THE 1996 ASPET OTTO KRAYER AWARD LECTURE:

Edson X. Albuquerque, Manickavasagom Alkondon, Edna F. R. Pereira, Newton G. Castro, Andre Schrattenholz, Catão T. F. Barbosa, Rafael Bonfante-Cabarcas, Yasco Aracava, Howard M. Eisenberg, and Alfred Maelicke

Properties of Neuronal Nicotinic Acetylcholine Receptors: Pharmacological Characterization and Modulation of Synaptic Function^,
J Pharmacol Exp Ther 1997 280: 1117-1136. [Full Text] [PDF]  

ANALGESIA AND DRUGS OF ABUSE:

Li He and N. M. Lee

DynorphinA-(2-17) Restores Spinal/Supraspinal Morphine Synergy in Morphine-Tolerant Mice
J Pharmacol Exp Ther 1997 280: 1210-1214. [Abstract] [Full Text] [PDF]  

D. M. Tomkins, S. V. Otton, N. Joharchi, N-Y. Li, R. F. Balster, R. F. Tyndale, and E. M. Sellers

Effect of Cytochrome P450 2D1 Inhibition on Hydrocodone Metabolism and its Behavioral Consequences in Rats
J Pharmacol Exp Ther 1997 280: 1374-1382. [Abstract] [Full Text] [PDF]  

Pilar Sánchez-Blázquez, Antonio García-España, and Javier Garzón

Antisense Oligodeoxynucleotides to Opioid Mu and Delta Receptors Reduced Morphine Dependence in Mice: Role of Delta-2 Opioid Receptors
J Pharmacol Exp Ther 1997 280: 1423-1431. [Abstract] [Full Text] [PDF]  

AUTONOMIC PHARMACOLOGY:

Hiroyuki Arakawa, Hiroshi Kodama, Nobuya Matsuoka, and Isamu Yamaguchi

Stress Increases Plasma Enzyme Activity in Rats: Differential Effects of Adrenergic and Cholinergic Blockades
J Pharmacol Exp Ther 1997 280: 1296-1303. [Abstract] [Full Text] [PDF]  

BEHAVIORAL PHARMACOLOGY:

James P. Zacny, Kim Conley, and Sandy Marks

Comparing the Subjective, Psychomotor and Physiological Effects of Intravenous Nalbuphine and Morphine in Healthy Volunteers
J Pharmacol Exp Ther 1997 280: 1159-1169. [Abstract] [Full Text] [PDF]  

Nobuya Matsuoka and Thomas G. Aigner

FK960 [N-(4-Acetyl-1-piperazinyl)-p-fluorobenzamide Monohydrate], a Novel Potential Antidementia Drug, Improves Visual Recognition Memory in Rhesus Monkeys: Comparison with Physostigmine
J Pharmacol Exp Ther 1997 280: 1201-1209. [Abstract] [Full Text] [PDF]  

Keith L. Shelton and Robert L. Balster

Effects of -Aminobutyric Acid Agonists and N-Methyl-D-aspartate Antagonists on a Multiple Schedule of Ethanol and Saccharin Self-administration in Rats
J Pharmacol Exp Ther 1997 280: 1250-1260. [Abstract] [Full Text] [PDF]  

Richard B. Carter, Paul L. Wood, Scott Wieland, Jon E. Hawkinson, Delia Belelli, Jeremy J. Lambert, H. Steve White, Harold H. Wolf, Seid Mirsadeghi, S. Hasan Tahir, Michael B. Bolger, Nancy C. Lan, and Kelvin W. Gee

Characterization of the Anticonvulsant Properties of Ganaxolone (CCD 1042; 3-Hydroxy-3-methyl-5-pregnan-20-one), a Selective, High-Affinity, Steroid Modulator of the -Aminobutyric Acid_A Receptor
J Pharmacol Exp Ther 1997 280: 1284-1295. [Abstract] [Full Text] [PDF]  

CARDIOVASCULAR PHARMACOLOGY:

Evgeny P. Anyukhovsky, Eugene A. Sosunov, and Michael R. Rosen

Electrophysiologic Effects of Nibentan (HE-11) on Canine Cardiac Tissue
J Pharmacol Exp Ther 1997 280: 1137-1146. [Abstract] [Full Text] [PDF]  

Ketil Haugan, Michael Shalmi, Jørgen Søberg Petersen, Niels Marcussen, Jesper Spannow, and Sten Christensen

Effects of Renal Papillary-Medullary Lesion on the Antihypertensive Effect of Furosemide and Development of Salt-Sensitive Hypertension in Dahl-S Rats
J Pharmacol Exp Ther 1997 280: 1415-1422. [Abstract] [Full Text] [PDF]  

CELLULAR AND MOLECULAR PHARMACOLOGY:

Tao Yang, Dirk J. Snyders, and Dan M. Roden

Inhibition of Cardiac Potassium Currents by the Vesnarinone Analog OPC-18790: Comparison with Quinidine and Dofetilide
J Pharmacol Exp Ther 1997 280: 1170-1175. [Abstract] [Full Text] [PDF]  

Shigeo Fujii, Kimiko Kameyama, Masahiro Hosono, Yutaka Hayashi, and Kenji Kitamura

Effect of Cilnidipine, a Novel Dihydropyridine Ca⁺⁺-channel antagonist, on N-type Ca⁺⁺ Channel in Rat Dorsal Root Ganglion Neurons
J Pharmacol Exp Ther 1997 280: 1184-1191. [Abstract] [Full Text] [PDF]  

Jin Chen, Vincent Ziboh, and Shri N. Giri

Up-regulation of Platelet-activating Factor Receptors in Lung and Alveolar Macrophages in the Bleomycin-Hamster Model of Pulmonary Fibrosis
J Pharmacol Exp Ther 1997 280: 1219-1227. [Abstract] [Full Text] [PDF]  

Peiwen Sun, Stanley G. Rane, Palur G. Gunasekar, Joseph L. Borowitz, and Gary E. Isom

Modulation of the NMDA Receptor by Cyanide: Enhancement of Receptor-Mediated Responses
J Pharmacol Exp Ther 1997 280: 1341-1348. [Abstract] [Full Text] [PDF]  

Artur W. Wamil, Wolfgang Löscher, and Michael J. McLean

Trans-2-en-valproic Acid Limits Action Potential Firing Frequency in Mouse Central Neurons in Cell Culture
J Pharmacol Exp Ther 1997 280: 1349-1356. [Abstract] [Full Text] [PDF]  

J. A. Coffield, N. Bakry, R.-d. Zhang, J. Carlson, L. G. Gomella, and L. L. Simpson

In Vitro Characterization of Botulinum Toxin Types A, C and D Action on Human Tissues: Combined Electrophysiologic, Pharmacologic and Molecular Biologic Approaches
J Pharmacol Exp Ther 1997 280: 1489-1498. [Abstract] [Full Text] [PDF]  

CHEMOTHERAPY/GENE THERAPY:

Lixin Cui, Luisa Locatelli, Meng-Yu Xie, and Jean-Pierre Sommadossi

Effect of Nucleoside Analogs on Neurite Regeneration and Mitochondrial DNA Synthesis in PC-12 Cells
J Pharmacol Exp Ther 1997 280: 1228-1234. [Abstract] [Full Text] [PDF]  

Michael J. Parr, Dana Masin, Pieter R. Cullis, and Marcel B. Bally

Accumulation of Liposomal Lipid and Encapsulated Doxorubicin in Murine Lewis Lung Carcinoma: The Lack of Beneficial Effects by Coating Liposomes with Poly(ethylene glycol)
J Pharmacol Exp Ther 1997 280: 1319-1327. [Abstract] [Full Text] [PDF]  

Lawrence D. Mayer, Graeme Dougherty, Troy O. Harasym, and Marcel B. Bally

The Role of Tumor-Associated Macrophages in the Delivery of Liposomal Doxorubicin to Solid Murine Fibrosarcoma Tumors
J Pharmacol Exp Ther 1997 280: 1406-1414. [Abstract] [Full Text] [PDF]  

DRUG METABOLISM AND DISPOSITION:

Hitoshi Ishizuka, Kumiko Konno, Hideo Naganuma, Kunihiro Sasahara, Yukinori Kawahara, Kayoko Niinuma, Hiroshi Suzuki, and Yuichi Sugiyama

Temocaprilat, a Novel Angiotensin-Converting Enzyme Inhibitor, is Excreted in Bile via an ATP-dependent Active Transporter (cMOAT) That is Deficient in Eisai Hyperbilirubinemic Mutant Rats (EHBR)
J Pharmacol Exp Ther 1997 280: 1304-1311. [Abstract] [Full Text] [PDF]  

Nacide Ercan-Fang and Frank Q. Nuttall

The Effect of Caffeine and Caffeine Analogs on Rat Liver Phosphorylase a Activity
J Pharmacol Exp Ther 1997 280: 1312-1318. [Abstract] [Full Text] [PDF]  

Takashi Izumi, Kazuko Hosiyama, Sachiko Enomoto, Kunihiro Sasahara, and Yuichi Sugiyama

Pharmacokinetics of Troglitazone, an Antidiabetic Agent: Prediction of In Vivo Stereoselective Sulfation and Glucuronidation from In Vitro Data
J Pharmacol Exp Ther 1997 280: 1392-1400. [Abstract] [Full Text] [PDF]  

Marion B. Sewer, Dennis R. Koop, and Edward T. Morgan

Differential Inductive and Suppressive Effects of Endotoxin and Particulate Irritants on Hepatic and Renal Cytochrome P-450 Expression
J Pharmacol Exp Ther 1997 280: 1445-1454. [Abstract] [Full Text] [PDF]  

Oleg Khatsenko and Yutaka Kikkawa

Nitric Oxide Differentially Affects Constitutive Cytochrome P450 Isoforms in Rat Liver
J Pharmacol Exp Ther 1997 280: 1463-1470. [Abstract] [Full Text] [PDF]  

GASTROINTESTINAL PHARMACOLOGY:

Adrienne Nguyen, Michael Camilleri, Louis J. Kost, Alejandro Metzger, Michael G. Sarr, Russell B. Hanson, Sara L. Fett, and Alan R. Zinsmeister

SDZ HTF 919 Stimulates Canine Colonic Motility and Transit In Vivo
J Pharmacol Exp Ther 1997 280: 1270-1276. [Abstract] [Full Text] [PDF]  

NEUROPHARMACOLOGY:

Jim Yu, Eduardo R. Butelman, James H. Woods, Brian T. Chait, and Mary Jeanne Kreek

Dynorphin A (1-8) Analog, E-2078, Is Stable in Human and Rhesus Monkey Blood
J Pharmacol Exp Ther 1997 280: 1147-1151. [Abstract] [Full Text] [PDF]  

Ronald K. Freund and Michael R. Palmer

Beta Adrenergic Sensitization of -Aminobutyric Acid Receptors to Ethanol Involves a Cyclic AMP/Protein Kinase A Second-Messenger Mechanism
J Pharmacol Exp Ther 1997 280: 1192-1200. [Abstract] [Full Text] [PDF]  

Sarah A. Thomas, Thomas J. Abbruscato, Victor J. Hruby, and Thomas P. Davis

The Entry of [D-Penicillamine^2,5]Enkephalin into the Central Nervous System: Saturation Kinetics and Specificity
J Pharmacol Exp Ther 1997 280: 1235-1240. [Abstract] [Full Text] [PDF]  

F. Lejeune, A. Newman-Tancredi, V. Audinot, and M. J. Millan

Interactions of (+)- and ()-8- and 7-Hydroxy-2-(Di-n-Propylamino)tetralin at Human (h)D₃, hD₂ and h Serotonin_1A Receptors and Their Modulation of the Activity of Serotoninergic and Dopaminergic Neurones in Rats
J Pharmacol Exp Ther 1997 280: 1241-1249. [Abstract] [Full Text] [PDF]  

Keisuke Hirai, Koki Kato, Takahiro Nakayama, Hitomi Hayako, Yuji Ishihara, Giichi Goto, and Masaomi Miyamoto

Neurochemical Effects of 3-[1-(Phenylmethyl)-4-Piperidinyl]-1-(2,3,4,5-Tetrahydro-1H-1-Benzazepin-8-yl)-1-Propanone Fumarate (TAK-147), a Novel Acetylcholinesterase Inhibitor, in Rats
J Pharmacol Exp Ther 1997 280: 1261-1269. [Abstract] [Full Text] [PDF]  

Philippe Marin, Brigitte Hamon, Jacques Glowinski, and Joël Prémont

Nicotine-Induced Inhibition of Neuronal Phospholipase A2
J Pharmacol Exp Ther 1997 280: 1277-1283. [Abstract] [Full Text] [PDF]  

Jong M. Rho, Sean D. Donevan, and Michael A. Rogawski

Barbiturate-Like Actions of the Propanediol Dicarbamates Felbamate and Meprobamate
J Pharmacol Exp Ther 1997 280: 1383-1391. [Abstract] [Full Text] [PDF]  

Alfonso Tortorella, Toivo Halonen, Niaz Sahibzada, and Karen Gale

A Crucial Role of the -Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Subtype of Glutamate Receptors in Piriform and Perirhinal Cortex for the Initiation and Propagation of Limbic Motor Seizures
J Pharmacol Exp Ther 1997 280: 1401-1405. [Abstract] [Full Text] [PDF]  

Lihong Teng, Peter A. Crooks, Patricia K. Sonsalla, and Linda P. Dwoskin

Lobeline and Nicotine Evoke [³H]Overflow from Rat Striatal Slices Preloaded with [³H]Dopamine: Differential Inhibition of Synaptosomal and Vesicular [³H]Dopamine Uptake
J Pharmacol Exp Ther 1997 280: 1432-1444. [Abstract] [Full Text] [PDF]  

PROSTAGLANDINS, LEUKOTRIENES AND OTHER EICOSANOIDS:

Daniela Dumitriu, Stéphane Prié, Sylvie G. Bernier, Gaétan Guillemette, and Pierre Sirois

Mechanism of Action of Leukotriene D₄ on Guinea Pig Tracheal Smooth Muscle Cells: Roles of Ca⁺⁺ Influx and Intracellular Ca⁺⁺ Release
J Pharmacol Exp Ther 1997 280: 1357-1365. [Abstract] [Full Text] [PDF]  

M. Yamasaki, T. Matsumoto, S. Fukuda, T. Nakayama, H. Nagaya, and Y. Ashida

Involvement of Thromboxane A₂ and Histamine in Experimental Allergic Rhinitis of Guinea Pigs
J Pharmacol Exp Ther 1997 280: 1471-1479. [Abstract] [Full Text] [PDF]  

PULMONARY PHARMACOLOGY:

James L. Ellis

Role of Soluble Guanylyl Cyclase in the Relaxations to a Nitric Oxide Donor and to Nonadrenergic Nerve Stimulation in Guinea Pig Trachea and Human Bronchus
J Pharmacol Exp Ther 1997 280: 1215-1218. [Abstract] [Full Text] [PDF]  

Randy L. Bell, Richard R. Harris, Peter E. Malo, Jennifer B. Bouska, Thomas K. Shaughnessy, Keren I. Hulkower, Clint D. W. Brooks, and George W. Carter

ABT-761 Attenuates Bronchoconstriction and Pulmonary Inflammation in Rodents
J Pharmacol Exp Ther 1997 280: 1366-1373. [Abstract] [Full Text] [PDF]  

RENAL PHARMACOLOGY:

David P. Brooks, Maurizio Valente, Giuseppe Petrone, P. Dennis Depalma, Massimo Sbacchi, and Geoffrey D. Clarke

Comparison of the Water Diuretic Activity of Kappa Receptor Agonists and a Vasopressin Receptor Antagonist in Dogs
J Pharmacol Exp Ther 1997 280: 1176-1183. [Abstract] [Full Text] [PDF]  

TOXICOLOGY:

Charles W. Laidley, Ephraim Cohen, and John E. Casida

Protein Phosphatase in Neuroblastoma Cells: [³H]Cantharidin Binding Site in Relation to Cytotoxicity
J Pharmacol Exp Ther 1997 280: 1152-1158. [Abstract] [Full Text] [PDF]  

Armin Wolf, Christian-F. Trendelenburg, Carmen Diez-Fernandez, Pilar Prieto, Simone Houy, Wolfgang E. Trommer, and André Cordier

Cyclosporine A-Induced Oxidative Stress in Rat Hepatocytes
J Pharmacol Exp Ther 1997 280: 1328-1334. [Abstract] [Full Text] [PDF]  

Youn-Sook Cho, Mee-Jeong Kim, Joo-Young Lee, and Jin-Ho Chung

The Role of Thiols in Protecting against Simultaneous Toxicity of Menadione to Platelet Plasma and Intracellular Membranes
J Pharmacol Exp Ther 1997 280: 1335-1340. [Abstract] [Full Text] [PDF]  

Takiko Oguro, Eiko Kaneko, Satoshi Numazawa, Susumu Imaoka, Yoshihiko Funae, and Takemi Yoshida

Induction of Hepatic Heme Oxygenase and Changes in Cytochrome P-450s in Response to Oxidative Stress Produced by Stilbenes and Stilbene Oxides in Rats
J Pharmacol Exp Ther 1997 280: 1455-1462. [Abstract] [Full Text] [PDF]  

Thomas L. Wallace, Scott A. Bazemore, Karsten Holm, Peter M. Markham, J. Paul Shea, Nilabh Chaudhary, and Paul A. Cossum

Pharmacokinetics and Distribution of a ³³P-labeled Anti-Human Immunodeficiency Virus Oligonucleotide (AR177) after Single- and Multiple-Dose Intravenous Administration to Rats
J Pharmacol Exp Ther 1997 280: 1480-1488. [Abstract] [Full Text] [PDF]  

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