ANALGESIA AND DRUGS OF ABUSE:

Ilmar Jurna, Wolfgang Kömen, Joseph Baldauf, and Wolfgang Fleischer

Analgesia by Dihydrocodeine Is Not Due to Formation of Dihydromorphine: Evidence from Nociceptive Activity in Rat Thalamus
J Pharmacol Exp Ther 1997 281: 1164-1170. [Abstract] [Full Text] [PDF]  

Stuart A. Dunbar and Tony L. Yaksh

Spinal Infusion of N-methyl-D-aspartate Antagonist MK801 Induces Hypersensitivity to the Spinal Alpha-2 Agonist ST91 in the Rat
J Pharmacol Exp Ther 1997 281: 1219-1225. [Abstract] [Full Text] [PDF]  

Matthew J. Hepburn, Patrick J. Little, Jeanine Gingras, and Cynthia M. Kuhn

Differential Effects of Naltrindole on Morphine-Induced Tolerance and Physical Dependence in Rats
J Pharmacol Exp Ther 1997 281: 1350-1356. [Abstract] [Full Text] [PDF]  

Diego Bustamante, Carlos Paeile, Jean-Claude Willer, and Daniel Le Bars

Effects of Intrathecal or Intracerebroventricular Administration of Nonsteroidal Anti-inflammatory Drugs on a C-Fiber Reflex in Rats
J Pharmacol Exp Ther 1997 281: 1381-1391. [Abstract] [Full Text] [PDF]  

Susan F. Law and Terry Reisine

Changes in the Association of G Protein Subunits with the Cloned Mouse Delta Opioid Receptor on Agonist Stimulation
J Pharmacol Exp Ther 1997 281: 1476-1486. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

David B. Bylund, Laurie J. Iversen, William J. Matulka, and David M. Chacko

Characterization of Alpha-2D Adrenergic Receptor Subtypes in Bovine Ocular Tissue Homogenates
J Pharmacol Exp Ther 1997 281: 1171-1177. [Abstract] [Full Text] [PDF]  

A. Leonardi, J. P. Hieble, L. Guarneri, D. P. Naselsky, E. Poggesi, G. Sironi, A. C. Sulpizio, and R. Testa

Pharmacological Characterization of the Uroselective Alpha-1 Antagonist Rec 15/2739 (SB 216469): Role of the Alpha-1L Adrenoceptor in Tissue Selectivity, Part I
J Pharmacol Exp Ther 1997 281: 1272-1283. [Abstract] [Full Text] [PDF]  

R. Testa, L. Guarneri, P. Angelico, E. Poggesi, C. Taddei, G. Sironi, D. Colombo, A. C. Sulpizio, D. P. Naselsky, J. P. Hieble, and A. Leonardi

Pharmacological Characterization of the Uroselective Alpha-1 Antagonist Rec 15/2739 (SB 216469): Role of the Alpha-1L Adrenoceptor in Tissue Selectivity, Part II
J Pharmacol Exp Ther 1997 281: 1284-1293. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Chyan E. Lau, Yunxia Wang, and John L. Falk

Differential Reinforcement of Low Rate Performance, Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Modeling: Independent Interaction of Alprazolam and Caffeine
J Pharmacol Exp Ther 1997 281: 1013-1029. [Abstract] [Full Text] [PDF]  

Mark K. Greenwald, Maxine L. Stitzer, and Kathleen A. Haberny

Human Pharmacology of the Opioid Neuropeptide Dynorphin A(1-13)
J Pharmacol Exp Ther 1997 281: 1154-1163. [Abstract] [Full Text] [PDF]  

Rubén A. Velázquez, Kelley F. Kitto, and Alice A. Larson

CP-96,345, which Inhibits [³H] Substance P Binding, Selectively Inhibits the Behavioral Response to Intrathecally Administered N-Methyl-D-Aspartate, but not Substance P, in the Mouse
J Pharmacol Exp Ther 1997 281: 1231-1237. [Abstract] [Full Text] [PDF]  

Karin Fattinger, Davide Verotta, and Neal L. Benowitz

Pharmacodynamics of Acute Tolerance to Multiple Nicotinic Effects in Humans
J Pharmacol Exp Ther 1997 281: 1238-1246. [Abstract] [Full Text] [PDF]  

Richard J. Bertz, Patricia D. Kroboth, Frank J. Kroboth, Ian J. Reynolds, Firoozeh Salek, C. Eugene Wright, and Randall B. Smith

Alprazolam in Young and Elderly Men: Sensitivity and Tolerance to Psychomotor, Sedative and Memory Effects
J Pharmacol Exp Ther 1997 281: 1317-1329. [Abstract] [Full Text] [PDF]  

S. J. Manley and H. J. Little

Enhancement of Amphetamine- and Cocaine-Induced Locomotor Activity after Chronic Ethanol Administration
J Pharmacol Exp Ther 1997 281: 1330-1339. [Abstract] [Full Text] [PDF]  

G. Y. H. Mcclure, G. R. Wenger, and D. E. Mcmillan

Effects of Drugs on Response Duration Differentiation. V: Differential Effects under Temporal Response Differentiation Schedules
J Pharmacol Exp Ther 1997 281: 1357-1367. [Abstract] [Full Text] [PDF]  

G. Y. H. Mcclure and D. E. Mcmillan

Effects of Drugs on Response Duration Differentiation. VI: Differential Effects under Differential Reinforcement of Low Rates of Responding Schedules
J Pharmacol Exp Ther 1997 281: 1368-1380. [Abstract] [Full Text] [PDF]  

Michela Marinelli, Françoise Rougé-Pont, Véronique Deroche, Michel Barrot, Cécile De Jésus-Oliveira, Michel Le Moal, and Pier Vincenzo Piazza

Glucocorticoids and Behavioral Effects of Psychostimulants. I: Locomotor Response to Cocaine Depends on Basal Levels of Glucocorticoids
J Pharmacol Exp Ther 1997 281: 1392-1400. [Abstract] [Full Text] [PDF]  

Véronique Deroche, Michela Marinelli, Michel Le Moal, and Pier Vincenzo Piazza

Glucocorticoids and Behavioral Effects of Psychostimulants. II: Cocaine Intravenous Self-administration and Reinstatement Depend on Glucocorticoid Levels
J Pharmacol Exp Ther 1997 281: 1401-1407. [Abstract] [Full Text] [PDF]  

Una D. Mccann, Jie Yuan, George Hatzidimitriou, and George A. Ricaurte

Selective Serotonin Reuptake Inhibitors Dissociate Fenfluramine's Anorectic and Neurotoxic Effects: Importance of Dose, Species and Drug
J Pharmacol Exp Ther 1997 281: 1487-1498. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Kristy D. Lake, David R. Compton, Karoly Varga, Billy R. Martin, and George Kunos

Cannabinoid-Induced Hypotension and Bradycardia in Rats Is Mediated by CB₁-Like Cannabinoid Receptors
J Pharmacol Exp Ther 1997 281: 1030-1037. [Abstract] [Full Text] [PDF]  

Ping Li, Carlos M. Ferrario, and K. Bridget Brosnihan

Nonpeptide Angiotensin II Antagonist Losartan Inhibits Thromboxane A₂-Induced Contractions in Canine Coronary Arteries
J Pharmacol Exp Ther 1997 281: 1065-1070. [Abstract] [Full Text] [PDF]  

Markus Flesch, Heiko Kilter, Bodo Cremers, Olaf Lenz, Michael Südkamp, Ferdinand Kuhn-Regnier, and Michael Böhm

Acute Effects of Nitric Oxide and Cyclic GMP on Human Myocardial Contractility
J Pharmacol Exp Ther 1997 281: 1340-1349. [Abstract] [Full Text] [PDF]  

Shiro Hoshida, Kazuhiro Aoki, Masashi Nishida, Nobushige Yamashita, Junsuke Igarashi, Masatsugu Hori, Tsunehiko Kuzuya, and Michihiko Tada

Effects of Preconditioning with Ebselen on Glutathione Metabolism and Stress Protein Expression
J Pharmacol Exp Ther 1997 281: 1471-1475. [Abstract] [Full Text] [PDF]  

Rae Yuan, Masahiro Sumi, and Leslie Z. Benet

Investigation of Aortic CYP3A Bioactivation of Nitroglycerin In Vivo
J Pharmacol Exp Ther 1997 281: 1499-1505. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Ying Ruan, Hong Kan, and Kafait U. Malik

Beta Adrenergic Receptor Stimulated Prostacyclin Synthesis in Rabbit Coronary Endothelial Cells Is Mediated by Selective Activation of Phospholipase D: Inhibition by Adenosine 35-Cyclic Monophosphate
J Pharmacol Exp Ther 1997 281: 1038-1046. [Abstract] [Full Text] [PDF]  

Kazuo Ishii, Kaoru M. Ito, Daisuke Uemura, and Katsuaki Ito

Possible Mechanism of Palytoxin-Induced Ca⁺⁺ Mobilization in Porcine Coronary Artery
J Pharmacol Exp Ther 1997 281: 1077-1084. [Abstract] [Full Text] [PDF]  

Kouichiro Minami, Makiko Minami, and R. Adron Harris

Inhibition of 5-Hydroxytryptamine Type 2A Receptor-Induced Currents by n-Alcohols and Anesthetics
J Pharmacol Exp Ther 1997 281: 1136-1143. [Abstract] [Full Text] [PDF]  

Marco Raiteri, Lorenzo Arnaboldi, Paul Mcgeady, Michael H. Gelb, Daniela Verri, Carlo Tagliabue, Pierangelo Quarato, Patrizia Ferraboschi, Enzo Santaniello, Rodolfo Paoletti, Remo Fumagalli, and Alberto Corsini

Pharmacological Control of the Mevalonate Pathway: Effect on Arterial Smooth Muscle Cell Proliferation
J Pharmacol Exp Ther 1997 281: 1144-1153. [Abstract] [Full Text] [PDF]  

Xue Zhang, James W. Anderson, and David Fedida

Characterization of Nifedipine Block of the Human Heart Delayed Rectifier, hKv1.5
J Pharmacol Exp Ther 1997 281: 1247-1256. [Abstract] [Full Text] [PDF]  

R. L. McDonald, D. J. Roberts, A. C. V. Palmer, S. G. Ball, P. F. T. Vaughan, and C. Peers

Regulation of [Ca⁺⁺]_i in Human Neuroblastoma (SH-SY5Y) Cells Expressing Recombinant Rat Angiotensin_1A Receptors by Angiotensin II and Carbachol
J Pharmacol Exp Ther 1997 281: 1257-1263. [Abstract] [Full Text] [PDF]  

Henry M. Sarau, Don E. Griswold, William Potts, James J. Foley, Dulcie B. Schmidt, Edward F. Webb, Lenox D. Martin, Mary E. Brawner, Nabil A. Elshourbagy, Andrew D. Medhurst, Giuseppe A. M. Giardina, and Douglas W. P. Hay

Nonpeptide Tachykinin Receptor Antagonists: I. Pharmacological and Pharmacokinetic Characterization of SB 223412, a Novel, Potent and Selective Neurokinin-3 Receptor Antagonist
J Pharmacol Exp Ther 1997 281: 1303-1311. [Abstract] [Full Text] [PDF]  

Tawny K. Dahring, Gina H. Lu, James M. Hamby, Brian L. Batley, Alan J. Kraker, and Robert L. Panek

Inhibition of Growth Factor-Mediated Tyrosine Phosphorylation in Vascular Smooth Muscle by PD 089828, a New Synthetic Protein Tyrosine Kinase Inhibitor
J Pharmacol Exp Ther 1997 281: 1446-1456. [Abstract] [Full Text] [PDF]  

Manar D. El-Dada and Maryka Quik

Involvement of Nitric Oxide in Nicotinic Receptor-Mediated Myopathy
J Pharmacol Exp Ther 1997 281: 1463-1470. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Jacob Golenser, Abraham Domb, Doron Teomim, Appolinaire Tsafack, Orna Nisim, Prem Ponka, Wijnand Eling, and Z. Ioav Cabantchik

The Treatment of Animal Models of Malaria with Iron Chelators by Use of a Novel Polymeric Device for Slow Drug Release
J Pharmacol Exp Ther 1997 281: 1127-1135. [Abstract] [Full Text] [PDF]  

Margarita Arboix, Odalys Gonzalez Paz, Tina Colombo, and Maurizio D'Incalci

Multidrug Resistance-Reversing Agents Increase Vinblastine Distribution in Normal Tissues Expressing the P-Glycoprotein but Do Not Enhance Drug Penetration in Brain and Testis
J Pharmacol Exp Ther 1997 281: 1226-1230. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

A. S. Gross, G. Mikus, D. Ratge, H. Wisser, and M. Eichelbaum

Pharmacokinetics and Pharmacodynamics of the Enantiomers of Gallopamil
J Pharmacol Exp Ther 1997 281: 1102-1112. [Abstract] [Full Text] [PDF]  

Eriko Koyama, Kan Chiba, Masanao Tani, and Takashi Ishizaki

Reappraisal of Human CYP Isoforms Involved in Imipramine N-Demethylation and 2-Hydroxylation: A Study Using Microsomes Obtained from Putative Extensive and Poor Metabolizers of S-Mephenytoin and Eleven Recombinant Human CYPs
J Pharmacol Exp Ther 1997 281: 1199-1210. [Abstract] [Full Text] [PDF]  

ENDOCRINE PHARMACOLOGY:

Hye Jung Lee, Gary Riley, Olufumni Johnson, Jeffrey L. Cleland, Norman Kim, Margarita Charnis, Leonie Bailey, Eileen Duenas, Azin Shahzamani, Melinda Marian, Andrew J. S. Jones, and Scott D. Putney

In Vivo Characterization of Sustained-Release Formulations of Human Growth Hormone
J Pharmacol Exp Ther 1997 281: 1431-1439. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

Thomas A. Hinterleitner, John D. Valentich, Jih-Ho Cha, Peter Will, Ann Welton, and Don W. Powell

Platelet-Activating Factor Contributes to Immune Cell and Oxidant-Mediated Intestinal Secretion^,
J Pharmacol Exp Ther 1997 281: 1264-1271. [Abstract] [Full Text] [PDF]  

Irmgard Th. Lippe, Christof H. Wachter, and Peter Holzer

Neurokinin A-Induced Vasoconstriction and Muscular Contraction in the Rat Isolated Stomach: Mediation by Distinct and Unusual Neurokinin₂ Receptors
J Pharmacol Exp Ther 1997 281: 1294-1302. [Abstract] [Full Text] [PDF]  

C. W. Song, K. Y. Lee, C. D. Kim, T-M. Chang, and W. Y. Chey

Effect of Cisapride and Renzapride on Gastrointestinal Motility and Plasma Motilin Concentration in Dogs
J Pharmacol Exp Ther 1997 281: 1312-1316. [Abstract] [Full Text] [PDF]  

Tomohiro Terada, Hideyuki Saito, Mayumi Mukai, and Ken-Ichi Inui

Characterization of Stably Transfected Kidney Epithelial Cell Line Expressing Rat H⁺/Peptide Cotransporter PEPT1: Localization of PEPT1 and Transport of -Lactam Antibiotics
J Pharmacol Exp Ther 1997 281: 1415-1421. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Bao G. Xue, Edward R. Whittemore, Chong H. Park, Richard M. Woodward, Nancy C. Lan, and Kelvin W. Gee

Partial Agonism by 3,21-Dihydroxy-5-pregnan-20-one at the -Aminobutyric Acid_A Receptor Neurosteroid Site
J Pharmacol Exp Ther 1997 281: 1095-1101. [Abstract] [Full Text] [PDF]  

Ingeborg van den Beukel, Fred A. Dijcks, Patrick Vanderheyden, Georges Vauquelin, and Marga Oortgiesen

Differential Muscarinic Receptor Binding of Acetylcholinesterase Inhibitors in Rat Brain, Human Brain and Chinese Hamster Ovary Cells Expressing Human Receptors
J Pharmacol Exp Ther 1997 281: 1113-1119. [Abstract] [Full Text] [PDF]  

P. Mares, A. Mikulecká, and M. Pometlová

Anticonvulsant Action of 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline in Immature Rats: Comparison with the Effects on Motor Performance
J Pharmacol Exp Ther 1997 281: 1120-1126. [Abstract] [Full Text] [PDF]  

S. K. Norris and A. E. King

The Stereo-Isomers of the Anticonvulsant ARL 12495AA Limit Sustained Repetitive Firing and Modify Action Potential Properties of Rat Hippocampal Neurons in Vitro
J Pharmacol Exp Ther 1997 281: 1191-1198. [Abstract] [Full Text] [PDF]  

Sarah A. Thomas and Malcolm B. Segal

The Passage of Azidodeoxythymidine into and within the Central Nervous System: Does It Follow the Parent Compound, Thymidine?
J Pharmacol Exp Ther 1997 281: 1211-1218. [Abstract] [Full Text] [PDF]  

Hideo Tsukada, Takeharu Kakiuchi, Ichiro Ando, and Yasuomi Ouchi

Functional Activation of Cerebral Blood Flow Abolished by Scopolamine Is Reversed by Cognitive Enhancers Associated with Cholinesterase Inhibition: A Positron Emission Tomography Study in Unanesthetized Monkeys
J Pharmacol Exp Ther 1997 281: 1408-1414. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

A. Rouleau, M. Garbarg, X. Ligneau, C. Mantion, P. Lavie, C. Advenier, J.-M. Lecomte, M. Krause, H. Stark, W. Schunack, and J.-C. Schwartz

Bioavailability, Antinociceptive and Antiinflammatory Properties of BP 2-94, a Histamine H₃ Receptor Agonist Prodrug
J Pharmacol Exp Ther 1997 281: 1085-1094. [Abstract] [Full Text] [PDF]  

Domenico Pratico, Natalie P. Murphy, and Desmond J. Fitzgerald

Interaction of a Thrombin Inhibitor and a Platelet GP IIb/IIIa Antagonist In Vivo: Evidence That Thrombin Mediates Platelet Aggregation and Subsequent Thromboxane A₂ Formation During Coronary Thrombolysis
J Pharmacol Exp Ther 1997 281: 1178-1185. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

Jin Chen and Shri N. Giri

Differences in Platelet-Activating Factor Receptor Mediated Ca⁺⁺ Response Between Hamster and Guinea Pig Alveolar Macrophages
J Pharmacol Exp Ther 1997 281: 1047-1058. [Abstract] [Full Text] [PDF]  

J. Tamaoki, A. Chiyotani, H. Takemura, K. Konno, T. Matsumoto, and Y. Ashida

Stimulation of Airway Mucociliary Transport and Epithelial Ciliary Motility by the Triazolopyridazin Derivative TAK-225
J Pharmacol Exp Ther 1997 281: 1186-1190. [Abstract] [Full Text] [PDF]  

Poh-Gek Forkert, Kathy S. Collins, Taylor F. Dowsley, and Gregory M. Ross

Immunochemical Assay for Recognition of 2-S-Glutathionyl Acetate, a Glutathione Conjugate Derived from 1,1-Dichloroethylene-Epoxide
J Pharmacol Exp Ther 1997 281: 1422-1430. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

Richard M. Edwards, Elwood Stack, and Walter Trizna

-Ketoglutarate Transport in Rat Renal Brush-Border and Basolateral Membrane Vesicles
J Pharmacol Exp Ther 1997 281: 1059-1064. [Abstract] [Full Text] [PDF]  

Allan M. Evans, Angelo Mancinelli, and Antonio Longo

Excretion and Metabolism of Propionyl-L-carnitine in the Isolated Perfused Rat Kidney
J Pharmacol Exp Ther 1997 281: 1071-1076. [Abstract] [Full Text] [PDF]  

David P. Brooks, Shujath M. Ali, Lisa C. Contino, Elwood Stack, Todd A. Fredrickson, John Feild, and Richard M. Edwards

Phosphate Excretion and Phosphate Transporter Messenger RNA in Uremic Rats Treated with Phosphonoformic Acid
J Pharmacol Exp Ther 1997 281: 1440-1445. [Abstract] [Full Text] [PDF]  

Hunjoo Ha, Sang H. Lee, and K. Hwan Kim

Effects of Rebamipide in a Model of Experimental Diabetes and on the Synthesis of Transforming Growth Factor- and Fibronectin, and Lipid Peroxidation Induced by High Glucose in Cultured Mesangial Cells
J Pharmacol Exp Ther 1997 281: 1457-1462. [Abstract] [Full Text] [PDF]  

ERRATA:

Correction for vol. 277, p. 423
J Pharmacol Exp Ther 1997 281: 1506. [Full Text] [PDF]  

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