ARTICLES:

DW Snyder, CD Sommers, JL Bobbitt, and ED Mihelich

Characterization of the contractile effects of human recombinant nonpancreatic secretory phospholipase A2 (PLA2) and other PLA2s on guinea pig lung pleural strips
J Pharmacol Exp Ther 1993 266: 1147-1155. [Abstract] [PDF]  

JD Vickers

U73122 affects the equilibria between the phosphoinositides as well as phospholipase C activity in unstimulated and thrombin-stimulated human and rabbit platelets
J Pharmacol Exp Ther 1993 266: 1156-1163. [Abstract] [PDF]  

WS Enochs, MJ Nilges, and HM Swartz

The minocycline-induced thyroid pigment and several synthetic models: identification and characterization by electron paramagnetic resonance spectroscopy
J Pharmacol Exp Ther 1993 266: 1164-1176. [Abstract] [PDF]  

LT Meltzer, BW Caprathe, CL Christoffersen, AE Corbin, JC Jaen, FW Ninteman, TA Pugsley, KA Serpa, YH Shih, and SZ Whetzel

Pharmacological profile of the dopamine partial agonist, (+/-)-PD 128483 and its enantiomers
J Pharmacol Exp Ther 1993 266: 1177-1189. [Abstract] [PDF]  

K Yokotani, Y Okuma, K Nakamura, and Y Osumi

Release of endogenous acetylcholine from a vascularly perfused rat stomach in vitro; inhibition by M3 muscarinic autoreceptors and alpha-2 adrenoceptors
J Pharmacol Exp Ther 1993 266: 1190-1195. [Abstract] [PDF]  

Z Abolfathi, C Fiset, M Gilbert, K Moerike, PM Belanger, and J Turgeon

Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans
J Pharmacol Exp Ther 1993 266: 1196-1201. [Abstract] [PDF]  

Y Hattori, H Nakaya, J Nishihira, and M Kanno

A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: a role of protein kinase C
J Pharmacol Exp Ther 1993 266: 1202-1212. [Abstract] [PDF]  

A Doble, T Canton, S Dreisler, O Piot, A Boireau, JM Stutzmann, MC Bardone, J Rataud, M Roux, and G Roussel

RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent
J Pharmacol Exp Ther 1993 266: 1213-1226. [Abstract] [PDF]  

L Zhang, JL Weiner, and PL Carlen

Potentiation of gamma-aminobutyric acid type A receptor-mediated synaptic currents by pentobarbital and diazepam in immature hippocampal CA1 neurons
J Pharmacol Exp Ther 1993 266: 1227-1235. [Abstract] [PDF]  

DP Devine, P Leone, D Pocock, and RA Wise

Differential involvement of ventral tegmental mu, delta and kappa opioid receptors in modulation of basal mesolimbic dopamine release: in vivo microdialysis studies
J Pharmacol Exp Ther 1993 266: 1236-1246. [Abstract] [PDF]  

JX Liu, K Tanonaka, Y Ohtsuka, Y Sakai, and S Takeo

Improvement of ischemia/reperfusion-induced contractile dysfunction of perfused hearts by class Ic antiarrhythmic agents
J Pharmacol Exp Ther 1993 266: 1247-1254. [Abstract] [PDF]  

J Fioramonti, C Dupuy, J Dupuy, and L Bueno

The mycotoxin, deoxynivalenol, delays gastric emptying through serotonin-3 receptors in rodents
J Pharmacol Exp Ther 1993 266: 1255-1260. [Abstract] [PDF]  

JU Adams, RJ Tallarida, EB Geller, and MW Adler

Isobolographic superadditivity between delta and mu opioid agonists in the rat depends on the ratio of compounds, the mu agonist and the analgesic assay used
J Pharmacol Exp Ther 1993 266: 1261-1267. [Abstract] [PDF]  

MJ Marks, SR Grady, and AC Collins

Downregulation of nicotinic receptor function after chronic nicotine infusion
J Pharmacol Exp Ther 1993 266: 1268-1276. [Abstract] [PDF]  

T Chikai, R Oishi, and K Saeki

Microdialysis study of the effects of sedative drugs on extracellular histamine in the striatum of freely moving rats
J Pharmacol Exp Ther 1993 266: 1277-1281. [Abstract] [PDF]  

E Dicker and AI Cederbaum

Requirement for iron for the production of hydroxyl radicals by rat liver quinone reductase
J Pharmacol Exp Ther 1993 266: 1282-1290. [Abstract] [PDF]  

RC Falcone, SJ Hubbs, JD Vanderloo, JC Prosser, J Little, B Gomes, D Aharony, and RD Krell

Characterization of bradykinin receptors in guinea pig gall bladder
J Pharmacol Exp Ther 1993 266: 1291-1299. [Abstract] [PDF]  

T Kimura, T Miyaoka, PA Saunders, ML Baker, AS Hume, I Yamamoto, and IK Ho

Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration
J Pharmacol Exp Ther 1993 266: 1300-1305. [Abstract] [PDF]  

A Choquet, R Magous, and JP Bali

Gastric mucosal endogenous prostanoids are involved in the cellular regulation of acid secretion from isolated parietal cells
J Pharmacol Exp Ther 1993 266: 1306-1311. [Abstract] [PDF]  

J de Jong, PR Schoofs, AM Snabilie, A Bast, and WJ van der Vijgh

The role of biotransformation in anthracycline-induced cardiotoxicity in mice
J Pharmacol Exp Ther 1993 266: 1312-1320. [Abstract] [PDF]  

WF Oellerich and KU Malik

Neuropeptide Y modulates the vascular response to periarterial nerve stimulation primarily by a postjunctional action in the isolated perfused rat kidney
J Pharmacol Exp Ther 1993 266: 1321-1329. [Abstract] [PDF]  

MI Damaj, SP Welch, and BR Martin

Involvement of calcium and L-type channels in nicotine-induced antinociception
J Pharmacol Exp Ther 1993 266: 1330-1338. [Abstract] [PDF]  

DC Yang, B Goldstin, AE Moormann, DL Flynn, and GW Gullikson

SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae
J Pharmacol Exp Ther 1993 266: 1339-1347. [Abstract] [PDF]  

GS Friedrichs, L Chi, SC Black, PJ Manley, JY Oh, and BR Lucchesi

Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels
J Pharmacol Exp Ther 1993 266: 1348-1354. [Abstract] [PDF]  

SS Negus, ER Butelman, Y Al, and JH Woods

Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys
J Pharmacol Exp Ther 1993 266: 1355-1363. [Abstract] [PDF]  

M Farre, R de la Torre, M Llorente, X Lamas, B Ugena, J Segura, and J Cami

Alcohol and cocaine interactions in humans
J Pharmacol Exp Ther 1993 266: 1364-1373. [Abstract] [PDF]  

CA Stockmeier, JJ DiCarlo, Y Zhang, P Thompson, and HY Meltzer

Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors
J Pharmacol Exp Ther 1993 266: 1374-1384. [Abstract] [PDF]  

C Alcaraz, MV Milanes, and ML Vargas

Chronic kappa opioid receptor antagonism produces supersensitivity to U- 50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level
J Pharmacol Exp Ther 1993 266: 1385-1389. [Abstract] [PDF]  

AC Collins, E Romm, S Selvaag, S Turner, and MJ Marks

A comparison of the effects of chronic nicotine infusion on tolerance to nicotine and cross-tolerance to ethanol in long- and short-sleep mice
J Pharmacol Exp Ther 1993 266: 1390-1397. [Abstract] [PDF]  

CM de Fiebre and AC Collins

A comparison of the development of tolerance to ethanol and cross- tolerance to nicotine after chronic ethanol treatment in long- and short-sleep mice
J Pharmacol Exp Ther 1993 266: 1398-1406. [Abstract] [PDF]  

FL Smith, SP Welch, DS Dombrowski, and WL Dewey

The role of endogenous opioids as mediators of the hypothermic effects of intrathecally administered calcium and calcitonin gene-related peptide in mice
J Pharmacol Exp Ther 1993 266: 1407-1415. [Abstract] [PDF]  

T Okamura, M Enokibori, and N Toda

Neurogenic and non-neurogenic relaxations caused by nicotine in isolated dog superficial temporal artery
J Pharmacol Exp Ther 1993 266: 1416-1421. [Abstract] [PDF]  

CA Sargent, GJ Grover, MJ Antonaccio, and JR McCullough

The cardioprotective, vasorelaxant and electrophysiological profile of the large conductance calcium-activated potassium channel opener NS-004
J Pharmacol Exp Ther 1993 266: 1422-1429. [Abstract] [PDF]  

LF Tseng and KA Collins

Spinal involvement of both dynorphin A and Met-enkephalin in the antinociception induced by intracerebroventricularly administered bremazocine but not morphine in the mouse
J Pharmacol Exp Ther 1993 266: 1430-1438. [Abstract] [PDF]  

MB McClurkan, JL Valentine, L Arnold, and SM Owens

Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats
J Pharmacol Exp Ther 1993 266: 1439-1445. [Abstract] [PDF]  

HJ Carlisle and MJ Stock

Thermoregulatory effects of beta adrenoceptors: effects of selective agonists and the interaction of antagonists with isoproterenol and BRL- 35135 in the cold
J Pharmacol Exp Ther 1993 266: 1446-1453. [Abstract] [PDF]  

MD Meglasson, JM Wilson, JH Yu, DD Robinson, BM Wyse, and CJ de Souza

Antihyperglycemic action of guanidinoalkanoic acids: 3- guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys
J Pharmacol Exp Ther 1993 266: 1454-1462. [Abstract] [PDF]  

V Casado, G Allende, J Mallol, R Franco, C Lluis, and EI Canela

Thermodynamic analysis of agonist and antagonist binding to membrane- bound and solubilized A1 adenosine receptors
J Pharmacol Exp Ther 1993 266: 1463-1474. [Abstract] [PDF]  

ME Wylam, RW Samsel, PT Schumacker, and JG Umans

Extracellular calcium and intrinsic tone in the human umbilical artery
J Pharmacol Exp Ther 1993 266: 1475-1481. [Abstract] [PDF]  

CL Cowan, JJ Palacino, S Najibi, and RA Cohen

Potassium channel-mediated relaxation to acetylcholine in rabbit arteries
J Pharmacol Exp Ther 1993 266: 1482-1489. [Abstract] [PDF]  

M Malcangio and NG Bowery

Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro
J Pharmacol Exp Ther 1993 266: 1490-1496. [Abstract] [PDF]  

CM Venturini, RM Palmer, and S Moncada

Vascular smooth muscle contains a depletable store of a vasodilator which is light-activated and restored by donors of nitric oxide
J Pharmacol Exp Ther 1993 266: 1497-1500. [Abstract] [PDF]  

DR Ramjit, JJ Jr Lynch, GR Sitko, MJ Mellott, MA Holahan, II Stabilito, MT Stranieri, G Zhang, RJ Lynch, and PD Manno

Antithrombotic effects of MK-0852, a platelet fibrinogen receptor antagonist, in canine models of thrombosis
J Pharmacol Exp Ther 1993 266: 1501-1511. [Abstract] [PDF]  

K Takeuchi, T Ohuchi, H Miyake, and S Okabe

Stimulation by nitric oxide synthase inhibitors of gastric and duodenal HCO3- secretion in rats
J Pharmacol Exp Ther 1993 266: 1512-1519. [Abstract] [PDF]  

PM Schiffers, HA van der Heijden, GE Fazzi, HA Boudier, and JG De Mey

Tonic tone in arteries exposed continuously to angiotensin II in vitro
J Pharmacol Exp Ther 1993 266: 1520-1527. [Abstract] [PDF]  

E Patterson

Coronary vascular injury following transient coronary artery occlusion: prevention by pretreatment with deferoxamine, dimethylthiourea and N-2- mercaptoproprionyl glycine
J Pharmacol Exp Ther 1993 266: 1528-1535. [Abstract] [PDF]  

RC Carneiro, EP Pereira, J Cipolla-Neto, and RP Markus

Age-related changes in melatonin modulation of sympathetic neurotransmission
J Pharmacol Exp Ther 1993 266: 1536-1540. [Abstract] [PDF]  

M Watanabe, D Rominger, SD Hurt, EB De Souza, and SW Tam

[3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo
J Pharmacol Exp Ther 1993 266: 1541-1548. [Abstract] [PDF]  

R Fern, BR Ransom, PK Stys, and SG Waxman

Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam
J Pharmacol Exp Ther 1993 266: 1549-1555. [Abstract] [PDF]  

RL Kline and DF Cechetto

Renal effects of rilmenidine in anesthetized rats: importance of renal nerves
J Pharmacol Exp Ther 1993 266: 1556-1562. [Abstract] [PDF]  

GB Kaplan, DJ Greenblatt, MA Kent, and MM Cotreau-Bibbo

Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding
J Pharmacol Exp Ther 1993 266: 1563-1572. [Abstract] [PDF]  

PT Brackley, DR Bell, SK Choi, K Nakanishi, and PN Usherwood

Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins
J Pharmacol Exp Ther 1993 266: 1573-1580. [Abstract] [PDF]  

K Yasoshima, F Yamasaki, T Shinkawa, K Yoshitomi, and M Imai

Effect of a novel diuretic, 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)- 4(IH)-quinolinone-4-oxime-o- sulfonic acid, potassium salt (M17055) on Na+ and K+ transport in the distal nephron segments
J Pharmacol Exp Ther 1993 266: 1581-1588. [Abstract] [PDF]  

F Yamasaki, K Yoshitomi, T Shinkawa, and M Imai

Effects of amiloride and a novel diuretic, 7-chloro-2,3-dihydro-1-(2- methylbenzoyl)-4(1H)-quinolinone-4-oxime-o-su lfonic acid, potassium salt (M17055), on calcium transport in the rabbit connecting tubule
J Pharmacol Exp Ther 1993 266: 1589-1593. [Abstract] [PDF]  

A Ray and KM MacLeod

A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP- generating agents
J Pharmacol Exp Ther 1993 266: 1594-1601. [Abstract] [PDF]  

C Alcaraz, ML Vargas, T Fuente, and MV Milanes

Chronic naloxone treatment induces supersensitivity to a mu but not to a kappa agonist at the hypothalamus-pituitary-adrenocortical axis level
J Pharmacol Exp Ther 1993 266: 1602-1606. [Abstract] [PDF]  

J Liu, Y Liu, C Madhu, and CD Klaassen

Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice
J Pharmacol Exp Ther 1993 266: 1607-1613. [Abstract] [PDF]  

N Okamura, M Hirai, Y Tanigawara, K Tanaka, M Yasuhara, K Ueda, T Komano, and R Hori

Digoxin-cyclosporin A interaction: modulation of the multidrug transporter P-glycoprotein in the kidney
J Pharmacol Exp Ther 1993 266: 1614-1619. [Abstract] [PDF]  

R Hori, N Okamura, T Aiba, and Y Tanigawara

Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney
J Pharmacol Exp Ther 1993 266: 1620-1625. [Abstract] [PDF]  

MF Hare, KM McGinnis, and WD Atchison

Methylmercury increases intracellular concentrations of Ca++ and heavy metals in NG108-15 cells
J Pharmacol Exp Ther 1993 266: 1626-1635. [Abstract] [PDF]  

NJ Reynolds, GJ Fisher, CE Griffiths, A Tavakkol, HS Talwar, PE Rowse, TA Hamilton, and JJ Voorhees

Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo [published erratum appears in J Pharmacol Exp Ther 1994 Feb;268(2):1072]
J Pharmacol Exp Ther 1993 266: 1636-1642. [Abstract] [PDF]  

M Samoszuk, D Ehrlich, and E Ramzi

Preclinical safety studies of glucose oxidase
J Pharmacol Exp Ther 1993 266: 1643-1648. [Abstract] [PDF]  

SJ Weber, TJ Abbruscato, EA Brownson, AW Lipkowski, R Polt, A Misicka, RC Haaseth, H Bartosz, VJ Hruby, and TP Davis

Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs
J Pharmacol Exp Ther 1993 266: 1649-1655. [Abstract] [PDF]  

MP Waalkes, BA Diwan, CM Weghorst, JM Ward, JM Rice, MG Cherian, and RA Goyer

Further evidence of the tumor-suppressive effects of cadmium in the B6C3F1 mouse liver and lung: late stage vulnerability of tumors to cadmium and the role of metallothionein
J Pharmacol Exp Ther 1993 266: 1656-1663. [Abstract] [PDF]  

M Kawamura, Z Terashita, H Okuda, Y Imura, A Shino, M Nakao, and K Nishikawa

TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats
J Pharmacol Exp Ther 1993 266: 1664-1669. [Abstract] [PDF]  

SA Elgebaly, ME Allam, S Houser, F Hashmi, F Forouhar, and D Miano

Cyclocreatine inhibits neutrophil accumulation in the myocardium of a canine model of coronary artery occlusion and reperfusion
J Pharmacol Exp Ther 1993 266: 1670-1677. [Abstract] [PDF]  

DM Lawrence and JM Bidlack

The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein
J Pharmacol Exp Ther 1993 266: 1678-1683. [Abstract] [PDF]  

MA Osinski and P Bass

Chronic denervation of rat jejunum results in cholinergic supersensitivity due to reduction of cholinesterase activity
J Pharmacol Exp Ther 1993 266: 1684-1690. [Abstract] [PDF]  

CJ Dunn, LA Galinet, H Wu, RA Nugent, ST Schlachter, ND Staite, DG Aspar, GA Elliott, NA Essani, and NA Rohloff

Demonstration of novel anti-arthritic and anti-inflammatory effects of diphosphonates
J Pharmacol Exp Ther 1993 266: 1691-1698. [Abstract] [PDF]  

S Kojima, T Icho, M Hayashi, Y Kajiwara, K Kitabatake, and K Kubota

Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity
J Pharmacol Exp Ther 1993 266: 1699-1704. [Abstract] [PDF]  

Z Nie, X Yuan, SG Madamba, and GR Siggins

Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal
J Pharmacol Exp Ther 1993 266: 1705-1712. [Abstract] [PDF]  

DJ Cole, PM Patel, L Reynolds, JC Drummond, and S Marcantonio

Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume
J Pharmacol Exp Ther 1993 266: 1713-1717. [Abstract] [PDF]  

AV Miller-Wing, JM Hanesworth, MF Sardinia, KL Hall, JW Wright, RC Speth, KL Grove, and JW Harding

Central angiotensin IV binding sites: distribution and specificity in guinea pig brain
J Pharmacol Exp Ther 1993 266: 1718-1726. [Abstract] [PDF]  

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