emilio Clementi, Clara Sciorati, Flaminio Cattabeni, and Orazio Cantoni

Calcium-Dependent Mitochondrial Formation of Species Mediating DNA Single Strand Breakage in U937 Cells Exposed to Sublethal Concentrations of Tert-Butylhydroperoxide
J Pharmacol Exp Ther 1997 283: 66-74. [Abstract] [Full Text] [PDF]  

Tsuyoshi Ooie, Tetsuya Terasaki, Hiroshi Suzuki, and Yuichi Sugiyama

Kinetic Evidence for Active Efflux Transport across the Blood-Brain Barrier of Quinolone Antibiotics
J Pharmacol Exp Ther 1997 283: 293-304. [Abstract] [Full Text] [PDF]  

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