ARTICLES:

VM Showalter, DR Compton, BR Martin, and ME Abood

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands
J Pharmacol Exp Ther 1996 278: 989-999. [Abstract] [PDF]  

LC Trost and JJ Lemasters

The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury
J Pharmacol Exp Ther 1996 278: 1000-1005. [Abstract] [PDF]  

Y Tsutsumi, T Kihira, S Tsunoda, H Kamada, S Nakagawa, Y Kaneda, T Kanamori, and T Mayumi

Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation
J Pharmacol Exp Ther 1996 278: 1006-1011. [Abstract] [PDF]  

SL Waters and RG Schnellmann

Extracellular acidosis and chloride channel inhibitors act in the late phase of cellular injury to prevent death
J Pharmacol Exp Ther 1996 278: 1012-1017. [Abstract] [PDF]  

NR Kitteringham, C Davis, N Howard, M Pirmohamed, and BK Park

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene
J Pharmacol Exp Ther 1996 278: 1018-1027. [Abstract] [PDF]  

T Takahashi, K Takahashi, S Kishi-Tanikawa, K Tsuchida, H Araki, and S Higuchi

Effects of a new calcium antagonist, CD-832, on isoproterenol-induced myocardial ischemia in dogs with partial coronary stenosis
J Pharmacol Exp Ther 1996 278: 1028-1033. [Abstract] [PDF]  

JA Schriefer, EP Broudy, and AH Hassen

Endopeptidase inhibitors decrease myocardial ischemia/reperfusion injury in an in vivo rabbit model
J Pharmacol Exp Ther 1996 278: 1034-1039. [Abstract] [PDF]  

MJ Owens, CA Ballenger, DL Knight, and CB Nemeroff

Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4- iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat
J Pharmacol Exp Ther 1996 278: 1040-1049. [Abstract] [PDF]  

TC Krejcie, TK Henthorn, CU Niemann, C Klein, DK Gupta, WB Gentry, CA Shanks, and MJ Avram

Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly
J Pharmacol Exp Ther 1996 278: 1050-1057. [Abstract] [PDF]  

M Tominaga, H Tsukada, M Hosokawa, H Nakamura, T Taniguchi, S Ueda, M Sakai, and M Okuma

ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro
J Pharmacol Exp Ther 1996 278: 1058-1063. [Abstract] [PDF]  

N Bel and F Artigas

In vivo effects of the simultaneous blockade of serotonin and norepinephrine transporters on serotonergic function. Microdialysis studies
J Pharmacol Exp Ther 1996 278: 1064-1072. [Abstract] [PDF]  

MA Wilson, R Biscardi, MD Smith, and SP Wilson

Effects of benzodiazepine agonist exposure on corticotropin-releasing factor content and hormonal stress responses: divergent responses in male and ovariectomized female rats
J Pharmacol Exp Ther 1996 278: 1073-1082. [Abstract] [PDF]  

E Malatynska, Y Wang, RJ Knapp, S Waite, S Calderon, K Rice, VJ Hruby, HI Yamamura, and WR Roeske

Human delta opioid receptor: functional studies on stably transfected Chinese hamster ovary cells after acute and chronic treatment with the selective nonpeptidic agonist SNC-80
J Pharmacol Exp Ther 1996 278: 1083-1089. [Abstract] [PDF]  

GP Thomas, GR Ferrier, and SE Howlett

Losartan exerts antiarrhythmic activity independent of angiotensin II receptor blockade in simulated ventricular ischemia and reperfusion
J Pharmacol Exp Ther 1996 278: 1090-1097. [Abstract] [PDF]  

RB Raffa, ML Haslego, CA Maryanoff, FJ Villani, EE Codd, CD Connelly, RP Martinez, JJ Schupsky, JA Buben, WN Wu, AN Takacs, and LA Mckown

Unexpected antinociceptive effect of the N-oxide (RWJ 38705) of tramadol hydrochloride
J Pharmacol Exp Ther 1996 278: 1098-1104. [Abstract] [PDF]  

M Weiss, EM Schneider, J Tarnow, S Mettler, M Krone, A Teschemacher, and H Lemoine

Is inhibition of oxygen radical production of neutrophils by sympathomimetics mediated via beta-2 adrenoceptors?
J Pharmacol Exp Ther 1996 278: 1105-1113. [Abstract] [PDF]  

O Masso, SF Alino, M Lejarreta, F Blasco, and J Piulats

Specific serological response by active immunization with GD3-bearing liposomes
J Pharmacol Exp Ther 1996 278: 1114-1120. [Abstract] [PDF]  

PJ Emmerson, MJ Clark, A Mansour, H Akil, JH Woods, and F Medzihradsky

Characterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor
J Pharmacol Exp Ther 1996 278: 1121-1127. [Abstract] [PDF]  

RD Spealman

Dopamine D3 receptor agonists partially reproduce the discriminative stimulus effects of cocaine in squirrel monkeys
J Pharmacol Exp Ther 1996 278: 1128-1137. [Abstract] [PDF]  

JG Hensler, LS Cervera, HA Miller, and J Corbitt

Expression and modulation of 5-hydroxytryptamine1A receptors in P11 cells
J Pharmacol Exp Ther 1996 278: 1138-1145. [Abstract] [PDF]  

T Minami, E Okuda-Ashitaka, H Mori, S Ito, and O Hayaishi

Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice
J Pharmacol Exp Ther 1996 278: 1146-1152. [Abstract] [PDF]  

RW Foltin and MW Fischman

Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans
J Pharmacol Exp Ther 1996 278: 1153-1164. [Abstract] [PDF]  

Y Caraco, J Sheller, and AJ Wood

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions
J Pharmacol Exp Ther 1996 278: 1165-1174. [Abstract] [PDF]  

ES Rocha, KL Swanson, Y Aracava, JE Goolsby, A Maelicke, and EX Albuquerque

Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons
J Pharmacol Exp Ther 1996 278: 1175-1187. [Abstract] [PDF]  

GP McCallum, AC Weedon, P Krug, and JR Bend

Microsomal cytochrome P450 peroxygenase metabolism of arachidonic acid in guinea pig liver
J Pharmacol Exp Ther 1996 278: 1188-1194. [Abstract] [PDF]  

CM Heesch, BH Negus, JE Bost, JH Keffer, RW 2nd Snyder, and EJ Eichhorn

Effects of cocaine on anterior pituitary and gonadal hormones
J Pharmacol Exp Ther 1996 278: 1195-1200. [Abstract] [PDF]  

EJ Barbarito, CE Lau, and JL Falk

Tolerance to the anxiolytic effects of the triazolobenzodiazepines triazolam and alprazolam, as measured by the ingestion of a hypertonic sodium chloride solution in rats
J Pharmacol Exp Ther 1996 278: 1201-1208. [Abstract] [PDF]  

S Dionisotti, S Ferrara, C Molta, C Zocchi, and E Ongini

Labeling of A2A adenosine receptors in human platelets by use of the new nonxanthine antagonist radioligand [3H]SCH 58261
J Pharmacol Exp Ther 1996 278: 1209-1214. [Abstract] [PDF]  

JD Deupree, KA Hinton, DR Cerutis, and DB Bylund

Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes
J Pharmacol Exp Ther 1996 278: 1215-1227. [Abstract] [PDF]  

ME Beyer, G Slesak, and HM Hoffmeister

Significance of endothelinB receptors for myocardial contractility and myocardial energy metabolism
J Pharmacol Exp Ther 1996 278: 1228-1234. [Abstract] [PDF]  

CS Bockman, I Gonzalez-Cabrera, and PW Abel

Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats
J Pharmacol Exp Ther 1996 278: 1235-1243. [Abstract] [PDF]  

TA Lewis, AE Munson, and KL McCoy

Gallium arsenide selectively suppresses antigen processing by splenic macrophages for CD4+ T cell activation
J Pharmacol Exp Ther 1996 278: 1244-1251. [Abstract] [PDF]  

NA Sharif, SX Xu, ST Miller, DA Gamache, and JM Yanni

Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases
J Pharmacol Exp Ther 1996 278: 1252-1261. [Abstract] [PDF]  

NE Cameron and MA Cotter

Effects of a nonpeptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats: interaction with the renin-angiotensin system
J Pharmacol Exp Ther 1996 278: 1262-1268. [Abstract] [PDF]  

A Hirasaki, KA Jones, WJ Perkins, and DO Warner

Use of nitric oxide-nucleophile adducts as biological sources of nitric oxide: effects on airway smooth muscle
J Pharmacol Exp Ther 1996 278: 1269-1275. [Abstract] [PDF]  

KJ Scheidegger, JM Wood, H van Essen, and HA Struijker-Boudier

Effects of prolonged blockade of the renin angiotensin system on striated muscle microcirculation of spontaneously hypertensive rats
J Pharmacol Exp Ther 1996 278: 1276-1281. [Abstract] [PDF]  

MB Gatch, SS Negus, NK Mello, S Archer, and JM Bidlack

Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule- controlled behavior and thermal nociception in rhesus monkeys
J Pharmacol Exp Ther 1996 278: 1282-1289. [Abstract] [PDF]  

MD Aceto, SM Scates, JA Lowe, and BR Martin

Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal
J Pharmacol Exp Ther 1996 278: 1290-1295. [Abstract] [PDF]  

AI Haj-Yehia and LZ Benet

In vivo depletion of free thiols does not account for nitroglycerin- induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance
J Pharmacol Exp Ther 1996 278: 1296-1305. [Abstract] [PDF]  

TL Wallace, SA Bazemore, DJ Kornbrust, and PA Cossum

Single-dose hemodynamic toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after intravenous infusion to cynomolgus monkeys
J Pharmacol Exp Ther 1996 278: 1306-1312. [Abstract] [PDF]  

TL Wallace, SA Bazemore, DJ Kornbrust, and PA Cossum

Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys
J Pharmacol Exp Ther 1996 278: 1313-1317. [Abstract] [PDF]  

PC Endresen, T Loennechen, H Kildalsen, and J Aarbakke

Apoptosis and transmethylation metabolites in HL-60 cells
J Pharmacol Exp Ther 1996 278: 1318-1324. [Abstract] [PDF]  

WJ Wu and SB Pruett

Suppression of splenic natural killer cell activity in a mouse model for binge drinking. I. Direct effects of ethanol and its major metabolites are not primarily responsible for decreased natural killer cell activity
J Pharmacol Exp Ther 1996 278: 1325-1330. [Abstract] [PDF]  

WJ Wu and SB Pruett

Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system
J Pharmacol Exp Ther 1996 278: 1331-1339. [Abstract] [PDF]  

C Xu and ME Reith

Modeling of the pH dependence of the binding of WIN 35,428 to the dopamine transporter in rat striatal membranes: is the bioactive form positively charged or neutral?
J Pharmacol Exp Ther 1996 278: 1340-1348. [Abstract] [PDF]  

CR Turner, VL Cohan, JB Cheng, HJ Showell, CJ Pazoles, and JW Watson

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4
J Pharmacol Exp Ther 1996 278: 1349-1355. [Abstract] [PDF]  

VL Cohan, HJ Showell, DA Fisher, CJ Pazoles, JW Watson, CR Turner, and JB Cheng

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633
J Pharmacol Exp Ther 1996 278: 1356-1361. [Abstract] [PDF]  

D Nakai, T Seita, T Terasaki, S Iwasa, Y Shoji, Y Mizushima, and Y Sugiyama

Cellular uptake mechanism for oligonucleotides: involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinoma cell line, HCT-15
J Pharmacol Exp Ther 1996 278: 1362-1372. [Abstract] [PDF]  

GJ Marek and GK Aghajanian

LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex
J Pharmacol Exp Ther 1996 278: 1373-1382. [Abstract] [PDF]  

TK Chang and GD Bellward

Peripubertal androgen imprinting of rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase: pretranslational regulation and impact on microsomal drug activation
J Pharmacol Exp Ther 1996 278: 1383-1391. [Abstract] [PDF]  

ZY Wei, F Karim, and SC Roerig

Spinal morphine/clonidine antinociceptive synergism: involvement of G proteins and N-type voltage-dependent calcium channels
J Pharmacol Exp Ther 1996 278: 1392-1407. [Abstract] [PDF]  

J Lakritz, A Chang, A Weir, S Nishio, D Hyde, R Philpot, A Buckpitt, and C Plopper

Cellular and metabolic basis of Clara cell tolerance to multiple doses of cytochrome P450-activated cytotoxicants. I: Bronchiolar epithelial reorganization and expression of cytochrome P450 monooxygenases in mice exposed to multiple doses of naphthalene
J Pharmacol Exp Ther 1996 278: 1408-1418. [Abstract] [PDF]  

JP Desjardins, BS Sproat, B Beijer, M Blaschke, M Dunkel, W Gerdes, J Ludwig, V Reither, T Rupp, and PL Iversen

Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections
J Pharmacol Exp Ther 1996 278: 1419-1427. [Abstract] [PDF]  

S Iwata, GH Hewlett, ST Ferrell, AJ Czernik, KF Meiri, and ME Gnegy

Increased in vivo phosphorylation state of neuromodulin and synapsin I in striatum from rats treated with repeated amphetamine
J Pharmacol Exp Ther 1996 278: 1428-1434. [Abstract] [PDF]  

YT Shen, P Cervoni, T Claus, and SF Vatner

Differences in beta 3-adrenergic receptor cardiovascular regulation in conscious primates, rats and dogs
J Pharmacol Exp Ther 1996 278: 1435-1443. [Abstract] [PDF]  

C May, RI James, R Gunther, and RS McIvor

Methotrexate dose-escalation studies in transgenic mice and marrow transplant recipients expressing drug-resistant dihydrofolate reductase activity
J Pharmacol Exp Ther 1996 278: 1444-1451. [Abstract] [PDF]  

TR Wiernicki, JS Bean, C Dell, A Williams, D Wood, RF Kauffman, and JP Singh

Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran
J Pharmacol Exp Ther 1996 278: 1452-1459. [Abstract] [PDF]  

M Alkondon, ES Rocha, A Maelicke, and EX Albuquerque

Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha- Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release
J Pharmacol Exp Ther 1996 278: 1460-1471. [Abstract] [PDF]  

EF Pereira, M Alkondon, JM McIntosh, and EX Albuquerque

Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin- sensitive neuronal nicotinic receptors in hippocampal neurons
J Pharmacol Exp Ther 1996 278: 1472-1483. [Abstract] [PDF]  

L Foissier, M Lonchampt, F Coge, and E Canet

In vitro down-regulation of antigen-induced IL-5 gene expression and protein production by cAMP-specific phosphodiesterase type 4 inhibitor
J Pharmacol Exp Ther 1996 278: 1484-1490. [Abstract] [PDF]  

PM Friden, TS Olson, R Obar, LR Walus, and SD Putney

Characterization, receptor mapping and blood-brain barrier transcytosis of antibodies to the human transferrin receptor
J Pharmacol Exp Ther 1996 278: 1491-1498. [Abstract] [PDF]  

AE Kelley, EP Bless, and CJ Swanson

Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats
J Pharmacol Exp Ther 1996 278: 1499-1507. [Abstract] [PDF]  

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