ARTICLES:

K Groen, DD Breimer, EJ Jansen, and CF van Bezooijen

The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study
J Pharmacol Exp Ther 1994 268: 531-536. [Abstract] [PDF]  

TV Dunwiddie and L Diao

Extracellular adenosine concentrations in hippocampal brain slices and the tonic inhibitory modulation of evoked excitatory responses
J Pharmacol Exp Ther 1994 268: 537-545. [Abstract] [PDF]  

G Mikus, F Bochner, M Eichelbaum, P Horak, AA Somogyi, and S Spector

Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism
J Pharmacol Exp Ther 1994 268: 546-551. [Abstract] [PDF]  

SZ Wang, SZ Zhu, and EE el-Fakahany

Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase
J Pharmacol Exp Ther 1994 268: 552-557. [Abstract] [PDF]  

CJ Tseng, LL Chou, LP Ger, and CS Tung

Cardiovascular effects of angiotensin III in brainstem nuclei of normotensive and hypertensive rats
J Pharmacol Exp Ther 1994 268: 558-564. [Abstract] [PDF]  

MI Christie and GW Smith

Cardiovascular and renal hemodynamic effects of A-68930 in the conscious dog: a comparison with fenoldopam
J Pharmacol Exp Ther 1994 268: 565-570. [Abstract] [PDF]  

H Ito, H Sogabe, T Nakarai, Y Sato, M Tomoi, M Kadowaki, M Matsuo, K Tokoro, and K Yoshida

Pharmacological profile of FK480, a novel cholecystokinin type-A receptor antagonist: comparison to loxiglumide
J Pharmacol Exp Ther 1994 268: 571-575. [Abstract] [PDF]  

S Suzuki, Y Takata, S Kubota, S Ozaki, and H Kato

Characterization of the alpha-1 adrenoceptors in the mesenteric vasculature from deoxycorticosterone-salt hypertensive rats: studies on vasoconstriction, radioligand binding and postreceptor events
J Pharmacol Exp Ther 1994 268: 576-583. [Abstract] [PDF]  

M Tsutsui, N Yanagihara, K Minami, H Kobayashi, Y Nakashima, A Kuroiwa, and F Izumi

C-type natriuretic peptide stimulates catecholamine synthesis through the accumulation of cyclic GMP in cultured bovine adrenal medullary cells
J Pharmacol Exp Ther 1994 268: 584-589. [Abstract] [PDF]  

CY Chen and CS Chen

Stereoselective disposition of ibuprofen in patients with renal dysfunction
J Pharmacol Exp Ther 1994 268: 590-594. [Abstract] [PDF]  

E Ronken, AH Mulder, and AN Schoffelmeer

Chronic activation of mu- and kappa-opioid receptors in cultured catecholaminergic neurons from rat brain causes neuronal supersensitivity without receptor desensitization
J Pharmacol Exp Ther 1994 268: 595-599. [Abstract] [PDF]  

RP Rubin and MA Adolf

Cyclic AMP regulation of calcium mobilization and amylase release from isolated permeabilized rat parotid cells
J Pharmacol Exp Ther 1994 268: 600-606. [Abstract] [PDF]  

DL Hammond, A Stapelfeld, EJ Drower, MA Savage, L Tam, and RH Mazur

Antinociception produced by oral, subcutaneous or intrathecal administration of SC-39566, an opioid dipeptide arylalkylamide, in the rodent
J Pharmacol Exp Ther 1994 268: 607-615. [Abstract] [PDF]  

RA Mathot, EA van Schaick, MW Langemeijer, W Soudijn, DD Breimer, AP Ijzerman, and M Danhof

Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat
J Pharmacol Exp Ther 1994 268: 616-624. [Abstract] [PDF]  

R Pohorecki, BJ Howard, M Matsushita, PM Stemmer, GL Becker, and DF Landers

Isoflurane isomers differ in preservation of ATP in anoxic rat hepatocytes
J Pharmacol Exp Ther 1994 268: 625-628. [Abstract] [PDF]  

KA Freeman and RJ Tallarida

A quantitative study of dopamine control in the rat striatum
J Pharmacol Exp Ther 1994 268: 629-638. [Abstract] [PDF]  

T Okamoto, S Mizoguchi, H Terasaki, and T Morioka

Safety of high-dose of nafamostat mesilate: toxicological study in beagles
J Pharmacol Exp Ther 1994 268: 639-644. [Abstract] [PDF]  

MJ Eaton, KJ Lookingland, and KE Moore

Effects of the selective dopaminergic D2 agonist quinelorane on the activity of dopaminergic and noradrenergic neurons projecting to the diencephalon of the rat
J Pharmacol Exp Ther 1994 268: 645-652. [Abstract] [PDF]  

CS Wong, YF Su, WD Watkins, and KJ Chang

Opioid agonist binding affinity is increased by magnesium in the presence of guanosine diphosphate but decreased by magnesium in the presence of guanyl-5'-yl imidodiphosphate
J Pharmacol Exp Ther 1994 268: 653-661. [Abstract] [PDF]  

KM Hurlbut, RM Maiorino, M Mayersohn, RC Dart, DC Bruce, and HV Aposhian

Determination and metabolism of dithiol chelating agents. XVI: Pharmacokinetics of 2,3-dimercapto-1-propanesulfonate after intravenous administration to human volunteers
J Pharmacol Exp Ther 1994 268: 662-668. [Abstract] [PDF]  

M Takano, Y Ohishi, M Okuda, M Yasuhara, and R Hori

Transport of gentamicin and fluid-phase endocytosis markers in the LLC- PK1 kidney epithelial cell line
J Pharmacol Exp Ther 1994 268: 669-674. [Abstract] [PDF]  

Y Wu, HC Rosenberg, TH Chiu, and V Ramsey-Williams

Regional changes in [3H]zolpidem binding to brain benzodiazepine receptors in flurazepam tolerant rat: comparison with changes in [3H]flunitrazepam binding
J Pharmacol Exp Ther 1994 268: 675-682. [Abstract] [PDF]  

KP Mayfield and LG D'Alecy

Delta-1 opioid agonist acutely increases hypoxic tolerance
J Pharmacol Exp Ther 1994 268: 683-688. [Abstract] [PDF]  

JE Fox-Threlkeld, EE Daniel, F Christinck, VJ Hruby, S Cipris, and Z Woskowska

Identification of mechanisms and sites of actions of mu and delta opioid receptor activation in the canine intestine
J Pharmacol Exp Ther 1994 268: 689-700. [Abstract] [PDF]  

PE Stewart and DL Hammond

Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat
J Pharmacol Exp Ther 1994 268: 701-708. [Abstract] [PDF]  

LA Marshall, JD Winkler, DE Griswold, B Bolognese, A Roshak, CM Sung, EF Webb, and R Jacobs

Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation
J Pharmacol Exp Ther 1994 268: 709-717. [Abstract] [PDF]  

RL Papke, AG Craig, and SF Heinemann

Inhibition of nicotinic acetylcholine receptors by bis (2,2,6,6- tetramethyl- 4-piperidinyl) sebacate (Tinuvin 770), an additive to medical plastics
J Pharmacol Exp Ther 1994 268: 718-726. [Abstract] [PDF]  

FC Tortella, L Robles, JM Witkin, and AH Newman

Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile
J Pharmacol Exp Ther 1994 268: 727-733. [Abstract] [PDF]  

J Balthasar and HL Fung

Utilization of antidrug antibody fragments for the optimization of intraperitoneal drug therapy: studies using digoxin as a model drug
J Pharmacol Exp Ther 1994 268: 734-739. [Abstract] [PDF]  

LA Burns, TL Spriggs, BA Fuchs, and AE Munson

Gallium arsenide-induced increase in serum corticosterone is not responsible for suppression of the IgM antibody response
J Pharmacol Exp Ther 1994 268: 740-746. [Abstract] [PDF]  

F Bertolino, JP Valentin, M Maffre, B Jover, AM Bessac, and GW John

Prevention of thromboxane A2 receptor-mediated pulmonary hypertension by a nonpeptide angiotensin II type 1 receptor antagonist
J Pharmacol Exp Ther 1994 268: 747-752. [Abstract] [PDF]  

KK Miller and CR Lupica

Morphine-induced excitation of pyramidal neurons is inhibited by cholecystokinin in the CA1 region of the rat hippocampal slice
J Pharmacol Exp Ther 1994 268: 753-761. [Abstract] [PDF]  

S Abe, J Nishimura, M Nakamura, and H Kanaide

Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery
J Pharmacol Exp Ther 1994 268: 762-771. [Abstract] [PDF]  

V Ralevic, A Rubino, and G Burnstock

Prejunctional modulation of sensory-motor nerve-mediated vasodilatation of the rat mesenteric arterial bed by opioid peptides
J Pharmacol Exp Ther 1994 268: 772-778. [Abstract] [PDF]  

H Shimamoto, Y Shimamoto, CY Kwan, and EE Daniel

Amplification of 5-hydroxytryptamine-induced contractile responses via 5-hydroxytryptamine receptors and alpha-adrenoceptors in dog mesenteric artery and vein
J Pharmacol Exp Ther 1994 268: 779-784. [Abstract] [PDF]  

DD Mousseau, X Sun, and AA Larson

An antinociceptive effect of capsaicin in the adult mouse mediated by the NH2-terminus of substance P
J Pharmacol Exp Ther 1994 268: 785-790. [Abstract] [PDF]  

U Bickel, S Yamada, and WM Pardridge

Synthesis and bioactivity of monobiotinylated DALDA: a mu-specific opioid peptide designed for targeted brain delivery
J Pharmacol Exp Ther 1994 268: 791-796. [Abstract] [PDF]  

KD Adkison, AA Artru, KM Powers, and DD Shen

Contribution of probenecid-sensitive anion transport processes at the brain capillary endothelium and choroid plexus to the efficient efflux of valproic acid from the central nervous system
J Pharmacol Exp Ther 1994 268: 797-805. [Abstract] [PDF]  

RM Woodward, L Polenzani, and R Miledi

Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes
J Pharmacol Exp Ther 1994 268: 806-817. [Abstract] [PDF]  

A Terzic, A Jahangir, and Y Kurachi

HOE-234, a second generation K+ channel opener, antagonizes the ATP- dependent gating of cardiac ATP-sensitive K+ channels
J Pharmacol Exp Ther 1994 268: 818-825. [Abstract] [PDF]  

Y Yagil

The effects of adenosine on water and sodium excretion
J Pharmacol Exp Ther 1994 268: 826-835. [Abstract] [PDF]  

L Fang, RJ Knapp, R Horvath, TO Matsunaga, RC Haaseth, VJ Hruby, F Porreca, and HI Yamamura

Characterization of [3H]naltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens: evidence for delta opioid receptor heterogeneity
J Pharmacol Exp Ther 1994 268: 836-846. [Abstract] [PDF]  

CM Handler, TC Piliero, EB Geller, and MW Adler

Effect of ambient temperature on the ability of mu-, kappa- and delta- selective opioid agonists to modulate thermoregulatory mechanisms in the rat
J Pharmacol Exp Ther 1994 268: 847-855. [Abstract] [PDF]  

HN Bhargava, GA Matwyshyn, AK Rattan, KL Koo, and GA Tejwani

beta-Endorphin-like immunoreactivity in discrete brain regions, spinal cord, pituitary gland and peripheral tissues of U-50,488H-tolerant and - abstinent rats
J Pharmacol Exp Ther 1994 268: 856-861. [Abstract] [PDF]  

SE Mulroney, C Skudlarek, A Shemer, MD Lumpkin, and KJ Kellar

Tandospirone stimulates prolactin secretion in the rat by an action at serotonin-1A receptors
J Pharmacol Exp Ther 1994 268: 862-867. [Abstract] [PDF]  

I Gorenne, C Labat, JP Gascard, X Norel, R Muller-Peddinghaus, KH Mohrs, WA Taylor, PJ Gardiner, and C Brink

(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways
J Pharmacol Exp Ther 1994 268: 868-872. [Abstract] [PDF]  

FS Wang, JJ Rady, and JM Fujimoto

Elimination of the antianalgesic action of dynorphin A by spinal transsection in barbital-anesthetized mice
J Pharmacol Exp Ther 1994 268: 873-880. [Abstract] [PDF]  

GF Wilkinson, K McKechnie, IA Dainty, and MR Boarder

P2Y purinoceptor and nucleotide receptor-induced relaxation of precontracted bovine aortic collateral artery rings: differential sensitivity to suramin and indomethacin
J Pharmacol Exp Ther 1994 268: 881-887. [Abstract] [PDF]  

RJ Heaslip, LJ Lombardo, JM Golankiewicz, BA Ilsemann, DY Evans, BD Sickels, JK Mudrick, J Bagli, and BM Weichman

Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641
J Pharmacol Exp Ther 1994 268: 888-896. [Abstract] [PDF]  

H Hohage, DM Morth, IU Querl, and J Greven

Regulation by protein kinase C of the contraluminal transport system for organic cations in rabbit kidney S2 proximal tubules
J Pharmacol Exp Ther 1994 268: 897-901. [Abstract] [PDF]  

AH Campos and JB Calixto

Mechanisms involved in the contractile responses of kinins in rat portal vein rings: mediation by B1 and B2 receptors
J Pharmacol Exp Ther 1994 268: 902-909. [Abstract] [PDF]  

SJ De Kimpe, D Van Heuven-Nolsen, JG van Amsterdam, MW Radomski, and FP Nijkamp

Induction of nitric oxide release by interferon-gamma inhibits vasodilation and cyclic GMP increase in bovine isolated mesenteric arteries
J Pharmacol Exp Ther 1994 268: 910-915. [Abstract] [PDF]  

IM Maisonneuve and MJ Kreek

Acute tolerance to the dopamine response induced by a binge pattern of cocaine administration in male rats: an in vivo microdialysis study
J Pharmacol Exp Ther 1994 268: 916-921. [Abstract] [PDF]  

AM Birchall, J Bishop, D Bradshaw, A Cline, J Coffey, LH Elliott, VM Gibson, A Greenham, TJ Hallam, and W Harris

Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation
J Pharmacol Exp Ther 1994 268: 922-929. [Abstract] [PDF]  

Q Xia, JZ Sheng, KK Tai, and TM Wong

Effects of chronic U50,488H treatment on binding and mechanical responses of the rat hearts [published erratum appears in J Pharmacol Exp Ther 1994 Aug;270(2):839]
J Pharmacol Exp Ther 1994 268: 930-934. [Abstract] [PDF]  

KD Burris, TM Filtz, S Chumpradit, MP Kung, C Foulon, JG Hensler, HF Kung, and PB Molinoff

Characterization of [125I](R)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'- propenyl)amino] tetralin binding to dopamine D3 receptors in rat olfactory tubercle
J Pharmacol Exp Ther 1994 268: 935-942. [Abstract] [PDF]  

GE De Lander and GJ 2nd Keil

Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor agonists in mice
J Pharmacol Exp Ther 1994 268: 943-951. [Abstract] [PDF]  

R Kalfin, N Maulik, RM Engelman, GA Cordis, K Milenov, L Kasakov, and DK Das

Protective role of intracoronary vasoactive intestinal peptide in ischemic and reperfused myocardium
J Pharmacol Exp Ther 1994 268: 952-958. [Abstract] [PDF]  

Q Liu, Y Horio, K Fujimoto, and H Fukui

Does the [3H]mepyramine binding site represent the histamine H1 receptor? Re-examination of the histamine H1 receptor with quinine
J Pharmacol Exp Ther 1994 268: 959-964. [Abstract] [PDF]  

Y Kojima, T Takahashi, M Fujina, and C Owyang

Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory inhibitory G protein and calcium N-channels
J Pharmacol Exp Ther 1994 268: 965-970. [Abstract] [PDF]  

B Cemerikic, R Zamah, and MS Ahmed

Opioids regulation of human chorionic gonadotropin release from trophoblast tissue is mediated by gonadotropin releasing hormone
J Pharmacol Exp Ther 1994 268: 971-977. [Abstract] [PDF]  

B Gaston, JM Drazen, A Jansen, DA Sugarbaker, J Loscalzo, W Richards, and JS Stamler

Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro
J Pharmacol Exp Ther 1994 268: 978-984. [Abstract] [PDF]  

LD Todorov, RA Bjur, and DP Westfall

Inhibitory and facilitatory effects of purines on transmitter release from sympathetic nerves
J Pharmacol Exp Ther 1994 268: 985-989. [Abstract] [PDF]  

S Guimaraes, D Moura, MQ Paiva, and MJ Vaz-da-Silva

Lack of pre- and postjunctional beta adrenoceptor-mediated effects in the canine saphenous vein at birth
J Pharmacol Exp Ther 1994 268: 990-995. [Abstract] [PDF]  

BR Bianchi, TR Miller, DG Witte, and CW Lin

Novel CCK analogues and bombesin: a detailed analysis between phosphoinositide breakdown and high-dose inhibition of pancreatic enzyme secretion in three rodent species
J Pharmacol Exp Ther 1994 268: 996-1002. [Abstract] [PDF]  

RK Rao, S Levenson, SN Fang, VJ Hruby, HI Yamamura, and F Porreca

Characterization of SNF 9007, a novel cholecystokinin/opoid ligand in mouse ileum in vitro: evidence for involvement of cholecystokininA and cholecystokininB receptors in regulation of ion transport
J Pharmacol Exp Ther 1994 268: 1003-1009. [Abstract] [PDF]  

M Nakajima, A Inui, A Teranishi, M Miura, Y Hirosue, M Okita, N Himori, S Baba, and M Kasuga

Effects of pancreatic polypeptide family peptides on feeding and learning behavior in mice
J Pharmacol Exp Ther 1994 268: 1010-1014. [Abstract] [PDF]  

LW Zhou, SP Zhang, ZH Qin, and B Weiss

In vivo administration of an oligodeoxynucleotide antisense to the D2 dopamine receptor messenger RNA inhibits D2 dopamine receptor-mediated behavior and the expression of D2 dopamine receptors in mouse striatum
J Pharmacol Exp Ther 1994 268: 1015-1023. [Abstract] [PDF]  

H Fujisaki, M Mise, Y Ishii, H Yamada, and K Oguri

Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase
J Pharmacol Exp Ther 1994 268: 1024-1031. [Abstract] [PDF]  

T Asano, A McWatters, T An, K Matsushima, and ES Kleinerman

Liposomal muramyl tripeptide up-regulates interleukin-1 alpha, interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 gene expression in human monocytes
J Pharmacol Exp Ther 1994 268: 1032-1039. [Abstract] [PDF]  

A Di Giannuario, S Pieretti, M Luzi, and A Loizzo

Subchronic treatment with fragments of beta-endorphin prevents electroencephalographic seizures and behavioral alterations induced by centrally administered beta-endorphin in the rabbit
J Pharmacol Exp Ther 1994 268: 1040-1050. [Abstract] [PDF]  

AJ Windebank, MD Blexrud, and PC de Groen

Potential neurotoxicity of the solvent vehicle for cyclosporine
J Pharmacol Exp Ther 1994 268: 1051-1056. [Abstract] [PDF]  

K Varga, NS Gantenberg, and G Kunos

Endogenous gamma-aminobutyric acid (GABA) mediates ethanol inhibition of vagally mediated reflex bradycardia elicited from aortic baroreceptors
J Pharmacol Exp Ther 1994 268: 1057-1062. [Abstract] [PDF]  

D Felsen, P Ernsberger, PM Sutaria, RJ Nejat, P Nguyen, M May, DS Breslin, DN Marion, and ED Jr Vaughan

Identification, localization and functional analysis of imidazoline and alpha adrenergic receptors in canine prostate
J Pharmacol Exp Ther 1994 268: 1063-1071. [Abstract] [PDF]  

ERRATUM
J Pharmacol Exp Ther 1994 268: 1072. [Abstract]  

ERRATA:

M Quik, B Collier, G Goldstein, and T Audhya

Thymopoietin inhibits function and ligand binding to nicotinic receptors at the neuromuscular junction [retraction of Quik M, Collier B, Audhya T, Goldstein G. In: J Pharmacol Exp Ther 1990 Sep;254(3):1113- 9]
J Pharmacol Exp Ther 1994 268: 1072.  

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