ANALGESIA AND DRUGS OF ABUSE:

David D. Hood, Kathryn A. Mallak, Robert L. James, Robin Tuttle, and James C. Eisenach

Enhancement of Analgesia from Systemic Opioid in Humans by Spinal Cholinesterase Inhibition
J Pharmacol Exp Ther 1997 282: 86-92. [Abstract] [Full Text] [PDF]  

Scott J. O'Neill, Mark A. Collins, Hugh O. Pettit, Robert W. McNutt, and Kwen-Jen Chang

Antagonistic Modulation Between the Delta Opioid Agonist BW373U86 and the Mu Opioid Agonist Fentanyl in Mice
J Pharmacol Exp Ther 1997 282: 271-277. [Abstract] [Full Text] [PDF]  

Frank C. Tortella, Jany Rose, Lydia Robles, J. Edward Moreton, John Hughes, and John C. Hunter

EEG Spectral Analysis of the Neuroprotective Kappa Opioids Enadoline and PD117302
J Pharmacol Exp Ther 1997 282: 286-293. [Abstract] [Full Text] [PDF]  

Carla Ghelardini, Nicoletta Galeotti, Fulvio Gualtieri, Cristina Bellucci, Dina Manetti, Alberto Giotti, Petra Malmberg-Aiello, Alessandro Galli, and Alessandro Bartolini

Antinociceptive Profile of 3--tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): A Novel Analgesic with a Presynaptic Cholinergic Mechanism of Action
J Pharmacol Exp Ther 1997 282: 430-439. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

Elena Arteche, Giuseppe Strippoli, Gervaise Loirand, Pierre Pacaud, Luz Candenas, Juan-Carlos Moltó, Luisa Souto, Javier Fernandez, Manuel Norte, Julio D. Martín, and Jean-Pierre Savineau

An Analysis of the Mechanisms Involved in the Okadaic Acid-Induced Contraction of the Estrogen-Primed Rat Uterus
J Pharmacol Exp Ther 1997 282: 201-207. [Abstract] [Full Text] [PDF]  

D. J. Martin, P. Lluel, E. Guillot, A. Coste, D. Jammes, and I. Angel

Comparative Alpha-1 Adrenoceptor Subtype Selectivity and Functional Uroselectivity of Alpha-1 Adrenoceptor Antagonists
J Pharmacol Exp Ther 1997 282: 228-235. [Abstract] [Full Text] [PDF]  

Dean D. Schwartz

Activation of Alpha-2 Adrenergic Receptors Inhibits Norepinephrine Release by a Pertussis Toxin-Insensitive Pathway Independent of Changes in Cytosolic Calcium in Cultured Rat Sympathetic Neurons
J Pharmacol Exp Ther 1997 282: 248-255. [Abstract] [Full Text] [PDF]  

Alfred Lanzafame, Arthur Christopoulos, and Fred Mitchelson

Three Allosteric Modulators Act at a Common Site, Distinct from that of Competitive Antagonists, at Muscarinic Acetylcholine M₂ Receptors
J Pharmacol Exp Ther 1997 282: 278-285. [Abstract] [Full Text] [PDF]  

Yuichiro Kojima, Yasuhiro Tsunoda, and Chung Owyang

Adenosine 3,5-Cyclic Monophosphate-Stimulated Ca⁺⁺ Efflux and Acetylcholine Release in Ileal Myenteric Plexus Are Mediated by N-Type Ca⁺⁺ Channels: Inhibition by the Kappa Opioid Receptor Agonist
J Pharmacol Exp Ther 1997 282: 403-409. [Abstract] [Full Text] [PDF]  

Satoshi Gando, Yuichi Hattori, Yasuhiro Akaishi, Jun Nishihira, and Morio Kanno

Impaired Contractile Response to Beta Adrenoceptor Stimulation in Diabetic Rat Hearts: Alterations in Beta Adrenoceptors-G Protein-Adenylate Cyclase System and Phospholamban Phosphorylation
J Pharmacol Exp Ther 1997 282: 475-484. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

S. Stevens Negus, Nancy K. Mello, Philip S. Portoghese, and Chai-En Lin

Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys
J Pharmacol Exp Ther 1997 282: 44-55. [Abstract] [Full Text] [PDF]  

Jeffrey A. Vivian, Helena M. T. Barros, Andre Manitiu, and Klaus A. Miczek

Ultrasonic Vocalizations In Rat Pups: Modulation at the -Aminobutyric Acid_A Receptor Complex and the Neurosteroid Recognition Site^,
J Pharmacol Exp Ther 1997 282: 318-325. [Abstract] [Full Text] [PDF]  

Carol A. Paronis and James H. Woods

Ventilation in Morphine-Maintained Rhesus Monkeys. I: Effects of Naltrexone and Abstinence-Associated Withdrawal^,
J Pharmacol Exp Ther 1997 282: 348-354. [Abstract] [Full Text] [PDF]  

Carol A. Paronis and James H. Woods

Ventilation in Morphine-Maintained Rhesus Monkeys. II: Tolerance to the Antinociceptive But Not the Ventilatory Effects of Morphine^,
J Pharmacol Exp Ther 1997 282: 355-362. [Abstract] [Full Text] [PDF]  

Dale M. Edgar, Wesley F. Seidel, Kelvin W. Gee, Nancy C. Lan, George Field, Haiji Xia, Jon E. Hawkinson, Scott Wieland, Richard B. Carter, and Paul L. Wood

CCD-3693: An Orally Bioavailable Analog of the Endogenous Neuroactive Steroid, Pregnanolone, Demonstrates Potent Sedative Hypnotic Actions in the Rat
J Pharmacol Exp Ther 1997 282: 420-429. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Nobuyuki Ohte, Che-Ping Cheng, Makoto Suzuki, and William C. Little

The Cardiac Effects of Pimobendan (But Not Amrinone) Are Preserved at Rest and During Exercise in Conscious Dogs with Pacing-Induced Heart Failure
J Pharmacol Exp Ther 1997 282: 23-31. [Abstract] [Full Text] [PDF]  

Leif Carlsson, Gregory J Amos, Birgit Andersson, Lissen Drews, Göran Duker, and Gunilla Wadstedt

Electrophysiological Characterization of the Prokinetic Agents Cisapride and Mosapride in Vivo and in Vitro: Implications for Proarrhythmic Potential?
J Pharmacol Exp Ther 1997 282: 220-227. [Abstract] [Full Text] [PDF]  

Shinichi Fukuyama, Yoshimi Hirasawa, Yasuko Kato, Mie Nishio, Mitsuko Ohno, Shigetaka Nishino, Kazuhiro Maeda, Masayuki Kato, and Yasuhiro Kita

Structure-Activity Relationships of Spontaneous Nitric Oxide Releasers, FK409 and its Derivatives
J Pharmacol Exp Ther 1997 282: 236-242. [Abstract] [Full Text] [PDF]  

Arpad Tosaki and Dipak K. Das

Extracellular Mg⁺⁺ Manipulation Prevents the Proarrhythmic Activity of Cromakalim in Ischemic/Reperfused Diabetic Hearts
J Pharmacol Exp Ther 1997 282: 309-317. [Abstract] [Full Text] [PDF]  

Harald Brunv and and Ketil Grong

Carvedilol Retards Sudden Loss of Contraction during Early Regional Myocardial Ischemia in Feline Hearts
J Pharmacol Exp Ther 1997 282: 363-368. [Abstract] [Full Text] [PDF]  

John J. Lopez, Elazer R. Edelman, Alon Stamler, Mark G. Hibberd, Pottumarthi Prasad, Ronald P. Caputo, Joseph P. Carrozza, Pamela S. Douglas, Frank W. Sellke, and Michael Simons

Basic Fibroblast Growth Factor in a Porcine Model of Chronic Myocardial Ischemia: A Comparison of Angiographic, Echocardiographic and Coronary Flow Parameters
J Pharmacol Exp Ther 1997 282: 385-390. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Yukun Yuan and William D. Atchison

Action of Methylmercury on GABA_A Receptor-Mediated Inhibitory Synaptic Transmission Is Primarily Responsible for Its Early Stimulatory Effects on Hippocampal CA1 Excitatory Synaptic Transmission
J Pharmacol Exp Ther 1997 282: 64-73. [Abstract] [Full Text] [PDF]  

Jiang-Hong Ye and Joseph J. McArdle

Waglerin-1 Modulates -Aminobutyric Acid Activated Current of Murine Hypothalamic Neurons
J Pharmacol Exp Ther 1997 282: 74-80. [Abstract] [Full Text] [PDF]  

Annamaria De Luca, Sabata Pierno, Fedele Natuzzi, Carlo Franchini, Andrea Duranti, Giovanni Lentini, Vincenzo Tortorella, Harald Jockusch, and Diana Conte Camerino

Evaluation of the Antimyotonic Activity of Mexiletine and Some New Analogs on Sodium Currents of Single Muscle Fibers and on the Abnormal Excitability of the Myotonic ADR Mouse
J Pharmacol Exp Ther 1997 282: 93-100. [Abstract] [Full Text] [PDF]  

Juan Bernal, Jung-Ha Lee, Leanne L. Cribbs, and Edward Perez-Reyes

Full Reversal of Pb⁺⁺ Block of L-Type Ca⁺⁺ Channels Requires Treatment with Heavy Metal Antidotes
J Pharmacol Exp Ther 1997 282: 172-180. [Abstract] [Full Text] [PDF]  

Atsuo Tahara, Yuichi Tomura, Koh-Ichi Wada, Toshiyuki Kusayama, Junko Tsukada, Masahiro Takanashi, Takeyuki Yatsu, Wataru Uchida, and Akihiro Tanaka

Pharmacological Profile of YM087, A Novel Potent Nonpeptide Vasopressin V_1A and V₂ Receptor Antagonist, in Vitro and in Vivo
J Pharmacol Exp Ther 1997 282: 301-308. [Abstract] [Full Text] [PDF]  

Martha I. Dávila-García, John L. Musachio, David C. Perry, Yingxian Xiao, Andrew Horti, Edythe D. London, Robert F. Dannals, and Kenneth J. Kellar

[¹²⁵I]IPH, an Epibatidine Analog, Binds with High Affinity to Neuronal Nicotinic Cholinergic Receptors
J Pharmacol Exp Ther 1997 282: 445-451. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Augustine U. Orjih

Heme Polymerase Activity and the Stage Specificity of Antimalarial Action of Chloroquine
J Pharmacol Exp Ther 1997 282: 108-112. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Hiroyuki Sasabe, Tetsuya Terasaki, Akira Tsuji, and Yuichi Sugiyama

Carrier-Mediated Hepatic Uptake of Quinolone Antibiotics in the Rat
J Pharmacol Exp Ther 1997 282: 162-171. [Abstract] [Full Text] [PDF]  

Dylan Sutton, Alison M. Butler, Louise Nadin, and Michael Murray

Role of CYP3A4 in Human Hepatic Diltiazem N-Demethylation: Inhibition of CYP3A4 Activity by Oxidized Diltiazem Metabolites
J Pharmacol Exp Ther 1997 282: 294-300. [Abstract] [Full Text] [PDF]  

Linda K. Ludden, Thomas M. Ludden, Jerry M. Collins, Helen S. Pentikis, and John M. Strong

Effect of Albumin on the Estimation, In Vitro, of Phenytoin V_max and K_m Values: Implications for Clinical Correlation
J Pharmacol Exp Ther 1997 282: 391-396. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

Zbigniew K. Krowicki, Nicole A. Nathan, and Pamela J. Hornby

Opposing Effects of Vasoactive Intestinal Polypeptide on Gastric Motor Function in the Dorsal Vagal Complex and the Nucleus Raphe Obscurus of the Rat
J Pharmacol Exp Ther 1997 282: 14-22. [Abstract] [Full Text] [PDF]  

Sushanta Chakder and Satish Rattan

L-Arginine Deficiency Causes Suppression of Nonadrenergic Noncholinergic Nerve-Mediated Smooth Muscle Relaxation: Role of L-Citrulline Recycling
J Pharmacol Exp Ther 1997 282: 378-384. [Abstract] [Full Text] [PDF]  

Xi-Long Zheng, Shalini Mokashi, and Morley D. Hollenberg

Contractile Action of Ethanol in Guinea Pig Gastric Smooth Muscle: Inhibition by Tyrosine Kinase Inhibitors and Comparison with the Contractile Action of Epidermal Growth Factor-Urogastrone
J Pharmacol Exp Ther 1997 282: 485-495. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

María Isolde Rudolph, Maria de los Angeles García, Marcia Sepulveda, Enrique Brandan, Karin Reinicke, Sandra Nicovani, and Leonor Villan

Ethodin: Pharmacological Evidence of the Interaction between Smooth Muscle and Mast Cells in the Myometrium
J Pharmacol Exp Ther 1997 282: 256-261. [Abstract] [Full Text] [PDF]  

Christopher Bolton and Carolyn Paul

MK-801 Limits Neurovascular Dysfunction during Experimental Allergic Encephalomyelitis
J Pharmacol Exp Ther 1997 282: 397-402. [Abstract] [Full Text] [PDF]  

John J. Breton and Marie C. Chabot-Fletcher

The Natural Product Hymenialdisine Inhibits Interleukin-8 Production in U937 Cells by Inhibition of Nuclear Factor-B
J Pharmacol Exp Ther 1997 282: 459-466. [Abstract] [Full Text] [PDF]  

David M. Essayan, Anne Kagey-Sobotka, Lawrence M. Lichtenstein, and Shau-Ku Huang

Differential Regulation of Human Antigen-Specific Th1 and Th2 Lymphocyte Responses by Isozyme Selective Cyclic Nucleotide Phosphodiesterase Inhibitors
J Pharmacol Exp Ther 1997 282: 505-512. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Claude Guéniau and Claude Oberlander

The Kappa Opioid Agonist Niravoline Decreases Brain Edema in the Mouse Middle Cerebral Artery Occlusion Model of Stroke
J Pharmacol Exp Ther 1997 282: 1-6. [Abstract] [Full Text] [PDF]  

Charles R. Breese, Michael J. Marks, Judy Logel, Cathy E. Adams, Bernadette Sullivan, Allan C. Collins, and Sherry Leonard

Effect of Smoking History on [³H]Nicotine Binding in Human Postmortem Brain
J Pharmacol Exp Ther 1997 282: 7-13. [Abstract] [Full Text] [PDF]  

Sharon R. Grady, Elizabeth U. Grun, Michael J. Marks, and Allan C. Collins

Pharmacological Comparison of Transient and Persistent [³H]Dopamine Release from Mouse Striatal Synaptosomes and Response to Chronic L-Nicotine Treatment
J Pharmacol Exp Ther 1997 282: 32-43. [Abstract] [Full Text] [PDF]  

Shigeru Okuyama, Shigeyuki Chaki, Ryoko Yoshikawa, Yoshiko Suzuki, Shin-Ichi Ogawa, Yasuko Imagawa, Naoya Kawashima, Yoko Ikeda, Toshihito Kumagai, Atsuro Nakazato, Masashi Nagamine, and Kazuyuki Tomisawa

In Vitro and In Vivo Characterization of the Dopamine D₄ Receptor, Serotonin 5-HT_2A Receptor and Alpha-1 Adrenoceptor Antagonist (R)-(+)-2-Amino-4-(4-Fluorophenyl)- 5-[1-[4-(4-Fluorophenyl)-4-Oxobutyl]Pyrrolidin-3-yl]Thiazole (NRA0045)
J Pharmacol Exp Ther 1997 282: 56-63. [Abstract] [Full Text] [PDF]  

Jörg Huwyler, Gert Fricker, Michael Török, Markus Schneider, and Jürgen Drewe

Transport of Clonidine Across Cultured Brain Microvessel Endothelial Cells
J Pharmacol Exp Ther 1997 282: 81-85. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Adrian Newman-Tancredi, Jean-Michel Rivet, Mauricette Brocco, Pierre Lacroix, Valérie Audinot, Laetitia Cistarelli, and Alain Gobert

S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: I. Interaction with Cloned Human (h)5-HT_1A, Dopamine hD₂/hD₃ and h_2A-Adrenergic Receptors in Relation to Modulation of Cortical Monoamine Release and Activity in Models of Potential Antidepressant Activity
J Pharmacol Exp Ther 1997 282: 132-147. [Abstract] [Full Text] [PDF]  

Mark J. Millan, Stephan Hjorth, Rosario Samanin, Rudy Schreiber, Robert Jaffard, Brigitte De Ladonchamps, Sylvie Veiga, Bertrand Goument, Jean-Louis Peglion, Michael Spedding, and Mauricette Brocco

S 15535, A Novel Benzodioxopiperazine Ligand of Serotonin (5-HT)_1A Receptors: II. Modulation of Hippocampal Serotonin Release in Relation to Potential Anxiolytic Properties
J Pharmacol Exp Ther 1997 282: 148-161. [Abstract] [Full Text] [PDF]  

A. Newman-Tancredi, V. Audinot, C. Chaput, and L.Verrièle and M. J. Millan

[³⁵S]Guanosine-5-O-(3-thio)triphosphate Binding as a Measure of Efficacy at Human Recombinant Dopamine D_4.4 Receptors: Actions of Antiparkinsonian and Antipsychotic Agents
J Pharmacol Exp Ther 1997 282: 181-191. [Abstract] [Full Text] [PDF]  

Lee E. Schechter

The Potassium Channel Blockers 4-Aminopyridine and Tetraethylammonium Increase the Spontaneous Basal Release of [³H]5-Hydroxytryptamine in Rat Hippocampal Slices
J Pharmacol Exp Ther 1997 282: 262-270. [Abstract] [Full Text] [PDF]  

E. R. Whittemore, V. I. Ilyin, and R. M. Woodward

Antagonism of N-Methyl-D-Aspartate Receptors by  Site Ligands: Potency, Subtype-Selectivity and Mechanisms of Inhibition
J Pharmacol Exp Ther 1997 282: 326-338. [Abstract] [Full Text] [PDF]  

M. I. Damaj, G. S. Patrick, K. R. Creasy, and B. R. Martin

Pharmacology of Lobeline, A Nicotinic Receptor Ligand
J Pharmacol Exp Ther 1997 282: 410-419. [Abstract] [Full Text] [PDF]  

Lucette Garreau, Patrick Emond, Catherine Belzung, Denis Guilloteau, Yves Frangin, Jean-Claude Besnard, and Sylvie Chalon

N-(3-Iodoprop-2E-enyl)-2-carbomethoxy-3-(3,4-dichlorophenyl)nortropane (-CDIT), a Tropane Derivative: Pharmacological Characterization as a Specific Ligand for the Dopamine Transporter in the Rodent Brain
J Pharmacol Exp Ther 1997 282: 467-474. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Bardia Askari, Caroline P. Bell-Quilley, David Fulton, John Quilley, and John C. McGiff

Analysis of Eicosanoid Mediation of the Renal Functional Effects of Hyperchloremia^,
J Pharmacol Exp Ther 1997 282: 101-107. [Abstract] [Full Text] [PDF]  

H. Kan, Y. Ruan, and K. U. Malik

Signal Transduction Mechanism(s) Involved in Prostacyclin Production Elicited by Acetylcholine in Coronary Endothelial Cells of Rabbit Heart
J Pharmacol Exp Ther 1997 282: 113-122. [Abstract] [Full Text] [PDF]  

V. Escrig, A. Ubeda, M. L. Ferrandiz, J. Darias, J. M. Sanchez, M. J. Alcaraz, and M. Paya

Variabilin: A Dual Inhibitor of Human Secretory and Cytosolic Phospholipase A₂ With Anti-inflammatory Activity
J Pharmacol Exp Ther 1997 282: 123-131. [Abstract] [Full Text] [PDF]  

Karen A. Willoughby, Sandra F. Moore, Billy R. Martin, and Earl F. Ellis

The Biodisposition and Metabolism of Anandamide in Mice
J Pharmacol Exp Ther 1997 282: 243-247. [Abstract] [Full Text] [PDF]  

Adam P. Curnock, Peter A. Robson, Christopher M. Yea, David Moss, Suresh Gadher, T. Andrew Thomson, Robert Westwood, Erik Ruuth, and Richard A. Williamson

Potencies of Leflunomide and HR325 as Inhibitors of Prostaglandin Endoperoxide H Synthase-1 and -2: Comparison with Nonsteroidal Anti-Inflammatory Drugs
J Pharmacol Exp Ther 1997 282: 339-347. [Abstract] [Full Text] [PDF]  

Keyvan Mahboubi, Wilson Young, and Nicholas R. Ferreri

Induction of Prostaglandin Endoperoxide Synthase-2 by Serine-Threonine Phosphatase Inhibition
J Pharmacol Exp Ther 1997 282: 452-458. [Abstract] [Full Text] [PDF]  

Mun-Chual Rho, Norimichi Nakahata, Hideshi Nakamura, Akio Murai, and Yasushi Ohizumi

Involvement of Phospholipase C-2 in Activation of Mitogen-Activated Protein Kinase and Phospholipase A₂ by Zooxanthellatoxin-A in Rabbit Platelets
J Pharmacol Exp Ther 1997 282: 496-504. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

Allison Fryer, Yuh-Chin Huang, Gopna Rao, David Jacoby, Edward Mancilla, Richard Whorton, Claude A. Piantadosi, Thomas Kennedy, and John Hoidal

Selective O-Desulfation Produces Nonanticoagulant Heparin that Retains Pharmacological Activity in the Lung^,
J Pharmacol Exp Ther 1997 282: 208-219. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

David S. Miller, Gert Fricker, and Juergen Drewe

p-Glycoprotein-Mediated Transport of a Fluorescent Rapamycin Derivative in Renal Proximal Tubule
J Pharmacol Exp Ther 1997 282: 440-444. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

H. Vasken Aposhian, Alex Arroyo, Mariano E. Cebrian, Luz María Del Razo, Katherine M. Hurlbut, Richard C. Dart, Diego Gonzalez-Ramirez, Helmut Kreppel, Hernan Speisky, Allan Smith, Maria E. Gonsebatt, Patricia Ostrosky-Wegman, and Mary M. Aposhian

DMPS-Arsenic Challenge Test. I: Increased Urinary Excretion of Monomethylarsonic Acid in Humans Given Dimercaptopropane Sulfonate
J Pharmacol Exp Ther 1997 282: 192-200. [Abstract] [Full Text] [PDF]  

Ben-Bo Song, David J. Anderson, and Jochen Schacht

Protection from Gentamicin Ototoxicity by Iron Chelators in Guinea Pig In Vivo^,
J Pharmacol Exp Ther 1997 282: 369-377. [Abstract] [Full Text] [PDF]  

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