VX-765, an orally available selective interleukin converting enzyme (ICE)/caspase-1 inhibitor exhibits potent anti-inflammatory activities by inhibiting the release of IL-1b and IL-18

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  Figure 1. Dose response curve for VRT-043198 (triangles) in hypoxia-induced apoptosis in NT2 cells. NT2 cells were incubated with 100% N2 at 37�C for 18 h in the presence or absence of compound�

  Figure 2. Dose response curve for VRT-043198 (triangles) and Vertex�s pancaspase inhibitor (circles) in anti-Fas antibody-induced apoptosis in Jurkat cells�