ANALGESIA AND DRUGS OF ABUSE:

R. Nadeson and C. S. Goodchild

Antinociceptive Properties of Propofol: Involvement of Spinal Cord -Aminobutyric Acid_A Receptors
J Pharmacol Exp Ther 1997 282: 1181-1186. [Abstract] [Full Text] [PDF]  

Mark J. Field, Elizabeth F. Holloman, Scott McCleary, John Hughes, and Lakhbir Singh

Evaluation of Gabapentin and S-(+)-3-Isobutylgaba in a Rat Model of Postoperative Pain
J Pharmacol Exp Ther 1997 282: 1242-1246. [Abstract] [Full Text] [PDF]  

H. R. Garner, Timothy F. Burke, C. David Lawhorn, Joanne M. Stoner, and William D. Wessinger

Butorphanol-Mediated Antinociception in Mice: Partial Agonist Effects and Mu Receptor Involvement^,
J Pharmacol Exp Ther 1997 282: 1253-1261. [Abstract] [Full Text] [PDF]  

Bruce Nock, Michele Wich, and Theodore J. Cicero

Chronic Exposure to Morphine Increases Corticosteroid-Binding Globulin
J Pharmacol Exp Ther 1997 282: 1262-1268. [Abstract] [Full Text] [PDF]  

Alice A. Larson and Kelley F. Kitto

Manipulations of Zinc in the Spinal Cord, by Intrathecal Injection of Zinc Chloride, Disodium-Calcium-EDTA, or Dipicolinic Acid, Alter Nociceptive Activity in Mice
J Pharmacol Exp Ther 1997 282: 1319-1325. [Abstract] [Full Text] [PDF]  

Alice A. Larson and Kelley F. Kitto

Mutual Antagonism Between Nerve Growth Factor and Substance P N-terminal Activity on Nociceptive Activity in Mice
J Pharmacol Exp Ther 1997 282: 1345-1350. [Abstract] [Full Text] [PDF]  

Juhana J. Idänpään-Heikkilä, Gisèle Guilbaud, and Valérie Kayser

Prevention of Tolerance to the Antinociceptive Effects of Systemic Morphine by a Selective Cholecystokinin-B Receptor Antagonist in a Rat Model of Peripheral Neuropathy
J Pharmacol Exp Ther 1997 282: 1366-1372. [Abstract] [Full Text] [PDF]  

Liza Leventhal, Lesley B. Stevens, Grace C. Rossi, Gavril W. Pasternak, and Richard J. Bodnar

Antisense Mapping of the MOR-1 Opioid Receptor Clone: Modulation of Hyperphagia Induced by DAMGO
J Pharmacol Exp Ther 1997 282: 1402-1407. [Abstract] [Full Text] [PDF]  

Carolyn A. Fairbanks and George L. Wilcox

Acute Tolerance To Spinally Administered Morphine Compares Mechanistically with Chronically Induced Morphine Tolerance
J Pharmacol Exp Ther 1997 282: 1408-1417. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

Donald A. Heck and David B. Bylund

Mechanism of Down-regulation of Alpha-2 Adrenergic Receptor Subtypes
J Pharmacol Exp Ther 1997 282: 1219-1227. [Abstract] [Full Text] [PDF]  

Serafim Guimarães, Maria Q. Paiva, and Oduvaldo Pereira

-Adrenoceptor-Mediated Prejunctional Effects of Chloroethylclonidine in the Canine Saphenous Vein
J Pharmacol Exp Ther 1997 282: 1326-1330. [Abstract] [Full Text] [PDF]  

Donald B. Hoover and David A. Neely

Differentiation of Muscarinic Receptors Mediating Negative Chronotropic and Vasoconstrictor Responses to Acetylcholine in Isolated Rat Hearts
J Pharmacol Exp Ther 1997 282: 1337-1344. [Abstract] [Full Text] [PDF]  

Sujata Persad, Vijayan Elimban, Jasvinder Kaila, and Naranjan S. Dhalla

Biphasic Alterations in Cardiac Beta-Adrenoceptor Signal Transduction Mechanism Due to Oxyradicals
J Pharmacol Exp Ther 1997 282: 1623-1631. [Abstract] [Full Text] [PDF]  

R. S. Wagner, C. J. Smith, A. M. Taylor, and R. A. Rhoades

Phosphodiesterase Inhibition Improves Agonist-Induced Relaxation of Hypertensive Pulmonary Arteries
J Pharmacol Exp Ther 1997 282: 1650-1657. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

James P. Zacny, Kim Conley, and Jeff Galinkin

Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Buprenorphine and Morphine in Healthy Volunteers
J Pharmacol Exp Ther 1997 282: 1187-1197. [Abstract] [Full Text] [PDF]  

M. I. Damaj, W. Glassco, M. J. Marks, B. Slobe, J. R. James, E. L. May, J. A. Rosecrans, A. C. Collins, and B. R. Martin

Pharmacological Investigation of (+)- and ()-cis-2,3,3a,4,5,9b-Hexahydro-1-methyl-1H-pyrrolo[3,2-h]isoquinoline, a Bridged-Nicotine Analog
J Pharmacol Exp Ther 1997 282: 1425-1434. [Abstract] [Full Text] [PDF]  

Nancy A. Ator and Roland R. Griffiths

Selectivity in the Generalization Profile in Baboons Trained to Discriminate Lorazepam: Benzodiazepines, Barbiturates and Other Sedative/Anxiolytics
J Pharmacol Exp Ther 1997 282: 1442-1457. [Abstract] [Full Text] [PDF]  

Jesse Brodkin and Joseph M. Moerschbaecher

SR141716A Antagonizes the Disruptive Effects of Cannabinoid Ligands on Learning in Rats
J Pharmacol Exp Ther 1997 282: 1526-1532. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Stéphane Prié, Tack Ki Leung, Peter Cernacek, James W. Ryan, and Jocelyn Dupuis

The Orally Active ET_A Receptor Antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenyl-propionic acid (LU 135252) Prevents the Development of Pulmonary Hypertension and Endothelial Metabolic Dysfunction in Monocrotaline-Treated Rats
J Pharmacol Exp Ther 1997 282: 1312-1318. [Abstract] [Full Text] [PDF]  

Shawn G. Clark and Leslie C. Fuchs

Role of Nitric Oxide and Ca⁺⁺-Dependent K⁺ Channels in Mediating Heterogeneous Microvascular Responses to Acetylcholine in Different Vascular Beds
J Pharmacol Exp Ther 1997 282: 1473-1479. [Abstract] [Full Text] [PDF]  

Masayuki Endou, Yasuto Tanito, and Fukuichiro Okumura

A Comparison Between Chronotropic Effects of Neostigmine and Edrophonium in Isolated Guinea Pig Right Atrium
J Pharmacol Exp Ther 1997 282: 1480-1486. [Abstract] [Full Text] [PDF]  

John C. Clapham and Nicholas C. Turner

Effects of the Glucocorticoid II Receptor Antagonist Mifepristone on Hypertension in the Obese Zucker Rat
J Pharmacol Exp Ther 1997 282: 1503-1508. [Abstract] [Full Text] [PDF]  

Jose A. Gutierrez, Shawn G. Clark, Ararat D. Giulumian, and Leslie C. Fuchs

Superoxide Anions Contribute to Impaired Regulation of Blood Pressure by Nitric Oxide During the Development of Cardiomyopathy
J Pharmacol Exp Ther 1997 282: 1643-1649. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Mitsutoshi Kimura and Masahiko Ogihara

Proliferation of Adult Rat Hepatocytes by Hepatocyte Growth Factor Is Potentiated by Both Phenylephrine and Metaproterenol
J Pharmacol Exp Ther 1997 282: 1146-1154. [Abstract] [Full Text] [PDF]  

Chao-Sheng Huang, Jin-Ho Song, Keiichi Nagata, Jay Z Yeh, and Toshio Narahashi

Effects of the Neuroprotective Agent Riluzole on the High Voltage-Activated Calcium Channels of Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 1997 282: 1280-1290. [Abstract] [Full Text] [PDF]  

Roberto T. Sudo and Thomas E. Nelson

Changes in Ryanodine-Induced Contractures by Stimulus Frequency in Malignant Hyperthermia Susceptible and Malignant Hyperthermia Nonsusceptible Dog Skeletal Muscle
J Pharmacol Exp Ther 1997 282: 1331-1336. [Abstract] [Full Text] [PDF]  

Irina A. Omelchenko, Cole S. Nelson, and Charles N. Allen

Lead Inhibition of N-Methyl-D-aspartate Receptors Containing NR2A, NR2C and NR2D Subunits
J Pharmacol Exp Ther 1997 282: 1458-1464. [Abstract] [Full Text] [PDF]  

Michele Solem, Thomas McMahon, and Robert O. Messing

Protein Kinase A Regulates Inhibition of N- and P/Q-type Calcium Channels by Ethanol in PC12 Cells
J Pharmacol Exp Ther 1997 282: 1487-1495. [Abstract] [Full Text] [PDF]  

L. S. Aspinwall, I. Bermudez, L. A. King, and K. A. Wafford

The Interactions of Hexachlorocyclohexane Isomers with Human -Aminobutyric Acid_A Receptors Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 1997 282: 1557-1564. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Torunn Fiskerstrand, Per Magne Uel, and and Helga Refsum

Folate Depletion Induced by Methotrexate Affects Methionine Synthase Activity and Its Susceptibility to Inactivation by Nitrous Oxide
J Pharmacol Exp Ther 1997 282: 1305-1311. [Abstract] [Full Text] [PDF]  

Sibylle K. M. Koller-Lucae, Herbert Schott, and Reto A. Schwendener

Interactions with Human Blood in Vitro and Pharmacokinetic Properties in Mice of Liposomal N⁴-Octadecyl-1--D-arabinofuranosylcytosine, A New Anticancer Drug
J Pharmacol Exp Ther 1997 282: 1572-1580. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Zhen-Yu Wu, B. Mark Smithers, and Michael S. Roberts

Tissue and Perfusate Pharmacokinetics of Melphalan in Isolated Perfused Rat Hindlimb
J Pharmacol Exp Ther 1997 282: 1131-1138. [Abstract] [Full Text] [PDF]  

Josephine M. Glover, Janet M. Leeds, Timothy G. K. Mant, Dipti Amin, Daniel L. Kisner, Joan E. Zuckerman, Richard S. Geary, Arthur A. Levin, and William R. Shanahan, Jr.

Phase I Safety and Pharmacokinetic Profile of an Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide (ISIS 2302)
J Pharmacol Exp Ther 1997 282: 1173-1180. [Abstract] [Full Text] [PDF]  

Jing Lin and John R. Cashman

N-Oxygenation of Phenethylamine to the trans-Oxime by Adult Human Liver Flavin-Containing Monooxygenase and Retroreduction of Phenethylamine Hydroxylamine by Human Liver Microsomes
J Pharmacol Exp Ther 1997 282: 1269-1279. [Abstract] [Full Text] [PDF]  

Jeffrey C. Stevens, Rebecca B. White, Shih Hsein Hsu, and Michel Martinet

Human Liver CYP2B6-Catalyzed Hydroxylation of RP 73401
J Pharmacol Exp Ther 1997 282: 1389-1395. [Abstract] [Full Text] [PDF]  

Delphine Valente, Marcel Delaforge, Saik Urien, Dominique Guivarc'H, Raymond Vienet, Jean-Marc Grognet, and Eric Ezan

Metabolite Involvement in Bromocriptine-Induced Prolactin Inhibition in Rats
J Pharmacol Exp Ther 1997 282: 1418-1424. [Abstract] [Full Text] [PDF]  

Yasuhiro Masubuchi, Takashi Iwasa, Shin Hosokawa, Tokuji Suzuki, Toshiharu Horie, Susumu Imaoka, Yoshihiko Funae, and Shizuo Narimatsu

Selective Deficiency of Debrisoquine 4-Hydroxylase Activity in Mouse Liver Microsomes
J Pharmacol Exp Ther 1997 282: 1435-1441. [Abstract] [Full Text] [PDF]  

Ger-Jan Sanderink, Bruno Bournique, Jeffrey Stevens, Martine Petry, and Michel Martinet

Involvement of Human CYP1A Isoenzymes in the Metabolism and Drug Interactions of Riluzole In Vitro
J Pharmacol Exp Ther 1997 282: 1465-1472. [Abstract] [Full Text] [PDF]  

Katsuko Takasawa, Tetsuya Terasaki, Hiroshi Suzuki, Tsuyoshi Ooie, and Yuichi Sugiyama

Distributed Model Analysis of 3-Azido-3-Deoxythymidine and 2,3-Dideoxyinosine Distribution in Brain Tissue and Cerebrospinal Fluid
J Pharmacol Exp Ther 1997 282: 1509-1517. [Abstract] [Full Text] [PDF]  

Jörg Huwyler, Jing Yang, and William M. Pardridge

Receptor Mediated Delivery of Daunomycin Using Immunoliposomes: Pharmacokinetics and Tissue Distribution in the Rat
J Pharmacol Exp Ther 1997 282: 1541-1546. [Abstract] [Full Text] [PDF]  

E. S. Messina, R. F. Tyndale, and E. M. Sellers

A Major Role for CYP2A6 in Nicotine C-Oxidation by Human Liver Microsomes
J Pharmacol Exp Ther 1997 282: 1608-1614. [Abstract] [Full Text] [PDF]  

ENDOCRINE PHARMACOLOGY:

Chi Yang, Bumsup Lee, Ter-Hsin Chen, and Walter H. Hsu

Mechanisms of Bradykinin-Induced Insulin Secretion in Clonal beta Cell Line RINm5F
J Pharmacol Exp Ther 1997 282: 1247-1252. [Abstract] [Full Text] [PDF]  

H. Neal Bramson, David Hermann, Kenneth W. Batchelor, Frank W. Lee, Michael K. James, and Stephen V. Frye

Unique Preclinical Characteristics of GG745, A Potent Dual Inhibitor of 5AR
J Pharmacol Exp Ther 1997 282: 1496-1502. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

J. L. Elmhurst, P.-A. Betti, and P. K. Rangachari

Intestinal Effects of Isoprostanes: Evidence for the Involvement of Prostanoid EP and TP Receptors
J Pharmacol Exp Ther 1997 282: 1198-1205. [Abstract] [Full Text] [PDF]  

D. Ghanekar, E. M. Hadac, E. L. Holicky, and L. J. Miller

Differences in Partial Agonist Action at Cholecystokinin Receptors of Mouse and Rat Are Dependent on Parameters Extrinsic to Receptor Structure: Molecular Cloning, Expression and Functional Characterization of the Mouse Type A Cholecystokinin Receptor
J Pharmacol Exp Ther 1997 282: 1206-1212. [Abstract] [Full Text] [PDF]  

Shinichi Kato, Takuya Hirata, Motohiro Kitamura, and Koji Takeuchi

Gastric Hyperemic Response During Vagally Mediated Acid Secretion by TRH Analog in Rats
J Pharmacol Exp Ther 1997 282: 1351-1357. [Abstract] [Full Text] [PDF]  

Jon M. Goldhill, Terez Shea-Donohue, Nasima Ali, and Victor M. Piñeiro-Carrero

Tachykinergic Neurotransmission Is Enhanced in Small Intestinal Circular Muscle in a Rabbit Model of Inflammation
J Pharmacol Exp Ther 1997 282: 1373-1378. [Abstract] [Full Text] [PDF]  

Yuko Muto, Taku Nagao, and Tetsuro Urushidani

The Putative Phospholipase C Inhibitor U73122 and Its Negative Control, U73343, Elicit Unexpected Effects on the Rabbit Parietal Cell
J Pharmacol Exp Ther 1997 282: 1379-1388. [Abstract] [Full Text] [PDF]  

Elaine M. Conner, Stephen Brand, Jonathan M. Davis, F. Stephen Laroux, Vito J. Palombella, John W. Fuseler, David Y. Kang, Robert E. Wolf, and Matthew B. Grisham

Proteasome Inhibition Attenuates Nitric Oxide Synthase Expression, VCAM-1 Transcription and the Development of Chronic Colitis
J Pharmacol Exp Ther 1997 282: 1615-1622. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

Gordon Todderud, Xina Nair, Debbie Lee, Julie Alford, Lynda Davern, Paul Stanley, Carol Bachand, Philippe Lapointe, Anne Marinier, Alain Martel, Marcel Menard, John J. Wright, Jurgen Bajorath, Diane Hollenbaugh, Alejandro Aruffo, and Kenneth M. Tramposch

BMS-190394, a Selectin Inhibitor, Prevents Rat Cutaneous Inflammatory Reactions
J Pharmacol Exp Ther 1997 282: 1298-1304. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Andrea Köppen, Jochen Klein, Christina Erb, and Konrad Löffelholz

Acetylcholine Release and Choline Availability in Rat Hippocampus: Effects of Exogenous Choline and Nicotinamide
J Pharmacol Exp Ther 1997 282: 1139-1145. [Abstract] [Full Text] [PDF]  

Wei Tang, Jan Palaty, and Frank S. Abbott

Time Course of -Fluorinated Valproic Acid in Mouse Brain and Serum and its Effect on Synaptosomal -Aminobutyric Acid Levels in Comparison to Valproic Acid
J Pharmacol Exp Ther 1997 282: 1163-1172. [Abstract] [Full Text] [PDF]  

Marike Lancel, Johannes Faulhaber, Thomas Schiffelholz, Elena Romeo, Flavia Di Michele, Florian Holsboer, and Rainer Rupprecht

Allopregnanolone Affects Sleep in a Benzodiazepine-Like Fashion
J Pharmacol Exp Ther 1997 282: 1213-1218. [Abstract] [Full Text] [PDF]  

Robert E. Joseph, Jr., Wei-Jen Tsai, Li-I Tsao, Tsung-Ping Su, and Edward J. Cone

In Vitro Characterization of Cocaine Binding Sites in Human Hair
J Pharmacol Exp Ther 1997 282: 1228-1241. [Abstract] [Full Text] [PDF]  

George P. Brown, Ke Yang, Ouathek Ouerfelli, Kelly M. Standifer, David Byrd, and Gavril W. Pasternak

³H-Morphine-6-Glucuronide Binding in Brain Membranes and an MOR-1-Transfected Cell Line
J Pharmacol Exp Ther 1997 282: 1291-1297. [Abstract] [Full Text] [PDF]  

Si-Jia Zhu, Michael P. Kavanaugh, Mark S. Sonders, Susan G. Amara, and Nancy R. Zahniser

Activation of Protein Kinase C Inhibits Uptake, Currents and Binding Associated with the Human Dopamine Transporter Expressed in Xenopus Oocytes
J Pharmacol Exp Ther 1997 282: 1358-1365. [Abstract] [Full Text] [PDF]  

Zhiming Zhang, Yasuyuki Miyoshi, Paul A. Lapchak, Frank Collins, Dana Hilt, Carl Lebel, Richard Kryscio, and Don M. Gash

Dose Response to Intraventricular Glial Cell Line-Derived Neurotrophic Factor Administration in Parkinsonian Monkeys
J Pharmacol Exp Ther 1997 282: 1396-1401. [Abstract] [Full Text] [PDF]  

Stuart B. Mazzone, Colin F. Hinrichsen, and Dominic P. Geraghty

Substance P Receptors in Brain Stem Respiratory Centers of the Rat: Regulation of NK1 Receptors by Hypoxia
J Pharmacol Exp Ther 1997 282: 1547-1556. [Abstract] [Full Text] [PDF]  

Q. Li, N. A. Muma, G. Battaglia, and L. D. Van De Kar

A Desensitization of Hypothalamic 5-HT_1A Receptors by Repeated Injections of Paroxetine: Reduction in the Levels of G_i and G_o Proteins and Neuroendocrine Responses, but Not in the Density of 5-HT_1A Receptors
J Pharmacol Exp Ther 1997 282: 1581-1590. [Abstract] [Full Text] [PDF]  

Glenn T. Gobbel, Thelma Y.-Y. Chan, and Pak H. Chan

Nitric Oxide- and Superoxide-Mediated Toxicity in Cerebral Endothelial Cells
J Pharmacol Exp Ther 1997 282: 1600-1607. [Abstract] [Full Text] [PDF]  

Christopher S. Breivogel, Laura J. Sim, and Steven R. Childers

Regional Differences in Cannabinoid Receptor/G-protein Coupling in Rat Brain
J Pharmacol Exp Ther 1997 282: 1632-1642. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Thomas Klein, Felix Reutter, Horst Schweer, Hannsjörg W. Seyberth, and Rolf M. Nüsing

Generation of the Isoprostane 8-Epi-prostaglandin F₂ In Vitro and In Vivo via the Cyclooxygenases
J Pharmacol Exp Ther 1997 282: 1658-1665. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

R. B. Dowling, M. Johnson, P. J. Cole, and R. Wilson

The Effect of Rolipram, a Type IV Phosphodiesterase Inhibitor, on Pseudomonas aeruginosa Infection of Respiratory Mucosa
J Pharmacol Exp Ther 1997 282: 1565-1571. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Jesper Spannow, Klaus Thomsen, Jørgen Søberg Petersen, Ketil Haugan, and Sten Christensen

Influence of Renal Nerves and Sodium Balance on the Acute Antidiuretic Effect of Bendroflumethiazide in Rats with Diabetes Insipidus
J Pharmacol Exp Ther 1997 282: 1155-1162. [Abstract] [Full Text] [PDF]  

Kathryn M. Shanahan, Allan M. Evans, and Roger L. Nation

Disposition of Morphine in the Rat Isolated Perfused Kidney: Concentration Ranging Studies
J Pharmacol Exp Ther 1997 282: 1518-1525. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

William F. Salminen, Jr., Richard Voellmy, and Stephen M. Roberts

Differential Heat Shock Protein Induction by Acetaminophen and a Nonhepatotoxic Regioisomer, 3-Hydroxyacetanilide, in Mouse Liver
J Pharmacol Exp Ther 1997 282: 1533-1540. [Abstract] [Full Text] [PDF]  

Robert F. Stachlewitz, Gavin E. Arteel, James A. Raleigh, Henry D. Connor, Ronald P. Mason, and Ronald G. Thurman

Development and Characterization of a New Model of Tacrine-Induced Hepatotoxicity: Role of the Sympathetic Nervous System and Hypoxia-Reoxygenation
J Pharmacol Exp Ther 1997 282: 1591-1599. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.