Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

Data Supplement

Files in this Data Supplement:

Data Supplement - Fig. S1. Targeted disruption of the Tph1 gene locus. A. Targeting strategy to replace exon 3 with the selection cassette. �X� depicts the homologous recombination event. B. Southern blot analysis using a 5�external probe to confirm the proper targeted band after SpeI digestion of ES cell genomic DNA.
Data Supplement - Supplemental Data Table 1. Comparison of 5-HT levels in Tph1 wild-type (+/+), heterozygous (+/-), and homozygous null (-/-) mice. ...
Data Supplement - Supplemental Data Table 2. Comparison of urinary parameters in Tph1 wild-type (+/+) and homozygous null (-/-) mice...
Data Supplement - Supplemental Data Table 3. Change of 5-HT levels in the intestine and brain following administration of LP-533401...
Data Supplement - Supplemental Data Table 4. Change of 5-HT levels in the intestine and the brain following administration of pCPA and LP-615819...
Data Supplement - Supplemental Data Table 5. Change of 5-HT levels in the intestine and the brain following administration of LP-615819...
Data Supplement - Supplemental Data Table 6. Effect of LP-615819 on cisplatin-induced emesis in the ferret...