ARTICLES:

DS Houston and PM Vanhoutte

Comparison of serotonergic receptor subtypes on the smooth muscle and endothelium of the canine coronary artery
J Pharmacol Exp Ther 1988 244: 1-10. [Abstract] [PDF]  

DD Schwartz and DC Eikenburg

Enhanced endogenous neurotransmitter overflow in the isolated perfused rat kidney after chronic epinephrine administration: lack of a prejunctional beta adrenoceptor influence
J Pharmacol Exp Ther 1988 244: 11-18. [Abstract] [PDF]  

V Gisclard, VM Miller, and PM Vanhoutte

Effect of 17 beta-estradiol on endothelium-dependent responses in the rabbit
J Pharmacol Exp Ther 1988 244: 19-22. [Abstract] [PDF]  

BJ Aungst, NJ Rogers, and E Shefter

Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption promoter
J Pharmacol Exp Ther 1988 244: 23-27. [Abstract] [PDF]  

SP Welch, CW Cooper, and WL Dewey

An investigation of the antinociceptive activity of calcitonin gene- related peptide alone and in combination with morphine: correlation to 45Ca++ uptake by synaptosomes
J Pharmacol Exp Ther 1988 244: 28-33. [Abstract] [PDF]  

PM Beardsley and RL Balster

Evaluation of antagonists of the discriminative stimulus and response rate effects of phencyclidine
J Pharmacol Exp Ther 1988 244: 34-40. [Abstract] [PDF]  

WS Lai and EE el-Fakahany

Regulation of [3H]phorbol-12,13-dibutyrate binding sites in mouse neuroblastoma cells: simultaneous down-regulation by phorbol esters and desensitization of their inhibition of muscarinic receptor function
J Pharmacol Exp Ther 1988 244: 41-50. [Abstract] [PDF]  

WD Winters, AJ Hance, GG Cadd, DD Quam, and JL Benthuysen

Ketamine- and morphine-induced analgesia and catalepsy. I. Tolerance, cross-tolerance, potentiation, residual morphine levels and naloxone action in the rat
J Pharmacol Exp Ther 1988 244: 51-57. [Abstract] [PDF]  

PL Wood, DJ Steel, HS Kim, B Petrack, and CA Altar

Inhibition of climbing and mossy fiber input to mouse cerebellar Purkinje cells by cholecystokinin
J Pharmacol Exp Ther 1988 244: 58-62. [Abstract] [PDF]  

CW Stevens, MS Monasky, and TL Yaksh

Spinal infusion of opiate and alpha-2 agonists in rats: tolerance and cross-tolerance studies
J Pharmacol Exp Ther 1988 244: 63-70. [Abstract] [PDF]  

DW Hay, RM Muccitelli, KA Wilson, MA Wasserman, and TJ Torphy

Functional antagonism by salbutamol suggests differences in the relative efficacies and dissociation constants of the peptidoleukotrienes in guinea pig trachea
J Pharmacol Exp Ther 1988 244: 71-78. [Abstract] [PDF]  

SF Gonsalves and DW Gallager

Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration
J Pharmacol Exp Ther 1988 244: 79-83. [Abstract] [PDF]  

PJ Kadowitz, WM Armstead, PY Roland, AL Hyman, and HL Lippton

Inhibitory effects of diltiazem on vasoconstrictor responses in the cat
J Pharmacol Exp Ther 1988 244: 84-90. [Abstract] [PDF]  

Z Gregus, C Madhu, and CD Klaassen

Species variation in toxication and detoxication of acetaminophen in vivo: a comparative study of biliary and urinary excretion of acetaminophen metabolites
J Pharmacol Exp Ther 1988 244: 91-99. [Abstract] [PDF]  

PJ Gengo, N Bowling, VL Wyss, and JS Hayes

Effects of prolonged phenylephrine infusion on cardiac adrenoceptors and calcium channels
J Pharmacol Exp Ther 1988 244: 100-105. [Abstract] [PDF]  

ML Cohen, RW Fuller, KD Kurz, CJ Parli, NR Mason, DB Meyers, JK Smallwood, and RE Toomey

Preclinical pharmacology of a new serotonergic receptor antagonist, LY281067
J Pharmacol Exp Ther 1988 244: 106-112. [Abstract] [PDF]  

GF Rush, D Alberts, S Lupo, LA Yodis, TH Brown, and GJ Durant

Toxicity of H2-receptor antagonists to isolated rat hepatocytes: structure-activity relationships
J Pharmacol Exp Ther 1988 244: 113-117. [Abstract] [PDF]  

SJ Grossman and DJ Jollow

Role of dapsone hydroxylamine in dapsone-induced hemolytic anemia
J Pharmacol Exp Ther 1988 244: 118-125. [Abstract] [PDF]  

WK Bickel, ML Stitzer, IA Liebson, and GE Bigelow

Acute physical dependence in man: effects of naloxone after brief morphine exposure
J Pharmacol Exp Ther 1988 244: 126-132. [Abstract] [PDF]  

GH Caughey, F Leidig, NF Viro, and JA Nadel

Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase
J Pharmacol Exp Ther 1988 244: 133-137. [Abstract] [PDF]  

WM Armstead, R Mirro, CW Leffler, and DW Busija

The role of prostanoids in the mediation of responses to KC-404, a novel cerebrovasodilator
J Pharmacol Exp Ther 1988 244: 138-143. [Abstract] [PDF]  

SJ Offord, GA Ordway, and A Frazer

Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat
J Pharmacol Exp Ther 1988 244: 144-153. [Abstract] [PDF]  

DD Gillespie, DH Manier, E Sanders-Bush, and F Sulser

The serotonin/norepinephrine-link in brain. II. Role of serotonin in the regulation of beta adrenoceptors in the low agonist affinity conformation
J Pharmacol Exp Ther 1988 244: 154-159. [Abstract] [PDF]  

TM Reilly, PC Wong, WA Price, and PB Timmermans

Characterization of the functional antagonism and antihypertensive activity displayed by a monoclonal antibody to angiotensin II
J Pharmacol Exp Ther 1988 244: 160-165. [Abstract] [PDF]  

TA Slotkin, B Levant, L Orband-Miller, KL Queen, and S Stasheff

Do sympathetic neurons coordinate cellular development in the heart and kidney? Effects of neonatal central and peripheral catecholaminergic lesions on cardiac and renal nucleic acids and proteins
J Pharmacol Exp Ther 1988 244: 166-172. [Abstract] [PDF]  

F Ruff, JF Zander, Y Edoute, MC Santais, NA Flavahan, TJ Verbeuren, and PM Vanhoutte

Beta-2 adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves
J Pharmacol Exp Ther 1988 244: 173-180. [Abstract] [PDF]  

LJ Ignarro, RE Byrns, GM Buga, KS Wood, and G Chaudhuri

Pharmacological evidence that endothelium-derived relaxing factor is nitric oxide: use of pyrogallol and superoxide dismutase to study endothelium-dependent and nitric oxide-elicited vascular smooth muscle relaxation
J Pharmacol Exp Ther 1988 244: 181-189. [Abstract] [PDF]  

JG Gerber and NA Payne

Endogenous adenosine modulates gastric acid secretion to histamine in canine parietal cells
J Pharmacol Exp Ther 1988 244: 190-194. [Abstract] [PDF]  

JW Simpkins, M Smulkowski, R Dixon, and R Tuttle

Evidence for the delivery of narcotic antagonists to the colon as their glucuronide conjugates
J Pharmacol Exp Ther 1988 244: 195-205. [Abstract] [PDF]  

TP Kenakin and PJ Novak

Classification of phenoxybenzamine/prazosin-resistant contractions of rat spleen to norepinephrine by Schild analysis: similarities and differences to postsynaptic alpha-2 adrenoceptors
J Pharmacol Exp Ther 1988 244: 206-212. [Abstract] [PDF]  

R Pohorecki, R Head, and EF Domino

Effects of selected muscarinic cholinergic antagonists on [3H]acetylcholine release from rat hippocampal slices
J Pharmacol Exp Ther 1988 244: 213-217. [Abstract] [PDF]  

NM Porter, M Radulovacki, and RD Green

Desensitization of adenosine and dopamine receptors in rat brain after treatment with adenosine analogs
J Pharmacol Exp Ther 1988 244: 218-225. [Abstract] [PDF]  

KP Minneman, GK Mumford, and PW Abel

High efficiency coupling of alpha-1 adrenergic receptors to inositol phospholipid metabolism revealed by denervation of rat vas deferens
J Pharmacol Exp Ther 1988 244: 226-230. [Abstract] [PDF]  

HC Porchet, NL Benowitz, and LB Sheiner

Pharmacodynamic model of tolerance: application to nicotine
J Pharmacol Exp Ther 1988 244: 231-236. [Abstract] [PDF]  

JM Moerschbaecher, C Devia, and C Brocklehurst

Differential antagonism by naltrexone of the effects of opioids on a fixed-ratio discrimination in rats
J Pharmacol Exp Ther 1988 244: 237-246. [Abstract] [PDF]  

JC Eisenach

Intravenous clonidine produces hypoxemia by a peripheral alpha-2 adrenergic mechanism
J Pharmacol Exp Ther 1988 244: 247-252. [Abstract] [PDF]  

IJ Weinstein, LB Hough, and KR Gogas

Cross-tolerance and cross-sensitization between morphine analgesia and naloxone-sensitive and cimetidine-sensitive stress-induced analgesia
J Pharmacol Exp Ther 1988 244: 253-258. [Abstract] [PDF]  

G Babany, RE Morris, I Babany, and RE Kates

Evaluation of the in vivo dose-response relationship of immunosuppressive drugs using a mouse heart transplant model: application to cyclosporine
J Pharmacol Exp Ther 1988 244: 259-262. [Abstract] [PDF]  

FA Redegeld, GA Hofman, and J Noordhoek

Conjugative clearance of 1-naphthol and disposition of its glucuronide and sulfate conjugates in the isolated perfused rat kidney
J Pharmacol Exp Ther 1988 244: 263-267. [Abstract] [PDF]  

WE Mol, GN Fokkema, B Weert, and DK Meijer

Mechanisms for the hepatic uptake of organic cations. Studies with the muscle relaxant vecuronium in isolated rat hepatocytes
J Pharmacol Exp Ther 1988 244: 268-275. [Abstract] [PDF]  

TJ Verbeuren, FH Jordaens, H Bult, and AG Herman

The endothelium inhibits the penetration of serotonin and norepinephrine in the isolated canine saphenous vein
J Pharmacol Exp Ther 1988 244: 276-282. [Abstract] [PDF]  

F Ballet, Y Chretien, C Rey, and R Poupon

Differential response of normal and cirrhotic liver to vasoactive agents. A study in the isolated perfused rat liver
J Pharmacol Exp Ther 1988 244: 283-289. [Abstract] [PDF]  

A Ogbaghebriel and PE Dresel

Effects of cytochalasin-B and phloretin on digitalis inotropy
J Pharmacol Exp Ther 1988 244: 290-296. [Abstract] [PDF]  

N Toda, S Inoue, K Bian, and T Okamura

Endothelium-dependent and independent responses to prostaglandin H2 and arachidonic acid in isolated dog cerebral arteries
J Pharmacol Exp Ther 1988 244: 297-302. [Abstract] [PDF]  

T Nabeshima, A Katoh, and T Kameyama

Inhibition of enkephalin degradation attenuated stress-induced motor suppression (conditioned suppression of motility)
J Pharmacol Exp Ther 1988 244: 303-309. [Abstract] [PDF]  

JE Leysen, A Eens, W Gommeren, P van Gompel, J Wynants, and PA Janssen

Identification of nonserotonergic [3H]ketanserin binding sites associated with nerve terminals in rat brain and with platelets; relation with release of biogenic amine metabolites induced by ketanserin- and tetrabenazine-like drugs
J Pharmacol Exp Ther 1988 244: 310-321. [Abstract] [PDF]  

JF Brien, BE McLaughlin, SM Kobus, JH Kawamoto, K Nakatsu, and GS Marks

Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta
J Pharmacol Exp Ther 1988 244: 322-327. [Abstract] [PDF]  

JH Kawamoto, JF Brien, GS Marks, and K Nakatsu

Mechanism of glyceryl trinitrate-induced vasodilation. II. Lack of evidence for specific binding of GTN to bovine pulmonary vein
J Pharmacol Exp Ther 1988 244: 328-334. [Abstract] [PDF]  

K Yokotani, K Yokotani, Y Okuma, and Y Osumi

Sympathoadrenomedullary system mediation of the prostaglandin E2- induced central inhibition of gastric acid output in rats
J Pharmacol Exp Ther 1988 244: 335-340. [Abstract] [PDF]  

PL van Giersbergen and W de Jong

Antagonism by naltrexone of the hypotension and bradycardia induced by alpha-methyldopa in conscious normotensive rats
J Pharmacol Exp Ther 1988 244: 341-347. [Abstract] [PDF]  

A Lukas and GR Ferrier

Electrophysiological effects of amrinone and milrinone in an isolated canine cardiac tissue model of ischemia and reperfusion
J Pharmacol Exp Ther 1988 244: 348-354. [Abstract] [PDF]  

M Hagiwara, M Inagaki, K Kanamura, H Ohta, and H Hidaka

Inhibitory effects of aminoglycosides on renal protein phosphorylation by protein kinase C
J Pharmacol Exp Ther 1988 244: 355-360. [Abstract] [PDF]  

RN Mascardo and G Eilon

The cysteine protease inhibitor, E-64, stimulates the polarization and locomotor responses of endothelial cells to wounding
J Pharmacol Exp Ther 1988 244: 361-367. [Abstract] [PDF]  

JP O'Callaghan and DB Miller

Acute exposure of the neonatal rat to triethyltin results in persistent changes in neurotypic and gliotypic proteins
J Pharmacol Exp Ther 1988 244: 368-378. [Abstract] [PDF]  

KW Gee, RE Brinton, and BS McEwen

Regional distribution of a Ro5 4864 binding site that is functionally coupled to the gamma-aminobutyric acid/benzodiazepine receptor complex in rat brain
J Pharmacol Exp Ther 1988 244: 379-383. [Abstract] [PDF]  

MJ Panzenbeck, W Tan, MA Hajdu, and IH Zucker

Prostaglandins mediate the increased sensitivity of left ventricular reflexes after captopril treatment in conscious dogs
J Pharmacol Exp Ther 1988 244: 384-390. [Abstract] [PDF]  

EB De Souza, WK Schmidt, and MJ Kuhar

Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic
J Pharmacol Exp Ther 1988 244: 391-402. [Abstract] [PDF]  

RN Willette, S Morrison, HN Sapru, and DJ Reis

Stimulation of opiate receptors in the dorsal pontine tegmentum inhibits reflex contraction of the urinary bladder
J Pharmacol Exp Ther 1988 244: 403-409. [Abstract] [PDF]  

SR Wachtel and FJ White

Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies
J Pharmacol Exp Ther 1988 244: 410-416. [Abstract] [PDF]  

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