Abstract
This paper examines the influence of pyridoxine (PYD) and pyridoxal phosphate (PYP) on convulsions induced by hyperbaric oxygen (OHP) and the potentiation of those convulsions by hydrazinopropionic acid (HPA) and aminooxyacetic acid (AOAA). Neither PYD nor PYP altered the incidence of convulsions in animals exposed to OHP alone or after pretreatment with HPA or AOAA. PYD, however, caused a further significant reduction in the time to onset of convulsions in HPA-treated animals exposed to OHP. PYD increased the OHP-induced decline in γ-aminobutyric acid (GABA), while PYP tended to oppose it. PYP caused a reversal of the GABA increase due to HPA and AOAA in OHP-exposed animals, but not in HPA-treated animals which were not exposed. Once again, changes in GABA levels were found to be independent of the toxic effects of OHP.
Footnotes
- Received November 12, 1973.
- Accepted March 22, 1974.
- © 1974 by The Williams & Wilkins Co.
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