ARTICLES:

Y Shin, KJ Romstedt, DD Miller, and DR Feller

Interactions of nonprostanoid trimetoquinol analogs with thromboxane A2/prostaglandin H2 receptors in human platelets, rat vascular endothelial cells and rat vascular smooth muscle cells
J Pharmacol Exp Ther 1993 267: 1017-1023. [Abstract] [PDF]  

A Rengasamy and RA Johns

Inhibition of nitric oxide synthase by a superoxide generating system
J Pharmacol Exp Ther 1993 267: 1024-1027. [Abstract] [PDF]  

RM Edwards, EJ Stack, M Pullen, and P Nambi

Endothelin inhibits vasopressin action in rat inner medullary collecting duct via the ETB receptor
J Pharmacol Exp Ther 1993 267: 1028-1033. [Abstract] [PDF]  

A Chaudhary, RA Lane, D Woo, and RJ Herman

Multiple-dose lorazepam kinetics: shuttling of lorazepam glucuronide between the circulation and the gut during day- and night-time dosing intervals in response to feeding
J Pharmacol Exp Ther 1993 267: 1034-1038. [Abstract] [PDF]  

SP Boom and FG Russel

Cimetidine uptake and interactions with cationic drugs in freshly isolated proximal tubular cells of the rat
J Pharmacol Exp Ther 1993 267: 1039-1044. [Abstract] [PDF]  

A Tosaki, P Szerdahelyi, RM Engelman, and DK Das

Effects of extracellular magnesium manipulation on reperfusion-induced arrhythmias and myocardial ion shifts in isolated ischemic reperfused rat hearts
J Pharmacol Exp Ther 1993 267: 1045-1053. [Abstract] [PDF]  

C Blandizzi, G Tarkovacs, G Natale, M Del Tacca, and ES Vizi

Functional evidence that [3H]acetylcholine and [3H]noradrenaline release from guinea pig ileal myenteric plexus and noradrenergic terminals is modulated by different presynaptic alpha-2 adrenoceptor subtypes
J Pharmacol Exp Ther 1993 267: 1054-1060. [Abstract] [PDF]  

M Gardmark, M Ekblom, R Bouw, and M Hammarlund-Udenaes

Quantification of effect delay and acute tolerance development to morphine in the rat
J Pharmacol Exp Ther 1993 267: 1061-1067. [Abstract] [PDF]  

Z Gregus, T Fekete, F Varga, and CD Klaassen

Effect of valproic acid on glycine conjugation of benzoic acid
J Pharmacol Exp Ther 1993 267: 1068-1075. [Abstract] [PDF]  

L Carlsson, L Drews, G Duker, and G Schiller-Linhardt

Attenuation of proarrhythmias related to delayed repolarization by low- dose lidocaine in the anesthetized rabbit
J Pharmacol Exp Ther 1993 267: 1076-1080. [Abstract] [PDF]  

JH Li, A Shaw, and ST Kau

Stereoselective blockade of amphibian epithelial sodium channels by amiloride analogs
J Pharmacol Exp Ther 1993 267: 1081-1084. [Abstract] [PDF]  

A Tsuji, A Saheki, I Tamai, and T Terasaki

Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier
J Pharmacol Exp Ther 1993 267: 1085-1090. [Abstract] [PDF]  

YX Wang, CI Poon, and CC Pang

Vascular pharmacodynamics of NG-nitro-L-arginine methyl ester in vitro and in vivo
J Pharmacol Exp Ther 1993 267: 1091-1099. [Abstract] [PDF]  

A Rubino, V Ralevic, and G Burnstock

The P1-purinoceptors that mediate the prejunctional inhibitory effect of adenosine on capsaicin-sensitive nonadrenergic noncholinergic neurotransmission in the rat mesenteric arterial bed are of the A1 subtype
J Pharmacol Exp Ther 1993 267: 1100-1104. [Abstract] [PDF]  

MA Hossain and N Weiner

Dopaminergic functional supersensitivity: effects of chronic L-dopa and carbidopa treatment in an animal model of Parkinson's disease
J Pharmacol Exp Ther 1993 267: 1105-1111. [Abstract] [PDF]  

A Zembowicz, RJ Hatchett, W Radziszewski, and RJ Gryglewski

Inhibition of endothelial nitric oxide synthase by ebselen. Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase
J Pharmacol Exp Ther 1993 267: 1112-1118. [Abstract] [PDF]  

MD Sauro and B Thomas

Tyrphostin attenuates platelet-derived growth factor-induced contraction in aortic smooth muscle through inhibition of protein tyrosine kinase(s)
J Pharmacol Exp Ther 1993 267: 1119-1125. [Abstract] [PDF]  

CS Bockman, WB Jeffries, and PW Abel

Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium
J Pharmacol Exp Ther 1993 267: 1126-1133. [Abstract] [PDF]  

R Chavez, C Bravo, C Zazueta, J Pichardo, A Uribe, N Corona, H Reyes-Vivas, C Gonzalez, and E Chavez

Ionophoretic-like properties of ketorolac for calcium
J Pharmacol Exp Ther 1993 267: 1134-1139. [Abstract] [PDF]  

JL Boyer, ER Lazarowski, XH Chen, and TK Harden

Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase
J Pharmacol Exp Ther 1993 267: 1140-1146. [Abstract] [PDF]  

D Raeburn and JA Karlsson

Effects of isoenzyme-selective inhibitors of cyclic nucleotide phosphodiesterase on microvascular leak in guinea pig airways in vivo
J Pharmacol Exp Ther 1993 267: 1147-1152. [Abstract] [PDF]  

KW Kim and BM Cox

Inhibition of norepinephrine release from rat cortex slices by opioids: differences among agonists in sensitivities to antagonists suggest receptor heterogeneity
J Pharmacol Exp Ther 1993 267: 1153-1160. [Abstract] [PDF]  

N Priymenko, JP Ferre, A Rascol, G Costes, and PL Toutain

Migrating motor complex of the intestine and absorption of a biliary excreted drug in the dog
J Pharmacol Exp Ther 1993 267: 1161-1167. [Abstract] [PDF]  

CK Buckner, N Liberati, D Dea, D Lengel, C Stinson-Fisher, J Campbell, S Miller, A Shenvi, and RD Krell

Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect- acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig
J Pharmacol Exp Ther 1993 267: 1168-1175. [Abstract] [PDF]  

Y Chen and DB Hoover

Pharmacological characterization of the pressor response to tachykinins in isolated perfused rat kidney
J Pharmacol Exp Ther 1993 267: 1176-1180. [Abstract] [PDF]  

PA Cossum, H Sasmor, D Dellinger, L Truong, L Cummins, SR Owens, PM Markham, JP Shea, and S Crooke

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats
J Pharmacol Exp Ther 1993 267: 1181-1190. [Abstract] [PDF]  

LP Feigen, NS Nicholson, LW King, JG Campion, FS Tjoeng, and SG Panzer-Knodle

SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid- phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis
J Pharmacol Exp Ther 1993 267: 1191-1197. [Abstract] [PDF]  

TW Vickroy, WL Malphurs, and NC Defiebre

Absence of receptor reserve at hippocampal muscarinic autoreceptors which inhibit stimulus-dependent acetylcholine release
J Pharmacol Exp Ther 1993 267: 1198-1204. [Abstract] [PDF]  

UD Sohn, KM Harnett, G De Petris, J Behar, and P Biancani

Distinct muscarinic receptors, G proteins and phospholipases in esophageal and lower esophageal sphincter circular muscle
J Pharmacol Exp Ther 1993 267: 1205-1214. [Abstract] [PDF]  

L Turski and DN Stephens

Effect of the beta-carboline abecarnil on spinal reflexes in mice and on muscle tone in genetically spastic rats: a comparison with diazepam
J Pharmacol Exp Ther 1993 267: 1215-1220. [Abstract] [PDF]  

RM Maiorino, MM Aposhian, ZF Xu, Y Li, RL Polt, and HV Aposhian

Determination and metabolism of dithiol chelating agents. XV. The meso- 2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat
J Pharmacol Exp Ther 1993 267: 1221-1226. [Abstract] [PDF]  

KH Dykstra, A Arya, DM Arriola, PM Bungay, PF Morrison, and RL Dedrick

Microdialysis study of zidovudine (AZT) transport in rat brain
J Pharmacol Exp Ther 1993 267: 1227-1236. [Abstract] [PDF]  

WA Schumacher, TE Steinbacher, CL Heran, SM Seiler, IM Michel, and ML Ogletree

Comparison of thrombin active site and exosite inhibitors and heparin in experimental models of arterial and venous thrombosis and bleeding
J Pharmacol Exp Ther 1993 267: 1237-1242. [Abstract] [PDF]  

WA Van Sickle, PK Wilson, MW Wannamaker, JR Cooper, MA Flanagan, JR McCarthy, P Bey, and RL Jackson

An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza- trans-decal-3 beta-ol (MDL 28,815)
J Pharmacol Exp Ther 1993 267: 1243-1249. [Abstract] [PDF]  

MT Piascik, MS Smith, KW Barron, and EE Soltis

The regulation of regional hemodynamics by alpha-1 adrenoceptor subtypes in the conscious rat
J Pharmacol Exp Ther 1993 267: 1250-1255. [Abstract] [PDF]  

JB Richards, KE Sabol, and LS Seiden

Fluoxetine prevents the disruptive effects of fenfluramine on differential-reinforcement-of-low-rate 72-second schedule performance
J Pharmacol Exp Ther 1993 267: 1256-1263. [Abstract] [PDF]  

M Goto, JJ Lemasters, and RG Thurman

Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat
J Pharmacol Exp Ther 1993 267: 1264-1268. [Abstract] [PDF]  

ER Butelman, SS Negus, Y Ai, BR de Costa, and JH Woods

Kappa opioid antagonist effects of systemically administered nor- binaltorphimine in a thermal antinociception assay in rhesus monkeys
J Pharmacol Exp Ther 1993 267: 1269-1276. [Abstract] [PDF]  

M Asano, K Masuzawa-Ito, T Matsuda, Y Suzuki, H Oyama, M Shibuya, and K Sugita

Functional role of charybdotoxin-sensitive K+ channels in the resting state of cerebral, coronary and mesenteric arteries of the dog
J Pharmacol Exp Ther 1993 267: 1277-1285. [Abstract] [PDF]  

DC Bode, LT Hamel, and MB Wax

Distinct profiles of phosphodiesterase isozymes in cultured cells derived from nonpigmented and pigmented ocular ciliary epithelium
J Pharmacol Exp Ther 1993 267: 1286-1291. [Abstract] [PDF]  

DY Li, DR Varma, TK Chatterjee, H Fernandez, D Abran, and S Chemtob

Fewer PGE2 and PGF2 alpha receptors in brain synaptosomes of newborn than of adult pigs
J Pharmacol Exp Ther 1993 267: 1292-1297. [Abstract] [PDF]  

B Christensen and PM Ueland

Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts. Homocysteine remethylation as determinant of enzyme inactivation and homocysteine export
J Pharmacol Exp Ther 1993 267: 1298-1303. [Abstract] [PDF]  

EK Jackson, WA Herzer, and F Suzuki

KF17837 is an A2 adenosine receptor antagonist in vivo
J Pharmacol Exp Ther 1993 267: 1304-1310. [Abstract] [PDF]  

CA Sannerud, RJ Marley, SL Serdikoff, AJ Alastra, C Cohen, and SR Goldberg

Tolerance to the behavioral effects of chlordiazepoxide: pharmacological and biochemical selectivity
J Pharmacol Exp Ther 1993 267: 1311-1320. [Abstract] [PDF]  

HA Thomas, N Ling, ET Wei, F Berree, A Cobas, and H Rapoport

Novel anti-inflammatory undecapeptides that contain anisolyated glutamic acid derivatives
J Pharmacol Exp Ther 1993 267: 1321-1326. [Abstract] [PDF]  

SA Khan, WR Mathews, and KD Meisheri

Role of calcium-activated K+ channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide
J Pharmacol Exp Ther 1993 267: 1327-1335. [Abstract] [PDF]  

MC Hernandez, LR Flores, and BM Bayer

Immunosuppression by morphine is mediated by central pathways
J Pharmacol Exp Ther 1993 267: 1336-1341. [Abstract] [PDF]  

PL Martin, M Kelly, and NJ Cusack

(-)-2-(N-propyl-N-2-thienylethylamino)-5-hydroxytetralin (N-0923), a selective D2 dopamine receptor agonist demonstrates the presence of D2 dopamine receptors in the mouse vas deferens but not in the rat vas deferens
J Pharmacol Exp Ther 1993 267: 1342-1348. [Abstract] [PDF]  

JR Clague, R Harvey, and GA Langer

Protamine and other polycationic drugs inhibit calcium leak in cardiac cells during metabolic inhibition and free radical exposure
J Pharmacol Exp Ther 1993 267: 1349-1354. [Abstract] [PDF]  

A Tosaki, P Szerdahelyi, RM Engelman, and DK Das

Potassium channel openers and blockers: do they possess proarrhythmic or antiarrhythmic activity in ischemic and reperfused rat hearts?
J Pharmacol Exp Ther 1993 267: 1355-1362. [Abstract] [PDF]  

P Thatikunta, S Chakder, and S Rattan

Nitric oxide synthase inhibitor inhibits catecholamines release caused by hypogastric sympathetic nerve stimulation
J Pharmacol Exp Ther 1993 267: 1363-1368. [Abstract] [PDF]  

F Costa and I Biaggioni

Adenosine activates afferent fibers in the forearm, producing sympathetic stimulation in humans
J Pharmacol Exp Ther 1993 267: 1369-1374. [Abstract] [PDF]  

V Casolaro, S Meliota, O Marino, V Patella, A de Paulis, G Guidi, and G Marone

Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells
J Pharmacol Exp Ther 1993 267: 1375-1385. [Abstract] [PDF]  

DB Vaupel, WR Lange, and ED London

Effects of verapamil on morphine-induced euphoria, analgesia and respiratory depression in humans
J Pharmacol Exp Ther 1993 267: 1386-1394. [Abstract] [PDF]  

P Li and DD Smyth

Suppressed renal response to 2,6-dimethyl clonidine but not clonidine in one kidney-one clip hypertensive rats
J Pharmacol Exp Ther 1993 267: 1395-1400. [Abstract] [PDF]  

M Runge-Morris and RF Novak

Effects of phenelzine and hydralazine on hydrogen peroxide production and proteolysis in human red blood cells
J Pharmacol Exp Ther 1993 267: 1401-1406. [Abstract] [PDF]  

GB Weiss, B Sturm, and NR Levens

Rapid reversal of angiotensin I-induced contractions in rat carotid arteries after acute and chronic treatment with the angiotensin- converting enzyme inhibitor, 3-[(5-amino-1-carboxy-1S- pentyl)amino]2,3,4,5-tetrahydro-2-oxo- 3S-1H-1-benzazepena-1-acetic acid (CGS 16617)
J Pharmacol Exp Ther 1993 267: 1407-1413. [Abstract] [PDF]  

LG Aguayo and JM Alarcon

Modulation of the developing rat sympathetic GABAA receptor by Zn++, benzodiazepines, barbiturates and ethanol
J Pharmacol Exp Ther 1993 267: 1414-1422. [Abstract] [PDF]  

AF Hajj-Ali and PC Wong

Beta adrenoceptor blockade in rabbit inhibits the renin-releasing effect of AT1 receptor antagonist losartan
J Pharmacol Exp Ther 1993 267: 1423-1427. [Abstract] [PDF]  

RP Simon, M Niro, and R Gwinn

Brain acidosis induced by hypercarbic ventilation attenuates focal ischemic injury
J Pharmacol Exp Ther 1993 267: 1428-1431. [Abstract] [PDF]  

AM Andrews and DL Murphy

2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission
J Pharmacol Exp Ther 1993 267: 1432-1439. [Abstract] [PDF]  

LT Wong, MR Escobar, DD Smyth, and DS Sitar

Gender-associated differences in rat renal tubular amantadine transport and absence of stereoselective transport inhibition by quinine and quinidine in distal tubules
J Pharmacol Exp Ther 1993 267: 1440-1444. [Abstract] [PDF]  

NH Chen and ME Reith

Dopamine and serotonin release-regulating autoreceptor sensitivity in A9/A10 cell body and terminal areas after withdrawal of rats from continuous infusion of cocaine
J Pharmacol Exp Ther 1993 267: 1445-1453. [Abstract] [PDF]  

RC Boldry, TN Chase, and TM Engber

Influence of previous exposure to levodopa on the interaction between dizocilpine and dopamine D1 and D2 agonists in rats with 6- hydroxydopamine-induced lesions
J Pharmacol Exp Ther 1993 267: 1454-1459. [Abstract] [PDF]  

ME McNerney and HH Szeto

Prenatal nicotine exposure evokes changes in the incidence and degree of fetal electrocortical activation
J Pharmacol Exp Ther 1993 267: 1460-1469. [Abstract] [PDF]  

SD Comer, ST Lac, LK Curtis, and ME Carroll

Effects of buprenorphine and naltrexone on reinstatement of cocaine- reinforced responding in rats
J Pharmacol Exp Ther 1993 267: 1470-1477. [Abstract] [PDF]  

P Aagaard and M McKinney

Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors
J Pharmacol Exp Ther 1993 267: 1478-1483. [Abstract] [PDF]  

P Jr Riekkinen, M Riekkinen, and J Sirvio

Cholinergic drugs regulate passive avoidance performance via the amygdala
J Pharmacol Exp Ther 1993 267: 1484-1492. [Abstract] [PDF]  

JE Piletz and K Sletten

Nonadrenergic imidazoline binding sites on human platelets
J Pharmacol Exp Ther 1993 267: 1493-1502. [Abstract] [PDF]  

O Traub and RC Webb

Angiotensin-converting enzyme inhibition during development alters calcium regulation in adult hypertensive rats
J Pharmacol Exp Ther 1993 267: 1503-1508. [Abstract] [PDF]  

H Kovacic, P Gallice, M Sarrazin, and A Crevat

Chloride dependent intracellular pH increase induced by bepridil in human red blood cells: a possible involvement in correction of ischemic acidosis
J Pharmacol Exp Ther 1993 267: 1509-1514. [Abstract] [PDF]  

P Chan, JW Langston, and DA Di Monte

MK-801 temporarily prevents MPTP-induced acute dopamine depletion and MPP+ elimination in the mouse striatum
J Pharmacol Exp Ther 1993 267: 1515-1520. [Abstract] [PDF]  

E Leung, JM Rapp, LK Walsh, KD Zeitung, and RM Eglen

Characterization of angiotensin II receptors in smooth muscle preparations of the guinea pig in vitro
J Pharmacol Exp Ther 1993 267: 1521-1528. [Abstract] [PDF]  

WR Mathews and SW Kerr

Biological activity of S-nitrosothiols: the role of nitric oxide
J Pharmacol Exp Ther 1993 267: 1529-1537. [Abstract] [PDF]  

K Yoshida, A Morimoto, T Makisumi, and N Murakami

Cardiovascular, thermal and behavioral sensitization to methamphetamine in freely moving rats
J Pharmacol Exp Ther 1993 267: 1538-1543. [Abstract] [PDF]  

M Yamada, A Terzic, I Findlay, A Jahangir, WK Shen, and Y Kurachi

YM934, a novel K+ channel opener, activates ATP-sensitive K+ channels in cardiac myocytes
J Pharmacol Exp Ther 1993 267: 1544-1549. [Abstract] [PDF]  

R Rabinovici, PJ Bugelski, KM Esser, LM Hillegass, DE Griswold, J Vernick, and G Feuerstein

Tumor necrosis factor-alpha mediates endotoxin-induced lung injury in platelet activating factor-primed rats
J Pharmacol Exp Ther 1993 267: 1550-1557. [Abstract] [PDF]  

K Fischer-Stenger, DA Dove Pettit, and GA Cabral

Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events
J Pharmacol Exp Ther 1993 267: 1558-1565. [Abstract] [PDF]  

KM Linner, SE Nicol, and BM Sharp

IL-1 beta modulates the concanavalin-A-induced expression of proenkephalin A mRNA in murine thymocytes
J Pharmacol Exp Ther 1993 267: 1566-1572. [Abstract] [PDF]  

ME Lajiness, CL Chio, and RM Huff

D2 dopamine receptor stimulation of mitogenesis in transfected Chinese hamster ovary cells: relationship to dopamine stimulation of tyrosine phosphorylations
J Pharmacol Exp Ther 1993 267: 1573-1581. [Abstract] [PDF]  

Y Qian, B Hitzemann, GL Yount, JD White, and R Hitzemann

D1 and D2 dopamine receptor turnover and D2 messenger RNA levels in the neuroleptic-responsive and the neuroleptic nonresponsive lines of mice
J Pharmacol Exp Ther 1993 267: 1582-1590. [Abstract] [PDF]  

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