Abstract
Cultured methylcholanthrene-transformed 3T3 mouse fibroblasts secrete large amounts of prostaglandin into the medium. Prostaglandin biosynthesis by these cells can be stimulated by arachidonic acid and, to a much lesser extent, by glutathione and porphyrin. In the presence of hydroquinone, prostaglandin production is increased; the most striking increases are seen at concentrations that are lethal. Porphyrins, when added to cells in the presence of lethal levels of hydroquinone, inhibit stimulation of prostaglandin E2 synthesis but stimulate the production of prostaglandin F2alpha.
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