ARTICLES:

CS Cook, C Hauswald, JA Oppermann, and GL Schoenhard

Involvement of cytochrome P-450IIIA in metabolism of potassium canrenoate to an epoxide: mechanism of inhibition of the epoxide formation by spironolactone and its sulfur-containing metabolite
J Pharmacol Exp Ther 1993 266: 1-7. [Abstract] [PDF]  

CB Baron, J Pompeo, D Blackman, and RF Coburn

Common phosphatidylinositol 4,5-bisphosphate pools are involved in carbachol and serotonin activation of tracheal smooth muscle
J Pharmacol Exp Ther 1993 266: 8-15. [Abstract] [PDF]  

RC Gupta, J Neumann, and AM Watanabe

Comparison of adenosine and muscarinic receptor-mediated effects on protein phosphatase inhibitor-1 activity in the heart
J Pharmacol Exp Ther 1993 266: 16-22. [Abstract] [PDF]  

TA Glauser, AN Nelson, DE Zembower, JJ Lipsky, and RM Weinshilboum

Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase
J Pharmacol Exp Ther 1993 266: 23-32. [Abstract] [PDF]  

M Bak, M Shalmi, JS Petersen, LB Poulsen, and S Christensen

Effects of angiotensin-converting enzyme inhibition on renal adaptations to acute furosemide administration in conscious rats
J Pharmacol Exp Ther 1993 266: 33-40. [Abstract] [PDF]  

RG Carpentier, BR Coleman, and DJ Patel

Cocaine enhances postrest and paired-stimulation potentiation in rat papillary muscle
J Pharmacol Exp Ther 1993 266: 41-46. [Abstract] [PDF]  

PR Mayeux and SV Shah

Intracellular calcium mediates the cytotoxicity of lipid A in LLC-PK1 cells
J Pharmacol Exp Ther 1993 266: 47-51. [Abstract] [PDF]  

K Chiba, K Kobayashi, K Manabe, M Tani, T Kamataki, and T Ishizaki

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation
J Pharmacol Exp Ther 1993 266: 52-59. [Abstract] [PDF]  

H Ogura and TG Aigner

MK-801 impairs recognition memory in rhesus monkeys: comparison with cholinergic drugs
J Pharmacol Exp Ther 1993 266: 60-64. [Abstract] [PDF]  

KU Petersen, P Cormann, HJ Macherey, G Sprakties, and JM Winterhager

Electrogenic and electroneutral HCO3-secretion by guinea pig gallbladder epithelium: discriminatory abilities of Cl- channel blockers
J Pharmacol Exp Ther 1993 266: 65-73. [Abstract] [PDF]  

M Kadowaki, Y Nagakura, M Tomoi, J Mori, and M Kohsaka

Effect of FK1052, a potent 5-hydroxytryptamine3 and 5- hydroxytryptamine4 receptor dual antagonist, on colonic function in vivo
J Pharmacol Exp Ther 1993 266: 74-80. [Abstract] [PDF]  

VM Lakshmi, TV Zenser, MB Mattammal, and BB Davis

Phenylbutazone peroxidatic metabolism and conjugation
J Pharmacol Exp Ther 1993 266: 81-88. [Abstract] [PDF]  

M Elhamri, B Ferrier, M Martin, and G Baverel

Effect of valproate, sodium 2-propyl-4-pentenoate and sodium 2-propyl-2- pentenoate on renal substrate uptake and ammoniagenesis in the rat
J Pharmacol Exp Ther 1993 266: 89-96. [Abstract] [PDF]  

E Nisoli, C Tonello, R Imhof, R Scherschlicht, M da Prada, and MO Carruba

Neurochemical and behavioral evidence that Ro 41-9067 is a selective presynaptic dopamine receptor agonist
J Pharmacol Exp Ther 1993 266: 97-105. [Abstract] [PDF]  

KM Standifer, JA Clark, and GW Pasternak

Modulation of Mu1 opioid binding by magnesium: evidence for multiple receptor conformations
J Pharmacol Exp Ther 1993 266: 106-113. [Abstract] [PDF]  

Y Shibouta, Y Inada, M Ojima, T Wada, M Noda, T Sanada, K Kubo, Y Kohara, T Naka, and K Nishikawa

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H- tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116)
J Pharmacol Exp Ther 1993 266: 114-120. [Abstract] [PDF]  

AE Takemori, HH Loh, and NM Lee

Suppression by dynorphin A and [des-Tyr1]dynorphin A peptides of the expression of opiate withdrawal and tolerance in morphine-dependent mice
J Pharmacol Exp Ther 1993 266: 121-124. [Abstract] [PDF]  

MJ Antonaccio, D Normandin, R Serafino, and S Moreland

Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle
J Pharmacol Exp Ther 1993 266: 125-132. [Abstract] [PDF]  

EA Johnson, CE Tsai, YH Shahan, and AJ Azzaro

Serotonin 5-HT1A receptors mediate inhibition of tyrosine hydroxylation in rat striatum
J Pharmacol Exp Ther 1993 266: 133-141. [Abstract] [PDF]  

C Russo, M Marchi, GC Andrioli, P Cavazzani, and M Raiteri

Enhancement of glycine release from human brain cortex synaptosomes by acetylcholine acting at M4 muscarinic receptors
J Pharmacol Exp Ther 1993 266: 142-146. [Abstract] [PDF]  

M Nordstrom, T Abrahamsson, M Ervik, E Forshult, and CG Regardh

Central nervous and systemic kinetics of ramipril and ramiprilat in the conscious dog
J Pharmacol Exp Ther 1993 266: 147-152. [Abstract] [PDF]  

B Longoni, GC Demontis, and RW Olsen

Enhancement of gamma-aminobutyric acidA receptor function and binding by the volatile anesthetic halothane
J Pharmacol Exp Ther 1993 266: 153-159. [Abstract] [PDF]  

PC Churchill and VR Ellis

Purinergic P2y receptors stimulate renin secretion by rat renal cortical slices
J Pharmacol Exp Ther 1993 266: 160-163. [Abstract] [PDF]  

DP Brooks, G Giardina, M Gellai, G Dondio, RM Edwards, G Petrone, PD DePalma, M Sbacchi, M Jugus, and P Misiano

Opiate receptors within the blood-brain barrier mediate kappa agonist- induced water diuresis
J Pharmacol Exp Ther 1993 266: 164-171. [Abstract] [PDF]  

AJ Barbier and RA Lefebvre

Involvement of the L-arginine: nitric oxide pathway in nonadrenergic noncholinergic relaxation of the cat gastric fundus
J Pharmacol Exp Ther 1993 266: 172-178. [Abstract] [PDF]  

LY Wing, CF Chan, and MJ Jiang

Acetylpolyamines decrease blood pressure, [Ca++]i and isometric force of vascular smooth muscle
J Pharmacol Exp Ther 1993 266: 179-183. [Abstract] [PDF]  

KJ Slavik and JE Szilagyi

Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia
J Pharmacol Exp Ther 1993 266: 184-191. [Abstract] [PDF]  

G Drapeau, R Audet, L Levesque, D Godin, and F Marceau

Development and in vivo evaluation of metabolically resistant antagonists of B1 receptors for kinins
J Pharmacol Exp Ther 1993 266: 192-199. [Abstract] [PDF]  

H Mizumoto, A Karasawa, and K Kubo

Diuretic and renal protective effects of 8-(noradamantan-3-yl)-1,3- dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism
J Pharmacol Exp Ther 1993 266: 200-206. [Abstract] [PDF]  

JS Kahle and CW Cotman

L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3- dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices
J Pharmacol Exp Ther 1993 266: 207-215. [Abstract] [PDF]  

C Rundfeldt and W Loscher

Anticonvulsant efficacy and adverse effects of phenytoin during chronic treatment in amygdala-kindled rats
J Pharmacol Exp Ther 1993 266: 216-223. [Abstract] [PDF]  

KT Wilson, Y Xie, MW Musch, and EB Chang

Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon
J Pharmacol Exp Ther 1993 266: 224-230. [Abstract] [PDF]  

K Williams

Effects of Agelenopsis aperta toxins on the N-methyl-D-aspartate receptor: polyamine-like and high-affinity antagonist actions
J Pharmacol Exp Ther 1993 266: 231-236. [Abstract] [PDF]  

SZ Wang and EE el-Fakahany

Application of transfected cell lines in studies of functional receptor subtype selectivity of muscarinic agonists
J Pharmacol Exp Ther 1993 266: 237-243. [Abstract] [PDF]  

M Ekblom, M Hammarlund-Udenaes, and L Paalzow

Modeling of tolerance development and rebound effect during different intravenous administrations of morphine to rats
J Pharmacol Exp Ther 1993 266: 244-252. [Abstract] [PDF]  

DH Wolsing and JS Rosenbaum

The mechanism for the rapid desensitization in bradykinin-stimulated inositol monophosphate production in NG108-15 cells involves interaction of a single receptor with multiple signaling pathways
J Pharmacol Exp Ther 1993 266: 253-261. [Abstract] [PDF]  

TA Deisher, H Narita, P Zera, R Ginsburg, MR Bristow, ME Billingham, MB Fowler, and BB Hoffman

Protective effect of clentiazem against epinephrine-induced cardiac injury in rats
J Pharmacol Exp Ther 1993 266: 262-269. [Abstract] [PDF]  

G Piedimonte, C Bertrand, P Geppetti, RM Snider, MC Desai, and JA Nadel

A new NK1 receptor antagonist (CP-99,994) prevents the increase in tracheal vascular permeability produced by hypertonic saline
J Pharmacol Exp Ther 1993 266: 270-273. [Abstract] [PDF]  

T Jones-Dombi and P Churchill

The baroreceptor mechanism for controlling renin secretion: effect of calcium channel blockers
J Pharmacol Exp Ther 1993 266: 274-278. [Abstract] [PDF]  

D Mohuczy-Dominiak and LC Garg

Alpha-2 adrenoceptors in medullary thick ascending limbs of the rabbit kidney
J Pharmacol Exp Ther 1993 266: 279-287. [Abstract] [PDF]  

JW Lenders, R Kvetnansky, K Pacak, DS Goldstein, IJ Kopin, and G Eisenhofer

Extraneuronal metabolism of endogenous and exogenous norepinephrine and epinephrine in rats
J Pharmacol Exp Ther 1993 266: 288-293. [Abstract] [PDF]  

RB Marala and SJ Mustafa

Direct evidence for the coupling of A2-adenosine receptor to stimulatory guanine nucleotide-binding-protein in bovine brain striatum
J Pharmacol Exp Ther 1993 266: 294-300. [Abstract] [PDF]  

MT Griffin, EA Thomas, and FJ Ehlert

Kinetics of activation and in vivo muscarinic receptor binding of N-(2- bromoethyl)-4-piperidinyl diphenylacetate: an analog of 4-DAMP mustard
J Pharmacol Exp Ther 1993 266: 301-305. [Abstract] [PDF]  

DC Underwood, RR Osborn, LB Novak, JK Matthews, SJ Newsholme, BJ Undem, JM Hand, and TJ Torphy

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram
J Pharmacol Exp Ther 1993 266: 306-313. [Abstract] [PDF]  

JJ Buccafusco, CA Lapp, RS Aronstam, AC Hays, and LC Shuster

Role of prostanoids in the regulation of central cholinergic receptor sensitivity
J Pharmacol Exp Ther 1993 266: 314-322. [Abstract] [PDF]  

ML Adams, B Sewing, JB Forman, ER Meyer, and TJ Cicero

Opioid-induced suppression of rat testicular function
J Pharmacol Exp Ther 1993 266: 323-328. [Abstract] [PDF]  

ET Iwamoto and L Marion

Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats
J Pharmacol Exp Ther 1993 266: 329-338. [Abstract] [PDF]  

SB Penner, DD Smyth, and GB Glavin

Effects of neuropeptide Y and [Leu31,Pro34] neuropeptide Y on experimental gastric lesion formation and gastric secretion in the rat
J Pharmacol Exp Ther 1993 266: 339-343. [Abstract] [PDF]  

T Kanayama, Y Kimura, and S Mizogami

A new prostacyclin analog, KP-10614, inhibits platelet- polymorphonuclear leukocyte interaction and limits experimental infarct size in rat heart
J Pharmacol Exp Ther 1993 266: 344-349. [Abstract] [PDF]  

S Ofori, O Bugnon, and M Schorderet

Agonist-induced desensitization of dopamine D-1 receptors in bovine retina and rat striatum
J Pharmacol Exp Ther 1993 266: 350-357. [Abstract] [PDF]  

J Galitzky, M Reverte, C Carpene, M Lafontan, and M Berlan

Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines
J Pharmacol Exp Ther 1993 266: 358-366. [Abstract] [PDF]  

T Ishine, Y Miyauchi, and MK Uchida

Ca(++)-independent relaxation mediated by beta adrenoceptor in Ca(++)- independent contraction of uterine smooth muscle
J Pharmacol Exp Ther 1993 266: 367-373. [Abstract] [PDF]  

RE Kramer

Effects of diltiazem on calcium metabolism in cultured bovine glomerulosa cells: relationships to the actions of angiotensin II and potassium
J Pharmacol Exp Ther 1993 266: 374-384. [Abstract] [PDF]  

F Knoflach, U Drescher, L Scheurer, P Malherbe, and H Mohler

Full and partial agonism displayed by benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes
J Pharmacol Exp Ther 1993 266: 385-391. [Abstract] [PDF]  

S Chakder and S Rattan

The entire vasoactive intestinal polypeptide molecule is required for the activation of the vasoactive intestinal polypeptide receptor: functional and binding studies on opossum internal anal sphincter smooth muscle
J Pharmacol Exp Ther 1993 266: 392-399. [Abstract] [PDF]  

Y Liu, H Kreppel, J Liu, S Choudhuri, and CD Klaassen

Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein
J Pharmacol Exp Ther 1993 266: 400-406. [Abstract] [PDF]  

GE Billman

Effect of calcium channel antagonists on cocaine-induced malignant arrhythmias: protection against ventricular fibrillation
J Pharmacol Exp Ther 1993 266: 407-416. [Abstract] [PDF]  

BA Fuchs and SB Pruett

Morphine induces apoptosis in murine thymocytes in vivo but not in vitro: involvement of both opiate and glucocorticoid receptors
J Pharmacol Exp Ther 1993 266: 417-423. [Abstract] [PDF]  

BA Sorg, SY Chen, and PW Kalivas

Time course of tyrosine hydroxylase expression after behavioral sensitization to cocaine
J Pharmacol Exp Ther 1993 266: 424-430. [Abstract] [PDF]  

R Hitzemann, Y Qian, and B Hitzemann

Dopamine and acetylcholine cell density in the neuroleptic responsive (NR) and neuroleptic nonresponsive (NNR) lines of mice
J Pharmacol Exp Ther 1993 266: 431-438. [Abstract] [PDF]  

C Legrand, S Mhaouty, C Rigolot, and JP Maltier

Heterogeneity of alpha-2 adrenoceptors in pregnant rat uterus: identification of subtypes and autoradiographic distribution
J Pharmacol Exp Ther 1993 266: 439-449. [Abstract] [PDF]  

RF Kauffman, JS Bean, WE Bloomquist, and ML Cohen

Vascular serotonin 5-hydroxytryptamine2 receptor blockade by LY215840: lack of effect upon neointima formation in balloon-injured rat carotid arteries
J Pharmacol Exp Ther 1993 266: 450-455. [Abstract] [PDF]  

I Findlay

Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle
J Pharmacol Exp Ther 1993 266: 456-467. [Abstract] [PDF]  

MJ Miller, S Chotinaruemol, H Sadowska-Krowikca, XJ Zhang, JA McIntyre, and DA Clark

Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199)
J Pharmacol Exp Ther 1993 266: 468-472. [Abstract] [PDF]  

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