Abstract
The vascular responses of the isolated perfused rat liver to epinephrine were found to be very similar to that organ's response in vivo, namely a prompt and (lose-dependent vaso-constriction which reduces blood flow. This effect of epinephrine could be blocked or reversed by dihydroergotamine. By contrast, drug-induced potassium and glucose losses from the perfused organ are slow and are less than those which might be expected from this organ in vivo.
Footnotes
- Accepted April 21, 1965.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.