Abstract
An extension of the series of analogs reported previously is presented. The fact that simple dimethylalkylammonium groups could maintain hemicholinium-3-like activity is demonstrated. The dimethylallyl derivative was the most active alkyl group studied, being one-half as active as hemicholinium-3. Maximum activity was expected for a group three carbons in length with one double bond (i.e., allyl group) since this grouping most resembles the 3-methyl-pyridinium system which was shown previously to be highly active. It was also shown that addition of a second methyl group to the 3-methylpyridinium system, regardless of position, decreased activity. From this it was concluded that the geometric aspects of the receptor for the 3-methylpyridinium analog are highly specific.
Footnotes
- Received January 23, 1969.
- Accepted April 1, 1969.
- © 1969 by The Williams & Wilkins Co.
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