ARTICLES:

B McAdam, RM Keimowitz, M Maher, and DJ Fitzgerald

Transdermal modification of platelet function: an aspirin patch system results in marked suppression of platelet cyclooxygenase
J Pharmacol Exp Ther 1996 277: 559-564. [Abstract] [PDF]  

A Hara and Y Abiko

Protective effects of dilazep and its novel derivative, K-7259, on mechanical and metabolic derangements induced by hydrogen peroxide in the isolated perfused rat heart
J Pharmacol Exp Ther 1996 277: 565-571. [Abstract] [PDF]  

T Kawata, S Hashimoto, and T Koike

The angiotensin receptor antagonist 2-ethoxy-1-[[2'-(1H- tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV11974) attenuates the tubuloglomerular feedback response during NO synthase blockade in rats
J Pharmacol Exp Ther 1996 277: 572-577. [Abstract] [PDF]  

LJ Bristow, KL Flatman, PH Hutson, JJ Kulagowski, PD Leeson, L Young, and MD Tricklebank

The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents
J Pharmacol Exp Ther 1996 277: 578-585. [Abstract] [PDF]  

DR Compton, MD Aceto, J Lowe, and BR Martin

In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of delta 9-tetrahydrocannabinol-induced responses and apparent agonist activity
J Pharmacol Exp Ther 1996 277: 586-594. [Abstract] [PDF]  

LY Lin, M Fujimoto, EW Distefano, DA Schmitz, A Jayasinghe, and AK Cho

Selective mechanism-based inactivation of rat CYP2D by 4- allyloxymethamphetamine
J Pharmacol Exp Ther 1996 277: 595-603. [Abstract] [PDF]  

EJ Gallaher, GE Jones, JK Belknap, and JC Crabbe

Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice
J Pharmacol Exp Ther 1996 277: 604-612. [Abstract] [PDF]  

TJ Phillips, CN Lessov, RD Harland, and SR Mitchell

Evaluation of potential genetic associations between ethanol tolerance and sensitization in BXD/Ty recombinant inbred mice
J Pharmacol Exp Ther 1996 277: 613-623. [Abstract] [PDF]  

JC Crabbe, TJ Phillips, EJ Gallaher, LI Crawshaw, and SR Mitchell

Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci
J Pharmacol Exp Ther 1996 277: 624-632. [Abstract] [PDF]  

K Fecho, KA Maslonek, LA Dykstra, and DT Lysle

Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats
J Pharmacol Exp Ther 1996 277: 633-645. [Abstract] [PDF]  

J Sawynok and A Reid

Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats
J Pharmacol Exp Ther 1996 277: 646-653. [Abstract] [PDF]  

XH Chen, EB Geller, and MW Adler

Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats
J Pharmacol Exp Ther 1996 277: 654-660. [Abstract] [PDF]  

RJ Thielen, NB Fangon, and A Frazer

4-(2'-Methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl] piperazine and 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- fluorobenzamido]ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors
J Pharmacol Exp Ther 1996 277: 661-670. [Abstract] [PDF]  

JJ Jr Lynch, AA Wallace, GL Stump, RF 3rd Stupienski, T Kothstein, and JR Gehret

Differential efficacy of the class III agent MK-499 against programmed stimulation-induced and ischemic-induced ventricular arrhythmias in a canine model of previous myocardial infarction
J Pharmacol Exp Ther 1996 277: 671-678. [Abstract] [PDF]  

KT Lin, A Dudhane, HP Godfrey, and PY Wong

Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4
J Pharmacol Exp Ther 1996 277: 679-684. [Abstract] [PDF]  

T Coleman, SW Ellis, IJ Martin, MS Lennard, and GT Tucker

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is N-demethylated by cytochromes P450 2D6, 1A2 and 3A4--implications for susceptibility to Parkinson's disease
J Pharmacol Exp Ther 1996 277: 685-690. [Abstract] [PDF]  

JF McAnulty and XQ Huang

The effects of administering quinacrine during ultraprofound hypothermia on warm ischemic kidney cortex tissue
J Pharmacol Exp Ther 1996 277: 691-699. [Abstract] [PDF]  

S Palea, M Corsi, W Artibani, E Ostardo, and C Pietra

Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate
J Pharmacol Exp Ther 1996 277: 700-705. [Abstract] [PDF]  

DM Fehr, DR Larach, KA Zangari, and HG Schuler

Halothane constricts bovine pulmonary arteries by release of intracellular calcium
J Pharmacol Exp Ther 1996 277: 706-713. [Abstract] [PDF]  

Y Wang, WR Mathews, DM Guido, and H Jaeschke

The 21-aminosteroid tirilazad mesylate protects against liver injury via membrane stabilization not inhibition of lipid peroxidation
J Pharmacol Exp Ther 1996 277: 714-720. [Abstract] [PDF]  

S Yamada, S Uchida, T Ohkura, R Kimura, M Yamaguchi, M Suzuki, and M Yamamoto

Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine
J Pharmacol Exp Ther 1996 277: 721-727. [Abstract] [PDF]  

GM Bores, FP Huger, W Petko, AE Mutlib, F Camacho, DK Rush, DE Selk, V Wolf, RW Jr Kosley, L Davis, and HM Vargas

Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine
J Pharmacol Exp Ther 1996 277: 728-738. [Abstract] [PDF]  

SG Holtzman

Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines
J Pharmacol Exp Ther 1996 277: 739-746. [Abstract] [PDF]  

T Katsuragi, K Matsuo, C Sato, K Honda, H Kamiya, and T Furukawa

Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments
J Pharmacol Exp Ther 1996 277: 747-752. [Abstract] [PDF]  

LC Nuttle and JM Farley

Frequency modulation of acetylcholine-induced oscillations in Ca++ and Ca(++)-activated Cl- current by cAMP in tracheal smooth muscle
J Pharmacol Exp Ther 1996 277: 753-760. [Abstract] [PDF]  

P Svensson, G Hesslow, and R Winton

Effect of ethanol on the excitability of the inferior olive in decerebrate ferret
J Pharmacol Exp Ther 1996 277: 761-767. [Abstract] [PDF]  

K Nunoya, Y Yokoi, K Kimura, T Kodama, M Funayama, K Inoue, K Nagashima, Y Funae, N Shimada, C Green, and T Kamataki

(+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM- 12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes
J Pharmacol Exp Ther 1996 277: 768-774. [Abstract] [PDF]  

P DeBoer and ED Abercrombie

Physiological release of striatal acetylcholine in vivo: modulation by D1 and D2 dopamine receptor subtypes
J Pharmacol Exp Ther 1996 277: 775-783. [Abstract] [PDF]  

MH Ossipov, CJ Kovelowski, H Wheeler-Aceto, A Cowan, JC Hunter, J Lai, TP Jr Malan, and F Porreca

Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone
J Pharmacol Exp Ther 1996 277: 784-788. [Abstract] [PDF]  

X Liu and JM Farley

Depletion and refilling of acetylcholine- and caffeine-sensitive Ca++ stores in tracheal myocytes
J Pharmacol Exp Ther 1996 277: 789-795. [Abstract] [PDF]  

X Liu and JM Farley

Acetylcholine-induced Ca++-dependent chloride current oscillations are mediated by inositol 1,4,5-trisphosphate in tracheal myocytes
J Pharmacol Exp Ther 1996 277: 796-804. [Abstract] [PDF]  

RE Pearce, AD Rodrigues, JA Goldstein, and A Parkinson

Identification of the human P450 enzymes involved in lansoprazole metabolism
J Pharmacol Exp Ther 1996 277: 805-816. [Abstract] [PDF]  

S McKinzie, GM Tyce, and S Brimijoin

Lowered norepinephrine turnover as a sign of impaired ganglionic transmission after preganglionic lesioning by acetylcholinesterase antibodies
J Pharmacol Exp Ther 1996 277: 817-822. [Abstract] [PDF]  

S Consolo, S Arnaboldi, S Ramponi, L Nannini, H Ladinsky, and G Baldi

Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT 1B receptors
J Pharmacol Exp Ther 1996 277: 823-830. [Abstract] [PDF]  

U Wenzel, I Gebert, H Weintraut, WM Weber, W Clauss, and H Daniel

Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells
J Pharmacol Exp Ther 1996 277: 831-839. [Abstract] [PDF]  

EM Kudlacz, SA Shatzer, RW Knippenberg, DE Logan, M Poirot, PL van Giersbergen, and TP Burkholder

In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK- 1/NK-2 tachykinin receptor antagonist
J Pharmacol Exp Ther 1996 277: 840-851. [Abstract] [PDF]  

TH de Boer, F Nefkens, A van Helvoirt, and AM van Delft

Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan
J Pharmacol Exp Ther 1996 277: 852-860. [Abstract] [PDF]  

N Haddjeri, P Blier, and C de Montigny

Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5- hydroxytryptamine system in the rat brain
J Pharmacol Exp Ther 1996 277: 861-871. [Abstract] [PDF]  

EG Silva, T Feres, LM Vianna, P Okuyama, and TB Paiva

Dual effect of clonidine on mesenteric artery adrenoceptors: agonistic (alpha-2) and antagonistic (alpha-1)
J Pharmacol Exp Ther 1996 277: 872-876. [Abstract] [PDF]  

CC Taylor, D Wu, Y Soong, JS Yee, and HH Szeto

kappa-Opioid agonist, U50,488H, stimulates ovine fetal pituitary- adrenal function via hypothalamic arginine-vasopressin and corticotrophin-releasing factor
J Pharmacol Exp Ther 1996 277: 877-884. [Abstract] [PDF]  

JA Gibbons, AA Hancock, CR Vitt, S Knepper, SA Buckner, ME Brune, I Milicic, JF Jr Kerwin, LS Richter, EW Taylor, KL Spear, RN Zuckermann, DC Spellmeyer, RA Braeckman, and WH Moos

Pharmacologic characterization of CHIR 2279, an N-substituted glycine peptoid with high-affinity binding for alpha 1-adrenoceptors
J Pharmacol Exp Ther 1996 277: 885-899. [Abstract] [PDF]  

S McLean, A Ganong, PA Seymour, DK Bryce, RT Crawford, J Morrone, LS Reynolds, AW Schmidt, S Zorn, J Watson, A Fossa, M DePasquale, T Rosen, A Nagahisa, M Tsuchiya, and J Heym

Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor
J Pharmacol Exp Ther 1996 277: 900-908. [Abstract] [PDF]  

MI Walton, W Gibson, GW Aherne, N Lawrence, TC Stephens, MN Smith, and AL Jackman

Preclinical pharmacology of CB30900, a novel dipeptide inhibitor of thymidylate synthase, in mice
J Pharmacol Exp Ther 1996 277: 909-916. [Abstract] [PDF]  

U Warpman, X Zhang, and A Nordberg

Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats
J Pharmacol Exp Ther 1996 277: 917-922. [Abstract] [PDF]  

ST Crooke, MJ Graham, JE Zuckerman, D Brooks, BS Conklin, LL Cummins, MJ Greig, CJ Guinosso, D Kornbrust, M Manoharan, HM Sasmor, T Schleich, KL Tivel, and RH Griffey

Pharmacokinetic properties of several novel oligonucleotide analogs in mice
J Pharmacol Exp Ther 1996 277: 923-937. [Abstract] [PDF]  

RM Maiorino, D Gonzalez-Ramirez, M Zuniga-Charles, Z Xu, KM Hurlbut, MM Aposhian, RC Dart, JS Woods, P Ostrosky-Wegman, ME Gonsebatt, and HV Aposhian

Sodium 2,3-dimercaptopropane-1-sulfonate challenge test for mercury in humans. III. Urinary mercury after exposure to mercurous chloride
J Pharmacol Exp Ther 1996 277: 938-944. [Abstract] [PDF]  

TR Ozolins, DL Siksay, and PG Wells

Modulation of embryonic glutathione peroxidase activity and phenytoin teratogenicity by dietary deprivation of selenium in CD-1 mice
J Pharmacol Exp Ther 1996 277: 945-953. [Abstract] [PDF]  

DA Cox, SW Watts, and ML Cohen

Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea
J Pharmacol Exp Ther 1996 277: 954-959. [Abstract] [PDF]  

MR Brandt and CP France

Discriminative stimulus effects on enadoline in pigeons
J Pharmacol Exp Ther 1996 277: 960-967. [Abstract] [PDF]  

JH Kehne, BM Baron, AA Carr, SF Chaney, J Elands, DJ Feldman, RA Frank, PL van Giersbergen, TC McCloskey, MP Johnson, DR McCarty, M Poirot, Y Senyah, BW Siegel, and C Widmaier

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile
J Pharmacol Exp Ther 1996 277: 968-981. [Abstract] [PDF]  

LC Wienkers, RC Steenwyk, PE Sanders, and PG Pearson

Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes
J Pharmacol Exp Ther 1996 277: 982-990. [Abstract] [PDF]  

JC Fleishaker, PG Pearson, LC Wienkers, LK Pearson, and GR Peters

Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability
J Pharmacol Exp Ther 1996 277: 991-998. [Abstract] [PDF]  

WY Chan, NC Wo, LL Cheng, and M Manning

Isosteric substitution of Asn5 in antagonists of oxytocin and vasopressin leads to highly selective and potent oxytocin and V1a receptor antagonists: new approaches for the design of potential tocolytics for preterm labor
J Pharmacol Exp Ther 1996 277: 999-1003. [Abstract] [PDF]  

H Asai, S Imaoka, T Kuroki, T Monna, and Y Funae

Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s
J Pharmacol Exp Ther 1996 277: 1004-1009. [Abstract] [PDF]  

M Nakajima, T Yamamoto, K Nunoya, T Yokoi, K Nagashima, K Inoue, Y Funae, N Shimada, T Kamataki, and Y Kuroiwa

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes
J Pharmacol Exp Ther 1996 277: 1010-1015. [Abstract] [PDF]  

S Kanes, K Dains, L Cipp, J Gatley, B Hitzemann, E Rasmussen, S Sanderson, M Silverman, and R Hitzemann

Mapping the genes for haloperidol-induced catalepsy
J Pharmacol Exp Ther 1996 277: 1016-1025. [Abstract] [PDF]  

MP Waalkes, BA Diwan, S Rehm, JM Ward, M Moussa, MG Cherian, and RA Goyer

Down-regulation of metallothionein expression in human and murine hepatocellular tumors: association with the tumor-necrotizing and antineoplastic effects of cadmium in mice
J Pharmacol Exp Ther 1996 277: 1026-1033. [Abstract] [PDF]  

R Mosqueda-Garcia, R Fernandez-Violante, T Hamakubo, and R Stainback

Vasopressin mediates the pressor effects of endothelin in the subfornical organ of the rat
J Pharmacol Exp Ther 1996 277: 1034-1042. [Abstract] [PDF]  

M Ohkura, Y Miyashita, T Nikai, J Suzuki, Y Komori, H Sugihara, and Y Ohizumi

Properties of Ca++ release induced by puff adder lectin, a novel lectin from the snake Bitis arietans, in sarcoplasmic reticulum
J Pharmacol Exp Ther 1996 277: 1043-1048. [Abstract] [PDF]  

KM Laughlin, SM Evans, WT Jenkins, M Tracy, CY Chan, EM Lord, and CJ Koch

Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]- N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors
J Pharmacol Exp Ther 1996 277: 1049-1057. [Abstract] [PDF]  

SG Kim, HC Chung, and JY Cho

Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride- induced hepatotoxicity: the role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression
J Pharmacol Exp Ther 1996 277: 1058-1066. [Abstract] [PDF]  

LR Walus, WM Pardridge, RM Starzyk, and PM Friden

Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies
J Pharmacol Exp Ther 1996 277: 1067-1075. [Abstract] [PDF]  

GE Duncan, DJ Knapp, KB Johnson, and GR Breese

Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity
J Pharmacol Exp Ther 1996 277: 1076-1089. [Abstract] [PDF]  

SA Masten, WJ Millard, JL Karlix, and KT Shiverick

Evaluation of immune parameters and lymphocyte production of prolactin- immunoreactive proteins after chronic administration of cocaine to pregnant rats
J Pharmacol Exp Ther 1996 277: 1090-1096. [Abstract] [PDF]  

N Makkonen, MR Hirvonen, T Teravainen, K Savolainen, and J Monkkonen

Different effects of three bisphosphonates on nitric oxide production by RAW 264 macrophage-like cells in vitro
J Pharmacol Exp Ther 1996 277: 1097-1102. [Abstract] [PDF]  

SW Watts, M Baez, and RC Webb

The 5-hydroxytryptamine2B receptor and 5-HT receptor signal transduction in mesenteric arteries from deoxycorticosterone acetate- salt hypertensive rats
J Pharmacol Exp Ther 1996 277: 1103-1113. [Abstract] [PDF]  

YM Hernandez, VF Raczkowski, KL Dretchen, and RA Gillis

Cocaine inhibits sympathetic neural activity by acting in the central nervous system and at the sympathetic ganglion
J Pharmacol Exp Ther 1996 277: 1114-1121. [Abstract] [PDF]  

K Johnson, L Churchill, MA Klitenick, MS Hooks, and PW Kalivas

Involvement of the ventral tegmental area in locomotion elicited from the nucleus accumbens or ventral pallidum
J Pharmacol Exp Ther 1996 277: 1122-1131. [Abstract] [PDF]  

CJ Allan, K Higashiura, M Martin, TA Morinelli, DT Kurtz, O Geoffroy, GP Meier, TW Gettys, and PV Halushka

Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q
J Pharmacol Exp Ther 1996 277: 1132-1139. [Abstract] [PDF]  

LR Williams, G Inouye, V Cummins, and MA Pelleymounter

Glial cell line-derived neurotrophic factor sustains axotomized basal forebrain cholinergic neurons in vivo: dose-response comparison to nerve growth factor and brain-derived neurotrophic factor
J Pharmacol Exp Ther 1996 277: 1140-1151. [Abstract] [PDF]  

G Gurujeyalakshmi, SN Iyer, MA Hollinger, and SN Giri

Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis
J Pharmacol Exp Ther 1996 277: 1152-1157. [Abstract] [PDF]  

TL Hartsell, LM Hinman, PR Hamann, and NF Schor

Determinants of the response of neuroblastoma cells to DNA damage: the roles of pre-treatment cell morphology and chemical nature of the damage
J Pharmacol Exp Ther 1996 277: 1158-1166. [Abstract] [PDF]  

ME Morgan, D Singhal, and BD Anderson

Quantitative assessment of blood-brain barrier damage during microdialysis
J Pharmacol Exp Ther 1996 277: 1167-1176. [Abstract] [PDF]  

Y Bjijou, L Stinus, M Le Moal, and M Cador

Evidence for selective involvement of dopamine D1 receptors of the ventral tegmental area in the behavioral sensitization induced by intra- ventral tegmental area injections of D-amphetamine
J Pharmacol Exp Ther 1996 277: 1177-1187. [Abstract] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.