Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Synthesis of AAK1 inhibitors
Supplemental References
Supplemental Figure 1 - LP-935509 is a potent inhibitor of AAK1 in enzyme and cellular assays
Supplemental Figure 2 - LP-935509 is an ATP competitive inhibitor of AAK1
Supplemental Figure 3 - BIKE knockout mice have a modest antinociceptive phenotype in the mouse SNL model
Supplemental Figure 4 - Pharmacokinetics of LP-935509 in mice
Supplemental Figure 5 - Pharmacokinetics of LP-935509 in rats
Supplemental Figure 6 - Gabapentin dose-response shows little separation between antineuropathic efficacy and motor impairment on rotarod
Supplemental Table 1 - Ambit results for LP-935509
Supplemental Table 2 - Liability screen results for LP-935509
Supplemental Table 3 - Drug levels for in vivo experiments
Supplemental Table 4 - Drug levels for animals used in study in Fig. 7B
Supplemental Table 5 - Drug levels for animals used in study in Fig. 9B
Supplemental Table 6 - Drug levels for satellite animals for Fig. 5(A)