ARTICLES:

RB Raffa, JJ Schupsky, DK Lee, and HI Jacoby

Characterization of endothelin-induced nociception in mice: evidence for a mechanistically distinct analgesic model
J Pharmacol Exp Ther 1996 278: 1-7. [Abstract] [PDF]  

T Pelissier, A Alloui, F Caussade, C Dubray, A Cloarec, J Lavarenne, and A Eschalier

Paracetamol exerts a spinal antinociceptive effect involving an indirect interaction with 5-hydroxytryptamine3 receptors: in vivo and in vitro evidence
J Pharmacol Exp Ther 1996 278: 8-14. [Abstract] [PDF]  

IA Omelchenko, CS Nelson, JL Marino, and CN Allen

The sensitivity of N-methyl-D-aspartate receptors to lead inhibition is dependent on the receptor subunit composition
J Pharmacol Exp Ther 1996 278: 15-20. [Abstract] [PDF]  

E Koyama, K Chiba, M Tani, and T Ishizaki

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers
J Pharmacol Exp Ther 1996 278: 21-30. [Abstract] [PDF]  

AA Somogyi, G Rumrich, G Fritzsch, and KJ Ullrich

Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubule
J Pharmacol Exp Ther 1996 278: 31-36. [Abstract] [PDF]  

DP Begany, JA Carcillo, WA Herzer, Z Mi, and EK Jackson

Inhibition of type IV phosphodiesterase by Ro 20-1724 attenuates endotoxin-induced acute renal failure
J Pharmacol Exp Ther 1996 278: 37-41. [Abstract] [PDF]  

TE Mertz, TB McClanahan, MA Flynn, P Juneau, EE Reynolds, H Hallak, L Bradford, and KP Gallagher

Endothelin A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/reperfusion in pigs
J Pharmacol Exp Ther 1996 278: 42-49. [Abstract] [PDF]  

DE McMillan, WL Sun, and WC Hardwick

Effects of drug discrimination history on the generalization of pentobarbital to other drugs
J Pharmacol Exp Ther 1996 278: 50-61. [Abstract] [PDF]  

JJ Cook, MA Holahan, EA Lyle, DR Ramjit, GR Sitko, MT Stranieri, RF 3rd Stupienski, AA Wallace, EL Hand, JR Gehret, T Kothstein, MD Drag, GY McCormick, JJ Perkins, NC Ihle, ME Duggan, GD Hartman, RJ Gould, and JJ Jr Lynch

Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217
J Pharmacol Exp Ther 1996 278: 62-73. [Abstract] [PDF]  

S Ohdo, N Ogawa, S Nakano, and S Higuchi

Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice
J Pharmacol Exp Ther 1996 278: 74-81. [Abstract] [PDF]  

X Wang, F Rondu, A Lamouri, R Dokhan, S Marc, E Touboul, B Pfeiffer, D Manechez, P Renard, B Guardiola-Lemaitre, JJ Godfroid, A Ktorza, and L Penicaud

Effect of S-21663 (PMS 812), an imidazoline derivative, on glucose tolerance and insulin secretion in a rat model of type II diabetes
J Pharmacol Exp Ther 1996 278: 82-89. [Abstract] [PDF]  

MO Urban, DJ Smith, and GF Gebhart

Involvement of spinal cholecystokininB receptors in mediating neurotensin hyperalgesia from the medullary nucleus raphe magnus in the rat
J Pharmacol Exp Ther 1996 278: 90-96. [Abstract] [PDF]  

IM Khan, M Marsala, MP Printz, P Taylor, and TL Yaksh

Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats
J Pharmacol Exp Ther 1996 278: 97-106. [Abstract] [PDF]  

U Bickel, OP Schumacher, YS Kang, and K Voigt

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat
J Pharmacol Exp Ther 1996 278: 107-113. [Abstract] [PDF]  

X Yang, HE Criswell, P Simson, S Moy, and GR Breese

Evidence for a selective effect of ethanol on N-methyl-d-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N- methyl-d-aspartate receptors
J Pharmacol Exp Ther 1996 278: 114-124. [Abstract] [PDF]  

YB Peng, Q Lin, and WD Willis

Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats
J Pharmacol Exp Ther 1996 278: 125-135. [Abstract] [PDF]  

DL Jr Saussy, AS Goetz, KL Queen, HK King, MW Lutz, and TJ Rimele

Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype
J Pharmacol Exp Ther 1996 278: 136-144. [Abstract] [PDF]  

B Levant, JD Moehlenkamp, KA Morgan, NL Leonard, and CC Cheng

Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site
J Pharmacol Exp Ther 1996 278: 145-153. [Abstract] [PDF]  

CL Martin, MA Palomo, and EG Mcmahon

Comparison of bidisomide, flecainide and dofetilide on action potential duration in isolated canine atria: effect of isoproterenol
J Pharmacol Exp Ther 1996 278: 154-162. [Abstract] [PDF]  

R Rosa, E Rodriguez-Farre, and C Sanfeliu

Cytotoxicity of hexachlorocyclohexane isomers and cyclodienes in primary cultures of cerebellar granule cells
J Pharmacol Exp Ther 1996 278: 163-169. [Abstract] [PDF]  

E Robert, P Bruelle, JE de La Coussaye, JM Juan, J Brugada, P Peray, M Dauzat, and JJ Eledjam

Electrophysiologic and proarrhythmogenic effects of therapeutic and toxic doses of imipramine: a study with high resolution ventricular epicardial mapping in rabbit hearts
J Pharmacol Exp Ther 1996 278: 170-178. [Abstract] [PDF]  

HG Owens, SG Kamerling, SR Stanton, and ML Keowen

Evaluation of detomidine-induced analgesia in horses with chronic hoof pain
J Pharmacol Exp Ther 1996 278: 179-184. [Abstract] [PDF]  

SM Aziz, MN Gillespie, PA Crooks, SF Tofiq, CP Tsuboi, JW Olson, and MP Gosland

The potential of a novel polyamine transport inhibitor in cancer chemotherapy
J Pharmacol Exp Ther 1996 278: 185-192. [Abstract] [PDF]  

RK Rao, Y Lopez, PJ Riviere, X Pascaud, JL Junien, and F Porreca

Nitric oxide modulates neuropeptide Y regulation of ion transport in mouse ileum
J Pharmacol Exp Ther 1996 278: 193-198. [Abstract] [PDF]  

S Katsoulis, WE Schmidt, R Schwarzhoff, UR Folsch, JG Jin, JR Grider, and GM Makhlouf

Inhibitory transmission in guinea pig stomach mediated by distinct receptors for pituitary adenylate cyclase-activating peptide
J Pharmacol Exp Ther 1996 278: 199-204. [Abstract] [PDF]  

H Saitoh, C Gerard, and BJ Aungst

The secretory intestinal transport of some beta-lactam antibiotics and anionic compounds: a mechanism contributing to poor oral absorption
J Pharmacol Exp Ther 1996 278: 205-211. [Abstract] [PDF]  

TW Vanderah, RN Bernstein, HI Yamamura, VJ Hruby, and F Porreca

Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors
J Pharmacol Exp Ther 1996 278: 212-219. [Abstract] [PDF]  

Y Fukuizumi, S Kobayashi, J Nishimura, and H Kanaide

The effects of calcitonin gene-related peptide on the cytosolic calcium concentration and force in the porcine coronary artery
J Pharmacol Exp Ther 1996 278: 220-231. [Abstract] [PDF]  

E Bellissant, T Denolle, P Sinnassamy, DG Bichet, JF Giudicelli, F Lecoz, JM Gandon, and H Allain

Systemic and regional hemodynamic and biological effects of a new kappa- opioid agonist, niravoline, in healthy volunteers
J Pharmacol Exp Ther 1996 278: 232-242. [Abstract] [PDF]  

T Kagaya, A Kajiwara, S Nagato, K Akasaka, and A Kubota

E2011 a novel, selective and reversible inhibitor of monoamine oxidase type A
J Pharmacol Exp Ther 1996 278: 243-251. [Abstract] [PDF]  

JH Fleisch, CT Armstrong, CR Roman, ED Mihelich, SM Spaethe, WT Jackson, JL Bobbitt, S Draheim, NJ Bach, RD Dillard, M Martinelli, R Fouts, and DW Snyder

Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor
J Pharmacol Exp Ther 1996 278: 252-257. [Abstract] [PDF]  

JE Malberg, KE Sabol, and LS Seiden

Co-administration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat
J Pharmacol Exp Ther 1996 278: 258-267. [Abstract] [PDF]  

I Kawikova, H Arakawa, BE Skoogh, CG Lofdahl, and J Lotvall

U46619 (a thromboxane A2 mimetic) induces airflow obstruction and airway plasma extravasation in the guinea pig: the role of histamine, cyclooxygenase metabolites, leukotrienes and PAF
J Pharmacol Exp Ther 1996 278: 268-276. [Abstract] [PDF]  

JH Liu, RS Malone, H Stallings, and PC Smith

Influence of renal failure in rats on the disposition of salicyl acyl glucuronide and covalent binding of salicylate to plasma proteins
J Pharmacol Exp Ther 1996 278: 277-283. [Abstract] [PDF]  

H Downes and PM Courogen

Contrasting effects of anesthetics in tadpole bioassays
J Pharmacol Exp Ther 1996 278: 284-296. [Abstract] [PDF]  

MG Melaragno and GD Fink

Inhibition of the slow pressor effect of angiotensin II contributes to the antihypertensive effect of angiotensin-converting enzyme inhibitors in renovascular hypertension
J Pharmacol Exp Ther 1996 278: 297-303. [Abstract] [PDF]  

ZR Vaz, VC Filho, RA Yunes, and JB Calixto

Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice
J Pharmacol Exp Ther 1996 278: 304-312. [Abstract] [PDF]  

C Larsson, P Simonsson, M Caron, and C Alling

Long-term exposure to ethanol increases the number and function of muscarinic M1 receptors in human neuroblastoma cells
J Pharmacol Exp Ther 1996 278: 313-319. [Abstract] [PDF]  

RJ Smith, JM Justen, AR McNab, CL Rosenbloom, AN Steele, PA Detmers, DC Anderson, and AM Manning

U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions
J Pharmacol Exp Ther 1996 278: 320-329. [Abstract] [PDF]  

D Boulay, D Duterte-Boucher, I Leroux-Nicollet, L Naudon, and J Costentin

Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine
J Pharmacol Exp Ther 1996 278: 330-337. [Abstract] [PDF]  

X Yang, AM Diehl, and GS Wand

Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum
J Pharmacol Exp Ther 1996 278: 338-346. [Abstract] [PDF]  

WL Jr Thomas, ES Cooke, and RP Jr Hammer

Cocaine-induced sensitization of metabolic activity in extrapyramidal circuits involves prior dopamine D1-like receptor stimulation
J Pharmacol Exp Ther 1996 278: 347-353. [Abstract] [PDF]  

CM O'Hara, L Tang, R Taussig, RD Todd, and KL O'Malley

Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines
J Pharmacol Exp Ther 1996 278: 354-360. [Abstract] [PDF]  

JR Pauly, MJ Marks, SF Robinson, JL van de Kamp, and AC Collins

Chronic nicotine and mecamylamine treatment increase brain nicotinic receptor binding without changing alpha 4 or beta 2 mRNA levels
J Pharmacol Exp Ther 1996 278: 361-369. [Abstract] [PDF]  

DY Li, D Abran, KG Peri, DR Varma, and S Chemtob

Inhibition of prostaglandin synthesis in newborn pigs increases cerebral microvessel prostaglandin F2 alpha and prostaglandin E2 receptors, their second messengers and vasoconstrictor response to adult levels
J Pharmacol Exp Ther 1996 278: 370-377. [Abstract] [PDF]  

JM Pearson, AE Schultze, KA Schwartz, MA Scott, JM Davis, and RA Roth

The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat
J Pharmacol Exp Ther 1996 278: 378-383. [Abstract] [PDF]  

RC Pierce, B Born, M Adams, and PW Kalivas

Repeated intra-ventral tegmental area administration of SKF-38393 induces behavioral and neurochemical sensitization to a subsequent cocaine challenge
J Pharmacol Exp Ther 1996 278: 384-392. [Abstract] [PDF]  

P Honore, V Chapman, J Buritova, and JM Besson

To what extent do spinal interactions between an alpha-2 adrenoceptor agonist and a mu opioid agonist influence noxiously evoked c-Fos expression in the rat? A pharmacological study
J Pharmacol Exp Ther 1996 278: 393-403. [Abstract] [PDF]  

WJ Wojcik, P Swoveland, X Zhang, and P Vanguri

Chronic intrathecal infusion of phosphorothioate or phosphodiester antisense oligonucleotides against cytokine responsive gene-2/IP-10 in experimental allergic encephalomyelitis of lewis rat
J Pharmacol Exp Ther 1996 278: 404-410. [Abstract] [PDF]  

BK Tolliver, LB Ho, MS Reid, and SP Berger

Evidence for involvement of ventral tegmental area cyclic AMP systems in behavioral sensitization to psychostimulants
J Pharmacol Exp Ther 1996 278: 411-420. [Abstract] [PDF]  

S Jilg, J Barsig, M Leist, S Kusters, HD Volk, and A Wendel

Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock
J Pharmacol Exp Ther 1996 278: 421-431. [Abstract] [PDF]  

R Kawatsu, SD Sanderson, I Blanco, N Kendall, AM Finch, SM Taylor, and D Colcher

Conformationally biased analogs of human C5a mediate changes in vascular permeability
J Pharmacol Exp Ther 1996 278: 432-440. [Abstract] [PDF]  

E Akullu, I Persson, L Bertilsson, I Johansson, F Rodrigues, and M Ingelman- Sundberg

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
J Pharmacol Exp Ther 1996 278: 441-446. [Abstract] [PDF]  

R Ishitani, M Kimura, K Sunaga, N Katsube, M Tanaka, and DM Chuang

An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture
J Pharmacol Exp Ther 1996 278: 447-454. [Abstract] [PDF]  

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