ANALGESIA AND DRUGS OF ABUSE:

Hemendra N. Bhargava, Jing-Tan Bian, and Shailendra Kumar

Mechanism of Attenuation of Morphine Antinociception by Chronic Treatment with L-Arginine
J Pharmacol Exp Ther 1997 281: 707-712. [Abstract] [Full Text] [PDF]  

Danièle M.-C. Ouellet and Gary M. Pollack

Pharmacodynamics and Tolerance Development During Multiple Intravenous Bolus Morphine Administration in Rats
J Pharmacol Exp Ther 1997 281: 713-720. [Abstract] [Full Text] [PDF]  

George Pugh, Jr., David J. Mason, Jr., Vera Combs, and Sandra P. Welch

Involvement of Dynorphin B in the Antinociceptive Effects of the Cannabinoid CP55,940 in the Spinal Cord
J Pharmacol Exp Ther 1997 281: 730-737. [Abstract] [Full Text] [PDF]  

Toyokazu Hiranuma, Kayoko Iwao, Ken Kitamura, Teruhiko Matsumiya, and Tetsuo Oka

Almost Complete Protection from [Met⁵]-Enkephalin-Arg⁶-Gly⁷-Leu⁸ (Met-enk-RGL) Hydrolysis in Membrane Preparations by the Combination of Amastatin, Captopril and Phosphoramidon
J Pharmacol Exp Ther 1997 281: 769-774. [Abstract] [Full Text] [PDF]  

Lisa R. Gerak and Charles P. France

Changes in Sensitivity to the Rate-Decreasing Effects of Opioids in Pigeons Treated Acutely or Chronically with l--Acetylmethadol
J Pharmacol Exp Ther 1997 281: 799-809. [Abstract] [Full Text] [PDF]  

Malcolm J. Sheardown, Harlan E. Shannon, Michael D. B. Swedberg, Peter D. Suzdak, Frank P. Bymaster, Preben H. Olesen, Charles H. Mitch, John S. Ward, and Per Sauerberg

M₁ Receptor Agonist Activity Is Not a Requirement for Muscarinic Antinociception
J Pharmacol Exp Ther 1997 281: 868-875. [Abstract] [Full Text] [PDF]  

Michael D. B. Swedberg, Malcolm J. Sheardown, Per Sauerberg, Preben H. Olesen, Peter D. Suzdak, Kristian T. Hansen, Frank P. Bymaster, John S. Ward, Charles H. Mitch, David O. Calligaro, Neil W. Delapp, and Harlan E. Shannon

Butylthio[2.2.2] (NNC 11-1053/LY297802): An Orally Active Muscarinic Agonist Analgesic
J Pharmacol Exp Ther 1997 281: 876-883. [Abstract] [Full Text] [PDF]  

Harlan E. Shannon, Malcolm J. Sheardown, Frank P. Bymaster, David O. Calligaro, Neil W. Delapp, Jaswant Gidda, Charles H. Mitch, Barry D. Sawyer, Peter W. Stengel, John S. Ward, David T. Wong, Preben H. Olesen, Peter D. Suzdak, Per Sauerberg, and Michael D. B. Swedberg

Pharmacology of Butylthio[2.2.2] (LY297802/NNC11-1053): A Novel Analgesic with Mixed Muscarinic Receptor Agonist and Antagonist Activity
J Pharmacol Exp Ther 1997 281: 884-894. [Abstract] [Full Text] [PDF]  

Nicoletta Galeotti, Carla Ghelardini, Laura Papucci, Sergio Capaccioli, Alessandro Quattrone, and Alessandro Bartolini

An Antisense Oligonucleotide on the Mouse Shaker-like Potassium Channel Kv1.1 Gene Prevents Antinociception Induced by Morphine and Baclofen
J Pharmacol Exp Ther 1997 281: 941-949. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

Martin S. Muntzel, Ayat Abe, and Jørgen S. Petersen

Effects of Adrenergic, Cholinergic and Ganglionic Blockade on Acute Depressor Responses to Metformin in Spontaneously Hypertensive Rats
J Pharmacol Exp Ther 1997 281: 618-623. [Abstract] [Full Text] [PDF]  

Bryan W. Wenger, Darrell L. Bryant, R. Thomas Boyd, and Dennis B. McKay

Evidence for Spare Nicotinic Acetylcholine Receptors and a 4 Subunit in Bovine Adrenal Chromaffin Cells: Studies using Bromoacetylcholine, Epibatidine, Cytisine and mAb35
J Pharmacol Exp Ther 1997 281: 905-913. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

Alexander Kulikov, Sylvie Aguerre, Olivier Berton, Andre Ramos, Pierre Mormede, and Francis Chaouloff

Central Serotonergic Systems in the Spontaneously Hypertensive and Lewis Rat Strains that Differ in the Elevated Plus-Maze Test of Anxiety
J Pharmacol Exp Ther 1997 281: 775-784. [Abstract] [Full Text] [PDF]  

Lucien T. Thompson and John F. Disterhoft

N-Methyl-D-Aspartate Receptors in Associative Eyeblink Conditioning: Both MK-801 and Phencyclidine Produce Task- and Dose-Dependent Impairments
J Pharmacol Exp Ther 1997 281: 928-940. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Jolanta Gutkowska, Suhayla Mukaddam-Daher, and Johanne Tremblay

The Peripheral Action of Clonidine Analog ST-91: Involvement of Atrial Natriuretic Factor
J Pharmacol Exp Ther 1997 281: 670-676. [Abstract] [Full Text] [PDF]  

Jacquelynn J. Cook, Gary R. Sitko, Marie A. Holahan, Maria T. Stranieri, Joan D. Glass, Ben C. Askew, Charles J. McIntyre, David A. Claremon, John J. Baldwin, George D. Hartman, Robert J. Gould, and Joseph J. Lynch, Jr.

Nonpeptide Glycoprotein IIb/IIIa Inhibitors. 15. Antithrombotic Efficacy of L-738,167, a Long-Acting GPIIb/IIIa Antagonist, Correlates with Inhibition of Adenosine Diphosphate-Induced Platelet Aggregation but not with Bleeding Time Prolongation
J Pharmacol Exp Ther 1997 281: 677-689. [Abstract] [Full Text] [PDF]  

Dilip Amin, Ruth Z. Rutledge, Saul N. Needle, Helen F. Galczenski, Kent Neuenschwander, Anthony C. Scotese, Martin P. Maguire, Ray C. Bush, Dave J. Hele, Glenda E. Bilder, and Mark H. Perrone

RPR 107393, a Potent Squalene Synthase Inhibitor and Orally Effective Cholesterol-Lowering Agent: Comparison with Inhibitors of HMG-CoA Reductase
J Pharmacol Exp Ther 1997 281: 746-752. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Menghang Xia, Sunil P. Sreedharan, David R. Bolin, Gary O. Gaufo, and Edward J. Goetzl

Novel Cyclic Peptide Agonist of High Potency and Selectivity for the Type II Vasoactive Intestinal Peptide Receptor
J Pharmacol Exp Ther 1997 281: 629-633. [Abstract] [Full Text] [PDF]  

Stanley Kalsner

Vasodilator Action of Calcium Antagonists in Coronary Arteries In Vitro
J Pharmacol Exp Ther 1997 281: 634-642. [Abstract] [Full Text] [PDF]  

Carmina Montoliu, Marta Llansola, Carmen Cucarella, Santiago Grisolía, and Vicente Felipo

Activation of the Metabotropic Glutamate Receptor mGluR5 Prevents Glutamate Toxicity in Primary Cultures of Cerebellar Neurons
J Pharmacol Exp Ther 1997 281: 643-647. [Abstract] [Full Text] [PDF]  

C. A. Kollias-Baker, J. Ruble, M. Jacobson, J. K. Harrison, M. Ozeck, J. C. Shryock, and L. Belardinelli

Agonist-Independent Effect of an Allosteric Enhancer of the A₁ Adenosine Receptor in CHO Cells Stably Expressing the Recombinant Human A₁ Receptor
J Pharmacol Exp Ther 1997 281: 761-768. [Abstract] [Full Text] [PDF]  

Pascal Daleau, Majed Khalifa, and Jacques Turgeon

Effects of Cadmium and Nisoldipine on the Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes
J Pharmacol Exp Ther 1997 281: 826-833. [Abstract] [Full Text] [PDF]  

Hiroaki Matsubayashi, Karen L. Swanson, and Edson X. Albuquerque

Amantadine Inhibits Nicotinic Acetylcholine Receptor Function in Hippocampal Neurons
J Pharmacol Exp Ther 1997 281: 834-844. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Pei Hu, Lixia Jin, and Thomas A. Baillie

Studies on the Metabolic Activation of Disulfiram in Rat. Evidence for Electrophilic S-Oxygenated Metabolites as Inhibitors of Aldehyde Dehydrogenase and Precursors of Urinary N-Acetylcysteine Conjugates
J Pharmacol Exp Ther 1997 281: 611-617. [Abstract] [Full Text] [PDF]  

Lingxiang Zhou, Richard R. Erickson, James P. Hardwick, Sang S. Park, Steven A. Wrighton, and Jordan L. Holtzman

Catalysis of the Cysteine Conjugation and Protein Binding of Acetaminophen by Microsomes from a Human Lymphoblast Line Transfected with the cDNAs of Various Forms of Human Cytochrome P450
J Pharmacol Exp Ther 1997 281: 785-790. [Abstract] [Full Text] [PDF]  

Bernhard Sperker, Thomas E. Mürdter, Monika Schick, Klaus Eckhardt, Klaus Bosslet, and Heyo K. Kroemer

Interindividual Variability in Expression and Activity of Human -Glucuronidase in Liver and Kidney: Consequences for Drug Metabolism
J Pharmacol Exp Ther 1997 281: 914-920. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

L. Harcouët, D. Lebrec, C. Rozé, C. Carbon, and R. Farinotti

Increased Intestinal Absorption of Cefixime by Nifedipine in the Rat Intestinal Perfusion Model: Evidence for a Neural Regulation
J Pharmacol Exp Ther 1997 281: 738-745. [Abstract] [Full Text] [PDF]  

IMMUNOPHARMACOLOGY:

Silvina Raiden, Mirta Giordano, Graciela Andonegui, Analía S. Trevani, Daniel H. López, Victor Nahmod, and Jorge R. Geffner

Losartan, a Selective Inhibitor of Subtype AT1 Receptors for Angiotensin II, Inhibits the Binding of N-Formylmethionyl-leucyl-phenylalanine to Neutrophil Receptors
J Pharmacol Exp Ther 1997 281: 624-628. [Abstract] [Full Text] [PDF]  

Karen E. Pedersen, Bruce S. Bochner, and Bradley J. Undem

Cysteinyl Leukotrienes Induce P-Selectin Expression in Human Endothelial Cells via a Non-CysLT₁ Receptor-Mediated Mechanism
J Pharmacol Exp Ther 1997 281: 655-662. [Abstract] [Full Text] [PDF]  

Susan L. Woulfe, Christine P. Bono, Michelle L. Zacheis, Joseph K. Welply, Dawn A. Kirschmann, Troy A. Baudino, Yang Wang, Deborah A. Stone, Gunnar J. Hanson, Jennifer L. Vuletich, Louis J. Bedell, Benjamin D. Schwartz, and Susan C. Howard

A Peptidomimetic that Specifically Inhibits Human Leukocyte Antigen DRB1^*0401-restricted T Cell Proliferation
J Pharmacol Exp Ther 1997 281: 663-669. [Abstract] [Full Text] [PDF]  

Scott P. Henry, Patricia C. Giclas, Janet Leeds, Michael Pangburn, Carol Auletta, Arthur A. Levin, and Douglas J. Kornbrust

Activation of the Alternative Pathway of Complement by a Phosphorothioate Oligonucleotide: Potential Mechanism of Action
J Pharmacol Exp Ther 1997 281: 810-816. [Abstract] [Full Text] [PDF]  

Chun C. Chao, Shuxian Hu, Katherine B. Shark, Wen S. Sheng, Genya Gekker, and Phillip K. Peterson

Activation of Mu Opioid Receptors Inhibits Microglial Cell Chemotaxis
J Pharmacol Exp Ther 1997 281: 998-1004. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Adrian J. Carter

Hippocampal Noradrenaline Release in Awake, Freely Moving Rats Is Regulated by Alpha-2 Adrenoceptors but Not by Adenosine Receptors
J Pharmacol Exp Ther 1997 281: 648-654. [Abstract] [Full Text] [PDF]  

Joseba Pineda, J. Angel Ruiz-Ortega, and Luisa Ugedo

Receptor Reserve and Turnover of Alpha-2 Adrenoceptors that Mediate the Clonidine-Induced Inhibition of Rat Locus Coeruleus Neurons In Vivo
J Pharmacol Exp Ther 1997 281: 690-698. [Abstract] [Full Text] [PDF]  

Xu-Feng Zhang, Xiu-Ti Hu, Francis J. White, and Marina E. Wolf

Increased Responsiveness of Ventral Tegmental Area Dopamine Neurons to Glutamate after Repeated Administration of Cocaine or Amphetamine Is Transient and Selectively Involves AMPA Receptors
J Pharmacol Exp Ther 1997 281: 699-706. [Abstract] [Full Text] [PDF]  

Flavio Moroni, Grazia Lombardi, Christian Thomsen, Patrizia Leonardi, Sabina Attucci, Fiamma Peruginelli, Serenella Albani Torregrossa, Domenico E. Pellegrini-Giampietro, Roberto Luneia, and Roberto Pellicciari

Pharmacological Characterization of 1-Aminoindan-1,5-dicarboxylic Acid, a Potent mGluR1 Antagonist
J Pharmacol Exp Ther 1997 281: 721-729. [Abstract] [Full Text] [PDF]  

Viviane Hechler, Charline Ratomponirina, and Michel Maitre

-Hydroxybutyrate Conversion into GABA Induces Displacement of GABA_B Binding that is Blocked by Valproate and Ethosuximide
J Pharmacol Exp Ther 1997 281: 753-760. [Abstract] [Full Text] [PDF]  

Sarah A. Thomas, Thomas J. Abbruscato, Vincent S. Hau, Terrence J. Gillespie, Joseph Zsigo, Victor J. Hruby, and Thomas P. Davis

Structure-Activity Relationships of a Series of [D-Ala²]Deltorphin I and II Analogues; in Vitro Blood-Brain Barrier Permeability and Stability
J Pharmacol Exp Ther 1997 281: 817-825. [Abstract] [Full Text] [PDF]  

E. D. Hall, P. K. Andrus, S. L. Smith, T. J. Fleck, H. M. Scherch, B. S. Lutzke, G. A. Sawada, J. S. Althaus, P. F. Vonvoigtlander, G. E. Padbury, P.G. Larson, J. R. Palmer, and G. L. Bundy

Pyrrolopyrimidines: Novel Brain-Penetrating Antioxidants with Neuroprotective Activity in Brain Injury and Ischemia Models
J Pharmacol Exp Ther 1997 281: 895-904. [Abstract] [Full Text] [PDF]  

Hiroshi Kawai, Hiroshi Nakai, Misao Suga, Satoshi Yuki, Toshiaki Watanabe, and Ken-Ichi Saito

Effects of a Novel Free Radical Scavenger, MCI-186, on Ischemic Brain Damage in the Rat Distal Middle Cerebral Artery Occlusion Model
J Pharmacol Exp Ther 1997 281: 921-927. [Abstract] [Full Text] [PDF]  

Thomas J. Gould and Paula C. Bickford

Age-Related Deficits in the Cerebellar Beta Adrenergic Signal Transduction Cascade in Fischer 344 Rats
J Pharmacol Exp Ther 1997 281: 965-971. [Abstract] [Full Text] [PDF]  

John Q. Wang and Jacqueline F. McGinty

The Full D₁ Dopamine Receptor Agonist SKF-82958 Induces Neuropeptide mRNA in the Normosensitive Striatum of Rats: Regulation of D₁/D₂ Interactions by Muscarinic Receptors
J Pharmacol Exp Ther 1997 281: 972-982. [Abstract] [Full Text] [PDF]  

Stéphane Schaak, Cécile Cayla, Régis Blaise, Françoise Quinchon, and Hervé Paris

HepG2 and SK-N-MC: Two Human Models to Study Alpha-2 Adrenergic Receptors of the Alpha-2C Subtype
J Pharmacol Exp Ther 1997 281: 983-991. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Jinshyun R. Wu-Wong, Douglas B. Dixon, William J. Chiou, and Terry J. Opgenorth

Endothelin Receptor Antagonists: Effect of Serum Albumin on Potency and Comparison of Pharmacological Characteristics
J Pharmacol Exp Ther 1997 281: 791-798. [Abstract] [Full Text] [PDF]  

B. W. Griffin, G. W. Williams, J. Y. Crider, and N. A. Sharif

FP Prostaglandin Receptors Mediating Inositol Phosphates Generation and Calcium Mobilization in Swiss 3T3 Cells: A Pharmacological Study
J Pharmacol Exp Ther 1997 281: 845-854. [Abstract] [Full Text] [PDF]  

Archibald McNicol and Cameron A. Robson

Thrombin Receptor-Activating Peptide Releases Arachidonic Acid from Human Platelets: A Comparison with Thrombin and Trypsin
J Pharmacol Exp Ther 1997 281: 861-867. [Abstract] [Full Text] [PDF]  

Martin J. Mangino, Janice E. Mangino, Bharat Kotadia, and Marek Sielczak

Effects of the 5-Lipoxygenase Inhibitor A-64077 on Intestinal Hypothermic Organ Preservation Injury
J Pharmacol Exp Ther 1997 281: 950-956. [Abstract] [Full Text] [PDF]  

B. Therese Kinsella, Daniel J. O'Mahony, and Garret A. Fitzgerald

The Human Thromboxane A₂ Receptor  Isoform (TP) Functionally Couples to the G Proteins G_q and G₁₁ In Vivo and is Activated by the Isoprostane 8-epi Prostaglandin F₂
J Pharmacol Exp Ther 1997 281: 957-964. [Abstract] [Full Text] [PDF]  

Masateru Yamada, Hisae Niki, Masamichi Yamashita, Suetsugu Mue, and Kazuo Ohuchi

Prostaglandin E₂ Production Dependent upon Cyclooxygenase-1 and Cyclooxygenase-2 and Its Contradictory Modulation by Auranofin in Rat Peritoneal Macrophages
J Pharmacol Exp Ther 1997 281: 1005-1012. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Beat Gassner, Andreas Wüthrich, Günter Scholtysik, and Marc Solioz

The Pyrethroids Permethrin and Cyhalothrin are Potent Inhibitors of the Mitochondrial Complex I
J Pharmacol Exp Ther 1997 281: 855-860. [Abstract] [Full Text] [PDF]  

Jiri Aubrecht, Mary E. P. Goad, Elizabeth M. Simpson, and Robert H. Schiestl

Expression of hyg^R in Transgenic Mice Causes Resistance to Toxic Effects of Hygromycin B In Vivo
J Pharmacol Exp Ther 1997 281: 992-997. [Abstract] [Full Text] [PDF]  

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