ARTICLES:

GA Weisman, JT Turner, and JS Fedan

Structure and function of P2 purinocepters
J Pharmacol Exp Ther 1996 277: 1-9. [PDF]  

SM Lanier, M Lafontan, LE Limbird, and H Paris

Summary of the ASPET-sponsored Colloquium: Alpha-2 adrenergic receptors: structure, function, and therapeutic implications, October 25-27, 1995
J Pharmacol Exp Ther 1996 277: 10-16. [PDF]  

P Provost and Y Merhi

BW755C, a dual lipoxygenase/cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs
J Pharmacol Exp Ther 1996 277: 17-21. [Abstract] [PDF]  

MA Oriowo, H Chapman, DM Kirkham, MV Sennitt, RR Jr Ruffolo, and MA Cawthorne

The selectivity in vitro of the stereoisomers of the beta-3 adrenoceptor agonist BRL 37344
J Pharmacol Exp Ther 1996 277: 22-27. [Abstract] [PDF]  

M Kinoshita, N Saito, T Noto, and H Tamaki

Reversible inhibition of rat gastric H+/K+-ATPase by T-330, 2-[2- dimethylaminobenzyl)sulfinyl]-1-(3-methylpyridine-2-yl)imidazole
J Pharmacol Exp Ther 1996 277: 28-33. [Abstract] [PDF]  

CE Costarella, JN Stallone, GW Rutecki, and FC Whittier

Testosterone causes direct relaxation of rat thoracic aorta
J Pharmacol Exp Ther 1996 277: 34-39. [Abstract] [PDF]  

RN Iyer and CW Bradberry

Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization
J Pharmacol Exp Ther 1996 277: 40-47. [Abstract] [PDF]  

F Brunner, K Schmidt, EB Nielsen, and B Mayer

Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery
J Pharmacol Exp Ther 1996 277: 48-53. [Abstract] [PDF]  

F Sanae, S Ohmae, D Kobayashi, K Takag, and K Miyamoto

Negative inotropic action of denbufylline through interfering with the calcium channel independently of its PDE IV inhibitory activity in guinea pig ventricle papillary muscles
J Pharmacol Exp Ther 1996 277: 54-60. [Abstract] [PDF]  

M Endoh, I Norota, HT Yang, S Fujita, and M Takanashi

The positive inotropic effect and the hydrolysis of phosphoinositide induced by endothelin-3 in rabbit ventricular myocardium: inhibition by a selective antagonist of ET(A) receptors, FR139317
J Pharmacol Exp Ther 1996 277: 61-70. [Abstract] [PDF]  

S Roux, T Tschopp, and HR Baumgartner

Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model
J Pharmacol Exp Ther 1996 277: 71-78. [Abstract] [PDF]  

MM Barzago, A Bortolotti, FF Stellari, L Diomede, M Algeri, S Efrati, M Salmona, and M Bonati

Placental transfer of valproic acid after liposome encapsulation during in vitro human placenta perfusion
J Pharmacol Exp Ther 1996 277: 79-86. [Abstract] [PDF]  

JM Witkin, JB Acri, G Wong, S Gleeson, and JE Barrett

Behavioral and biochemical characterization of benzodiazepine receptor partial agonists in pigeons
J Pharmacol Exp Ther 1996 277: 87-96. [Abstract] [PDF]  

ML Cohen, W Bloomquist, JM Schaus, DC Thompson, AD Susemichel, DA Calligaro, and I Cohen

LY353433, a potent, orally effective, long-acting 5-HT(4) receptor antagonist: comparison to cisapride and RS23597-190
J Pharmacol Exp Ther 1996 277: 97-104. [Abstract] [PDF]  

DM Gentile, ES Tomlinson, JL Maggs, BK Park, and DJ Back

Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation
J Pharmacol Exp Ther 1996 277: 105-112. [Abstract] [PDF]  

SM Waters, CS Konkoy, and TP Davis

Haloperidol and apomorphine differentially affect neuropeptidase activity
J Pharmacol Exp Ther 1996 277: 113-120. [Abstract] [PDF]  

A Stefani, P Calabresi, A Pisani, NB Mercuri, A Siniscalchi, and G Bernardi

Felbamate inhibits dihydropyridine-sensitive calcium channels in central neurons
J Pharmacol Exp Ther 1996 277: 121-127. [Abstract] [PDF]  

XL Ma, TL Yue, BL Lopez, FC Barone, TA Christopher, RR Jr Ruffolo, and GZ Feuerstein

Carvedilol, a new beta adrenoreceptor blocker and free radical scavenger, attenuates myocardial ischemia-reperfusion injury in hypercholesterolemic rabbits
J Pharmacol Exp Ther 1996 277: 128-136. [Abstract] [PDF]  

T Inoue, M Domae, K Yamada, and T Furukawa

Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1- piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland
J Pharmacol Exp Ther 1996 277: 137-143. [Abstract] [PDF]  

C Hillemeier, KN Bitar, U Sohn, and P Biancani

Protein kinase C mediates spontaneous tone in the cat lower esophageal sphincter
J Pharmacol Exp Ther 1996 277: 144-149. [Abstract] [PDF]  

PG Gunasekar, PW Sun, AG Kanthasamy, JL Borowitz, and GE Isom

Cyanide-induced neurotoxicity involves nitric oxide and reactive oxygen species generation after N-methyl-D-aspartate receptor activation
J Pharmacol Exp Ther 1996 277: 150-155. [Abstract] [PDF]  

P Lebrun, MH Antoine, R Ouedraogo, C Kane, M Dunne, M Hermann, A Herchuelz, B Masereel, J Delarge, P de Tullio, and B Pirotte

Activation of ATP-dependent K+ channels and inhibition of insulin release: effect of BPDZ 62
J Pharmacol Exp Ther 1996 277: 156-162. [Abstract] [PDF]  

A Guia, T Chau, D Bose, and R Bose

Mechanism of cardiac inotropy by phenamil, and epithelial sodium channel blocker
J Pharmacol Exp Ther 1996 277: 163-173. [Abstract] [PDF]  

H Fei and LH Frame

d-Sotalol terminates reentry by two mechanisms with different dependence on the duration of the excitable gap
J Pharmacol Exp Ther 1996 277: 174-185. [Abstract] [PDF]  

CM O'Hara, A Uhland-Smith, KL O'Malley, and RD Todd

Inhibition of dopamine synthesis by dopamine D2 and D3 but not D4 receptors
J Pharmacol Exp Ther 1996 277: 186-192. [Abstract] [PDF]  

RM Broad and BB Fredholm

A1, but not A2A, adenosine receptors modulate electrically stimulated [14C]acetylcholine release from rat cortex
J Pharmacol Exp Ther 1996 277: 193-197. [Abstract] [PDF]  

JB Acri, BK Siedleck, and JM Witkin

Effects of benztropine on behavioral and toxic effects of cocaine: comparison with atropine and the selective dopamine uptake inhibitor 1- [2-(diphenylmethoxy)ethyl]-4-(3-phenyl-propyl)-piperazine
J Pharmacol Exp Ther 1996 277: 198-206. [Abstract] [PDF]  

N Hoque, AN Hoque, H Hashizume, K Ichihara, and Y Abiko

K-7259, a novel dilazep derivative, and d-propranolol attenuate H2O2- induced cell damage
J Pharmacol Exp Ther 1996 277: 207-211. [Abstract] [PDF]  

RL Peltier, DH Li, D Lytle, CM Taylor, and MW Emmett-Oglesby

Chronic d-amphetamine or methamphetamine produces cross-tolerance to the discriminative and reinforcing stimulus effects of cocaine
J Pharmacol Exp Ther 1996 277: 212-218. [Abstract] [PDF]  

SE Shoaf and B Schmall

Pharmacokinetics of alpha-methyl-L-tryptophan in rhesus monkeys and calculation of the lumped constant for estimating the rate of serotonin synthesis
J Pharmacol Exp Ther 1996 277: 219-224. [Abstract] [PDF]  

Z Sarnyai, NK Mello, JH Mendelson, M Eros-Sarnyai, and G Mercer

Effects of cocaine on pulsatile activity of hypothalamic-pituitary- adrenal axis in male rhesus monkeys: neuroendocrine and behavioral correlates
J Pharmacol Exp Ther 1996 277: 225-234. [Abstract] [PDF]  

G Faintrenie and A Geloen

Alpha-1 adrenergic regulation of lactate production by white adipocytes
J Pharmacol Exp Ther 1996 277: 235-238. [Abstract] [PDF]  

MD Martin, T McCann, C Naleway, JS Woods, BG Leroux, and AM Bollen

The validity of spot urine samples for low-level occupational mercury exposure assessment and relationship to porphyrin and creatinine excretion rates
J Pharmacol Exp Ther 1996 277: 239-244. [Abstract] [PDF]  

MA Sattar and EJ Johns

Alpha-1 adrenoceptor subtypes involved in mediating adrenergically induced antinatriuresis and antidiuresis in two kidney, one clip Goldblatt and deoxycorticosterone acetate-salt hypertensive rats
J Pharmacol Exp Ther 1996 277: 245-252. [Abstract] [PDF]  

O Curet, G Damoiseau, N Aubin, N Sontag, V Rovei, and FX Jarreau

Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. I. Biochemical profile
J Pharmacol Exp Ther 1996 277: 253-264. [Abstract] [PDF]  

D Caille, OE Bergis, C Fankhauser, A Gardes, R Adam, T Charieras, A Grosset, V Rovei, and FX Jarreau

Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. II. Pharmacological profile
J Pharmacol Exp Ther 1996 277: 265-277. [Abstract] [PDF]  

K Kasamo, P Blier, and C De Montigny

Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain
J Pharmacol Exp Ther 1996 277: 278-286. [Abstract] [PDF]  

CA Lee, JH Lillibridge, SD Nelson, and JT Slattery

Effects of caffeine and theophylline on acetaminophen pharmacokinetics: P450 inhibition and activation
J Pharmacol Exp Ther 1996 277: 287-291. [Abstract] [PDF]  

SR Shelnutt, TM Badger, and SM Owens

Phencyclidine metabolite irreversible binding in the rat: gonadal steroid regulation and CYP2C11
J Pharmacol Exp Ther 1996 277: 292-298. [Abstract] [PDF]  

DA Cabrini, DJ Kyle, and JB Calixto

A pharmacological analysis of receptor subtypes and the mechanisms mediating the biphasic response induced by kinins in the rat stomach fundus in vitro
J Pharmacol Exp Ther 1996 277: 299-307. [Abstract] [PDF]  

GI Elmer and FR George

The role of specific eicosanoids in mediating the acute narcotic effects of ethanol
J Pharmacol Exp Ther 1996 277: 308-315. [Abstract] [PDF]  

M Kutzer, S Meer, S Haller, and J Greven

Basolateral glutarate transport by isolated S2 segments of rabbit kidney proximal tubules
J Pharmacol Exp Ther 1996 277: 316-320. [Abstract] [PDF]  

M Bourrie, V Meunier, Y Berger, and G Fabre

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes
J Pharmacol Exp Ther 1996 277: 321-332. [Abstract] [PDF]  

GM Campo, F Squadrito, D Altavilla, G Squadrito, A Avenoso, P Canale, M Ioculano, A Sperandeo, and AP Caputi

Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation
J Pharmacol Exp Ther 1996 277: 333-340. [Abstract] [PDF]  

DL Allen, WP Hoffman, P Marder, MR Matchett, PA Leiter, DL Abbott, and RK Wolff

The effects of LY293111Na, a leukotriene B4 receptor antagonist, on the pulmonary neutrophilia and CD11b expression caused by inhalation of a leukotriene B4 aerosol in rhesus monkeys
J Pharmacol Exp Ther 1996 277: 341-349. [Abstract] [PDF]  

T Ishibashi, CI Lee, and E Okabe

Skeletal sarcoplasmic reticulum dysfunction induced by reactive oxygen intermediates derived from photoactivated rose bengal
J Pharmacol Exp Ther 1996 277: 350-358. [Abstract] [PDF]  

LH Claye, EM Unterwald, A Ho, and MJ Kreek

Both dynorphin A(1-17) [Des-Tyr1]dynorphin A(2-17) inhibit adenylyl cyclase activity in rat caudate putamen
J Pharmacol Exp Ther 1996 277: 359-365. [Abstract] [PDF]  

SE Cross, Z Wu, and MS Roberts

The effect of protein binding on the deep tissue penetration and efflux of dermally applied salicylic acid, lidocaine and diazepam in the perfused rat hindlimb
J Pharmacol Exp Ther 1996 277: 366-374. [Abstract] [PDF]  

RM Maiorino, ZF Xu, and HV Aposhian

Determination and metabolism of dithiol chelating agents. XVII. In humans, sodium 2,3-dimercapto-1-propanesulfonate is bound to plasma albumin via mixed disulfide formation and is found in the urine as cyclic polymeric disulfides
J Pharmacol Exp Ther 1996 277: 375-384. [Abstract] [PDF]  

RM Carelli and SA Deadwyler

Dose-dependent transitions in nucleus accumbens cell firing and behavioral responding during cocaine self-administration sessions in rats
J Pharmacol Exp Ther 1996 277: 385-393. [Abstract] [PDF]  

J Ren, E Karpinski, and CG Benishin

The actions of prostaglandin E2 on potassium currents in rat tail artery vascular smooth muscle cells: regulation by protein kinase A and protein kinase C
J Pharmacol Exp Ther 1996 277: 394-402. [Abstract] [PDF]  

DM McKay, R Brattsand, E Wieslander, M Fung, K Croitoru, and MH Perdue

Budesonide inhibits T cell-initiated epithelial pathophysiology in an in vitro model of inflammation
J Pharmacol Exp Ther 1996 277: 403-410. [Abstract] [PDF]  

SJ Mihic and RA Harris

Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics
J Pharmacol Exp Ther 1996 277: 411-416. [Abstract] [PDF]  

MD Salducci, AM Chauvet-Monges, JP Tillement, E Albengres, B Testa, P Carrupt, and A Crevat

Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine A in isolated rat liver mitochondria
J Pharmacol Exp Ther 1996 277: 417-422. [Abstract] [PDF]  

GN Kumar, AD Rodrigues, AM Buko, and JF Denissen

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
J Pharmacol Exp Ther 1996 277: 423-431. [Abstract] [PDF]  

R Bonfante-Cabarcas, KL Swanson, M Alkondon, and EX Albuquerque

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. IV. Regulation by external Ca++ of alpha-bungarotoxin- sensitive receptor function and of rectification induced by internal Mg++
J Pharmacol Exp Ther 1996 277: 432-444. [Abstract] [PDF]  

JH Song and T Narahashi

Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin
J Pharmacol Exp Ther 1996 277: 445-453. [Abstract] [PDF]  

MI Damaj, SP Welch, and BR Martin

Characterization and modulation of acute tolerance to nicotine in mice
J Pharmacol Exp Ther 1996 277: 454-461. [Abstract] [PDF]  

A Liguori, WH Morse, and J Bergman

Respiratory effects of opioid full and partial agonists in rhesus monkeys
J Pharmacol Exp Ther 1996 277: 462-472. [Abstract] [PDF]  

M van den Buuse, SJ Morton, JL Cornish, and GA Head

Prolonged central effects of quinpirole on cardiovascular regulation
J Pharmacol Exp Ther 1996 277: 473-483. [Abstract] [PDF]  

EJ Bilsky, RN Bernstein, Z Wang, W Sadee, and F Porreca

Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice
J Pharmacol Exp Ther 1996 277: 484-490. [Abstract] [PDF]  

EJ Bilsky, RN Bernstein, VJ Hruby, RB Rothman, J Lai, and F Porreca

Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo
J Pharmacol Exp Ther 1996 277: 491-501. [Abstract] [PDF]  

M Kawamura, Y Imura, N Moriya, S Kita, H Fukushi, H Sugihara, K Nishikawa, and Z Terashita

Antithrombotic effects of TAK-029, a novel GPIIb/IIIa antagonist, in guinea pigs: comparative studies with ticlopidine, clopidogrel, aspirin, prostaglandin E1 and argatroban
J Pharmacol Exp Ther 1996 277: 502-510. [Abstract] [PDF]  

VJ Cunningham, SD Rosen, H Boyd, S Osman, RJ Davenport, RN Gunn, VW Pike, and PG Camici

Uptake of [N-methyl-11C]propionyl-L-carnitine (PLC) in human myocardium
J Pharmacol Exp Ther 1996 277: 511-517. [Abstract] [PDF]  

HY Wang, E Fiorica-Howells, H Pan, MD Gershon, and E Friedman

Myenteric ganglionic 5-hydroxytryptamine(1P) signal transmission is mediated via Go protein
J Pharmacol Exp Ther 1996 277: 518-524. [Abstract] [PDF]  

TM Zheng, HJ Caruncho, WJ Zhu, S Vicini, S Ikonomovic, DR Grayson, and E Costa

Chronic flumazenil alters GABA(A) receptor subunit mRNA expression, translation product assembly and channel function in neuronal cultures
J Pharmacol Exp Ther 1996 277: 525-533. [Abstract] [PDF]  

SC Makrides, PA Nygren, B Andrews, PJ Ford, KS Evans, EG Hayman, H Adari, M Uhlen, and CA Toth

Extended in vivo half-life of human soluble complement receptor type 1 fused to a serum albumin-binding receptor
J Pharmacol Exp Ther 1996 277: 534-542. [Abstract] [PDF]  

M Sato, HU Bryant, JA Dodge, H Davis, WF Matter, and CJ Vlahos

Effects of wortmannin analogs on bone in vitro and in vivo
J Pharmacol Exp Ther 1996 277: 543-550. [Abstract] [PDF]  

G Zhang, AH Lagrange, OK Ronnekleiv, and MJ Kelly

Tolerance of hypothalamic beta-endorphin neurons to mu-opioid receptor activation after chronic morphine
J Pharmacol Exp Ther 1996 277: 551-558. [Abstract] [PDF]  

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