ARTICLES:

R Zhuge and WH Hsu

The caffeine- and ryanodine-sensitive Ca++ store in porcine myometrial cells: its heterogeneity of all-or-none Ca++ release
J Pharmacol Exp Ther 1995 275: 1077-1083. [Abstract] [PDF]  

T Yoneyama, M Hori, T Tanaka, Y Matsuda, and H Karaki

Endothelin ETA and ETB receptors facilitating parasympathetic neurotransmission in the rabbit trachea
J Pharmacol Exp Ther 1995 275: 1084-1089. [Abstract] [PDF]  

BJ Brockel and SC Fowler

Effects of chronic haloperidol on reaction time and errors in a sustained attention task: partial reversal by anticholinergics and by amphetamine
J Pharmacol Exp Ther 1995 275: 1090-1098. [Abstract] [PDF]  

A Bado, JP Laigneau, L Moizo, Y Cherifi, and MJ Lewin

H3-receptor activation inhibits cholinergic stimulation of acid secretion in isolated rabbit fundic glands
J Pharmacol Exp Ther 1995 275: 1099-1103. [Abstract] [PDF]  

DS Albers and PK Sonsalla

Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: pharmacological profile of protective and nonprotective agents
J Pharmacol Exp Ther 1995 275: 1104-1114. [Abstract] [PDF]  

A Tosaki, DT Engelman, RM Engelman, and DK Das

Diabetes and ATP-sensitive potassium channel openers and blockers in isolated ischemic/reperfused hearts
J Pharmacol Exp Ther 1995 275: 1115-1123. [Abstract] [PDF]  

GD Zeevalk, E Derr-Yellin, and WJ Nicklas

Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3- nitropropionic acid and protection by NMDA receptor blockade
J Pharmacol Exp Ther 1995 275: 1124-1130. [Abstract] [PDF]  

BJ Ring, SN Binkley, L Roskos, and SA Wrighton

Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1'-hydroxy midazolam formation in vitro
J Pharmacol Exp Ther 1995 275: 1131-1135. [Abstract] [PDF]  

MM Prechel, AT Orawski, LL Maggiora, and WH Simmons

Effect of a new aminopeptidase P inhibitor, apstatin, on bradykinin degradation in the rat lung
J Pharmacol Exp Ther 1995 275: 1136-1142. [Abstract] [PDF]  

C Millar, JF Poyer, BT Gabelt, and PL Kaufman

Endothelin subtypes: effect on isolated rhesus monkey ciliary muscle
J Pharmacol Exp Ther 1995 275: 1143-1147. [Abstract] [PDF]  

A Boutros and J Wang

Ischemic preconditioning, adenosine and bethanechol protect spontaneously hypertensive isolated rat hearts
J Pharmacol Exp Ther 1995 275: 1148-1156. [Abstract] [PDF]  

M Magnon, P Gallix, and I Cavero

Intervessel (arteries and veins) and heart/vessel selectivities of therapeutically used calcium entry blockers: variable, vessel-dependent indexes
J Pharmacol Exp Ther 1995 275: 1157-1166. [Abstract] [PDF]  

L Belardinelli, JC Shryock, Y Zhang, PJ Scammells, R Olsson, D Dennis, P Milner, J Pfister, and SP Baker

1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells
J Pharmacol Exp Ther 1995 275: 1167-1176. [Abstract] [PDF]  

SA Longman, PG Tardi, MJ Parr, L Choi, PR Cullis, and MB Bally

Accumulation of protein-coated liposomes in an extravascular site: influence of increasing carrier circulation lifetimes
J Pharmacol Exp Ther 1995 275: 1177-1184. [Abstract] [PDF]  

JW Mandema and DR Wada

Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat
J Pharmacol Exp Ther 1995 275: 1185-1194. [Abstract] [PDF]  

T May, U Wolf, and J Wolffgramm

Striatal dopamine receptors and adenylyl cyclase activity in a rat model of alcohol addiction: effects of ethanol and lisuride treatment
J Pharmacol Exp Ther 1995 275: 1195-1203. [Abstract] [PDF]  

EB Fraser-Smith, JD Rosete, and RC Schatzman

Suppression by mycophenolate mofetil of the neointimal thickening caused by vascular injury in a rat arterial stenosis model
J Pharmacol Exp Ther 1995 275: 1204-1208. [Abstract] [PDF]  

RM Woodward, JE Huettner, M Tran, J Guastella, JF Keana, and E Weber

Pharmacology of 5-chloro-7-trifluoromethyl-1,4-dihydro-2,3- quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist
J Pharmacol Exp Ther 1995 275: 1209-1218. [Abstract] [PDF]  

S Kalsner

Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels
J Pharmacol Exp Ther 1995 275: 1219-1226. [Abstract] [PDF]  

BJ Day, S Shawen, SI Liochev, and JD Crapo

A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro
J Pharmacol Exp Ther 1995 275: 1227-1232. [Abstract] [PDF]  

MJ Janusz, SL Durham, CM Hare, JL Geary, AK Mandagere, JC Poole, TN Thompson, D Xu, MR Anagelastro, and JP Burkhart

Pharmacological evaluation of selected, orally active, peptidyl inhibitors of human neutrophil elastase
J Pharmacol Exp Ther 1995 275: 1233-1238. [Abstract] [PDF]  

F Sautel, N Griffon, P Sokoloff, JC Schwartz, C Launay, P Simon, J Costentin, A Schoenfelder, F Garrido, and A Mann

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents
J Pharmacol Exp Ther 1995 275: 1239-1246. [Abstract] [PDF]  

T Matsumoto, M Takahashi, I Nakae, and M Kinoshita

Vasorelaxing effect of S-nitrosocaptopril on dog coronary arteries: no cross-tolerance with nitroglycerin
J Pharmacol Exp Ther 1995 275: 1247-1253. [Abstract] [PDF]  

MG Bischof, K Redlich, C Schiller, MV Chirayath, M Uskokovic, M Peterlik, and HS Cross

Growth inhibitory effects on human colon adenocarcinoma-derived Caco-2 cells and calcemic potential of 1 alpha,25-dihydroxyvitamin D3 analogs: structure-function relationships
J Pharmacol Exp Ther 1995 275: 1254-1260. [Abstract] [PDF]  

SS Hegde, DW Bonhaus, W Stanley, RM Eglen, TM Moy, M Loeb, SG Shetty, A DeSouza, and J Krstenansky

Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist
J Pharmacol Exp Ther 1995 275: 1261-1266. [Abstract] [PDF]  

JM Witkin, S Brave, D French, and B Geter-Douglass

Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2- one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor
J Pharmacol Exp Ther 1995 275: 1267-1273. [Abstract] [PDF]  

TA Spalding, ES Burstein, H Brauner-Osborne, D Hill-Eubanks, and MR Brann

Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis
J Pharmacol Exp Ther 1995 275: 1274-1279. [Abstract] [PDF]  

SY Yousufzai, Z Ye, and AA Abdel-Latif

Prostaglandins mediate the stimulatory effects of endothelin-1 on cAMP accumulation and inositol-1,4,5-trisphosphate production and contraction in cat iris sphincter
J Pharmacol Exp Ther 1995 275: 1280-1287. [Abstract] [PDF]  

E Tagaya, J Tamaoki, A Chiyotani, and K Konno

Stimulation of opioid mu-receptors potentiates beta adrenoceptor- mediated relaxation of canine airway smooth muscle
J Pharmacol Exp Ther 1995 275: 1288-1292. [Abstract] [PDF]  

NJ Liu, T Xu, C Xu, CQ Li, YX Yu, HG Kang, and JS Han

Cholecystokinin octapeptide reverses mu-opioid-receptor-mediated inhibition of calcium current in rat dorsal root ganglion neurons
J Pharmacol Exp Ther 1995 275: 1293-1299. [Abstract] [PDF]  

H Barelli, Z Woskowska, S Cipris, JE Fox-Threlkeld, EE Daniel, JP Vincent, and F Checler

Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study
J Pharmacol Exp Ther 1995 275: 1300-1307. [Abstract] [PDF]  

Y Yuan and WD Atchison

Methylmercury acts at multiple sites to block hippocampal synaptic transmission
J Pharmacol Exp Ther 1995 275: 1308-1316. [Abstract] [PDF]  

MR Escobar, K Goralski, and DS Sitar

L(+)- and D(-)-lactate modulate rat renal tubular accumulation of amantadine in the presence and absence of bicarbonate
J Pharmacol Exp Ther 1995 275: 1317-1323. [Abstract] [PDF]  

C Marie, C Mossiat, JM Lecomte, JC Schwartz, and J Bralet

Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction
J Pharmacol Exp Ther 1995 275: 1324-1331. [Abstract] [PDF]  

WG Smith, AF Shaffer, JL Currie, JM Thompson, S Kim, T Rao, and PC Isakson

Characterization of 5-lipoxygenase inhibitors in biochemical and functional in vivo assays
J Pharmacol Exp Ther 1995 275: 1332-1338. [Abstract] [PDF]  

ML Nichols, D Bian, MH Ossipov, J Lai, and F Porreca

Regulation of morphine antiallodynic efficacy by cholecystokinin in a model of neuropathic pain in rats
J Pharmacol Exp Ther 1995 275: 1339-1345. [Abstract] [PDF]  

MB Gatch, SS Negus, ER Butelman, and NK Mello

Antinociceptive effects of cocaine/opioid combinations in rhesus monkeys
J Pharmacol Exp Ther 1995 275: 1346-1354. [Abstract] [PDF]  

TA Pugsley, MD Davis, HC Akunne, RG MacKenzie, YH Shih, G Damsma, H Wikstrom, SZ Whetzel, LM Georgic, and LW Cooke

Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907
J Pharmacol Exp Ther 1995 275: 1355-1366. [Abstract] [PDF]  

MR Weed and WL Woolverton

The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys
J Pharmacol Exp Ther 1995 275: 1367-1374. [Abstract] [PDF]  

M Wolzt, L Schmetterer, J Kastner, K Krejcy, G Zanaschka, C Unfried, and HG Eichler

Short-term drug effects on the signal-averaged electrocardiogram in healthy men: assessment of intra- and interindividual variability of spectral temporal mapping and time-domain analysis
J Pharmacol Exp Ther 1995 275: 1375-1381. [Abstract] [PDF]  

AJ Carter, WD Bechtel, M Grauert, P Harrison, H Merz, and W Stransky

BIII 277 CL is a potent and specific ion-channel blocker of the NMDA receptor-channel complex
J Pharmacol Exp Ther 1995 275: 1382-1389. [Abstract] [PDF]  

HK Im, WB Im, JF Pregenzer, DB Carter, and BJ Hamilton

U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors
J Pharmacol Exp Ther 1995 275: 1390-1395. [Abstract] [PDF]  

S Takahashi, E Nakamura, and S Okabe

Stimulatory effect of leminoprazole on secretion and synthesis of mucus by rabbit gastric mucosal cells
J Pharmacol Exp Ther 1995 275: 1396-1401. [Abstract] [PDF]  

JH Song and T Narahashi

Selective block of tetramethrin-modified sodium channels by (+/-)-alpha- tocopherol (vitamin E)
J Pharmacol Exp Ther 1995 275: 1402-1411. [Abstract] [PDF]  

LD McCauley and KW Gee

Influence of the estrus cycle on the discrimination of apparent neuroactive steroid site subtypes on the gamma-aminobutyric acidA receptor complex in the rat
J Pharmacol Exp Ther 1995 275: 1412-1417. [Abstract] [PDF]  

M Bencherif, CM Eisenhour, RJ Prince, PM Lippiello, and RJ Lukas

The "calcium antagonist" TMB-8 [3,4,5-trimethoxybenzoic acid 8- (diethylamino)octyl ester] is a potent, non-competitive, functional antagonist at diverse nicotinic acetylcholine receptor subtypes
J Pharmacol Exp Ther 1995 275: 1418-1426. [Abstract] [PDF]  

R Schleiffer, M Galluser, and F Raul

Intestinal absorption of calcium in vivo is dependent on endogenous nitric oxide
J Pharmacol Exp Ther 1995 275: 1427-1432. [Abstract] [PDF]  

B Korbmacher, U Sunderdiek, HD Schulte, G Arnold, and JD Schipke

Comparison between the effects of a novel Ca++ sensitizer and a phosphodiesterase inhibitor on stunned myocardium
J Pharmacol Exp Ther 1995 275: 1433-1441. [Abstract] [PDF]  

R Yu and MK Ticku

Effects of chronic pentobarbital treatment on the GABAA receptor complex in mammalian cortical neurons
J Pharmacol Exp Ther 1995 275: 1442-1446. [Abstract] [PDF]  

A Fujii, H Matsumoto, T Hashimoto, and Y Akimoto

Tenidap, an anti-inflammatory agent, discharges intracellular Ca++ store and inhibits Ca++ influx in cultured human gingival fibroblasts
J Pharmacol Exp Ther 1995 275: 1447-1452. [Abstract] [PDF]  

LM Ireland, CH Yan, LM Nelson, and WD Atchison

Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells
J Pharmacol Exp Ther 1995 275: 1453-1462. [Abstract] [PDF]  

JL Maggs, D Williams, M Pirmohamed, and BK Park

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man
J Pharmacol Exp Ther 1995 275: 1463-1475. [Abstract] [PDF]  

ZC Liu and JP Uetrecht

Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells
J Pharmacol Exp Ther 1995 275: 1476-1483. [Abstract] [PDF]  

TK Eisenstein, JJ Jr Meissler, TJ Rogers, EB Geller, and MW Adler

Mouse strain differences in immunosuppression by opioids in vitro
J Pharmacol Exp Ther 1995 275: 1484-1489. [Abstract] [PDF]  

S Pierno, A De Luca, D Tricarico, A Roselli, F Natuzzi, E Ferrannini, M Laico, and DC Camerino

Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers
J Pharmacol Exp Ther 1995 275: 1490-1496. [Abstract] [PDF]  

R Vezza, GG Nenci, and P Gresele

Thromboxane synthase inhibitors suppress more effectively the aggregation of thromboxane receptor-desensitized than that of normal platelets: role of adenylylcyclase up-regulation
J Pharmacol Exp Ther 1995 275: 1497-1505. [Abstract] [PDF]  

HJ Kim, P Rozman, and CD Klaassen

Acetaminophen does not decrease hepatic 3'-phosphoadenosine 5'- phosphosulfate in mice
J Pharmacol Exp Ther 1995 275: 1506-1511. [Abstract] [PDF]  

Z Zhong, HD Connor, RP Mason, W Qu, W Gao, JJ Lemasters, and RG Thurman

Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats
J Pharmacol Exp Ther 1995 275: 1512-1517. [Abstract] [PDF]  

DL Jr Williams, KL Murphy, NA Nolan, JA O'Brien, DJ Pettibone, SD Kivlighn, SM Krause, EV Jr Lis, GJ Zingaro, and RA Gabel

Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist
J Pharmacol Exp Ther 1995 275: 1518-1526. [Abstract] [PDF]  

M Chiba, JA Nishime, and JH Lin

Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor
J Pharmacol Exp Ther 1995 275: 1527-1534. [Abstract] [PDF]  

RM Craft, SR Henley, RC Haaseth, VJ Hruby, and F Porreca

Opioid antinociception in a rat model of visceral pain: systemic versus local drug administration
J Pharmacol Exp Ther 1995 275: 1535-1542. [Abstract] [PDF]  

CA Kanashiro, TB Paiva, AC Paiva, RN Prioste, J Aboulafia, and SI Shimuta

Angiotensin II tachyphylaxis in the guinea pig ileum and its prevention: a pharmacological and biochemical study
J Pharmacol Exp Ther 1995 275: 1543-1550. [Abstract] [PDF]  

LL Howell and LD Byrd

Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey
J Pharmacol Exp Ther 1995 275: 1551-1559. [Abstract] [PDF]  

MC Olianas and P Onali

Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb
J Pharmacol Exp Ther 1995 275: 1560-1567. [Abstract] [PDF]  

CH Yang, MH Shyr, TB Kuo, PP Tan, and SH Chan

Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration
J Pharmacol Exp Ther 1995 275: 1568-1574. [Abstract] [PDF]  

A Guidarelli, P Sestili, A Cossarizza, C Franceschi, F Cattabeni, and O Cantoni

Evidence for dissimilar mechanisms of enhancement of inorganic and organic hydroperoxide cytotoxicity by L-histidine
J Pharmacol Exp Ther 1995 275: 1575-1582. [Abstract] [PDF]  

MT Piascik, RD Guarino, MS Smith, EE Soltis, DL Jr Saussy, and DM Perez

The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle
J Pharmacol Exp Ther 1995 275: 1583-1589. [Abstract] [PDF]  

P Sanchez-Blazquez, A Garcia-Espana, and J Garzon

In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists
J Pharmacol Exp Ther 1995 275: 1590-1596. [Abstract] [PDF]  

I Kitchen, FM Leslie, M Kelly, R Barnes, TJ Crook, RG Hill, A Borsodi, G Toth, P Melchiorri, and L Negri

Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies
J Pharmacol Exp Ther 1995 275: 1597-1607. [Abstract] [PDF]  

JP Desjardins and PL Iversen

Inhibition of the rat cytochrome P450 3A2 by an antisense phosphorothioate oligodeoxynucleotide in vivo
J Pharmacol Exp Ther 1995 275: 1608-1613. [Abstract] [PDF]  

Y Dai and AI Cederbaum

Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line
J Pharmacol Exp Ther 1995 275: 1614-1622. [Abstract] [PDF]  

DR Bachvarov, E Saint-Jacques, JF Larrivee, L Levesque, F Rioux, G Drapeau, and F Marceau

Cloning and pharmacological characterization of the rabbit bradykinin B2 receptor
J Pharmacol Exp Ther 1995 275: 1623-1630. [Abstract] [PDF]  

H Saito, M Okuda, T Terada, S Sasaki, and K Inui

Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney
J Pharmacol Exp Ther 1995 275: 1631-1637. [Abstract] [PDF]  

BL Roth, EP Palvimaki, S Berry, N Khan, N Sachs, A Uluer, and MS Choudhary

5-Hydroxytryptamine2A (5-HT2A) receptor desensitization can occur without down-regulation
J Pharmacol Exp Ther 1995 275: 1638-1646. [Abstract] [PDF]  

JF Strasser, LK Fung, S Eller, SA Grossman, and WM Saltzman

Distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea and tracers in the rabbit brain after interstitial delivery by biodegradable polymer implants
J Pharmacol Exp Ther 1995 275: 1647-1655. [Abstract] [PDF]  

H Gurdal, N Tilakaratne, RD Brown, M Fonseca, E Friedman, and MD Johnson

The expression of alpha 1 adrenoceptor subtypes changes with age in the rat aorta
J Pharmacol Exp Ther 1995 275: 1656-1662. [Abstract] [PDF]  

HW Suh, PM Hudson, MK McMillian, KP Das, BC Wilson, GC Wu, and JS Hong

Long-term stimulation of nicotinic receptors is required to increase proenkephalin A mRNA levels and the delayed secretion of [Met5]- enkephalin in bovine adrenal medullary chromaffin cells
J Pharmacol Exp Ther 1995 275: 1663-1670. [Abstract] [PDF]  

HE Nye, BT Hope, MB Kelz, M Iadarola, and EJ Nestler

Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens
J Pharmacol Exp Ther 1995 275: 1671-1680. [Abstract] [PDF]  

J Koropatnick, DM Kloth, S Kadhim, JL Chin, and MG Cherian

Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line
J Pharmacol Exp Ther 1995 275: 1681-1687. [Abstract] [PDF]  

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