ARTICLES:

TJ Lee, S Sarwinski, T Ishine, CC Lai, and FY Chen

Inhibition of cerebral neurogenic vasodilation by L-glutamine and nitric oxide synthase inhibitors and its reversal by L-citrulline
J Pharmacol Exp Ther 1996 276: 353-358. [Abstract] [PDF]  

I Limon-Boulez, F Tesson, C Gargalidis-Moudanos, and A Parini

I2-imidazoline binding sites: relationship with different monoamine oxidase domains and identification of histidine residues mediating ligand binding regulation by H+1
J Pharmacol Exp Ther 1996 276: 359-364. [Abstract] [PDF]  

IR Coe, DP Dohrman, A Constantinescu, I Diamond, and AS Gordon

Activation of cyclic AMP-dependent protein kinase reverses tolerance of a nucleoside transporter to ethanol
J Pharmacol Exp Ther 1996 276: 365-369. [Abstract] [PDF]  

LL von Moltke, DJ Greenblatt, JS Harmatz, SX Duan, LM Harrel, MM Cotreau-Bibbo, GA Pritchard, CE Wright, and RI Shader

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole
J Pharmacol Exp Ther 1996 276: 370-379. [Abstract] [PDF]  

GJ Grover, CS Parham, DB Whigan, and JG Mitroka

BMS-180448, a novel glyburide-reversible cardioprotective agent, enhances postischemic recovery of contractile function in dogs
J Pharmacol Exp Ther 1996 276: 380-387. [Abstract] [PDF]  

MS Kleven and W Koek

Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon
J Pharmacol Exp Ther 1996 276: 388-397. [Abstract] [PDF]  

C Zocchi, E Ongini, A Conti, A Monopoli, A Negretti, PG Baraldi, and S Dionisotti

The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist
J Pharmacol Exp Ther 1996 276: 398-404. [Abstract] [PDF]  

FJ Ehlert, HS Oliff, and MT Griffin

The quaternary transformation products of N-(3-chloropropyl)-4- piperidinyl diphenylacetate and N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) have differential affinity for subtypes of the muscarinic receptor
J Pharmacol Exp Ther 1996 276: 405-410. [Abstract] [PDF]  

CK Chan, F Sannajust, and GA Head

Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits
J Pharmacol Exp Ther 1996 276: 411-420. [Abstract] [PDF]  

Y Kita, Y Hirasawa, S Fukuyama, K Ohkubo, Y Kato, H Takamatsu, M Ohno, S Nishino, M Kato, and J Seki

Oral biological activities of spontaneous nitric oxide releasers are accounted for by their nitric oxide-releasing rates and oral absorption manners
J Pharmacol Exp Ther 1996 276: 421-425. [Abstract] [PDF]  

JR Greene and A Mason

Effects of somatostatin and related peptides on the membrane potential and input resistance of rat ventral subicular neurons, in vitro
J Pharmacol Exp Ther 1996 276: 426-432. [Abstract] [PDF]  

Y Abe, R Ishisu, K Onishi, K Sekioka, A Narimatsu, and T Nakano

Calcium sensitization in perfused beating guinea pig heart by a positive inotropic agent MCI-154
J Pharmacol Exp Ther 1996 276: 433-439. [Abstract] [PDF]  

CW Stevens

Relative analgesic potency of mu, delta and kappa opioids after spinal administration in amphibians
J Pharmacol Exp Ther 1996 276: 440-448. [Abstract] [PDF]  

T Eissenberg, MK Greenwald, RE Johnson, IA Liebson, GE Bigelow, and ML Stitzer

Buprenorphine's physical dependence potential: antagonist-precipitated withdrawal in humans
J Pharmacol Exp Ther 1996 276: 449-459. [Abstract] [PDF]  

K Yamada, Y Noda, T Hasegawa, Y Komori, T Nikai, H Sugihara, and T Nabeshima

The role of nitric oxide in dizocilpine-induced impairment of spontaneous alternation behavior in mice
J Pharmacol Exp Ther 1996 276: 460-466. [Abstract] [PDF]  

H Imamura, Y Furukawa, H Nakano, M Kasama, Y Hoyano, and S Chiba

Selective inhibition by a class III antiarrhythmic agent, E-4031, of the negative chronotropic response to parasympathetic stimulation in anesthetized dogs
J Pharmacol Exp Ther 1996 276: 467-472. [Abstract] [PDF]  

TJ Opgenorth, AL Adler, SV Calzadilla, WJ Chiou, BD Dayton, DB Dixon, LJ Gehrke, L Hernandez, SR Magnuson, KC Marsh, EI Novosad, TW Von Geldern, JL Wessale, M Winn, and JR Wu-Wong

Pharmacological characterization of A-127722: an orally active and highly potent ETA-selective receptor antagonist
J Pharmacol Exp Ther 1996 276: 473-481. [Abstract] [PDF]  

X Yang, HE Criswell, and GR Breese

Nicotine-induced inhibition in medial septum involves activation of presynaptic nicotinic cholinergic receptors on gamma-aminobutyric acid- containing neurons
J Pharmacol Exp Ther 1996 276: 482-489. [Abstract] [PDF]  

PL Martin, RJ Jr Wysocki, RJ Barrett, JM May, and J Linden

Characterization of 8-(N-methylisopropyl)amino-N6-(5'-endohydroxy- endonorbornyl)-9-methyladenine (WRC-0571), a highly potent and selective, non-xanthine antagonist of A1 adenosine receptors
J Pharmacol Exp Ther 1996 276: 490-499. [Abstract] [PDF]  

BY Li, JW Nalwalk, LA Barker, P Cumming, ME Parsons, and LB Hough

Characterization of the antinociceptive properties of cimetidine and a structural analog
J Pharmacol Exp Ther 1996 276: 500-508. [Abstract] [PDF]  

AI Sacaan, F Menzaghi, JL Dunlop, LD Correa, KT Whelan, and GK Lloyd

Epibatidine: a nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: in vitro and in vivo evidence in rats
J Pharmacol Exp Ther 1996 276: 509-515. [Abstract] [PDF]  

NO Dalby and C Thomsen

Modulation of seizure activity in mice by metabotropic glutamate receptor ligands
J Pharmacol Exp Ther 1996 276: 516-522. [Abstract] [PDF]  

LR Gerak and CP France

Discriminative stimulus effects of nalbuphine in rhesus monkeys
J Pharmacol Exp Ther 1996 276: 523-531. [Abstract] [PDF]  

JS Mogil, B Kest, B Sadowski, and JK Belknap

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay
J Pharmacol Exp Ther 1996 276: 532-544. [Abstract] [PDF]  

TS Shippenberg, A LeFevour, and C Heidbreder

kappa-Opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine
J Pharmacol Exp Ther 1996 276: 545-554. [Abstract] [PDF]  

JW Proksch, LA Traylor, and PR Mayeux

Effects of lipid A on calcium homeostasis in renal proximal tubules
J Pharmacol Exp Ther 1996 276: 555-560. [Abstract] [PDF]  

RH Moseley, H Smit, BG Van Solkema, W Wang, and DK Meijer

Mechanisms for the hepatic uptake and biliary excretion of tributylmethylammonium: studies with rat liver plasma membrane vesicles
J Pharmacol Exp Ther 1996 276: 561-567. [Abstract] [PDF]  

D Liu, RJ Hariman, and JL Bauman

Cocaine concentration-effect relationship in the presence and absence of lidocaine: evidence of competitive binding between cocaine and lidocaine
J Pharmacol Exp Ther 1996 276: 568-577. [Abstract] [PDF]  

PY Sze

Glucocorticoid interactions with ethanol effects on synaptic plasma membranes: influence on [125I]calmodulin binding
J Pharmacol Exp Ther 1996 276: 578-584. [Abstract] [PDF]  

AH Lichtman, SA Cook, and BR Martin

Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement
J Pharmacol Exp Ther 1996 276: 585-593. [Abstract] [PDF]  

R Young and RA Glennon

A three-lever operant procedure differentiates the stimulus effects of R(-)-MDA from S(+)-MDA
J Pharmacol Exp Ther 1996 276: 594-601. [Abstract] [PDF]  

RB Raftogianis, MR Franklin, and RE Galinsky

Effect of lipid-free total parenteral nutrition on hepatic drug conjugation in rats
J Pharmacol Exp Ther 1996 276: 602-608. [Abstract] [PDF]  

EH Ohlstein, P Nambi, A Lago, DW Hay, G Beck, KL Fong, EP Eddy, P Smith, H Ellens, and JD Elliott

Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist
J Pharmacol Exp Ther 1996 276: 609-615. [Abstract] [PDF]  

A Cheramy, G Godeheu, M L'Hirondel, and J Glowinski

Cooperative contributions of cholinergic and NMDA receptors in the presynaptic control of dopamine release from synaptosomes of the rat striatum
J Pharmacol Exp Ther 1996 276: 616-625. [Abstract] [PDF]  

K Fecho, KA Maslonek, LA Dykstra, and DT Lysle

Assessment of the involvement of central nervous system and peripheral opioid receptors in the immunomodulatory effects of acute morphine treatment in rats
J Pharmacol Exp Ther 1996 276: 626-636. [Abstract] [PDF]  

A Bril, B Gout, M Bonhomme, L Landais, JF Faivre, P Linee, RH Poyser, and RR Jr Ruffolo

Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile of BRL-32872
J Pharmacol Exp Ther 1996 276: 637-646. [Abstract] [PDF]  

RB Raffa, JJ Schupsky, and HI Jacoby

Endothelin-induced nociception in mice: mediation by ETA and ETB receptors
J Pharmacol Exp Ther 1996 276: 647-651. [Abstract] [PDF]  

MY Farhat, S Abi-Younes, B Dingaan, R Vargas, and PW Ramwell

Estradiol increases cyclic adenosine monophosphate in rat pulmonary vascular smooth muscle cells by a nongenomic mechanism
J Pharmacol Exp Ther 1996 276: 652-657. [Abstract] [PDF]  

BJ Ring, J Catlow, TJ Lindsay, T Gillespie, LK Roskos, BJ Cerimele, SP Swanson, MA Hamman, and SA Wrighton

Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine
J Pharmacol Exp Ther 1996 276: 658-666. [Abstract] [PDF]  

DL Davies, M Bejanian, ES Parker, J Morland, MB Bolger, RD Brinton, and RL Alkana

Low level hyperbaric antagonism of diazepam's locomotor depressant and anticonvulsant properties in mice
J Pharmacol Exp Ther 1996 276: 667-675. [Abstract] [PDF]  

SJ Chung, VK Ramanathan, CM Brett, and KM Giacomini

Saturable disposition of taurine in the rat cerebrospinal fluid
J Pharmacol Exp Ther 1996 276: 676-682. [Abstract] [PDF]  

MR Ujhelyi, MB Bottorff, M Schur, K Roll, H Zhang, J Stewart, and ML Markel

Urine acidification affects the activity of the organic base transporter in a nonstereoselective manner
J Pharmacol Exp Ther 1996 276: 683-689. [Abstract] [PDF]  

EA Pasyk, S Cipris, and EE Daniel

A G protein, not cyclic AMP, mediates effects of VIP on the inwardly rectifying K+ channels in endothelial cells
J Pharmacol Exp Ther 1996 276: 690-696. [Abstract] [PDF]  

G Pineyro and P Blier

Regulation of 5-hydroxytryptamine release from rat midbrain raphe nuclei by 5-hydroxytryptamine1D receptors: effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration
J Pharmacol Exp Ther 1996 276: 697-707. [Abstract] [PDF]  

AA Seymour, MM Asaad, BE Abboa-Offei, PL Smith, WL Rogers, and CR Dorso

Determinants of in vivo activity of neutral endopeptidase 3.4.24.11 and angiotensin converting enzyme inhibitors
J Pharmacol Exp Ther 1996 276: 708-713. [Abstract] [PDF]  

KN Bitar, S Kothary, and PC Kothary

Somatostatin inhibits bombesin-stimulated Gi-protein via its own receptor in rabbit colonic smooth muscle cells
J Pharmacol Exp Ther 1996 276: 714-719. [Abstract] [PDF]  

DB Wainscott, VL Lucaites, JD Kursar, M Baez, and DL Nelson

Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences
J Pharmacol Exp Ther 1996 276: 720-727. [Abstract] [PDF]  

WS Powell, J Rokach, SP Khanapure, S Manna, M Hashefi, S Gravel, RJ Macleod, JR Falck, and RK Bhatt

Effects of metabolites of leukotriene B4 on human neutrophil migration and cytosolic calcium levels
J Pharmacol Exp Ther 1996 276: 728-736. [Abstract] [PDF]  

IG Campbell and I Feinberg

Noncompetitive NMDA channel blockade during waking intensely stimulates NREM delta
J Pharmacol Exp Ther 1996 276: 737-742. [Abstract] [PDF]  

A Capasso, A Di Giannuario, A Loizzo, S Pieretti, S Sagratella, and L Sorrentino

Dexamethasone selective inhibition of acute opioid physical dependence in isolated tissues
J Pharmacol Exp Ther 1996 276: 743-751. [Abstract] [PDF]  

J Jr Haynes, DW Killilea, PD Peterson, and WJ Thompson

Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic-3',5'-guanosine monophosphate-stimulated phosphodiesterase to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung
J Pharmacol Exp Ther 1996 276: 752-757. [Abstract] [PDF]  

MI Davis-Cox, TL Fletcher, JN Turner, D Szarowski, and W Shain

Three-day exposure to low-dose ethanol alters guanine nucleotide binding protein expression in the developing rat hippocampus
J Pharmacol Exp Ther 1996 276: 758-764. [Abstract] [PDF]  

K Maeda and M Fukuda

Arbutin: mechanism of its depigmenting action in human melanocyte culture
J Pharmacol Exp Ther 1996 276: 765-769. [Abstract] [PDF]  

SF Rosebrough and M Hashmi

Galactose-modified streptavidin-GC4 antifibrin monoclonal antibody conjugates: application for two-step thrombus/embolus imaging
J Pharmacol Exp Ther 1996 276: 770-775. [Abstract] [PDF]  

Y Daaka, H Friedman, and TW Klein

Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation
J Pharmacol Exp Ther 1996 276: 776-783. [Abstract] [PDF]  

VA Boundy, L Lu, and PB Molinoff

Differential coupling of rat D2 dopamine receptor isoforms expressed in Spodoptera frugiperda insect cells
J Pharmacol Exp Ther 1996 276: 784-794. [Abstract] [PDF]  

V De Gennaro Colonna, M Zoli, BP Settembrini, S Ciceri, A De Marco, SG Cella, LF Agnati, and EE Muller

Effects of single and short-term administration of clonidine on hypothalamic-pituitary somatotropic function of the adult male rat: an in situ hybridization study
J Pharmacol Exp Ther 1996 276: 795-800. [Abstract] [PDF]  

KR Gogas, JD Levine, and AI Basbaum

Differential contribution of descending controls to the antinociceptive actions of kappa and mu opioids: an analysis of formalin-evoked C-fos expression
J Pharmacol Exp Ther 1996 276: 801-809. [Abstract] [PDF]  

CD Manning, MM McLaughlin, GP Livi, LB Cieslinski, TJ Torphy, and MS Barnette

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B
J Pharmacol Exp Ther 1996 276: 810-818. [Abstract] [PDF]  

M Munir, L Lu, YH Wang, J Luo, BB Wolfe, and P McGonigle

Pharmacological and immunological characterization of N-methyl-D- aspartate receptors in human NT2-N neurons
J Pharmacol Exp Ther 1996 276: 819-828. [Abstract] [PDF]  

K Sakai, N Nakahata, H Ono, T Yamamoto, and Y Ohizumi

Homologous desensitization of thromboxane A2 receptor in 1321N1 human astrocytoma cells
J Pharmacol Exp Ther 1996 276: 829-836. [Abstract] [PDF]  

H Ali, OH Choi, PF Fraundorfer, K Yamada, HM Gonzaga, and MA Beaven

Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line
J Pharmacol Exp Ther 1996 276: 837-845. [Abstract] [PDF]  

KE Sabol, R Lew, JB Richards, GL Vosmer, and LS Seiden

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations
J Pharmacol Exp Ther 1996 276: 846-854. [Abstract] [PDF]  

R Lew, KE Sabol, C Chou, GL Vosmer, J Richards, and LS Seiden

Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part II: Radioligand binding and autoradiography studies
J Pharmacol Exp Ther 1996 276: 855-865. [Abstract] [PDF]  

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