ARTICLES:

MR Escobar and DS Sitar

Use of digitalis glycosides to identify the mechanisms of amantadine transport by renal tubules
J Pharmacol Exp Ther 1996 277: 1189-1194. [Abstract] [PDF]  

D Fulton, M Balazy, JC McGiff, and J Quilley

Possible contribution of platelet cyclooxygenase to the renal vascular action of 5,6-epoxyeicosatrienoic acid
J Pharmacol Exp Ther 1996 277: 1195-1199. [Abstract] [PDF]  

E Mocchegiani, D Bulian, L Santarelli, A Tibaldi, M Muzzioli, V Lesnikov, W Pierpaoli, and N Fabris

The zinc pool is involved in the immune-reconstituting effect of melatonin in pinealectomized mice
J Pharmacol Exp Ther 1996 277: 1200-1208. [Abstract] [PDF]  

Q Li and EJ Forsberg

Catecholamine secretion induced by nicotine is due to Ca++ channel but not Na+ channel activation in porcine adrenal chromaffin cells
J Pharmacol Exp Ther 1996 277: 1209-1214. [Abstract] [PDF]  

I Lepran, I Baczko, A Varro, and JG Papp

ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats
J Pharmacol Exp Ther 1996 277: 1215-1220. [Abstract] [PDF]  

LM Lichtenberger, C Ulloa, AL Vanous, JJ Romero, EJ Dial, PA Illich, and ET Walters

Zwitterionic phospholipids enhance aspirin's therapeutic activity, as demonstrated in rodent model systems
J Pharmacol Exp Ther 1996 277: 1221-1227. [Abstract] [PDF]  

MK Greenwald, HL June, ML Stitzer, and AP Marco

Comparative clinical pharmacology of short-acting mu opioids in drug abusers
J Pharmacol Exp Ther 1996 277: 1228-1236. [Abstract] [PDF]  

R Testa, L Guarneri, C Taddei, E Poggesi, P Angelico, A Sartani, A Leonardi, ON Gofrit, S Meretyk, and M Caine

Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline- induced contraction of human prostate and mesenteric artery
J Pharmacol Exp Ther 1996 277: 1237-1246. [Abstract] [PDF]  

SE Hemby, JE Smith, and SI Dworkin

The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats [published erratum appears in J Pharmacol Exp Ther 1996 Oct;279(1):442]
J Pharmacol Exp Ther 1996 277: 1247-1258. [Abstract] [PDF]  

WP Clarke, FD Yocca, and S Maayani

Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats
J Pharmacol Exp Ther 1996 277: 1259-1266. [Abstract] [PDF]  

J Rochford, AP Sen, and R Quirion

Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat
J Pharmacol Exp Ther 1996 277: 1267-1275. [Abstract] [PDF]  

L Chen, WW Nichols, C Mattsson, AC Teger-Nilsson, TG Saldeen, and JL Mehta

Inogatran, a novel direct low molecular weight thrombin inhibitor, given with, but not after, tissue-plasminogen activator, improves thrombolysis
J Pharmacol Exp Ther 1996 277: 1276-1283. [Abstract] [PDF]  

RJ Knapp, G Santoro, IA De Leon, KB Lee, SA Edsall, S Waite, E Malatynska, E Varga, SN Calderon, KC Rice, RB Rothman, F Porreca, WR Roeske, and HI Yamamura

Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors
J Pharmacol Exp Ther 1996 277: 1284-1291. [Abstract] [PDF]  

M Miyamoto, H Takahashi, K Kato, K Hirai, Y Ishihara, and G Goto

Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 - H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models
J Pharmacol Exp Ther 1996 277: 1292-1304. [Abstract] [PDF]  

A Rohlfs, C Rundfeldt, R Koch, and W Loscher

A comparison of the effects of valproate and its major active metabolite E-2-en-valproate on single unit activity of substantia nigra pars reticulata neurons in rats
J Pharmacol Exp Ther 1996 277: 1305-1314. [Abstract] [PDF]  

DJ Clements, GA Cabral, and KL McCoy

delta 9-Tetrahydrocannabinol selectively inhibits macrophage costimulatory activity and down-regulates heat-stable antigen expression
J Pharmacol Exp Ther 1996 277: 1315-1321. [Abstract] [PDF]  

MM Belcheva, MT Ho, EG Ignatova, LB Jefcoat, J Barg, Z Vogel, RJ McHale, FE Johnson, and CJ Coscia

Buprenorphine differentially alters opioid receptor adaptation in rat brain regions
J Pharmacol Exp Ther 1996 277: 1322-1327. [Abstract] [PDF]  

K Miyoshi, A Kanda, Y Nozawa, M Nakano, and H Miyake

Regional vascular effects of MPC-1304, a novel dihydropyridine derivative, in conscious normotensive and spontaneously hypertensive rats
J Pharmacol Exp Ther 1996 277: 1328-1336. [Abstract] [PDF]  

JS Zuzack, MR Burkard, DK Cuadrado, RA Greer, WM Selig, and ET Whalley

Evidence of a bradykinin B1 receptor in human ileum: pharmacological comparison to the rabbit aorta B1 receptor
J Pharmacol Exp Ther 1996 277: 1337-1343. [Abstract] [PDF]  

PM Kunko, JA Smith, MJ Wallace, JR Maher, JJ Saady, and SE Robinson

Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat
J Pharmacol Exp Ther 1996 277: 1344-1351. [Abstract] [PDF]  

U Ozkutlu, RA Shaffer, SJ Lewis, and JP Long

A-4, a tertiary amine analog of HC-3, lowers arterial pressure in spontaneously hypertensive rats
J Pharmacol Exp Ther 1996 277: 1352-1358. [Abstract] [PDF]  

WL Hasler, HC Soudah, and C Owyang

Mechanisms by which octreotide ameliorates symptoms in the dumping syndrome
J Pharmacol Exp Ther 1996 277: 1359-1365. [Abstract] [PDF]  

DL Greene, VS Hau, TJ Abbruscato, H Bartosz, A Misicka, AW Lipkowski, S Hom, TJ Gillespie, VJ Hruby, and TP Davis

Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability
J Pharmacol Exp Ther 1996 277: 1366-1375. [Abstract] [PDF]  

S Chakder, S Rathi, XL Ma, and S Rattan

Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter
J Pharmacol Exp Ther 1996 277: 1376-1382. [Abstract] [PDF]  

MJ Marks, SF Robinson, and AC Collins

Nicotinic agonists differ in activation and desensitization of 86Rb+ efflux from mouse thalamic synaptosomes
J Pharmacol Exp Ther 1996 277: 1383-1396. [Abstract] [PDF]  

FE Parkinson and JD Geiger

Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT1 MF-2 smooth muscle cells
J Pharmacol Exp Ther 1996 277: 1397-1401. [Abstract] [PDF]  

X Duan, C Plopper, P Brennan, and A Buckpitt

Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury
J Pharmacol Exp Ther 1996 277: 1402-1409. [Abstract] [PDF]  

W Loscher and H Lehmann

L-deprenyl (selegiline) exerts anticonvulsant effects against different seizure types in mice
J Pharmacol Exp Ther 1996 277: 1410-1417. [Abstract] [PDF]  

HE de Vries, MC Blom-Roosemalen, AG de Boer, TJ van Berkel, DD Breimer, and J Kuiper

Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro
J Pharmacol Exp Ther 1996 277: 1418-1423. [Abstract] [PDF]  

H Inoue, I Arai, S Shibata, and S Watanabe

NG-nitro-L-arginine methyl ester attenuates the maintenance and expression of methamphetamine-induced behavioral sensitization and enhancement of striatal dopamine release
J Pharmacol Exp Ther 1996 277: 1424-1430. [Abstract] [PDF]  

AN Gifford and CR Jr Ashby

Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A
J Pharmacol Exp Ther 1996 277: 1431-1436. [Abstract] [PDF]  

C Pifl, O Hornykiewicz, B Giros, and MG Caron

Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter
J Pharmacol Exp Ther 1996 277: 1437-1443. [Abstract] [PDF]  

J Song, PR Standley, F Zhang, D Joshi, S Gappy, JR Sowers, and JL Ram

Tamoxifen (estrogen antagonist) inhibits voltage-gated calcium current and contractility in vascular smooth muscle from rats
J Pharmacol Exp Ther 1996 277: 1444-1453. [Abstract] [PDF]  

MJ Raatikainen, CA Napolitano, P Druzgala, and DM Dennis

Electrophysiological effects of a novel, short-acting and potent ester derivative of amiodarone, ATI-2001, in guinea pig isolated heart
J Pharmacol Exp Ther 1996 277: 1454-1463. [Abstract] [PDF]  

I Puscas, M Coltau, and R Pasca

Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action
J Pharmacol Exp Ther 1996 277: 1464-1466. [Abstract] [PDF]  

RA Radcliffe and VG Erwin

Alterations in locomotor activity after microinjections of GBR-12909, selective dopamine antagonists or neurotensin into the medial prefrontal cortex
J Pharmacol Exp Ther 1996 277: 1467-1476. [Abstract] [PDF]  

DF Kump, RA Matulka, GF Burton, SD Jordan, and MP Holsapple

Alternations in splenocyte and thymocyte subpopulations in B6C3F1 mice exposed to cocaine plus diazinon
J Pharmacol Exp Ther 1996 277: 1477-1485. [Abstract] [PDF]  

RK Handa and JW Strandhoy

Nitric oxide mediates the inhibitory action of platelet-activating factor on angiotensin II-induced renal vasoconstriction, in vivo
J Pharmacol Exp Ther 1996 277: 1486-1491. [Abstract] [PDF]  

BF Cox and GJ Smits

Regional hemodynamic effects of purinergic P2 receptor subtype agonists in rats
J Pharmacol Exp Ther 1996 277: 1492-1500. [Abstract] [PDF]  

H Zhang, BK Weir, RL Macdonald, LS Marton, NJ Solenski, AL Kwan, and KS Lee

Mechanisms of [Ca++]i elevation induced by erythrocyte components in endothelial cells
J Pharmacol Exp Ther 1996 277: 1501-1509. [Abstract] [PDF]  

FJ Miao, N Benowitz, and JD Levine

Neural and endocrine circuits mediating inhibition of bradykinin- induced plasma extravasation by subcutaneous and spinal-intrathecal nicotine
J Pharmacol Exp Ther 1996 277: 1510-1516. [Abstract] [PDF]  

GE Billman and RL Hamlin

The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation [published erratum appears in J Pharmacol Exp Ther 1996 Oct;279(1):442]
J Pharmacol Exp Ther 1996 277: 1517-1526. [Abstract] [PDF]  

BJ Copeland, V Vogelsberg, NH Neff, and M Hadjiconstantinou

Protein kinase C activators decrease dopamine uptake into striatal synaptosomes
J Pharmacol Exp Ther 1996 277: 1527-1532. [Abstract] [PDF]  

DT Lysle, KE Hoffman, and LA Dykstra

Evidence for the involvement of the caudal region of the periaqueductal gray in a subset of morphine-induced alterations of immune status [published erratum appears in J Pharmacol Exp Ther 1996 Dec;279(3):1589]
J Pharmacol Exp Ther 1996 277: 1533-1540. [Abstract] [PDF]  

CJ Schmidt and GM Fadayel

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade
J Pharmacol Exp Ther 1996 277: 1541-1549. [Abstract] [PDF]  

A Kakee, T Terasaki, and Y Sugiyama

Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier
J Pharmacol Exp Ther 1996 277: 1550-1559. [Abstract] [PDF]  

DJ Cushing, JM Zgombick, DL Nelson, and ML Cohen

LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin- induced relaxation in canine coronary artery
J Pharmacol Exp Ther 1996 277: 1560-1566. [Abstract] [PDF]  

P Nambi, M Pullen, HL Wu, D Lee, D Saunders, R Heys, N Aiyar, J Leber, J Elliott, D Brooks, E Ohlstein, and R Ruffolo

Nonpeptide endothelin receptor antagonists. VII: Binding characteristics of [3H]SB 209670, a novel nonpeptide antagonist of endothelin receptors
J Pharmacol Exp Ther 1996 277: 1567-1571. [Abstract] [PDF]  

N Zimmermann, P Boknik, E Gams, JW Herzig, J Neumann, W Schmitz, H Scholz, and H Wenzlaff

Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium
J Pharmacol Exp Ther 1996 277: 1572-1578. [Abstract] [PDF]  

J Neumann, T Eschenhagen, IL Grupp, A Haverich, JW Herzig, S Hirt, P Kalmar, W Schmitz, H Scholz, B Stein, H Wenzlaff, and N Zimmermann

Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium
J Pharmacol Exp Ther 1996 277: 1579-1585. [Abstract] [PDF]  

MA Chapman and RE See

Differential effects of unique profile antipsychotic drugs on extracellular amino acids in the ventral pallidum and globus pallidus of rats
J Pharmacol Exp Ther 1996 277: 1586-1594. [Abstract] [PDF]  

DH Albert, RG Conway, TJ Magoc, P Tapang, DA Rhein, G Luo, JH Holms, SK Davidsen, JB Summers, and GW Carter

Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist
J Pharmacol Exp Ther 1996 277: 1595-1606. [Abstract] [PDF]  

M Yamada, M Watanabe, S Mue, and K Ohuchi

Platelet-activating factor production in stimulated macrophages is down- regulated by concurrently produced prostaglandin E2
J Pharmacol Exp Ther 1996 277: 1607-1614. [Abstract] [PDF]  

PJ McNamara, JA Meece, and E Paxton

Active transport of cimetidine and ranitidine into the milk of Sprague Dawley rats
J Pharmacol Exp Ther 1996 277: 1615-1621. [Abstract] [PDF]  

Y Uchida, T Jun, H Ninomiya, H Ohse, S Hasegawa, A Nomura, T Sakamoto, MS Sardessai, and F Hirata

Involvement of endothelins in immediate and late asthmatic responses of guinea pigs
J Pharmacol Exp Ther 1996 277: 1622-1629. [Abstract] [PDF]  

T Izumi, S Enomoto, K Hosiyama, K Sasahara, A Shibukawa, T Nakagawa, and Y Sugiyama

Prediction of the human pharmacokinetics of troglitazone, a new and extensively metabolized antidiabetic agent, after oral administration, with an animal scale-up approach
J Pharmacol Exp Ther 1996 277: 1630-1641. [Abstract] [PDF]  

YW Lee and TL Yaksh

Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists
J Pharmacol Exp Ther 1996 277: 1642-1648. [Abstract] [PDF]  

RR Arlen and PG Wells

Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate
J Pharmacol Exp Ther 1996 277: 1649-1658. [Abstract] [PDF]  

KK Nielsen, JP Flinois, P Beaune, and K Brosen

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways
J Pharmacol Exp Ther 1996 277: 1659-1664. [Abstract] [PDF]  

PG Forkert, RP Lee, TF Dowsley, JY Hong, and JB Ulreich

Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic
J Pharmacol Exp Ther 1996 277: 1665-1671. [Abstract] [PDF]  

K Fukuda, H Dan, M Takayama, F Kumano, M Saitoh, and S Tanaka

Hyaluronic acid increases proteoglycan synthesis in bovine articular cartilage in the presence of interleukin-1
J Pharmacol Exp Ther 1996 277: 1672-1675. [Abstract] [PDF]  

T Oguro, E Kaneko, Y Kaneko, S Numazawa, S Imaoka, Y Funae, T Mikami, and T Yoshida

Suppressed expression of phenobarbital-inducible hepatic cytochrome P- 450s in Eisai-hyperbilirubinuria rats (EHBR/Eis)
J Pharmacol Exp Ther 1996 277: 1676-1684. [Abstract] [PDF]  

M Garcia-Munoz, P Patino, SJ Young, and PM Groves

Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors
J Pharmacol Exp Ther 1996 277: 1685-1693. [Abstract] [PDF]  

AA Nanji, EK Yang, F Fogt, SM Sadrzadeh, and AJ Dannenberg

Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease
J Pharmacol Exp Ther 1996 277: 1694-1700. [Abstract] [PDF]  

M Kahonen, H Makynen, X Wu, P Arvola, A Pekki, and I Porsti

Angiotensin-converting enzyme inhibition attenuates arterial constrictor responses in experimental hypertension
J Pharmacol Exp Ther 1996 277: 1701-1709. [Abstract] [PDF]  

LJ Brunner, WM Bennett, and DR Koop

Selective suppression of rat hepatic microsomal activity during chronic cyclosporine nephrotoxicity
J Pharmacol Exp Ther 1996 277: 1710-1718. [Abstract] [PDF]  

P Sestili, G Brandi, L Brambilla, F Cattabeni, and O Cantoni

Hydrogen peroxide mediates the killing of U937 tumor cells elicited by pharmacologically attainable concentrations of ascorbic acid: cell death prevention by extracellular catalase or catalase from cocultured erythrocytes or fibroblasts
J Pharmacol Exp Ther 1996 277: 1719-1725. [Abstract] [PDF]  

KB Duncan-Achanzar, JT Jones, MF Burke, DE Carter, and HE 2nd Laird

Inorganic mercury chloride-induced apoptosis in the cultured porcine renal cell line LLC-PK1
J Pharmacol Exp Ther 1996 277: 1726-1732. [Abstract] [PDF]  

EM Sorenson and JP Gallagher

The membrane hyperpolarization of rat dorsolateral septal nucleus neurons is mediated by a novel nicotinic receptor
J Pharmacol Exp Ther 1996 277: 1733-1743. [Abstract] [PDF]  

MD Sauro, R Sudakow, and S Burns

In vivo effects of angiotensin II on vascular smooth muscle contraction and blood pressure are mediated through a protein tyrosine-kinase- dependent mechanism
J Pharmacol Exp Ther 1996 277: 1744-1750. [Abstract] [PDF]  

JM Matz, KP LaVoi, and MJ Blake

Adrenergic regulation of the heat shock response in brown adipose tissue
J Pharmacol Exp Ther 1996 277: 1751-1758. [Abstract] [PDF]  

V Libri, A Constanti, M Zibetti, and S Nistico

Effects of felbamate on muscarinic and metabotropic-glutamate agonist- mediated responses and magnesium-free or 4-aminopyridine-induced epileptiform activity in guinea pig olfactory cortex neurons in vitro
J Pharmacol Exp Ther 1996 277: 1759-1769. [Abstract] [PDF]  

LP Shearman, LM Collins, and JS Meyer

Characterization and localization of [125I]RTI-55-labeled cocaine binding sites in fetal and adult rat brain
J Pharmacol Exp Ther 1996 277: 1770-1783. [Abstract] [PDF]  

A Kume, LJ Jr Greenfield, RL Macdonald, and RL Albin

Felbamate inhibits [3H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor
J Pharmacol Exp Ther 1996 277: 1784-1792. [Abstract] [PDF]  

F Pica, O Franzese, C D'Onofrio, E Bonmassar, C Favalli, and E Garaci

Prostaglandin E2 induces apoptosis in resting immature and mature human lymphocytes: a c-Myc-dependent and Bcl-2-independent associated pathway
J Pharmacol Exp Ther 1996 277: 1793-1800. [Abstract] [PDF]  

RJ Smith and LM Sly

Type II collagen-induced arthritis in the diabetic-resistant biobreeding rat: inflammatory and histopathological features of joint pathology and effects of antiinflammatory and antirheumatic drugs on this chronic arthritic process
J Pharmacol Exp Ther 1996 277: 1801-1813. [Abstract] [PDF]  

VS Raju and MD Maines

Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart
J Pharmacol Exp Ther 1996 277: 1814-1822. [Abstract] [PDF]  

JE Roth, TF Murray, and PH Franklin

Regional distribution and characterization of [3H]dextrorphan binding sites in rat brain determined by quantitative autoradiography
J Pharmacol Exp Ther 1996 277: 1823-1836. [Abstract] [PDF]  

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