Abstract
Young, growing rats and puppies were fed on diets favorable for the absorption and retention of calcium and phosphorus. The vitamin D content of the diets was supplemented with irradiated ergosterol, and doses up to one thousand times the minimum effective dose of vitamin D were administered. Growth curves, calcium and phosphorus metabolism in rats, x-rays of the dogs, blood analyses for calcium and phosphorus, histology of the dog tissues, and calcium analyses on the tissues have been studied. No indications of toxic effects were obtained within the range of dosage used in these studies. We conclude that when the vitamin content of the diet is complete and adequate, an increase of the vitamin D intake in normal, growing rats and dogs, up to one thousand times the minimum effective dose produces no effect upon growth, calcium and phosphorus metabolism, blood calcium or phosphorus, or upon the histological structure or calcium content of the tissues.
Footnotes
- Received May 13, 1929.
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