Abstract
The response of an infra-annelid metazoan to agents which affect acetylcholine systems in more advanced organisms has been studied. Most notably, acetylcholine reversibly blocks egg deposition by the bdelloid rotifer Philodina acuticornis at an ED50 concentration of 6 x 10-5 M; no other gross functional or structural effects were noted up to lethal concentrations, 6 x 10-2 M. Physostigmine and neostigmine neither blocked egg deposition nor augmented the effect of acetylcholine; on the contrary, these two drugs, as well as atropine, tubocurarine, succinylcholine, and local anesthetics, decreased the egg retention produced by acetylcholine.
Footnotes
- Accepted July 24, 1964.
- The Williams & Wilkins Comapny
JPET articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.