Abstract
The influence of infusion of angiotensin, prostaglandin F2a, and cocaine on venoconstrictor responses to sympathetic nerve stimulation and norepinephrine was evaluated in the constant flow pump-perfused saphenous vein preparation of the dog. Infusion of angiotensin, 02 µ/min, increased mean arterial pressure but had no effect on saphenous vein perfusion pressure. Venoconstrictor responses to sympathetic nerve stimulation were enhanced, whereas responses to norepinephrine were not altered. Cocaine, 2 µg/min, and prostaglandin F2a 1 µg/min, had no effect on arterial pressure or saphenous vein perfusion pressure but markedly enhanced responses of the saphenous vein to both sympathetic nerve stimulation and injected norepinephrine. These studies indicate that angiotensin and prostaglandin F2a potentiate the response of the saphenous vein to sympathetic nerve stimulation by a different mechanism and suggest that both substances possess the capacity to act as modulators of adrenergic neurotransmission in venous smooth muscle.
Footnotes
- Received July 8, 1970.
- Accepted September 29, 1970.
- © 1971, by The Williams & Wilkins Company
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