ARTICLES:

PR Farina, AG Graham, CA Homon, ES Lazer, SE Hattox, PS Riska, RH Gundel, and CD Wegner

A prodrug of a 2,6-disubstituted 4-(2-arylethenyl)phenol is a selective and orally active 5-lipoxygenase inhibitor
J Pharmacol Exp Ther 1993 265: 483-489. [Abstract] [PDF]  

M Kageyama, T Yanagisawa, and N Taira

Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanisms, but not activation of ATP-sensitive potassium channels
J Pharmacol Exp Ther 1993 265: 490-497. [Abstract] [PDF]  

S Matsubara, R Matsubara, I Kusumi, T Koyama, and I Yamashita

Dopamine D1, D2 and serotonin2 receptor occupation by typical and atypical antipsychotic drugs in vivo
J Pharmacol Exp Ther 1993 265: 498-508. [Abstract] [PDF]  

JA Nathanson

Identification of octopaminergic agonists with selectivity for octopamine receptor subtypes
J Pharmacol Exp Ther 1993 265: 509-515. [Abstract] [PDF]  

Y Uejima, M Kokubo, J Oshida, H Kawabata, Y Kato, and K Fujii

5-Methyl-4H-3,1-benzoxazin-4-one derivatives: specific inhibitors of human leukocyte elastase
J Pharmacol Exp Ther 1993 265: 516-523. [Abstract] [PDF]  

BE Pichoff, CF Uyehara, and KT Nakamura

Effect of calcium agonists, BAY K 8644 and CGP 28392, on guinea pig airway smooth muscle function during development
J Pharmacol Exp Ther 1993 265: 524-528. [Abstract] [PDF]  

HK Im, WB Im, and K Tsuzuki

Selective block of transient Ca channel current in mouse neuroblastoma cells by U-88779E
J Pharmacol Exp Ther 1993 265: 529-535. [Abstract] [PDF]  

DJ Detweiler, JC Eisenach, C Tong, and C Jackson

A cholinergic interaction in alpha 2 adrenoceptor-mediated antinociception in sheep
J Pharmacol Exp Ther 1993 265: 536-542. [Abstract] [PDF]  

DM Dennis, J Shryock, and L Belardinelli

Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig
J Pharmacol Exp Ther 1993 265: 543-550. [Abstract] [PDF]  

EA Kalso, AF Sullivan, HJ McQuay, AH Dickenson, and BP Roques

Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat
J Pharmacol Exp Ther 1993 265: 551-558. [Abstract] [PDF]  

GJ Grover, S Dzwonczyk, PG Sleph, and CA Sargent

The ATP-sensitive potassium channel blocker glibenclamide (glyburide) does not abolish preconditioning in isolated ischemic rat hearts
J Pharmacol Exp Ther 1993 265: 559-564. [Abstract] [PDF]  

C Yurdaydin, ZQ Gu, G Nowak, C Fromm, AG Holt, and AS Basile

Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy
J Pharmacol Exp Ther 1993 265: 565-571. [Abstract] [PDF]  

R Schreiber and J de Vry

Studies on the neuronal circuits involved in the discriminative stimulus effects of 5-hydroxytryptamine1A receptor agonists in the rat
J Pharmacol Exp Ther 1993 265: 572-579. [Abstract] [PDF]  

MO Urban and DJ Smith

Role of neurotensin in the nucleus raphe magnus in opioid-induced antinociception from the periaqueductal gray
J Pharmacol Exp Ther 1993 265: 580-586. [Abstract] [PDF]  

CD Kurth, C Monitto, ML Albuquerque, P Feuer, E Anday, and L Shaw

Cocaine and its metabolites constrict cerebral arterioles in newborn pigs
J Pharmacol Exp Ther 1993 265: 587-591. [Abstract] [PDF]  

NE Goeders and JE Smith

Intracranial cocaine self-administration into the medial prefrontal cortex increases dopamine turnover in the nucleus accumbens
J Pharmacol Exp Ther 1993 265: 592-600. [Abstract] [PDF]  

SS Hegde and DE Clarke

Characterization of angiotensin receptors mediating the neuromodulatory effects of angiotensin in the vas deferens of the rabbit
J Pharmacol Exp Ther 1993 265: 601-608. [Abstract] [PDF]  

CA Sargent, PG Sleph, S Dzwonczyk, MA Smith, D Normandin, MJ Antonaccio, and GJ Grover

Cardioprotection in ischemic rat hearts with the SH-containing angiotensin-converting enzyme inhibitor zofenopril: possible involvement of the ATP-sensitive potassium channel
J Pharmacol Exp Ther 1993 265: 609-618. [Abstract] [PDF]  

GC Gao and ET Wei

Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury
J Pharmacol Exp Ther 1993 265: 619-625. [Abstract] [PDF]  

GD Nicol

The calcium channel antagonist, pimozide, blocks the cyclic GMP- activated current in rod photoreceptors
J Pharmacol Exp Ther 1993 265: 626-632. [Abstract] [PDF]  

SP Welch

Blockade of cannabinoid-induced antinociception by norbinaltorphimine, but not N,N-diallyl-tyrosine-Aib-phenylalanine-leucine, ICI 174,864 or naloxone in mice
J Pharmacol Exp Ther 1993 265: 633-640. [Abstract] [PDF]  

T Shirayama, K Matsumoto, and AJ Pappano

Carbachol-induced sodium current in guinea pig ventricular myocytes is not regulated by guanine nucleotides
J Pharmacol Exp Ther 1993 265: 641-648. [Abstract] [PDF]  

J Auta, E Romeo, A Kozikowski, D Ma, E Costa, and A Guidotti

Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3- indoleacetamide and imidazopyridine derivatives
J Pharmacol Exp Ther 1993 265: 649-656. [Abstract] [PDF]  

HM Sadeghi and DC Eikenburg

Is sympathetic neurotransmission in the rat mesentery modulated by prejunctional beta adrenoceptors?
J Pharmacol Exp Ther 1993 265: 657-663. [Abstract] [PDF]  

N Jaiswal, EA Tallant, RK Jaiswal, DI Diz, and CM Ferrario

Differential regulation of prostaglandin synthesis by angiotensin peptides in porcine aortic smooth muscle cells: subtypes of angiotensin receptors involved
J Pharmacol Exp Ther 1993 265: 664-673. [Abstract] [PDF]  

C Szabo, JA Mitchell, SS Gross, C Thiemermann, and JR Vane

Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide
J Pharmacol Exp Ther 1993 265: 674-680. [Abstract] [PDF]  

H Takahashi, H Ogata, K Kashiwada, M Ohira, and K Someya

Dosing rate-dependent relationship between propranolol plasma concentration and beta-blockade
J Pharmacol Exp Ther 1993 265: 681-689. [Abstract] [PDF]  

JB Schwartz, IF Troconiz, D Verotta, S Liu, and H Capili

Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil
J Pharmacol Exp Ther 1993 265: 690-698. [Abstract] [PDF]  

LA Merkel, LM Rivera, DJ Colussi, MH Perrone, GJ Smits, and BF Cox

In vitro and in vivo characterization of an A1-selective adenosine agonist, RG14202
J Pharmacol Exp Ther 1993 265: 699-706. [Abstract] [PDF]  

S Hjorth and T Sharp

In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (- )penbutolol
J Pharmacol Exp Ther 1993 265: 707-712. [Abstract] [PDF]  

M Parlani, B Conte, and S Manzini

Nonadrenergic, noncholinergic inhibitory control of the rat external urethral sphincter: involvement of nitric oxide
J Pharmacol Exp Ther 1993 265: 713-719. [Abstract] [PDF]  

JJ Jr Lynch, AA Wallace, LH Van der Gaag, EP Baskin, CM Bear, JR Gehret, T Kothstein, RF Stupienski, SD Appleby, and MC Sanguinetti

Cardiac electrophysiologic and antiarrhythmic actions of 3,4-dihydro-1'- [2-(benzofurazan-5-yl) ethyl]-6-methanesulfonamidospiro [(2H)-1- benzopyran-2,4'-piperidin]-4-one HCl (L-691,121), a novel class III agent
J Pharmacol Exp Ther 1993 265: 720-730. [Abstract] [PDF]  

SL Bramer, JL Au, and MG Wientjes

Gastrointestinal and hepatic first-pass elimination of 2',3'- dideoxyinosine in rats
J Pharmacol Exp Ther 1993 265: 731-738. [Abstract] [PDF]  

S Prisco, A Cagnotto, D Talone, A De Blasi, T Mennini, and E Esposito

Tertatolol, a new beta-blocker, is a serotonin (5-hydroxytryptamine1A) receptor antagonist in rat brain
J Pharmacol Exp Ther 1993 265: 739-744. [Abstract] [PDF]  

Y Noda, S Kurumiya, Y Miura, and M Oka

Comparative study of 2-(4-ethyl-1-piperazinyl)-4-(fluorophenyl)- 5,6,7,8,9, 10-hexahydrocycloocta[b]pyridine (AD-5423) and haloperidol for their pharmacological activities related to antipsychotic efficacy and/or adverse side-effects
J Pharmacol Exp Ther 1993 265: 745-751. [Abstract] [PDF]  

Y Nagakura, M Kadowaki, K Tokoro, M Tomoi, J Mori, and M Kohsaka

Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist
J Pharmacol Exp Ther 1993 265: 752-758. [Abstract] [PDF]  

WB Xiao, A Nordberg, and X Zhang

Effect of in vivo microdialysis of 1,2,3,4-tetrahydro-9-aminoacridine (THA) on the extracellular concentration of acetylcholine in the striatum of anesthetized rats
J Pharmacol Exp Ther 1993 265: 759-764. [Abstract] [PDF]  

G Bonanno and M Raiteri

gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor
J Pharmacol Exp Ther 1993 265: 765-770. [Abstract] [PDF]  

DM Lovinger and Q Zhou

Trichloroethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in nodose ganglion neurons from the adult rat
J Pharmacol Exp Ther 1993 265: 771-776. [Abstract] [PDF]  

ET Iwamoto and L Marion

Adrenergic, serotonergic and cholinergic components of nicotinic antinociception in rats
J Pharmacol Exp Ther 1993 265: 777-789. [Abstract] [PDF]  

Z Han, D Chatterjee, and JH Wyche

Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parental 8-Cl-cyclic AMP
J Pharmacol Exp Ther 1993 265: 790-794. [Abstract] [PDF]  

LA Burns, JA McCay, R Brown, and AE Munson

Arsenic in the sera of gallium arsenide-exposed mice inhibits bacterial growth and increases host resistance
J Pharmacol Exp Ther 1993 265: 795-800. [Abstract] [PDF]  

Y Furukawa, S Takayama, S Sawaki, Y Inoue, and S Chiba

A bradycardic agent, UL-FS 49, increases atrial force and decreases ventricular force in isolated, perfused heart preparations of dogs
J Pharmacol Exp Ther 1993 265: 801-806. [Abstract] [PDF]  

MP Owen

Functional characterization of alpha adrenoceptors on rabbit intrarenal arteries in vitro
J Pharmacol Exp Ther 1993 265: 807-812. [Abstract] [PDF]  

I Elayan, JW Gibb, GR Hanson, HK Lim, RL Foltz, and M Johnson

Short-term effects of 2,4,5-trihydroxyamphetamine, 2,4,5- trihydroxymethamphetamine and 3,4-dihydroxymethamphetamine on central tryptophan hydroxylase activity
J Pharmacol Exp Ther 1993 265: 813-818. [Abstract] [PDF]  

Y Abe, Y Kitada, and A Narimatsu

Effect of MCI-154, a cardiotonic agent, on regional contractile function and myocardial oxygen consumption in the presence and absence of coronary artery stenosis in dogs
J Pharmacol Exp Ther 1993 265: 819-825. [Abstract] [PDF]  

C Cazaubon, J Gougat, F Bousquet, P Guiraudou, R Gayraud, C Lacour, A Roccon, G Galindo, G Barthelemy, and B Gautret

Pharmacological characterization of SR 47436, a new nonpeptide AT1 subtype angiotensin II receptor antagonist
J Pharmacol Exp Ther 1993 265: 826-834. [Abstract] [PDF]  

P Sanchez-Blazquez and J Garzon

N-acetyl beta-endorphin-(1-31) and substance P regulate the supraspinal antinociception mediated by mu opioid and alpha-2 adrenoceptors but not by delta opioid receptors in the mouse
J Pharmacol Exp Ther 1993 265: 835-843. [Abstract] [PDF]  

M Yoshiyama, JR Roppolo, and WC de Groat

Effects of MK-801 on the micturition reflex in the rat--possible sites of action
J Pharmacol Exp Ther 1993 265: 844-850. [Abstract] [PDF]  

K Matsuno, K Matsunaga, T Senda, and S Mita

Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex
J Pharmacol Exp Ther 1993 265: 851-859. [Abstract] [PDF]  

RS Garcha, PS Sever, and AD Hughes

The action of amlodipine on human subcutaneous resistance arteries studied in vitro
J Pharmacol Exp Ther 1993 265: 860-865. [Abstract] [PDF]  

EW Karbon, ME Abreu, RH Erickson, C Kaiser, KJ Jr Natalie, DB Clissold, S Borosky, M Bailey, LA Martin, and MJ Pontecorvo

NPC 16377, a potent and selective sigma-ligand. I. Receptor binding, neurochemical and neuroendocrine profile
J Pharmacol Exp Ther 1993 265: 866-875. [Abstract] [PDF]  

DB Clissold, MJ Pontecorvo, BE Jones, ME Abreu, EW Karbon, RH Erickson, KJ Jr Natalie, S Borosky, T Hartman, and RS Mansbach

NPC 16377, a potent and selective sigma-ligand. II. Behavioral and neuroprotective profile
J Pharmacol Exp Ther 1993 265: 876-886. [Abstract] [PDF]  

MP Owen

Similarities and differences in the postjunctional role for neuropeptide Y in sympathetic vasomotor control of large vs. small arteries of rabbit renal and ear vasculature
J Pharmacol Exp Ther 1993 265: 887-895. [Abstract] [PDF]  

PJ Horan, KD Wild, A Misicka, A Lipkowski, RC Haaseth, VJ Hruby, SJ Weber, TP Davis, HI Yamamura, and F Porreca

Agonist and antagonist profiles of [D-Ala2,Glu4]deltorphin and its [Cys4]- and [Ser4]-substituted derivatives: further evidence of opioid delta receptor multiplicity
J Pharmacol Exp Ther 1993 265: 896-902. [Abstract] [PDF]  

S Foucart, D Bleakman, VP Bindokas, and RJ Miller

Neuropeptide Y and pancreatic polypeptide reduce calcium currents in acutely dissociated neurons from adult rat superior cervical ganglia
J Pharmacol Exp Ther 1993 265: 903-909. [Abstract] [PDF]  

PT Brackley and PN Usherwood

Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA?
J Pharmacol Exp Ther 1993 265: 910-919. [Abstract] [PDF]  

VN Mutafova-Yambolieva, KM Venkova, and LS Lasova

Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens
J Pharmacol Exp Ther 1993 265: 920-926. [Abstract] [PDF]  

B Ault and LM Hildebrand

Activation of nociceptive reflexes by peripheral kainate receptors
J Pharmacol Exp Ther 1993 265: 927-932. [Abstract] [PDF]  

MA Clark, SJ Humphrey, MP Smith, and JH Ludens

Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats
J Pharmacol Exp Ther 1993 265: 933-937. [Abstract] [PDF]  

MI Walton and P Workman

Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice
J Pharmacol Exp Ther 1993 265: 938-947. [Abstract] [PDF]  

JD Kaunitz, Y Nishizaki, K Kaneko, and PH Guth

Effect of orogastric nicotine on rat gastric mucosal gel thickness, surface cell viability and intracellular pH
J Pharmacol Exp Ther 1993 265: 948-954. [Abstract] [PDF]  

EL Lecluyse, SC Sutton, and JA Fix

In vitro effects of long-chain acylcarnitines on the permeability, transepithelial electrical resistance and morphology of rat colonic mucosa
J Pharmacol Exp Ther 1993 265: 955-962. [Abstract] [PDF]  

JM Ackerman, PA Johansen, D Clark, and FJ White

Electrophysiological effects of putative autoreceptor-selective dopamine agonists on A10 dopamine neurons
J Pharmacol Exp Ther 1993 265: 963-970. [Abstract] [PDF]  

LL Howell

Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys
J Pharmacol Exp Ther 1993 265: 971-978. [Abstract] [PDF]  

BH Shapiro, NA Pampori, PA Ram, and DJ Waxman

Irreversible suppression of growth hormone-dependent cytochrome P450 2C11 in adult rats neonatally treated with monosodium glutamate
J Pharmacol Exp Ther 1993 265: 979-984. [Abstract] [PDF]  

AY Valeyev, JL Barker, RA Cruciani, GD Lange, VV Smallwood, and LC Mahan

Characterization of the gamma-aminobutyric acidA receptor-channel complex composed of alpha 1 beta 2 and alpha 1 beta 3 subunits from rat brain
J Pharmacol Exp Ther 1993 265: 985-991. [Abstract] [PDF]  

JL Renfro, MA Brown, SL Parker, and LE Hightower

Relationship of thermal and chemical tolerance to transepithelial transport by cultured flounder renal epithelium
J Pharmacol Exp Ther 1993 265: 992-1000. [Abstract] [PDF]  

HE Criswell, KB Johnson, RA Mueller, and GR Breese

Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats
J Pharmacol Exp Ther 1993 265: 1001-1010. [Abstract] [PDF]  

AN Lopatin and CG Nichols

2,3-Butanedione monoxime (BDM) inhibition of delayed rectifier DRK1 (Kv2.1) potassium channels expressed in Xenopus oocytes
J Pharmacol Exp Ther 1993 265: 1011-1016. [Abstract] [PDF]  

Y Tamura, Y Sato, T Yokota, A Akaike, M Sasa, and S Takaori

Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons
J Pharmacol Exp Ther 1993 265: 1017-1025. [Abstract] [PDF]  

YT Shen and SF Vatner

Effects of a K+ATP channel opener, lemakalim, on systemic, coronary and regional vascular dynamics in conscious dogs: comparison with nifedipine, adenosine, nitroglycerin and acetylcholine
J Pharmacol Exp Ther 1993 265: 1026-1037. [Abstract] [PDF]  

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